Aging and disease

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Total 40 results are found

New Insights into the Roles and Mechanisms of Spermidine in Aging and Age-Related Diseases Yu-Qing Ni, You-Shuo Liu: 2021, 12 (8): 1948-1963 | DOI: 10.14336/AD.2021.0603; PDF (645KB)

Effects of Ketogenic Diet on Neuroinflammation in Neurodegenerative Diseases Ziying Jiang, Xi Yin, Miao Wang, Tong Chen, Yuanyuan Wang, Zhongbao Gao, Zhenfu Wang: 2022, 13 (4): 1146-1165 | DOI: 10.14336/AD.2021.1217; PDF (808KB)

Functions of Gut Microbiota Metabolites, Current Status and Future Perspectives Juan Liu, Yuzhu Tan, Hao Cheng, Dandan Zhang, Wuwen Feng, Cheng Peng: 2022, 13 (4): 1106-1126 | DOI: 10.14336/AD.2022.0104; PDF (1455KB)

Pharmacology and Potential Implications of Nicotinamide Adenine Dinucleotide Precursors Jing She, Rui Sheng, Zheng-Hong Qin: 2021, 12 (8): 1879-1897 | DOI: 10.14336/AD.2021.0523; PDF (621KB)

Identifying Dynamic Patterns of Polypharmacy for Patients with Dementia from Primary Care Electronic Health Records: A Machine Learning Driven Longitudinal Study Elisabetta Longo, Bruce Burnett, Sarah Bauermeister, Shang-Ming Zhou: 2023, 14 (2): 548-559 | DOI: 10.14336/AD.2022.0829; PDF (732KB)
Supplement; 1. Supplementary data.pdf (1432KB)

Depression and Dementia in Older Adults: A Neuropsychological Review Syuichi Tetsuka: 2021, 12 (8): 1920-1934 | DOI: 10.14336/AD.2021.0526; PDF (543KB)

Pathogeneses and Imaging Features of Cerebral White Matter Lesions of Vascular Origins Xiaoqin Wu, Jingyuan Ya, Da Zhou, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (8): 2031-2051 | DOI: 10.14336/AD.2021.0414; PDF (1249KB)

Extension of the Life Span by Acarbose: Is It Mediated by the Gut Microbiota? Baiyun Wu, Jiai Yan, Ju Yang, Yanping Xia, Dan Li, Feng Zhang, Hong Cao: 2022, 13 (4): 1005-1014 | DOI: 10.14336/AD.2022.0117; PDF (535KB)

A Unique Type of Highly-Activated Microglia Evoking Brain Inflammation via Mif/Cd74 Signaling Axis in Aged Mice Chenghao Jin, Yijie Shao, Xiaotao Zhang, Jiani Xiang, Ruize Zhang, Zeyu Sun, Shuhao Mei, Jingyi Zhou, Jianmin Zhang, Ligen Shi: 2021, 12 (8): 2125-2139 | DOI: 10.14336/AD.2021.0520; PDF (2051KB)
Supplement; 1. Supplementary data.pdf (1992KB)

The Effect of COVID-19-related Lockdowns on Diet and Physical Activity in Older Adults: A Systematic Review Elisabeth Anne Larson, Karlen Stade Bader-Larsen, Faidon Magkos: 2021, 12 (8): 1935-1947 | DOI: 10.14336/AD.2021.0606; PDF (772KB)

Mechanisms of Short-Chain Fatty Acids Derived from Gut Microbiota in Alzheimer's Disease Xiao-hang Qian, Ru-yan Xie, Xiao-li Liu, Sheng-di Chen, Hui-dong Tang: 2022, 13 (4): 1252-1266 | DOI: 10.14336/AD.2021.1215; PDF (642KB)

SIRT6 in Aging, Metabolism, Inflammation and Cardiovascular Diseases Zhenyang Guo, Peng Li, Junbo Ge, Hua Li: 2022, 13 (6): 1787-1822 | DOI: 10.14336/AD.2022.0413; PDF (2013KB)
Supplement; 1. Supplementary data.pdf (527KB)

Three Outbreaks of COVID-19 in a Single Nursing Home over Two Years of the SARS-CoV-2 Pandemic Vladan Čokić, Zorana Popovska, Olivera Lijeskić, Ljiljana Šabić, Olgica Djurković-Djaković: 2023, 14 (1): 99-111 | DOI: 10.14336/AD.2022.0624; PDF (821KB)

SIRT6 in Vascular Diseases, from Bench to Bedside Si-Chong Ren, Xiangqi Chen, Hui Gong, Han Wang, Chuan Wu, Pei-Heng Li, Xiao-Feng Chen, Jia-Hua Qu, Xiaoqiang Tang: 2022, 13 (4): 1015-1029 | DOI: 10.14336/AD.2021.1204; PDF (1325KB)

Extracellular Matrix Dynamics as an Emerging yet Understudied Hallmark of Aging and Longevity Cyril Statzer, Ji Young Cecilia Park, Collin Y Ewald: 2023, 14 (3): 670-693 | DOI: 10.14336/AD.2022.1116; PDF (1130KB)

Single-Cell RNA-Seq Reveals a Population of Smooth Muscle Cells Responsible for Atherogenesis Xiaofeng Shi, Shangming Zhu, Meijing Liu, Sara Saymuah Stone, Yao Rong, Ke Mao, Xiaopeng Xu, Chao Ma, Zhuoyuan Jiang, Yan Zha, Chun Yan, Xiaofan Yu, Di Wu, Guiyou Liu, Jidong Mi, Jianping Zhao, Yuan Li, Yuchuan Ding, Xiaogang Wang, Yong-Biao Zhang, Xunming Ji: 2022, 13 (6): 1939-1953 | DOI: 10.14336/AD.2022.0313; PDF (1594KB)

Melatonin as an Antioxidant Agent in Stroke: An Updated Review Junjie Wang, Shiqi Gao, Cameron Lenahan, Yichen Gu, Xiaoyu Wang, Yuanjian Fang, Weilin Xu, Haijian Wu, Yuanbo Pan, Anwen Shao, Jianmin Zhang: 2022, 13 (6): 1823-1844 | DOI: 10.14336/AD.2022.0405; PDF (679KB)

Cell Heterogeneity Uncovered by Single-Cell RNA Sequencing Offers Potential Therapeutic Targets for Ischemic Stroke Min Qiu, Jia-bin Zong, Quan-wei He, Yu-xiao Liu, Yan Wan, Man Li, Yi-fan Zhou, Jie-hong Wu, Bo Hu: 2022, 13 (5): 1436-1454 | DOI: 10.14336/AD.2022.0212; PDF (970KB)

The safety and efficacy of Ezetimibe Plus Statins on ASVD and Related Diseases Shuling Wan, Yuchuan Ding, Xunming Ji, Ran Meng: 2021, 12 (8): 1857-1871 | DOI: 10.14336/AD.2021.0412; PDF (604KB)

COVID-19 Pandemic and Osteoporosis in Elderly Patients Jun Tang: 2022, 13 (4): 960-969 | DOI: 10.14336/AD.2021.1201; PDF (418KB)

Serum from Older Adults Increases Apoptosis and Molecular Aging Markers in Human Hippocampal Progenitor Cells Chiara de Lucia, Tytus Murphy, Aleksandra Maruszak, Paul Wright, Timothy R Powell, Naomi Hartopp, Simone de Jong, Michael J O'Sullivan, Gerome Breen, Jack Price, Simon Lovestone, Sandrine Thuret: 2021, 12 (8): 2151-2172 | DOI: 10.14336/AD.2021.0409; PDF (1600KB)
Supplement; 1. Supplementary data.pdf (1416KB)

Mitochondrial Quality Control in Sarcopenia: Updated Overview of Mechanisms and Interventions Di Liu, Yi-bin Fan, Xiao-hua Tao, Wei-li Pan, Yu-xiang Wu, Xiu-hua Wang, Yu-qiong He, Wen-feng Xiao, Yu-sheng Li: 2021, 12 (8): 2016-2030 | DOI: 10.14336/AD.2021.0427; PDF (565KB)

Effect Of Exercise on Muscle Mass, Fat Mass, Bone Mass, Muscular Strength and Physical Performance in Community Dwelling Older Adults: Systematic Review and Meta-Analysis Alejandra González-Rocha, Lucia Mendez-Sanchez, María Araceli Ortíz-Rodríguez, Edgar Denova-Gutiérrez: 2022, 13 (5): 1421-1435 | DOI: 10.14336/AD.2022.0215; PDF (1149KB)
Supplement; 1. Supplementary data.pdf (960KB)

Metformin's Mechanisms in Attenuating Hallmarks of Aging and Age-Related Disease Fang-Fang Cheng, Yan-Li Liu, Jang Du, Jun-Tang Lin: 2022, 13 (4): 970-986 | DOI: 10.14336/AD.2021.1213; PDF (529KB)

Stem Cell Transplantation for Parkinson’s Disease: Current Challenges and Perspectives Xinlin Zeng, Hua Qin: 2022, 13 (6): 1652-1663 | DOI: 10.14336/AD.2022.0312; PDF (573KB)

Crosstalk between Lipid Rafts and Aging: New Frontiers for Delaying Aging Shuo Zhang, Neng Zhu, Jia Gu, Hong-Fang Li, Yun Qiu, Duan-Fang Liao, Li Qin: 2022, 13 (4): 1042-1055 | DOI: 10.14336/AD.2022.0116; PDF (637KB)

Roles of Ependymal Cells in the Physiology and Pathology of the Central Nervous System Shiyu Deng, Lin Gan, Chang Liu, Tongtong Xu, Shiyi Zhou, Yiyan Guo, Zhijun Zhang, Guo-Yuan Yang, Hengli Tian, Yaohui Tang: 2023, 14 (2): 468-483 | DOI: 10.14336/AD.2022.0826-1; PDF (754KB)

Longevity-Associated Transcription Factor ATF7 Promotes Healthspan by Suppressing Cellular Senescence and Systematic Inflammation Yaqun Huang, Ming-Xia Ge, Yu-Hong Li, Jing-Lin Li, Qin Yu, Fu-Hui Xiao, Hong-Shun Ao, Li-Qin Yang, Ji Li, Yonghan He, Qing-Peng Kong: | DOI: 10.14336/AD.2022.1217; PDF (1830KB)
Supplement; 1. Supplementary data.pdf (633KB)

Dysfunction of the Blood-brain Barrier in Cerebral Microbleeds: from Bedside to Bench Hai-ling Wang, Chun-lin Zhang, Yan-mei Qiu, An-qi Chen, Ya-nan Li, Bo Hu: 2021, 12 (8): 1898-1919 | DOI: 10.14336/AD.2021.0514; PDF (798KB)

The Applications of Focused Ultrasound (FUS) in Alzheimer’s Disease Treatment: A Systematic Review on Both Animal and Human Studies Xiaodan Liu, S. Sta Maria Naomi, Wu Lin Sharon, E. Jacobs Russell: 2021, 12 (8): 1977-2002 | DOI: 10.14336/AD.2021.0510; PDF (751KB)

Potential Crosstalk Between Parkinson's Disease and Energy Metabolism Meiqiu Liu, Qian Jiao, Xixun Du, Mingxia Bi, Xi Chen, Hong Jiang: 2021, 12 (8): 2003-2015 | DOI: 10.14336/AD.2021.0422; PDF (633KB)

Role of the cGAS-STING Pathway in Aging-related Endothelial Dysfunction Huilin Yu, Ke Liao, Yu Hu, Dingyi Lv, Minghao Luo, Qian Liu, Longxiang Huang, Suxin Luo: 2022, 13 (6): 1901-1918 | DOI: 10.14336/AD.2022.0316; PDF (2568KB)

Intestinal Inflammation and Parkinson’s Disease Yu Li, Yuanyuan Chen, Lili Jiang, Jingyu Zhang, Xuhui Tong, Dapeng Chen, Weidong Le: 2021, 12 (8): 2052-2068 | DOI: 10.14336/AD.2021.0418; PDF (1013KB)

Long RNA Profiles of Human Brain Extracellular Vesicles Provide New Insights into the Pathogenesis of Alzheimer’s Disease Dan Luo, Haotian Liu, Hanyou Liu, Wei Wu, Hanyang Zhu, Wei Ge, Chao Ma: 2023, 14 (1): 229-244 | DOI: 10.14336/AD.2022.0607; PDF (2525KB)
Supplement; 1. Supplementary data.pdf (1286KB); 2. Supplementary data.pdf (1891KB); 3. Supplementary data.pdf (1891KB)

The Added Value of Vessel Wall MRI in the Detection of Intraluminal Thrombus in Patients Suspected of Craniocervical Artery Dissection Yuehong Liu, Sijie Li, Ye Wu, Fang Wu, Ying Chang, Haibin Li, Xiuqin Jia, Luca Saba, Xunming Ji, Qi Yang, on behalf of the WISP Investigators: 2021, 12 (8): 2140-2150 | DOI: 10.14336/AD.2021.0502; PDF (904KB)
Supplement; 1. Supplementary data.pdf (86KB)

Effectiveness and Safety of Traditional Chinese Medicine in Treating COVID-19: Clinical Evidence from China Dongmei Xing, Zhibin Liu: 2021, 12 (8): 1850-1856 | DOI: 10.14336/AD.2021.0906; PDF (264KB)

Gene Therapy Strategies Targeting Aging-Related Diseases Jingyu Yu, Tianwen Li, Jianhong Zhu: 2023, 14 (2): 398-417 | DOI: 10.14336/AD.2022.00725; PDF (858KB)

The Metabolic Landscape in Osteoarthritis Xiaoxin Wu, Xiwei Fan, Ross Crawford, Yin Xiao, Indira Prasadam: 2022, 13 (4): 1166-1182 | DOI: 10.14336/AD.2021.1228; PDF (1194KB)

Targeting the Hepatic Microenvironment to Improve Ischemia/Reperfusion Injury: New Insights into the Immune and Metabolic Compartments Fengqiang Gao, Xun Qiu, Kai Wang, Chuxiao Shao, Wenjian Jin, Zhen Zhang, Xiao Xu: 2022, 13 (4): 1196-1214 | DOI: 10.14336/AD.2022.0109; PDF (843KB)

Activated or Impaired: An Overview of DNA Repair in Neurodegenerative Diseases Nan Qin, Anke Geng, Renhao Xue: 2022, 13 (4): 987-1004 | DOI: 10.14336/AD.2021.1212; PDF (843KB)

Cover Illustration

17 May 2023. VOL 14, ISSUE 3
Figure 6. Proliferative basal cells are found in low number in aged patients with lung pathology in the exchange zone. Representative IF pictures of p16^INK4A/Ki67/p63 and merged pictures with DAPI counterstaining in aged pathology cases with dysplastic airway-like structures. Scale bar: 25μm.

[Detail]

Cover Illustration

Figure 6. Proliferative basal cells are found in low number in aged patients with lung pathology in the exchange zone. Representative IF pictures of p16^INK4A/Ki67/p63 and merged pictures with DAPI counterstaining in aged pathology cases with dysplastic airway-like structures. Scale bar: 25μm.