Relationships between Mitochondrial Dysfunction and Neurotransmission Failure in Alzheimer’s Disease

Wong Kan Yin, Roy Jaydeep, Fung Man Lung, Heng Boon Chin, Zhang Chengfei, Lim Lee Wei

Table 2 Common mitochondrial dysfunctions associated with neurotransmission in Alzheimer’s disease.

Mitochondrial dysfunctions Acetylcholine Serotonin Dopamine Norepinephrine Histamine TCA cycle disturbance ++ + N.A. N.A. +? ETC impairment +? + + + +? Oxidative stress +? +? +? + + mtDNA damage N.A. N.A. + + +? Ca2+ dysregulation + N.A. N.A. + + Morphological change N.A. N.A. + + N.A. Transportation dysfunction N.A. + +? N.A. N.A. Membrane permeabilisation ++ + +? ++ +?