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Aging and Disease    2015, Vol. 6 Issue (1) : 38-47     DOI: 10.14336/AD.2014.0128
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Dizziness and Imbalance in the Elderly: Age-related Decline in the Vestibular System
Shinichi Iwasaki, Tatsuya Yamasoba
Department of Otolaryngology, Faculty of Medicine, University of Tokyo, Tokyo, Japan
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Abstract  

Dizziness and imbalance are amongst the most common complaints in older people, and are a growing public health concern since they put older people at a significantly higher risk of falling. Although the causes of dizziness in older people are multifactorial, peripheral vestibular dysfunction is one of the most frequent causes. Benign paroxysmal positional vertigo is the most frequent form of vestibular dysfunction in the elderly, followed by Meniere’s disease. Every factor associated with the maintenance of postural stability deteriorates during aging. Age-related deterioration of peripheral vestibular function has been demonstrated through quantitative measurements of the vestibulo-ocular reflex with rotational testing and of the vestibulo-collic reflex with testing of vestibular evoked myogenic potentials. Age-related decline of vestibular function has been shown to correlate with the age-related decrease in the number of vestibular hair cells and neurons. The mechanism of age-related cellular loss in the vestibular endorgan is unclear, but it is thought that genetic predisposition and cumulative effect of oxidative stress may both play an important role. Since the causes of dizziness in older people are multi-factorial, management of this disease should be customized according to the etiologies of each individual. Vestibular rehabilitation is found to be effective in treating both unilateral and bilateral vestibular dysfunction. Various prosthetic devices have also been developed to improve postural balance in older people. Although there have been no medical treatments improving age-related vestibular dysfunction, new medical treatments such as mitochondrial antioxidants or caloric restriction, which have been effective in preventing age-related hearing loss, should be ienvestigated in the future.

Keywords aging      vestibular      fall      rehabilitation     
Corresponding Authors: Shinichi Iwasaki   
Issue Date: 01 February 2015
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Shinichi Iwasaki
Tatsuya Yamasoba
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Shinichi Iwasaki,Tatsuya Yamasoba. Dizziness and Imbalance in the Elderly: Age-related Decline in the Vestibular System[J]. Aging and Disease, 2015, 6(1): 38-47.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0128     OR     http://www.aginganddisease.org/EN/Y2015/V6/I1/38
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