Emotional Lability at Disease Onset Is an Independent Prognostic Factor of Faster Disease Progression in Amyotrophic Lateral Sclerosis

Barć Krzysztof, Szacka Katarzyna, Nieporęcki Krzysztof, de Carvalho Mamede, Gromicho Marta, Grosskreutz Julian, Petri Susanne, Rödiger Annekathrin, Steinbach Robert, Uysal Hilmi, Kuźma-Kozakiewicz Magdalena

Table 5 Multiple regression analysis for the predictors of faster ALSFRS-R decline rate.

Predictor Unstandardized coefficients Standardized coefficients t-value p-value Emotional lability at onset 0.199 0.071 2.342 0.019 Gender 0.086 0.041 1.421 0.156 Site of onset 0.115 0.050 1.650 0.099 Initial weight loss 0.041 0.075 2.580 0.010 Diagnostic delay 0.010 0.260 9.008 <0.001 Age 0.009 0.108 3.686 <0.001 Cognitive impairment at onset 0.041 0.037 1.243 0.214