Sirtuins and their Biological Relevance in Aging and Age-Related Diseases

Zhao Lijun, Cao Jianzhong, Hu Kexin, He Xiaodong, Yun Dou, Tong Tanjun, Han Limin

Table 1 The location and enzymatic catalytic activity of sirtuins.

Sirtuin Class localization Enzymatic activity Sirt1 I Nuclear/Cytosolic Deacetylase,Deacylase Sirt2 I Nuclear/Cytosolic Deacetylase, Deacylase Sirt3 I Mitochondrial/ Nuclear/Cytosolic Deacetylase, Decrotonylase Sirt4 II Mitochondrial Deacetylase, ADP-ribosyltransferase, Lipoamidase, Deacylase Sirt5 III Mitochondrial/ Nuclear/Cytosolic Deacetylase, Desuccinylase, Demalonylase, Deglutarylase Sirt6 IV Nuclear/Cytosolic Deacetylase,Demyristoylase, ADP-ribosyltransferase, Deacylase Sirt7 IV Nucleolar/nuclear Deacetylase, Desuccinylase