Oxidative Stress at the Crossroads of Aging, Stroke and Depression

Shao Anwen, Lin Danfeng, Wang Lingling, Tu Sheng, Lenahan Cameron, Zhang Jianmin

Table 2 Antioxidants in Depression.

Antioxidants Anti-OS activity Mechanism of anti-OS activity and others Depression bay 60-7550 anti-OS downregulate gp91phox; activate the cAMP/cGMP-pVASP-CREB-BDNF signaling pathway p-chloro-diphenyl diselenide modulate glutamate neurotransmission homocysteine inhibit ROS by activating NMDA receptors vitamin D suppress OS 2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucopyranoside anti-OS; anti-inflammation reduce proinflammatory factors; restore the diminished Akt signaling pathway; faciliate astrocyte proliferation and neurogenesis vorinostat modulate NF-κB p65, COX-2 and phosphorylated JNK levels melatonin inhibit OS and inflammation naringenin iptakalim silymarin resveratrol honokiol oxytocin vanillin trigonelline quercetin α-tocopherol baicalin selenium-containing compounds ketamine increase glutamate release; affect energy metabolism mitochondrial uncoupling protein 2 anti-OS; anti-inflammation; anti-apoptosis downregulate the activation of NLRP3 inflammasome; suppress the ROS-TXNIP-NLRP3 pathway in astrocytes dl-3-n-butylphthalide inhibit OS, inflammatory responses and apoptosis indole-3-carbinol 25-methoxyhispidol A allicin reduce neuroinflammation, OS, iron overaccumulation; inhibit neuronal apoptosis in the hippocampus AVLE suppress the apoptosis of hippocampus cells via regulation of Bcl-2/Bax pathways