Retrospective
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Judith Campisi (1950-2024) - A Pioneering Geroscientist in Senescence and SASP
Kunlin Jin
Letter to the Editor
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Spatiotemporal Transcriptome Analysis Reveals Activation of the AP1 Pathway in the Ovarian Microenvironment during the Transition from Premenopause to Postmenopause
Wendi Pei, Xiaomin Cao, Puyao Zhang, Lin Fu, Ping Zhou, Ye Liu, Yong Fan, Fengqin Xu, Canhui Cao, Yang Yu
Perspectives
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“Post-Protean” Public Health and the Geroscience Hypothesis
Colin Farrelly
Review
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The Role of Glial Cells in Synaptic Dysfunction: Insights into Alzheimer's Disease Mechanisms
Yang Yu, Ran Chen, Kaiyue Mao, Maoyan Deng, Zhigang Li
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Gut Metabolites Acting on the Gut-Brain Axis: Regulating the Functional State of Microglia
Wenze Deng, Pengcheng Yi, Yanhong Xiong, Jun Ying, Yue Lin, Yao Dong, Gen Wei, Xifeng Wang, Fuzhou Hua
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Mitochondria: A Potential Rejuvenation Tool against Aging
Qian Hua Phua, Shi Yan Ng, Boon-Seng Soh
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Semaphorins: Missing Signals in Age-dependent Alteration of Neuromuscular Junctions and Skeletal Muscle Regeneration
Damon Fard, Alessandra Barbiera, Gabriella Dobrowolny, Luca Tamagnone, Bianca Maria Scicchitano
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Shedding Light on the Interaction Between Rif1 and Telomeres in Ovarian Cancer
Paweł Kordowitzki, Szymon Graczyk, Sylvia Mechsner, Jalid Sehouli
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Aging, Cellular Senescence, and Glaucoma
Yumeng Zhang, Shouyue Huang, Bing Xie, Yisheng Zhong
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Role and Potential Mechanisms of Nicotinamide Mononucleotide in Aging
Sajid Ur Rahman, Abdul Qadeer, Ziyun Wu
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Contribution of Direct Cerebral Vascular Transport in Brain Substance Clearance
Qiuting Wen, Haoyu Wang, E. Mark Haacke, Quan Jiang, Jiani Hu
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Healthy Aging in Times of Extreme Temperatures: Biomedical Approaches
Axel Kowald, Daniel Palmer, Riccardo Secci, Georg Fuellen
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Underlying Mechanisms and Treatment of Cellular Senescence-Induced Biological Barrier Interruption and Related Diseases
Ruize Sun, Juan Feng, Jue Wang
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MYC Oncogene: A Druggable Target for Treating Cancers with Natural Products
Ka Iong Chan, Siyuan Zhang, Guodong Li, Yida Xu, Liao Cui, Yitao Wang, Huanxing Su, Wen Tan, Zhangfeng Zhong
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Myelin Pathology in Alzheimer's Disease: Potential Therapeutic Opportunities
Zhihai Huang, J. Dedrick Jordan, Quanguang Zhang
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Mitochondria-mediated Ferroptosis in Diseases Therapy: From Molecular Mechanisms to Implications
Fuhai Feng, Shasha He, Xiaoling Li, Jiake He, Lianxiang Luo
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Autophagy in Neuroinflammation: A Focus on Epigenetic Regulation
Yu Chen, Junren Chen, Ziwei Xing, Cheng Peng, Dan Li
Short Communication
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Differential Effects of Endurance Exercise on Musculoskeletal and Hematopoietic Modulation in Old Mice
Zilin Wang, Hyun-Jaung Sim, Wenduo Liu, Jae Cheol Kim, Jeong-Chae Lee, Sung-Ho Kook, Sang Hyun Kim
Original Article
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Altered Osteoblast Metabolism with Aging Results in Lipid Accumulation and Oxidative Stress Mediated Bone Loss
Ananya Nandy, Alison Richards, Santosh Thapa, Alena Akhmetshina, Nikita Narayani, Elizabeth Rendina-Ruedy
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An Antibody-directed and Immune Response Modifier-augmented Photothermal Therapy Strategy Relieves Aging via Rapid Immune Clearance of Senescent Cells
Jiamei Han, Judun Zheng, Qian Li, Huanle Hong, Jing Yao, Jiao Wang, Robert Chunhua Zhao
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Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency
Feiyan Zhao, Long Yan, Xuehan Zhao, Jiaqi Wu, Ying Fang, Zhimin Xin, Hongmei Wang, Xiaokui Yang
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Responsiveness to Tocilizumab in Anti-Acetylcholine Receptor-Positive Generalized Myasthenia Gravis
Dongmei Jia, Fenghe Zhang, Huining Li, Yi Shen, Zhao Jin, Fu-Dong Shi, Chao Zhang
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Metformin Treatment Leads to Increased HIV Transcription and Gene Expression through Increased CREB Phosphorylation and Recruitment to the HIV LTR Promoter
Sahar Rezaei, Khalid A Timani, Johnny J He
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Mesenchymal Stem Cell-Derived Exosomes Promote Recovery of The Facial Nerve Injury through Regulating Macrophage M1 and M2 Polarization by Targeting the P38 MAPK/NF-Κb Pathway
Ruoyan Xue, Mengyao Xie, Zhiyuan Wu, Shu Wang, Yongli Zhang, Zhijin Han, Chen Li, Qi Tang, Liping Wang, Di Li, Shihua Wang, Hua Yang, Robert Chunhua Zhao
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Endogenous Alpha-Synuclein is Essential for the Transfer of Pathology by Exosome-Enriched Extracellular Vesicles, Following Inoculation with Preformed Fibrils in vivo
Katerina Melachroinou, Georgios Divolis, George Tsafaras, Mantia Karampetsou, Sotirios Fortis, Yannis Stratoulias, Gina Papadopoulou, Anastasios G Kriebardis, Martina Samiotaki, Kostas Vekrellis
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Synergistically Acting on Myostatin and Agrin Pathways Increases Neuromuscular Junction Stability and Endurance in Old Mice
Roberta Schellino, Marina Boido, Jan W Vrijbloed, Ruggero G Fariello, Alessandro Vercelli
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The Role of the Redox Enzyme p66Shc in Biological Aging of the Lung
Claudia F. Garcia Castro, Claudio Nardiello, Stefan Hadzic, Baktybek Kojonazarov, Simone Kraut, Mareike Gierhardt, Julia Schäffer, Mariola Bednorz, Karin Quanz, Jacqueline Heger, Martina Korfei, Jochen Wilhelm, Matthias Hecker, Marek Bartkuhn, Stefan Arnhold, Andreas Guenther, Werner Seeger, Rainer Schulz, Norbert Weissmann, Natascha Sommer, Oleg Pak
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The Impact of Frailty, Oropharyngeal Dysphagia and Malnutrition on Mortality in Older Patients Hospitalized for Covid-19
Alberto Martín-Martínez, Paula Viñas, Irene Carrillo, Josep Martos, Pere Clavé, Omar Ortega
