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2023
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Total 40 results are found
Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training
Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett
| DOI: 10.14336/AD.2024.0642
Supplement

1. Supplementary data.pdf (6754KB)

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals
Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, Rajpaul Attariwala
2024, 15 (4): 1831-1842 | DOI: 10.14336/AD.2023.0820
Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin
2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1
Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions
Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec, Maryam Farzaneh, Amir Anbiyaiee, Uzma Zaheer, Shahab Uddin, Mohadeseh Sheykhi-Sabzehpoush, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty
| DOI: 10.14336/AD.2024.0280
Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43
Jianxing Song
2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118
AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
| DOI: 10.14336/AD.2024.1492
Supplement

1. Supplementary data.pdf (1198KB)

2. TNIK Senomorphic Video.mp4.mp4 (14113KB)

Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function
Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao, Kay Jann, John M Ringman, Hanzhang Lu, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T Gold, Pauline Maillard, Claudia L Satizabal, Elyas Fadaee, Mohamad Habes, Lara Stables, Herpreet Singh, Bruce Fischl, Andre van der Kouwe, Kristin Schwab, Karl G Helmer, Steven M Greenberg, Danny J.J Wang, for the MarkVCID Consortium
2024, 15 (4): 1885-1898 | DOI: 10.14336/AD.2023.0321-2
Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model
Alison Basel, Sanat S. Bhadsavle, Katherine Z. Scaturro, Grace K. Parkey, Matthew N. Gaytan, Jai J. Patel, Kara N. Thomas, Michael C. Golding
| DOI: 10.14336/AD.2024.0722
Supplement

1. Supplementary data.pdf (1015KB)

The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
| DOI: 10.14336/AD.2024.1071
Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy
2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286
Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults
Tsubasa Tomoto, Rong Zhang
2024, 15 (4): 1672-1687 | DOI: 10.14336/AD.2023.1109-1
Engineered Mitochondrial Transplantation as An Anti-Aging Therapy
Rui Zhao, Chen Dong, Qian Liang, Jianlin Gao, Chi Sun, Zhifeng Gu, Yujuan Zhu
| DOI: 10.14336/AD.2024.0231
A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression?
Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong
| DOI: 10.14336/AD.2023.1227
Inflammatory Pathogenesis of Post-stroke Depression
Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin
2025, 16 (1): 209-238 | DOI: 10.14336/AD.2024.0203
A Framework for an Effective Healthy Longevity Clinic
Sergey Mironov, Olga Borysova, Ivan Morgunov, Zhongjun Zhou, Alexey Moskalev
| DOI: 10.14336/AD.2024.0328-1
Supplement

1. Supplementary data.pdf (502KB)

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease
Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis
2024, 15 (4): 1688-1725 | DOI: 10.14336/AD.2023.0814
Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances
Qianting Deng, Chongyun Wu, Emily Parker, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang
2024, 15 (4): 1537-1564 | DOI: 10.14336/AD.2023.0907
Tryptophan Metabolism in Alzheimer’s Disease with the Involvement of Microglia and Astrocyte Crosstalk and Gut-Brain Axis
Lushuang Xie, Qiaofeng Wu, Kelin Li, Mohammed A. S. Khan, Andrew Zhang, Bharati Sinha, Sihui Li, Sulie L. Chang, David L. Brody, Mark W. Grinstaff, Shuanhu Zhou, Gil Alterovitz, Pinghua Liu, Xin Wang
2024, 15 (5): 2168-2190 | DOI: 10.14336/AD.2024.0134
Brain Insulin Signaling is Associated with Late-Life Cognitive Decline
Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis
2024, 15 (5): 2205-2215 | DOI: 10.14336/AD.2023.1117
Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis
Aleksandra Mamchur, Natalia Sharashkina, Veronika Erema, Daria Kashtanova, Mikhail Ivanov, Maria Bruttan, Elena Zelenova, Eva Shelly, Valentina Ostapenko, Irina Dzhumaniiazova, Lorena Matkava, Vladimir Yudin, Anna Akopyan, Irina Strazhesko, Lilit Maytesyan, Irina Tarasova, Olga Beloshevskaya, Anton Keskinov, Sergey Kraevoy, Olga Tkacheva, Sergey Yudin
2025, 16 (1): 565-577 | DOI: 10.14336/AD.2024.0120
Supplement

1. Supplementary data.pdf (684KB)

Consequences of Aging on Bone
Lingli Zhang, Qiao Guan, Zhikun Wang, Jie Feng, Jun Zou, Bo Gao
2024, 15 (6): 2417-2452 | DOI: 10.14336/AD.2023.1115
Aging and Sex Differences in Brain Volume and Cerebral Blood Flow
Hiroto Kawano, Shigeki Yamada, Yoshiyuki Watanabe, Satoshi Ii, Tomohiro Otani, Hirotaka Ito, Ko Okada, Chifumi Iseki, Motoki Tanikawa, Shigeo Wada, Marie Oshima, Mitsuhito Mase, Kazumichi Yoshida
2024, 15 (5): 2216-2229 | DOI: 10.14336/AD.2023.1122
Supplement

1. Supplementary data movie-1.mp4 (19073KB)

2. Supplementary data.pdf (181KB)

3. Supplementary data movie-2.mp4 (875KB)

Alzheimer Disease Pathology and Neurodegeneration in Midlife Obesity: A Pilot Study
Mahsa Dolatshahi, Paul K Commean, Farzaneh Rahmani, Jingxia Liu, LaKisha Lloyd, Caitlyn Nguyen, Nancy Hantler, Maria Ly, Gary Yu, Joseph E Ippolito, Claude Sirlin, John C Morris, Tammie L.S Benzinger, Cyrus A Raji
2024, 15 (4): 1843-1854 | DOI: 10.14336/AD.2023.0707
Supplement

1. Supplementary data.pdf (178KB)

Deformability of Heterogeneous Red Blood Cells in Aging and Related Pathologies
Dmitry S. Prudinnik, Aigul Kussanova, Ivan A. Vorobjev, Alexander Tikhonov, Fazly I. Ataullakhanov, Natasha S. Barteneva
| DOI: 10.14336/AD.2024.0526
Expert Consensus on the Application of Stem Cells in Psoriasis Research and Clinical Trials
Ye-Hong Kuang, Wu Zhu, Ge Lin, La-Mei Cheng, Qun Qin, Zhi-Jun Huang, Yu-Ling Shi, Chun-Lei Zhang, Jin-Hua Xu, Ke-Xiang Yan, Cheng-Zhi Lv, Wei Li, Qin Han, Ilia Stambler, Lee Wei Lim, Sasanka Chakrabarti, Brun Ulfhake, Kyung-Jin Min, Georgina Ellison-Hughes, William C Cho, Kunlin Jin, Danni Yao, Chuanjian Lu, Robert Chunhua Zhao, Xiang Chen
| DOI: 10.14336/AD.2024.0012
Physical Exercise Counteracts Aging-Associated White Matter Demyelination Causing Cognitive Decline
Tanya H. Butt, Makoto Tobiume, Diane B. Re, Shingo Kariya
2024, 15 (5): 2136-2148 | DOI: 10.14336/AD.2024.0216
Lactylation: An Innovative Approach to Disease Control
Xiaoxin Jiang, Yanyan Yang, Xiaolu Li, Tianxiang Li, Tao Yu, Xiuxiu Fu
| DOI: 10.14336/AD.2024.0918
Vascular Aging and Atherosclerosis: A Perspective on Aging
Shudong Ma, Xuena Xie, Rong Yuan, Qiqi Xin, Yu Miao, Sean Xiao Leng, Keji Chen, Weihong Cong
2025, 16 (1): 33-48 | DOI: 10.14336/AD.2024.0201-1
A Combination Study of Pre- and Clinical Trial: Seaweed Consumption Reduces Aging-Associated Muscle Loss!
Jimin Hyun, Sang Yeoup Lee, Bomi Ryu, You-Jin Jeon
2024, 15 (6): 2813-2827 | DOI: 10.14336/AD.2023.0927
Supplement

1. Supplementary data.pdf (765KB)

Association of Plasma Markers of Alzheimer’s Disease, Neurodegeneration, and Neuroinflammation with the Choroid Plexus Integrity in Aging
Mustapha Bouhrara, Keenan A. Walker, Joseph S. R. Alisch, Zhaoyuan Gong, Caio H. Mazucanti, Alexandria Lewis, Abhay R. Moghekar, Lisa Turek, Victoria Collingham, Nader Shehadeh, Giovanna Fantoni, Mary Kaileh, Christopher M. Bergeron, Jan Bergeron, Susan M. Resnick, Josephine M. Egan
2024, 15 (5): 2230-2240 | DOI: 10.14336/AD.2023.1226
Senescent T Cells in Age-Related Diseases
Pei-Jie Yu, Mei Zhou, Yan Liu, Jie Du
2025, 16 (1): 321-344 | DOI: 10.14336/AD.2024.0219
Ovariectomy and High Fat-Sugar-Salt Diet Induced Alzheimer's Disease/Vascular Dementia Features in Mice
Sahar Sweetat, Moti Ben Shabat, Paschalis Theotokis, Nir Suissa, Eleni Karafoulidou, Olga Touloumi, Rami Abu-Fanne, Oded Abramsky, Gilly Wolf, Ann Saada, Amit Lotan, Nikolaos Grigoriadis, Hanna Rosenmann
2024, 15 (5): 2284-2300 | DOI: 10.14336/AD.2024.03110
The Role of Circadian Rhythm in Neurological Diseases: A Translational Perspective
Wanbin Huang, Jiabin Zong, Yu Zhang, Yanjie Zhou, Lily Zhang, Yajuan Wang, Zhengming Shan, Qingfang Xie, Ming Li, Songqing Pan, Zheman Xiao
2024, 15 (4): 1565-1587 | DOI: 10.14336/AD.2023.0921
Glial Cell Activation and Immune Responses in Glaucoma: A Systematic Review of Human Postmortem Studies of the Retina and Optic Nerve
Akanksha Salkar, Roshana Vander Wall, Devaraj Basavarajappa, Nitin Chitranshi, Gabriella E. Parilla, Mehdi Mirzaei, Peng Yan, Stuart Graham, Yuyi You
2024, 15 (5): 2069-2083 | DOI: 10.14336/AD.2024.0103
Supplement

1. Supplementary data.pdf (245KB)

PNA5, A Novel Mas Receptor Agonist, Improves Neurovascular and Blood-Brain-Barrier Function in a Mouse Model of Vascular Cognitive Impairment and Dementia
Christina Hoyer-Kimura, Meredith Hay, John P Konhilas, Helena W Morrison, Methawasin Methajit, Joshua Strom, Robin Polt, Victoria Salcedo, Joshua P Fricks, Anjna Kalya, Paulo W Pires
2024, 15 (4): 1927-1951 | DOI: 10.14336/AD.2023.0928
Genomic Insights into Dementia: Precision Medicine and the Impact of Gene-Environment Interaction
Anjali Tripathi, Vinay Kumar Pandey, Garima Sharma, Ashish Ranjan Sharma, Anam Taufeeq, Abhimanyu Kumar Jha, Jin-Chul Kim
2024, 15 (5): 2113-2135 | DOI: 10.14336/AD.2024.0322
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He
2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065
Targeting Cellular Senescence in Aging and Age-Related Diseases: Challenges, Considerations, and the Emerging Role of Senolytic and Senomorphic Therapies
Liyao Zheng, Shipei He, Hong Wang, Jinling Li, Yuanyuan Liu, Sijia Liu
2024, 15 (6): 2554-2594 | DOI: 10.14336/AD.2024.0206
ROS-Induced Endothelial Dysfunction in the Pathogenesis of Atherosclerosis
Ruiyi Yan, Xiao Zhang, Wenlong Xu, Jiayao Li, Yixin Sun, Shengyan Cui, Ran Xu, Wenjing Li, Liqun Jiao, Tao Wang
2025, 16 (1): 250-268 | DOI: 10.14336/AD.2024.0309
Current Advances and Future Perspectives on Mesenchymal Stem Cell-Derived Extracellular Vesicles in Alzheimer's Disease
Wenjing Zhang, Russell Uyemura, Kun Zhong, Rui Guo, Li Zhong
2024, 15 (5): 2015-2027 | DOI: 10.14336/AD.2023.1206