Aging and disease

Long-Term Improvement in Hippocampal-Dependent Learning Ability in Healthy, Aged Individuals Following High Intensity Interval Training Daniel G. Blackmore, Mia A. Schaumberg, Maryam Ziaei, Samuel Belford, Xuan Vinh To, Imogen O’Keeffe, Anne Bernard, Jules Mitchell, Emily Hume, Grace L. Rose, Thomas Shaw, Ashley York, Markus Barth, Elizabeth J. Cooper, Tina L. Skinner, Fatima Nasrallah, Stephan Riek, Perry F. Bartlett: | DOI: 10.14336/AD.2024.0642; PDF (1498KB)
Supplement; 1. Supplementary data.pdf (6754KB)

Visceral and Subcutaneous Abdominal Fat Predict Brain Volume Loss at Midlife in 10,001 Individuals Cyrus A Raji, Somayeh Meysami, Sam Hashemi, Saurabh Garg, Nasrin Akbari, Ahmed Gouda, Yosef Gavriel Chodakiewitz, Thanh Duc Nguyen, Kellyann Niotis, David A Merrill, Rajpaul Attariwala: 2024, 15 (4): 1831-1842 | DOI: 10.14336/AD.2023.0820; PDF (1480KB)

Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu: 2024, 15 (2): 565-583 | DOI: 10.14336/AD.2023.0519-1; PDF (1183KB)

Molecular Mechanisms of Phase Separation and Amyloidosis of ALS/FTD-linked FUS and TDP-43 Jianxing Song: 2024, 15 (5): 2084-2112 | DOI: 10.14336/AD.2023.1118; PDF (2060KB)

Human Aging and Age-Related Diseases: From Underlying Mechanisms to Pro-Longevity Interventions Piotr Paweł Chmielewski, Krzysztof Data, Bartłomiej Strzelec, Maryam Farzaneh, Amir Anbiyaiee, Uzma Zaheer, Shahab Uddin, Mohadeseh Sheykhi-Sabzehpoush, Paul Mozdziak, Maciej Zabel, Piotr Dzięgiel, Bartosz Kempisty: | DOI: 10.14336/AD.2024.0280; PDF (971KB)

Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis Dongmei Jia, Fenghe Zhang, Huining Li, Yi Shen, Zhao Jin, Fu-Dong Shi, Chao Zhang: 2024, 15 (2): 824-830 | DOI: 10.14336/AD.2023.0528; PDF (466KB)

Hallmarks of Skin Aging: Update Shifeng Jin, Kezhu Li, Xuanru Zong, Seokchan Eun, Naoki Morimoto, Shu Guo: 2023, 14 (6): 2167-2176 | DOI: 10.14336/AD.2023.0321; PDF (579KB)

Cross-Vendor Test-Retest Validation of Diffusion Tensor Image Analysis along the Perivascular Space (DTI-ALPS) for Evaluating Glymphatic System Function Xiaodan Liu, Giuseppe Barisano, Xingfeng Shao, Kay Jann, John M Ringman, Hanzhang Lu, Konstantinos Arfanakis, Arvind Caprihan, Charles DeCarli, Brian T Gold, Pauline Maillard, Claudia L Satizabal, Elyas Fadaee, Mohamad Habes, Lara Stables, Herpreet Singh, Bruce Fischl, Andre van der Kouwe, Kristin Schwab, Karl G Helmer, Steven M Greenberg, Danny J.J Wang, for the MarkVCID Consortium: 2024, 15 (4): 1885-1898 | DOI: 10.14336/AD.2023.0321-2; PDF (1783KB)

Alzheimer's Disease Puzzle: Delving into Pathogenesis Hypotheses Mohammad Nasb, Weichu Tao, Ning Chen: 2024, 15 (1): 43-73 | DOI: 10.14336/AD.2023.0608; PDF (1172KB)

Parental Alcohol Exposures Associate with Lasting Mitochondrial Dysfunction and Accelerated Aging in a Mouse Model Alison Basel, Sanat S. Bhadsavle, Katherine Z. Scaturro, Grace K. Parkey, Matthew N. Gaytan, Jai J. Patel, Kara N. Thomas, Michael C. Golding: | DOI: 10.14336/AD.2024.0722; PDF (1718KB)
Supplement; 1. Supplementary data.pdf (1015KB)

Inhibiting MicroRNA-141-3p Improves Musculoskeletal Health in Aged Mice Sagar Vyavahare, Sandeep Kumar, Kathryn Smith, Bharati Mendhe, Roger Zhong, Marion A. Cooley, Babak Baban, Carlos M. Isales, Mark Hamrick, William D Hill, Sadanand Fulzele: 2023, 14 (6): 2303-2618 | DOI: 10.14336/AD.2023.0310-1; PDF (1103KB)
Supplement; 1. Supplementary data.pdf (125KB)

The Interfascicular Matrix of Energy Storing Tendons Houses Heterogenous Cell Populations Disproportionately Affected by Aging Danae E. Zamboulis, Neil Marr, Luca Lenzi, Helen L. Birch, Hazel R. C. Screen, Peter D. Clegg, Chavaunne T. Thorpe: 2024, 15 (1): 295-310 | DOI: 10.14336/AD.2023.0425-1; PDF (1364KB)
Supplement; 1. Supplementary data.pdf (1021KB)

A Potential “Anti-Warburg Effect” in Circulating Tumor Cell-mediated Metastatic Progression? Zhuofeng Jiang, Jiapeng He, Binyu Zhang, Liping Wang, Chunhao Long, Boxi Zhao, Yufan Yang, Longxiang Du, Weiren Luo, Jianyang Hu, Xin Hong: | DOI: 10.14336/AD.2023.1227; PDF (1078KB)

Post-Stroke Neuropsychiatric Complications: Types, Pathogenesis, and Therapeutic Intervention Jing Zhou, Yijia Fangma, Zhong Chen, Yanrong Zheng: 2023, 14 (6): 2127-2152 | DOI: 10.14336/AD.2023.0310-2; PDF (939KB)

Human APOE4 Protects High-Fat and High-Sucrose Diet Fed Targeted Replacement Mice against Fatty Liver Disease Compared to APOE3 Patricia Huebbe, Stephanie Bilke, Johanna Rueter, Anke Schloesser, Graeme Campbel, Claus-C. Glüer, Ralph Lucius, Christoph Röcken, Andreas Tholey, Gerald Rimbach: 2024, 15 (1): 259-281 | DOI: 10.14336/AD.2023.0530; PDF (1348KB)

Brain Insulin Signaling is Associated with Late-Life Cognitive Decline Han Tong, Ana W. Capuano, Owen T. Carmichael, Kathryn L. Gwizdala, David A. Bennett, Rexford S. Ahima, Steven E. Arnold, Zoe Arvanitakis: 2024, 15 (5): 2205-2215 | DOI: 10.14336/AD.2023.1117; PDF (480KB)

Arterial Aging and Cerebrovascular Function: Impact of Aerobic Exercise Training in Older Adults Tsubasa Tomoto, Rong Zhang: 2024, 15 (4): 1672-1687 | DOI: 10.14336/AD.2023.1109-1; PDF (1470KB)

Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause Wendi Pei, Xiaomin Cao, Puyao Zhang, Lin Fu, Ping Zhou, Ye Liu, Yong Fan, Fengqin Xu, Canhui Cao, Yang Yu: 2024, 15 (2): 445-448 | DOI: 10.14336/AD.2023.0707-1; PDF (599KB)
Supplement; 1. Supplementary data.pdf (2374KB)

Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin: | DOI: 10.14336/AD.2024.0124-1; PDF (497KB)

New Clues to Cardiovascular Disease: Erythrocyte Lifespan Ziyu Lu, Yuanmin Li: 2023, 14 (6): 2003-2014 | DOI: 10.14336/AD.2023.0506; PDF (494KB)

Inflammatory Pathogenesis of Post-stroke Depression Xinyu Feng, Xiaojuan Ma, Juan Li, Qing Zhou, Yao Liu, Jingyi Song, Jiaqi Liu, Qingqing Situ, Lingyue Wang, Jingzhi Zhang, Facai Lin: | DOI: 10.14336/AD.2024.0203; PDF (1204KB)

Microglia Exhibit Distinct Heterogeneity Rather than M1/M2 Polarization within the Early Stage of Acute Ischemic Stroke Hongyu Ma, He Li, Yongxin Zhang, Yu Zhou, Hanchen Liu, Hongye Xu, Luojiang Zhu, Guanghao Zhang, Jing Wang, Zifu Li, Bo Hong, Wang Zhou, Pengfei Yang, Jianmin Liu: 2023, 14 (6): 2284-2302 | DOI: 10.14336/AD.2023.0505; PDF (2210KB)
Supplement; 1. Supplementary data.pdf (1726KB)

Microglia and Astrocytes in Alzheimer’s Disease: Significance and Summary of Recent Advances Qianting Deng, Chongyun Wu, Emily Parker, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang: 2024, 15 (4): 1537-1564 | DOI: 10.14336/AD.2023.0907; PDF (1606KB)

The Role of Microglia in Brain Metastases: Mechanisms and Strategies Ying Feng, Xueqing Hu, Yingru Zhang, Yan Wang: 2024, 15 (1): 169-185 | DOI: 10.14336/AD.2023.0514; PDF (826KB)

State of the Science on Brain Insulin Resistance and Cognitive Decline Due to Alzheimer’s Disease Elizabeth M Rhea, Manon Leclerc, Hussein N Yassine, Ana W Capuano, Han Tong, Vladislav A Petyuk, Shannon L Macauley, Xavier Fioramonti, Owen Carmichael, Frederic Calon, Zoe Arvanitakis: 2024, 15 (4): 1688-1725 | DOI: 10.14336/AD.2023.0814; PDF (1636KB)

Machine Learning-Based Decision-Making in Geriatrics: Aging Phenotype Calculator and Survival Prognosis Mamchur Aleksandra, Sharashkina Natalia, Erema Veronika, Kashtanova Daria, Ivanov Mikhail, Bruttan Maria, Zelenova Elena, Shelly Eva, Ostapenko Valentina, Dzhumaniiazova Irina, Matkava Lorena, Yudin Vladimir, Akopyan Anna, Strazhesko Irina, Maytesyan Lilit, Tarasova Irina, Beloshevskaya Olga, Keskinov Anton, Tkacheva Olga, Yudin Sergey: | DOI: 10.14336/AD.2024.0120; PDF (1057KB)
Supplement; 1. Supplementary data.pdf (684KB)

The Neglected Sibling: NLRP2 Inflammasome in the Nervous System László Ducza, Botond Gaál: 2024, 15 (3): 1006-1028 | DOI: 10.14336/AD.2023.0926-1; PDF (1102KB)
Supplement; 1. Supplementary data.pdf (279KB)

G9a Inhibition Promotes Neuroprotection through GMFB Regulation in Alzheimer’s Disease Aina Bellver-Sanchis, Qizhi Geng, Gemma Navarro, Pedro A. Ávila-López, Júlia Companys-Alemany, Laura Marsal-García, Raquel Larramona-Arcas, Lluisa Miró, Anna Perez-Bosque, Daniel Ortuño-Sahagún, Deb Ranjan Banerjee, Bhanwar Singh Choudhary, Francesc X Soriano, Coralie Poulard, Mercè Pallàs, Hai-Ning Du, Christian Griñán-Ferré: 2024, 15 (1): 311-337 | DOI: 10.14336/AD.2023.0424-2; PDF (1632KB)
Supplement; 1. Supplementary data.pdf (7444KB)

SARM1 Promotes Neurodegeneration and Memory Impairment in Mouse Models of Alzheimer's Disease Xuemeng Miao, Qian Wu, Siyu Du, Ludan Xiang, Siyao Zhou, Junzhe Zhu, Zirun Chen, Hui Wang, Xuyi Pan, Yiren Fan, Lihan Zhang, Jingkang Qian, Yuxuan Xing, Yiyang Xie, Lixin Hu, Haiyun Xu, Wei Wang, Ying Wang, Zhihui Huang: 2024, 15 (1): 390-407 | DOI: 10.14336/AD.2023.0516-1; PDF (2561KB)
Supplement; 1. Supplementary data.pdf (1704KB)

Identification of Cathepsin B as a Therapeutic Target for Ferroptosis of Macrophage after Spinal Cord Injury Jiaqi Xu, Yinghe Ding, Chaoran Shi, Feifei Yuan, Xiaolong Sheng, Yudong Liu, Yong Xie, Hongbin Lu, Chunyue Duan, Jianzhong Hu, Liyuan Jiang: 2024, 15 (1): 421-443 | DOI: 10.14336/AD.2023.0509; PDF (3165KB)
Supplement; 1. Supplementary data.pdf (2003KB)

Mitochondria: A Potential Rejuvenation Tool against Aging Qian Hua Phua, Shi Yan Ng, Boon-Seng Soh: 2024, 15 (2): 503-516 | DOI: 10.14336/AD.2023.0712; PDF (649KB)

Biomarkers of Aging and Relevant Evaluation Techniques: A Comprehensive Review Xue Tao, Ziman Zhu, Liguo Wang, Chunlin Li, Liwei Sun, Wei Wang, Weijun Gong: 2024, 15 (3): 977-1005 | DOI: 10.14336/AD.2023.00808-1; PDF (946KB)

Alzheimer Disease Pathology and Neurodegeneration in Midlife Obesity: A Pilot Study Mahsa Dolatshahi, Paul K Commean, Farzaneh Rahmani, Jingxia Liu, LaKisha Lloyd, Caitlyn Nguyen, Nancy Hantler, Maria Ly, Gary Yu, Joseph E Ippolito, Claude Sirlin, John C Morris, Tammie L.S Benzinger, Cyrus A Raji: 2024, 15 (4): 1843-1854 | DOI: 10.14336/AD.2023.0707; PDF (900KB)
Supplement; 1. Supplementary data.pdf (178KB)

Aging and Sex Differences in Brain Volume and Cerebral Blood Flow Hiroto Kawano, Shigeki Yamada, Yoshiyuki Watanabe, Satoshi Ii, Tomohiro Otani, Hirotaka Ito, Ko Okada, Chifumi Iseki, Motoki Tanikawa, Shigeo Wada, Marie Oshima, Mitsuhito Mase, Kazumichi Yoshida: 2024, 15 (5): 2216-2229 | DOI: 10.14336/AD.2023.1122; PDF (1565KB)
Supplement; 1. Supplementary data movie-1.mp4 (19073KB); 2. Supplementary data.pdf (181KB); 3. Supplementary data movie-2.mp4 (875KB)

The Emerging Role of Interleukin-(IL)-11/IL-11R in Bone Metabolism and Homeostasis: From Cytokine to Osteokine Bingzi Dong, Jingjing Zhu, Xian Chen, Hongyuan Jiang, Yujie Deng, Lili Xu, Yangang Wang, Shufa Li: 2023, 14 (6): 2113-2126 | DOI: 10.14336/AD.2023.0306; PDF (494KB)

Microbiota-Gut-Brain Axis Dysregulation in Alzheimer's Disease: Multi-Pathway Effects and Therapeutic Potential Linkai Qu, Yanwei Li, Fan Liu, Yimeng Fang, Jiaxuan He, Jiahui Ma, Ting Xu, Lei Wang, Pengyu Lei, Hao Dong, Libo Jin, Qinsi Yang, Wei Wu, Da Sun: 2024, 15 (3): 1108-1131 | DOI: 10.14336/AD.2023.0823-2; PDF (2004KB)

Chondroitin Sulfate Proteoglycans Revisited: Its Mechanism of Generation and Action for Spinal Cord Injury Rui Yang, Ying Zhang, Jianning Kang, Ce Zhang, Bin Ning: 2024, 15 (1): 153-168 | DOI: 10.14336/AD.2023.0512; PDF (1236KB)

Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway Ruoyan Xue, Mengyao Xie, Zhiyuan Wu, Shu Wang, Yongli Zhang, Zhijin Han, Chen Li, Qi Tang, Liping Wang, Di Li, Shihua Wang, Hua Yang, Robert Chunhua Zhao: 2024, 15 (2): 851-868 | DOI: 10.14336/AD.2023.0719-1; PDF (1776KB)
Supplement; 1. Supplementary data.pdf (505KB)

Amyloid Precursor Protein: A Regulatory Hub in Alzheimer's Disease Jiang Chen, Jun-Sheng Chen, Song Li, Fengning Zhang, Jie Deng, Ling-Hui Zeng, Jun Tan: 2024, 15 (1): 201-225 | DOI: 10.14336/AD.2023.0308; PDF (1307KB)
Supplement; 1. Supplementary data.pdf (125KB)

Myelin Pathology in Alzheimer's Disease: Potential Therapeutic Opportunities Zhihai Huang, J. Dedrick Jordan, Quanguang Zhang: 2024, 15 (2): 698-713 | DOI: 10.14336/AD.2023.0628; PDF (794KB)

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