The Critical Role of SIRT1 in Parkinson’s Disease: Mechanism and Therapeutic Considerations

Li Xuan, Feng Ya, Wang Xi-Xi, Truong Daniel, Wu Yun-Cheng

Table 1 Established biochemical and functional features of human sirtuins.

Function Sub-cellular localization Key targets References SIRT1 Deacetylase Nucleus Cytoplasm p53, NF-κB, IL-6, PARP-1, PPAR-γ, PGC-1α, FOXO, IGF-I,AP-1, HIF-1α [16-25] SIRT2 Deacetylase Cytoplasm α-tubulin, histone H4 [26, 27] SIRT3 Deacetylase Mitochondria Acetyl-CoA acetyltransferase, FOXO3, isocitrate dehydrogenase, NADH dehydrogenase, Ku70 [28-31] SIRT4 ADP-ribosyltransferase Mitochondria Malonyl-CoA decarboxylase [32] SIRT5 Deacetylase Mitochondria Cytochrome c, carbamoyl phosphate synthase [33, 34] SIRT6 Deacetylase ADP-ribosyltransferase Nucleus HIF-1α, c-Myc [35, 36] SIRT7 Deacetylase Nucleus Enzymes of nucleic acid metabolism, p53 [37, 38]