Letter to the Editor
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Therapeutic Promise of Exosomal CD73 for Diabetic Bone Disorders: Addressing Mechanistic and Translational Challenges
Jing Lu, DuJiang Yang, Canhao Lai, Xiaoyu Chen, Ruichen Li, GuoYou Wang
Editorial
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Decentralizing Pulmonary Screening for China’s Aging Population: From Hospitals to Communities
Leiwen Fu, Wei Shu, Yuxian Sun, Liang Li, Jian Du
Perspectives
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Targeting the Milieu in Neurodegenerative Disease: Time for “Imprecision Medicine”?
Joseph F Quinn
Review
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Circulating Cell-free DNA Fragmentomics Detection and Beyond
Tianliang Liu, Zhicheng Li, Shifu Chen, Jiasheng Zhong
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Age-related Vascular Alterations in the Choroid Plexus: Novel Insights from Pathophysiology and Imaging Studies
Zhe Sun, Chenyang Li, Dominique Leitner, Michelle Wu, Jiangyang Zhang, Thomas Wisniewski, Yulin Ge
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Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review
Chang Qi, Ming Qin, Yu Wang, Cong Li, Huiying Yan, Lina Feng, Mingquan Li
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Crossing Pathological Boundaries: Multi-Target Restoration of the Neurovascular Unit in Alzheimer's and Vascular Dementia—From Modern Therapeutics to Traditional Chinese Medicine
Tengyu Zhao, Pengyu Pan, Ying Jia, Yuhan Zhou, Xinyue Zhang, Huibo Guan, Quan Li, Yanyan Zhou
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Exploration and Application of Malignant Cell Heterogeneity Analysis with Single-Cell Transcriptome Sequencing Technology
Wen Zhang, Tianliang Liu, Ting Liu, Yu Zhang, Zhenguo Zhao, Xinxin Zhang, Xiaoyang Li, Jiasheng Zhong, Zhicheng Li, Shifu Chen, Libin Xu
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Gut Virome and Aging: Phage-Driven Microbial Stability and Immune Modulation
Kaleem Ullah, Rabia Kanwar, Saqib Ali, Saif Uddin, Izza Izza, Irfan Ahmad, Khalid J Alzahrani, Abdul Qadeer, Chun-Ting Chu, Chien-Chin Chen
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The Clinical Relevance of FTO as a Demethylase Beyond Cancer: Molecular Mechanisms and Therapeutic Opportunities
Cun-yang Guo, Yi-fei Du, Hui-cong Yan, Xin-ming Fan, Fang-qi Tian, Ping Xu
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From Dual Decline to Clinical Consequences: Mechanistic Pathways and Health Outcomes of Motoric Cognitive Risk Syndrome
Yiwei Zhao, Tao Wei, Bo Zhao, Yuanyuan Chen, Zhibin Wang, Yi Tang
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Recent Advances in Autophagy and Immunotherapy for the Clearance of Aggregated α-Synuclein in Parkinson’s Disease
Khoshnur Jannat, Sang-Bong Lee, Hong-Ryeol Jung, Rengasamy Balakrishnan, Yon-Suk Kim, Mujeeb Ur Rahman, Dong-Kug Choi
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Progress in Disease-Modifying Therapies for Parkinson's Disease
Shuyuan Zhang, Gang Shao, Bin Wu, Liang Xia, Lei Wang, Liwen Li, Kai Jin, Yangfan Zou, Caixing Sun
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TGF-β-Driven Atrial Fibrosis in Atrial Fibrillation: From Mechanistic Insights to Targeted Therapies
Chen Chen, Pengfei Chen, Wenxi Yu, Lingli Zhao, Yu Yang, Hua Qu, Changgeng Fu, Dazhuo Shi, Ming Guo
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Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System
Jinkun Xu, Hengzhen Li, Jianfeng Sun, Gaoming Liu, Yuming Yao, Dongliang Yuan, Wenfeng Xiao, Yusheng Li
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Lactylation Modification and Aging: A Molecular Link in the Life Process
Min Shi, Honyu Li, Haiyan Lin, Qiang Tang
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Hip Fragility Fractures: One Or Two Pathologies? A Systematic Review and Meta-Analysis of Demographic, Diagnostic and Therapeutic Aspects
José Luis Dinamarca-Montecinos, Miguel Yáñez, Ana Aguilera, Jean-Gabriel Minonzio
Short Communications
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Fever Induces Long-Term Synaptic Enhancement and Protects Learning in an Accelerated Aging Model
Fusheng Du, Qi Wan, Oleg O Glebov
Original Article
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Nuclear Protein Aggregates Disrupt RNA Processing and Alter Biomechanics in a Muscle Cell Model of OPMD
Milad Shademan, Sarah Flannery, Erik Bos, Tom M.J Evers, Vahid Sheikhhassani, Alireza Mashaghi, Benno Kusters, Baziel van Engelen, Thomas H Sharp, Roman Fischer, Benedikt M Kessler, Vered Raz
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Cross-Trait Meta-Analysis Reveals a Genetic Link between Inflammation and Aging in Giant Cell Arteritis
Laura Martínez-Gutiérrez, Inmaculada Rodriguez-Martin, Gonzalo Borrego-Yaniz, Martin Kerick, International GCA Consortium, UK GCA Consortium, Carlo Salvarani, José Hernández-Rodríguez, María Cinta Cid, Miguel Ángel González-Gay, Ann W Morgan, Javier Martín, Lourdes Ortiz-Fernández, Ana Márquez
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SCAP Interacts with Trim27 to Promote Vascular Neointimal Hyperplasia by Regulating the Stability and Ubiquitination of IκBα
Yingcheng Yao, Xing Wang, Chengcheng Xuan, Da Li, Wenqin Huang, Li Wei, Xiong Z Ruan, Danyang Li, Yaxi Chen
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D-2HG Inhibits Glutamine Synthetase Activity and Induces Senescence in IDH-Mutant Gliomas
Yuanlin Zhao, Jiankuan Shi, Yuan Yuan, Ying Yang, Xing Gao, Risheng Yang, Yuying Wang, Lijun Zhang, Jing Li, Peizhen Hu, Yingmei Wang, Chao Sun, Ruili Han, Yuqiao Xu, Zengshan Li, Zhe Wang, Yu Gu, Jing Ye
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Association of Unhealthy Lifestyles with Cataract Risk, and The Mediating Role of Metabolic Signature: Analysis of the UK Biobank Prospective Cohort
Jiao Qi, Kaimeng Su, Keke Zhang, Wenwen He, Jiaqi Meng, Yu Du, Yi Lu, Xiangjia Zhu
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Apolipoprotein CII: Cornerstone of Pathophysiological Interplay in Aortic Stenosis and type 2 Diabetes Mellitus
Nerea Corbacho-Alonso, Tamara Sastre-Oliva, Inés Perales-Sánchez, German Hernández-Fernandez, Emilio Blanco-López, Luis F López-Almodovar, Jorge Solis, Luis R Padial, Teresa Tejerina, Ana E Lopez-Jimenez, Laura Mourino-Alvarez, Maria G Barderas
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Linking Individual Variability of Multi-modal Connectivity, Lifestyle, Psycho-Social Factors and Cognition in Older Adults
Mingxian Zhang, Susanne Moebus, Nico Dragano, Nora Bittner, Svenja Caspers
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Homeostatic DNMT3a Activity Is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer’s Disease
Yanzhi Liu, Chi Him Poon, Long Sum Rachel Tse, Jaydeep Roy, Charlotte Theodora So, Benjamin Chun-Kit Tong, Kwok-Ming Yao, George Lim Tipoe, Harry Steinbusch, Luca Aquili, Allan Kalueff, King-Ho Cheung, Man-Lung Fung, Lee Wei Lim
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Cognitive Frailty and Health Care Utilization and Costs Among Middle-Aged and Older Adults: Findings from Four Longitudinal Cohort Studies
Yemin Yuan, Zhenyu Shi, Xiaolong Guan, Yiqi Xia, Yanshang Wang, Huaxin Si, Ping He
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Epigenetic Clocks Identify Harmful Epigenetic Aging Linked to Depression Severity and Cognitive Deficits in Major Depressive Disorder
Chao Liufu, Tao Pang, Haohao Zheng, Lei Yang, Li Yang, Xuebing Huang, Ying Qian, Suhua Chang
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PGC-1α Regulates Exercise Intensity-Dependent Atrial Remodeling and Fibrillation in Rats
Jingwen Xiao, Jiancheng Zhang, Yan Zhang, Yu Jiang, Chenqi Yang, Xiaona Lin, Zhengnan Lin
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Early Risk Prediction Model for Stroke-Heart Syndrome Following Endovascular Therapy
Lanjing Wang, Shuangfeng Huang, Yongle Wang, Omar Elmadhoun, Changhong Ren, Wenbo Zhao, Yao Yu, Guiyou Liu, Xunming Ji, Sijie Li
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Interaction between Brain Natriuretic Peptide and QTc Prolongation on Mortality in Patients with Stroke-Heart Syndrome
Yongle Wang, Mingyi He, Lanjing Wang, Omar Elmadhoun, Fangyan Liu, Wenbo Zhao, Changhong Ren, Yuchuan Ding, Xunming Ji, Sijie Li
