Aging and disease

Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett: 2025, 16 (3): 1732-1754 | DOI: 10.14336/AD.2024.0642; PDF (1507KB)
Supplement; 1. Supplementary data.pdf (6754KB)

Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin: 2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1; PDF (451KB)

AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov: | DOI: 10.14336/AD.2024.1492; PDF (1558KB)
Supplement; 1. Supplementary data.pdf (1198KB); 2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang: 2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071; PDF (1253KB)

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy: 2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286; PDF (1120KB)

Consequences of Aging on Bone Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao: 2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115; PDF (1209KB)

Inflammatory Pathogenesis of Post-stroke Depression Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin: 2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203; PDF (1207KB)

A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression? Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong: | DOI: 10.14336/AD.2023.1227; PDF (1082KB)

Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng: | DOI: 10.14336/AD.2024.1515; PDF (493KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva: 2025, 16 (3): 1242-1264 | DOI: 10.14336/AD.2024.0526; PDF (1188KB)

Vascular Aging and Atherosclerosis: A Perspective on Aging Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong: 2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1; PDF (810KB)

Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen: 2025, 16 (3): 1363-1377 | DOI: 10.14336/AD.2024.0012; PDF (615KB)

LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation Fedor Galkin, Feng Ren, Alex Zhavoronkov: | DOI: 10.14336/AD.2024.1697; PDF (899KB)

Involvement of Inheritance in Determining Telomere Length beyond Environmental and Lifestyle Factors Naheemat Modupeola Gold, Michael Ngozi Okeke, Yonghan He: 2024, 15 (6): 2470-2490 | DOI: 10.14336/AD.2023.1023; PDF (671KB)

Causality of Aging Hallmarks Bilu Huang, Xiaowen Hu: | DOI: 10.14336/AD.2025.0541; PDF (597KB)

Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu: 2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206; PDF (943KB)

Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis Aleksandra Mamchur, Natalia Sharashkina, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Elena Zelenova, Eva Shelly, Valentina Ostapenko, Irina Dzhumaniiazova, Lorena Matkava, Vladimir Yudin, Anna Akopyan, Irina Strazhesko, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Anton Keskinov, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin: 2025, 16 (1): 565-577 | DOI: 10.14336/AD.2024.0120; PDF (1073KB)
Supplement; 1. Supplementary data.pdf (684KB)

Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He: 2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065; PDF (1049KB)

Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies Yonglian Chen, Jinhui Wu: 2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407; PDF (635KB)

ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis Ruiyi Yan, Xiao Zhang, Wenlong Xu, Jiayao Li, Yixin Sun, Shengyan Cui, Ran Xu, Wenjing Li, Liqun Jiao, Tao Wang: 2025, 16 (1): 250-268 | DOI: 10.14336/AD.2024.0309; PDF (905KB)

Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang: 2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083; PDF (1129KB)

Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review Hyeon soo Kim, Haram Jung, Yong Ho Park, Su-Hak Heo, Sujin Kim, Minho Moon: 2025, 16 (2): 901-916 | DOI: 10.14336/AD.2024.0406; PDF (639KB)

Aging Gut Microbiome in Healthy and Unhealthy Aging Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han: 2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331; PDF (1158KB)

Senescent T Cells in Age-Related Diseases Pei-Jie Yu, Mei Zhou, Yan Liu, Jie Du: 2025, 16 (1): 321-344 | DOI: 10.14336/AD.2024.0219; PDF (722KB)

Aging and “Age-Related” Diseases - What Is the Relation? Wolfgang Kopp: 2025, 16 (3): 1316-1346 | DOI: 10.14336/AD.2024.0570; PDF (802KB)

Cellular Aging and Senescence in Cancer: A Holistic Review of Cellular Fate Determinants Muhammad Tufail, Yu-Qi Huang, Jia-Ju Hu, Jie Liang, Cai-Yun He, Wen-Dong Wan, Can-Hua Jiang, Hong Wu, Ning Li: 2025, 16 (3): 1483-1512 | DOI: 10.14336/AD.2024.0421; PDF (1028KB)

Therapeutic Potential of Quercetin as an Antioxidant for Bone-Muscle-Tendon Regeneration and Aging Jae Gyu Kim, Ashish Ranjan Sharma, Yeon-Hee Lee, Srijan Chatterjee, Yean Jung Choi, Roshani Rajvansh, Chiranjib Chakraborty, Sang-Soo Lee: 2025, 16 (3): 1414-1437 | DOI: 10.14336/AD.2024.0282; PDF (696KB)

Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen: 2025, 16 (2): 1059-1079 | DOI: 10.14336/AD.2024.0162; PDF (2552KB)
Supplement; 1. Supplementary data.pdf (275KB)

Recent Advances in Our Understanding of Age-Related Macular Degeneration: Mitochondrial Dysfunction, Redox Signaling, and the Complement System Francesco Buonfiglio, Christina A. Korb, Bernhard Stoffelns, Norbert Pfeiffer, Adrian Gericke: 2025, 16 (3): 1535-1575 | DOI: 10.14336/AD.2024.0124; PDF (1735KB)

Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal: 2025, 16 (5): 3055-3068 | DOI: 10.14336/AD.2024.0754; PDF (713KB)
Supplement; 1. Supplementary data.pdf (534KB)

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu: | DOI: 10.14336/AD.2024.1495; PDF (931KB)

Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat: 2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1; PDF (1706KB)
Supplement; 1. Supplementary data.pdf (290KB)

Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis Camila Cerna, Nicole Vidal-Herrera, Francisco Silva-Olivares, Daniela Álvarez, Camila González-Arancibia, Miltha Hidalgo, Pabla Aguirre, José González-Urra, Camila Astudillo-Guerrero, Michel Jara, Omar Porras, Gonzalo Cruz, Christian Hodar, Paola Llanos, Pamela Urrutia, Claudia Ibacache-Quiroga, Yulia Nevzorova, Francisco Javier Cubero, Marco Fuenzalida, Samanta Thomas-Valdés, Gonzalo Jorquera: | DOI: 10.14336/AD.2024.1089; PDF (1541KB)
Supplement; 1. Supplementary data.pdf (902KB)

Cerebellum and Aging: Update and Challenges Christopher L. McElroy, Brian Wang, Hongxia Zhang, Kunlin Jin: 2024, 15 (6): 2345-2360 | DOI: 10.14336/AD.2024.0220; PDF (440KB)

A Combination Study of Pre- and Clinical Trial: Seaweed Consumption Reduces Aging-Associated Muscle Loss! Jimin Hyun, Sang Yeoup Lee, Bomi Ryu, You-Jin Jeon: 2024, 15 (6): 2813-2827 | DOI: 10.14336/AD.2023.0927; PDF (1362KB)
Supplement; 1. Supplementary data.pdf (765KB)

Exercise-Induced Central Fatigue: Biomarkers and Non-Medicinal Interventions Ying Yang, Zhi Feng, Yu-hang Luo, Jue-miao Chen, Yu Zhang, Yi-jun Liao, Hui Jiang, Yinxi Long, Bo Wei: 2025, 16 (3): 1302-1315 | DOI: 10.14336/AD.2024.0567; PDF (469KB)

Over-the-Counter Anti-inflammatory Supplements for Adjunctive Rheumatoid Arthritis Therapy: A Comprehensive Narrative Review Saliba Fares, Mourad Omar, Aoun Laurence, Saif Abu-Baker, Almardini Shaza, Haddadin Fadi, Mina Jonathan, Khattar Georges, Sangaraju Koushik, Bou Sanayeh Elie, Morcos Zeina, Habib Toni, Al Saidi Ibrahim, Slobodnick Anastasia: 2025, 16 (1): 408-422 | DOI: 10.14336/AD.2024.0131; PDF (581KB)