Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis

Barć Krzysztof, Szacka Katarzyna, Nieporęcki Krzysztof, de Carvalho Mamede, Gromicho Marta, Grosskreutz Julian, Petri Susanne, Rödiger Annekathrin, Steinbach Robert, Uysal Hilmi, Kuźma-Kozakiewicz Magdalena

Table 4 Binary predictors of faster progression of the disease.

Predictor ALSFRS-R decline rate (median) n p-value* Disease onset Bulbar Limb 0.70 0.48 312 833 <0.0001 Gender Female Male 0.62 0.49 507 638 <0.0001 Initial weight loss1 Yes No 0.71 0.47 200 945 <0.0001 Cognition impairment at onset Yes No 0.58 0.54 134 1011 =0.30