Roles of Biomarkers in Myocardial Fibrosis

Ding Yuejia, Wang Yuan, Zhang Wanqin, Jia Qiujin, Wang Xiaoling, Li Yanyang, Lv Shichao, Zhang Junping

Table 2 Biomarkers of myocardial fibrosis (gene transcription).

MiRNA Study condition Pathway Main findings Reference miR-21 AS patients RECK,PDCD4, and TGF-β Predicts myocardial collagen expression [121] MI mice Jagged1 CFs?myofibroblasts transformation↑, myocardial fibrosis ↑ [122] Cardiac allograft transplantation model PTEN/AP-1 pathway Fibrosis gene program ↑, monocytes-fibroblasts transformation ↑ [123] LVNC paitients — Plasma miR-21, miR-29a, miR-30d and miR-133a↑ [124] miR-29 Pathological hypertrophy model — Cardiac miR-29a, mir-29c ↓ [127] Cardiac hypertrophy mice — Prevented Col1a1, Col1a2 and Col3a1 expression [128] miR-1 Myocardial hypertrophy model FBLN2 Cardiac remodeling ↓ [129] miR-378 TAC rats Paracrine mechanisms Cardiac fibrosis ↓ [130] miR-203 DCM rats PI3K/Akt signaling pathway Prevented cardiac Col I, Col III expression [131] miR-135a Cardiac hypertrophy model TGF-β/Smads pathway Associated with the α-SMA and Co I [132] miR-135a, miR-202-3p, miR-122, miR-195 and miR-328 Fibrosis model TGFβ1 signaling pathway Involved in the progression and development of myocardial fibrosis [132-136] miR-197-5P HF patients — miR-197-5P↑, associated with adverse cardiac events [138] miR-208, miR-499 AMI paitients — Mediates cardioblasts?cardiomyocytes transformation and muscle fiber specification [139] miR-101, miR-150 MI rats — Cardiac miR-101 and miR-150 ↓ [140-141] miR-144 MI model — miR-144 deletion: cardiac collagen content ↑, cardiac function ↓ [142] miR-101a MI rats — Intermittent aerobic exercise: cardiac miR-101a ↑ [143]