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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 213 results are found
Aligning Intrinsic Capacity and Geroscience: Linking Function with Biology
Sha Zhu, Lihua Tao, Chengcheng Fan, Yongzhe Wei, Jagadish K. Chhetri, Piu Chan
| DOI: 10.14336/AD.2025.1419
Increased Stability of Tristetraprolin mRNA Supports Bone Health and Decreases Frailty During Aging
Ramkumar Thiyagarajan, Lixia Zhang, Leticia Andrea Rojas Cortez, Kyu Hwan Kwack, Victoria Maglaras, Nanda Kumar Yellapu, Yukitomo Arao, Kenneth L. Seldeen, Perry J. Blackshear, Bruce R. Troen, Keith L. Kirkwood
| DOI: 10.14336/AD.2025.1243
Supplement

1. Supplementary data.pdf (1343KB)

Functional Pathways of the Gut Microbiome Associated with SCFA Profiles in Preclinical Alzheimer’s Disease
D.M. Sithara Dissanayaka, Thilini N. Jayasinghe, Hamid R. Sohrabi, S.R. Rainey-Smith, Kevin Taddei, Colin L. Masters, Ralph N. Martins, W.M.A.D. Binosha Fernando
| DOI: 10.14336/AD.2025.1539
Supplement

1. Supplementary data.pdf (1339KB)

Alternative Polyadenylation in Aging and Aging-Related Diseases
Mengqi Chen, Xiangyu Zhu, Lejia Hang, Zijie Yan, Li Xu, Fang Liu, Qiong Zhang, Jingjing Huang
| DOI: 10.14336/AD.2025.0882
Biological Age Should Anchor Age-Related Disease Research
Hanin Shakeel, Dana Jin, Kunlin Jin
| DOI: 10.14336/AD.2026.0108
Mortality among Older Adults Across Multimorbidity Categories and Lifestyle Patterns
Rafael Ogaz-González, Qian Zou, Javier Maroto-Rodriguez, Luis Miguel Gutiérrez-Robledo, Ricardo Escamilla-Santiago, Malaquías López-Cervantes, Eva Corpeleijn
| DOI: 10.14336/AD.2025.1012
Supplement

1. Supplementary data.pdf (691KB)

Genomic and Epigenomic Landscapes of Sarcopenia: From Molecular Etiology to Precision Interventions
Ji-Yong Sung, Jung Woo Lee
| DOI: 10.14336/AD.2025.1463
NPM1 in Aging-Related Multi-System Diseases: Molecular Mechanisms and Therapeutic Implications
Jiayao Li, Jiaqi Jin, Xinyu Yang, Wentao Gao, Haozhi Gong, Xvebing Feng, Huijie Fang, Rui Liu, Shihao Jiang, Yanping Shen, Xiaoting Liang, Yiming He, Liqun Jiao, Xiao Zhang, Tao Wang
| DOI: 10.14336/AD.2025.1258
USP3 Promotes Glioma Progression by Stabilizing PLK1 through Deubiquitination
Feng Yan, Yongzhi Shan, Yaming Wang, Xiaotong Fan, Penghu Wei, Guoguang Zhao
| DOI: 10.14336/AD.2025.01011
Supplement

1. Supplementary data.pdf (1081KB)

Expanding on Gut Microbiota Insights in Sarcopenia and Osteoporosis
Lei Chen, Cong Hong, Yu Xie
| DOI: 10.14336/AD.2025.1592
Perimenopausal Hormone Replacement Treatments as a Geroprotective Approach - Adapting Clinical Guidance
Jaron Rabinovici, Henk-Peter Oonk, Zhongwei Huang, Tashiya Mirando, Moran Zhou, Tzipora Strauss, Lia-Raluca Olari, Dominika Wilczok, Andrea B. Maier, Evelyne Bischof
| DOI: 10.14336/AD.2025.1391
Disease-Associated and Shared Gut Microbes of Sarcopenia and Osteoporosis: A Systematic Review and Meta-Analys
Cong Lu, Haochen Wang, Changjun Li, Houchen Lyu, Liusong Shen, Jian Zhang, Wenni Rong, Jie Wei, Chao Zeng, Guanghua Lei, Yilun Wang, Ning Wang
| DOI: 10.14336/AD.2025.1116
Supplement

1. Supplementary data.pdf (1192KB)

Oncology-Derived Strategies for Age-Related Diseases: Intersections of Oncogenesis, Senescence, and Immunity
Hao Li, Jingzeng Wang, Chao Liu, Xiaofen Wu
| DOI: 10.14336/AD.2025.1168
Mitochondrial Dysfunction in Alzheimer's disease: Focus on Dynamics and Electron Transport Chain
Jiehui Li, Gajendra Kumar, Yuqing Yan, Mengmeng Wang, Ling Xu, Haige Wu, Ye Gao, Yi wang, Yingyi Fan, Ying Bai
| DOI: 10.14336/AD.2025.1046
The Emerging Triad in Cancer and Aging: Cellular Senescence, Microbiome, and Tumor Microenvironment
Xi Gong, Shaogang Wang, Qidong Xia
| DOI: 10.14336/AD.2025.1495
A Combination of Low-Dose Δ9-THC and Celecoxib as a Therapeutic Strategy for Alzheimer’s Disease
Jian Zhang, Dexiao Zhu, Mei Hu, Mingzhe Pan, Chu Chen
| DOI: 10.14336/AD.2025.1206
Supplement

1. Supplementary data.pdf (4873KB)

Comprehensive Review of Therapeutic Efficacy and Underlying Mechanisms of Various Exercise Modalities in Treating Osteoporosis
Yangzheng Xie, Suyi Xu, Rushi Dai, Gaowei Xu, Huangjun Bao, Xiabin Dong, Ye Xu, Hongfeng Ruan, Lingying Chen, Keqi Fu
| DOI: 10.14336/AD.2025.0866
The Impact of Coronary Artery Disease on Brain Vascular and Metabolic Health: Links to Cognitive Function
Safa Sanami, Stefanie A. Tremblay, Ali Rezaei, Zacharie Potvin-Jutras, Dalia Sabra, Brittany Intzandt, Christine Gagnon, Amélie Mainville-Berthiaume, Lindsay Wright, Mathieu Gayda, Josep Iglesies-Grau, Anil Nigam, Louis Bherer, Claudine J. Gauthier
| DOI: 10.14336/AD.2025.1173
Supplement

1. Supplementary data.pdf (477KB)

Admission Neutrophil-to-Lymphocyte Ratio Predicts Short- and Long-Term Mortality in Hospitalized Older Adults: A Retrospective Multicenter Study
Luca Antognoli, Jacopo Sabbatinelli, Mirko Di Rosa, Leonardo Biscetti, Nives Fraticelli, Giulia Matacchione, Chiara Giordani, Adrianapia Maria Lamedica, Marco Malavolta, Massimiliano Fedecostante, Lucia Sciciola, Massimo Colciago, Luigi Pranno, Lucia Mancinelli, Federica Lenci, Federica Turchi, Francesco Spannella, Yuri Rosati, Maurizio Burattini, Salvatore Iuorio, Riccardo Sarzani, Antonio Cherubini, Fabrizia Lattanzio, Anna Rita Bonfigli, Angelica Giuliani, Liana Spazzafumo, Fabiola Olivieri
| DOI: 10.14336/AD.2025.1209
Supplement

1. Supplementary data.pdf (285KB)

Beyond Amyloid: Rethinking the Foundations of Alzheimer’s Disease Pathogenesis and Therapy
Kunlin Jin, Shaohua Yang, Michael J. Forster
| DOI: 10.14336/AD.2025.01119
New Perspectives on Gastric Inflammaging: Integrating Multi-Omics Mechanisms and Gerotherapeutic Strategies in Chronic Gastritis
Li Wang, Qiuye Chen, Houyan Zhang, Xin Zhao, Jinsheng Dong, Dongjie Wu, Yanjie Lian, Mingkun Liu, Hongliang Liu, Yaguang Chen, Qiu Chen, Wenliang Lyu, Yuning Bai
| DOI: 10.14336/AD.2025.1444
Single Cell RNAseq Analysis of Thyroid Hormone Effects on Retinal Glial Cells
Hongwei Ma, Shujuan Li, Yun Le, David Stanford, Willard M. Freeman, Xi-Qin Ding
| DOI: 10.14336/AD.2025.1221
Supplement

1. Supplementary data.pdf (1889KB)

Hv1 Upregulation Worsens Spinal, Spleen, and Lung Molecular Pathology and Impairs Locomotion after Spinal Cord Injury in Aged Male Mice
Zihui Wang, Yun Li, Hangnoh Lee, Zhuofan Lei, Long-Jun Wu, Junfang Wu
| DOI: 10.14336/AD.2025.1122
Supplement

1. Supplementary data.pdf (2345KB)

Pharmacological Activation of Mitophagy Confers Neuroprotective Benefits for Amyotrophic Lateral Sclerosis
Sen Huang, Ang Li, Yixia Ling, Xinyu Yang, Jiayu Wang, Jing Yuan, Dajiang Qin, Xiaoli Yao
| DOI: 10.14336/AD.2025.1224
Supplement

1. Supplementary data.pdf (475KB)

Sphingolipid Signaling and Metabolism in Neuronal and Glial Cells: Implications for Cerebrovascular and Neurodegenerative Disorders
M. Nurul Islam, Nawajes Mandal, Nashrifa Israt Khanom, Austin Luke Spivey, Anjlee Suresh Patel, Tanvir Ahmed, Rabia Islam, Mohammad Iqbal H. Bhuiyan
| DOI: 10.14336/AD.2025.1024
Engineering the Future of Longevity R&D: The Case for AI-Driven, Integrated Biotechnology Ecosystems
Alex Zhavoronkov, Chuen Yan Leung
| DOI: 10.14336/AD.2025.1313
Myokines in Aging: A Multi-Organ Network Perspective
Mei Xue, Chengcheng Liao, Yige Liu, Weidong Tian, Li Liao
| DOI: 10.14336/AD.2025.1040
Interthalamic Adhesion as a Potential Structural Regulator of Cerebrospinal Fluid Dynamics in the Third Ventricle
Shigeki Yamada, Ko Okada, Hirotaka Ito, Chifumi Iseki, Tomoyasu Yamanaka, Motoki Tanikawa, Tomohiro Otani, Satoshi Ii, Yoshiyuki Watanabe, Shigeo Wada, Marie Oshima, Mitsuhito Mase
| DOI: 10.14336/AD.2025.1352
Supplement

1. Supplementary data.pdf (145KB)

2. Supplementary video 1.mp4 (3822KB)

3. Supplementary video 2.mp4 (3475KB)

4. Supplementary video 3.mp4 (2084KB)

5. Supplementary video 4.mp4 (2759KB)

6. Supplementary video 5.mp4 (1501KB)

Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Julia Jelleschitz, Annette Brandt, Klara Brehm, Vanessa Schnell, Tobias Jung, Ina Bergheim, Annika Höhn
| DOI: 10.14336/AD.2025.1130
Supplement

1. Supplementary data.pdf (403KB)

Phosphorylated Ubiquitin as a Clinical Biomarker for Mitochondrial Damage in Neurodegenerative Diseases
Fabienne C. Fiesel, Jens O. Watzlawik, Michael G. Heckman, Sophia G. Blumenfeld, Michael J. Rigby, Mohammed Kehili, Katja Lohmann, Christine Klein, Derek P. Narendra, Clemens R. Scherzer, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Zbigniew K. Wszolek, Owen A. Ross, Wolfdieter Springer
| DOI: 10.14336/AD.2025.1220
Supplement

1. Supplementary data.pdf (1217KB)

Perspectives on Pathological Crosstalk between Malocclusion and Multi-organ Systems: The Hidden Face of an Iceberg
Thakur Prasad Chaturvedi, Ching-Hsin Chang, Prathap Somu, Navneet Kumar Dubey, Ming-Che Liu
| DOI: 10.14336/AD.2025.1377
Prospects and Challenges in Identifying Genetic Determinants of Age-Related Cerebral Small Vessel Disease
Polina S. Shlapakova, Larisa A. Dobrynina, Elena V. Gnedovskaya, Evgeny I. Rogaev
| DOI: 10.14336/AD.2025.1272
Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms
Abudureheman Maihemuti, Can Cui, Qianjin Wang, Reziwanguli Amuti, Wai Wang Chau, Senlin Chai, Ning Zhang, Ronald Man Yeung Wong, Ho Ko, Timothy Chi-Yui Kwok, Wing-Hoi Cheung
| DOI: 10.14336/AD.2025.1165
Supplement

1. Supplementary data.pdf (298KB)

Vascular Aging and Multi-Omic Regulation in Ischemic Stroke: Toward Precision Neurorepair
Denisa Floriana Pirscoveanu, Dirk M. Hermann, Mihaela Abuzan, Thorsten R. Doeppner, Liviu Martin, Aurel Popa-Wagner
| DOI: 10.14336/AD.2025.1363
Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Senescence in Aging and Alzheimer’s Disease
Li Sun, Chu Chen
| DOI: 10.14336/AD.2025.1201
Emerging Roles of Skeletal Muscle-Derived Exosomal miRNAs in Metabolic Regulation: A Perspective
Fei Zhang, Ziwen Wang, Zhong Wang
| DOI: 10.14336/AD.2025.1331
The Q4-Mood Framework: A Stratified Movement Intervention Model for Late-Life Depression
Kerui Liu, Zikang Hao, Junqi Lian
| DOI: 10.14336/AD.2025.1208
Supplement

1. Supplementary data.pdf (902KB)

Advancing Immunosenescence Research: Mechanistic Depth, Predictive Models, and Digital Translation for Global Equity
Danrui Cai, Hangyu Fu, Jiancang Ma, Fangshi Xu
| DOI: 10.14336/AD.2025.1151
Male Monocyte-Like Cells are Prone to a Senescence-Induced Pro-inflammatory State
Luan Hernando Samit, Julia Temp, Irene Algarra Flores, Olesya Vakhrusheva, Yury Ladilov, Maria Luisa Barcena
| DOI: 10.14336/AD.2025.0871
Supplement

1. Supplementary data.pdf (356KB)