Letter to the Editor
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Brain Regulates Neuronal Activity Directly through the Heartbeat: A New Pathway of Heart-Brain Interaction
Zhitian Wang, Junjian Zhang, Qing-Guo Ren
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Comment on: “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Hirofumi Rokutan
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Response to Letter to the Editor, “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Dong Tan, Chun Xu, Qing Zhu, Gang Fan, Qing-Tian Luo
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Spiritual Rejuvenation: An Alternative Way to Healthy Aging
Dalmacito A. Cordero
Editorial
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Mitochondrial Dysfunction in Aging and Age-related Disorders
Aida Adlimoghaddam
Commentary
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Enhancing Efficiency with an AI-Augmented Clinician in Neurology
Krish Kapadia, Sanskriti Ruwali, Tanvi Malav, Sridhar Seshadri, Abraham Seidmann, Daniel Z. Press, Vijaya B. Kolachalama
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Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat
Perspective
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Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke
Zhe Cheng, Hongrui Wang, Xiaokun Geng, Gary B. Rajah, Omar Elmadhoun, Guangge Peng, Yuchuan Ding
Opinion
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Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
Gudimetla Susmitha Mohan, Rahul Kumar
Review
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Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen
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Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin
Mariarosa Mezzanotte, Serena Stanga
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The Role of Protein S-Nitrosylation in Mitochondrial Quality Control in Central Nervous System Diseases
Fang Qiu, Yuqiang Liu, Zhiheng Liu
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Early Life Interventions: Impact on Aging and Longevity
Rong Yuan, Aida Adlimoghaddam, Yun Zhu, Xiuqi Han, Andrzej Bartke
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Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?
Xinxin Zuo
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The Mitochondrial Foundations of Parkinson’s Disease: Therapeutic Implications
Smijin K. Soman, Micah R. J. Woodruff, Ruben K. Dagda
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Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism
Marta Pokotylo, Norbert Brüggemann, Jannik Prasuhn
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Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen
Shweta Modgil, Tazbir Ahmed, Yaping Joyce Liao
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The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies
Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang
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Systemic Modulators: Potential Mechanism for the 5-HT System to Mediate Exercise Amelioration in Alzheimer's Disease
Qingxu Wu, Qiang He, Xianliang Zhang, Si Chen, Xiangli Xue
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The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen
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Histone Methylation, Energy Metabolism, and Alzheimer's Disease
Jiaqi Fu, Li An
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Physical Prehabilitation for Older Patients with Cancer before Complex Medical-Surgical Interventions: An Umbrella Review
Dana Loudovici-Krug, Louise André, Heiner Paul Blumensaat, Marion Granger, Laetitia Stefani, Josephine Kühnemund, Christina Lemhöfer, Claire Falandry
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The Double-Edged Effects of Substance P in the Pathology of Alzheimer’s Disease
Zihan Lin, Shuyao Yu, Yuling Yang, Hongyu Mu, Yidan Hu, Weihua Yu, Yang Lü
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Mechanisms of the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans and Mammals and Its Roles in Striated Muscles
Tongxiao Luan, Song Hu, Weihong Nie, Jia Liu, Li Jia, Shan Wang, Jing Zhou, Nina An, Yuting Duan, Aohua Wang, Mengru Xu, Yongjun Mao
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Ischemic Stroke and the Biological Hallmarks of Aging
Fangyuan Cheng, Bo Yan, Pan Liao, Han Gao, Zhenyu Yin, Dai Li, Ping Lei
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The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang
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The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives
Dan Zhou, Yumeng Lin, Zhongyu Han, Zhuyun Zhang, Le Lin, Shichong Lin, Qianke Yang
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Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease
Zhitian Wang, Lv Zhou, Na Zhao, Zhijun Zhang, Junjian Zhang, Qing-Guo Ren
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The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu
Original Article
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C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity
Kerry C. Ryan, Zahra Ashkavand, Jocelyn T. Laboy, Ling Wang, Margarida Barroso, Kenneth R. Norman
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Exercise Types: Physical Activity Mitigates Cardiac Aging and Enhances Mitochondrial Function via PKG-STAT3-Opa1 Axis
Reka Szekeres, Daniel Priksz, Mariann Bombicz, Beata Pelles-Tasko, Anna Szilagyi, Brigitta Bernat, Aniko Posa, Balazs Varga, Rudolf Gesztelyi, Sandor Somodi, Zoltan Szabo, Zoltan Szilvassy, Bela Juhasz
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Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia
Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal
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Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis
Yiran Huang, Nan Gao, Boren Liu, Weili Luo, Jianfei Chen, Yan Chen, Yong Bi, Zikai Zhou
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Impairment of the trans-Golgi-Lysosomal Pathway Accelerates Dopaminergic Neuronal Senescence in LRRK2R1627P Rats
Qiumei Yang, Shimin Pang, Chunsong Zhao, Yanyan Wang, Jing Lu, Zhenyu Yue, Piu Chan
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Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis
Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid, Amaya Puig-Kröger, Manuel D Gahete, Jorge Manzanares, Esther Caparrós, Rubén Francés
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Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians
Estrella Gómez-Tortosa, Pablo Agüero-Rabes, Alicia Ruiz-González, Sonia Wagner, Raquel Téllez, Ignacio Mahillo, Andrea Ruiz-Calvo, María José Sainz, Anna Lena Nystrom, Lucía Cremades-Jimeno, Teodoro del Ser, Pascual Sánchez-Juan
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Differential Roles of Astrocytic CSF1 in Alzheimer's Disease and Cerebral Amyloid Angiopathy: Insights from Transcriptomic Analysis
Chunyuan Li, Yashuang Chen, Shiqi Luo, Yan Yang, Xinnan Liu, Sijie Li, Wei Ge, Cong Han
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APOE ɛ4 and Insulin Resistance Influence Path-Integration-Based Navigation through Distinct Large-Scale Network Mechanisms
Karel M. Lopez-Vilaret, Marina Fernandez-Alvarez, Anne Bierbrauer, Nikolai Axmacher, Jose L. Cantero, Mercedes Atienza
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Modulation of Mitochondrial Dynamics by the Angiotensin System in Dopaminergic Neurons and Microglia
Aloia Quijano, Ana I. Rodriguez-Perez, María Alicia Costa-Besada, Andrea Lopez-Lopez, María J. Guerra, Jose Luis Labandeira-Garcia, Rita Valenzuela
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Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the LmnaG609G/G609G Mouse Model of Progeria
Stéphane Blouin, Markus A. Hartmann, Nadja Fratzl-Zelman, Phaedra Messmer, Daniel Whisenant, Michael R. Erdos, Francis S. Collins, Maria Eriksson, Charlotte Strandgren, Wayne A. Cabral, Thomas Dechat
