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2023
Impact Factor
7.0

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 181 results are found
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting
Xilong Guan, Xiaoling Zhu, Linan Zha, Wen Yu, Xiuqin Rao, Yanhong Xiong, Yu Jin, Mojiao Zhang, Tao Luo, Xiangfei Huang, Xifeng Wang, Fuzhou Hua, Jing Xu
| DOI: 10.14336/AD.2025.0675
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults
David Gómez-Ángel, Mercedes Sotos-Prieto, David Martínez-Gómez, Auxiliadora Graciani, Esther García-Esquinas, Fernando Rodríguez-Artalejo, Rosario Ortolá
| DOI: 10.14336/AD.2025.0347
Supplement

1. Supplementary data.pdf (694KB)

Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation
Tianwei Wang, Zhaoyang Zhang, Jian Liu, Liping Zhang, Qingbin Ni, Baoliang Sun, Jingyi Sun
| DOI: 10.14336/AD.2025.10630
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism
Marta Pokotylo, Norbert Brüggemann, Jannik Prasuhn
| DOI: 10.14336/AD.2025.0619
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI
Myung-Hoon Han, Mina Hwang, Hyuk Sung Kwon, So Young Moon, Yoo Kyoung Park, Jee Hyang Jeong, Seong Hye Choi, Seong-Ho Koh
| DOI: 10.14336/AD.2025.0646
Supplement

1. Supplementary data.pdf (1409KB)

Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk
Yating Li, Jinlin Shen, Li Zhang, Yang Luo
| DOI: 10.14336/AD.2025.0380
GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment
Mark D. Zuppichini, Abbey M. Hamlin, Quan Zhou, Esther Kim, Kayla Wyatt, Noah Reardon, Benjamin M. Hampstead, Thad A. Polk
| DOI: 10.14336/AD.2025.0334
Supplement

1. Supplementary data.pdf (901KB)

Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation
Qing Zou, Jianxin Zhou, Ying Li, Jiaming Shi, Jingying Huang, Cheng Zhuang, Hao Wu, Huanle Hong, Yanan Guo, Qian Li, Robert Chunhua Zhao, Jiao Wang
| DOI: 10.14336/AD.2025.0387
Supplement

1. Supplementary data.pdf (2106KB)

The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities
Binquan You, Dong Yi, Bingyin Wang, Hua Yan
| DOI: 10.14336/AD.2025.10620
Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease
Fengwen Jiang, Niya Wang, Qiang Meng
| DOI: 10.14336/AD.2025.0502
Regulatory and Influencing Factors of Digestive Function in Elderly People: Roles of the Gut Microbiota and Nutritional Interventions
Ka Li, Safia Arbab, Qiujing Du, Jiao Zhou, Yuwen Chen, Yali Tian, Li Qijie, Hanif Ullah, Ben Zhang
| DOI: 10.14336/AD.2025.0565
Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer
Pawel Kordowitzki, Arkadiusz Grzeczka
| DOI: 10.14336/AD.2025.0677
The Inflammasome-miR Axis in Alzheimer’s Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities
Botond Gaál, Roland Takács, Csaba Matta, Krisztián Juhász, Béla Fülesdi, Zoltán Szekanecz, Szilvia Benkő, László Ducza
| DOI: 10.14336/AD.2025.0353
Supplement

1. Supplementary data.pdf (220KB)

Glucose Metabolism, Lactate, Lactylation and Alzheimer’s Disease
Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun
| DOI: 10.14336/AD.2025.0338
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases
Yuxiang Du, Yong Xia
| DOI: 10.14336/AD.2025.0542
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief
Hong Wu, Jia-Yi Wu, Shao-Jie Gao, Lin Liu, Xin-Yi Dai, Wen-Lu Song, Long-Qing Zhang, Dai-Qiang Liu, Ying-Xin Tang, Ya-Qun Zhou, Wei Mei
| DOI: 10.14336/AD.2025.0530
Stroke Exacerbates Respiratory Disorder and Cognition Impairment in Mice with Cerebral Amyloid Angiopathy
YuXing Zhang, Ahmad El Hamamy, Zahid Iqbal, Arya Ranjan, Destiny Sumani, Hung Wen Lin, Louise D. McCullough, Jun Li
| DOI: 10.14336/AD.2025.0474
Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia
Fan Shi, Jun Chen
| DOI: 10.14336/AD.2025.0670
Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke
Ruoyao Cao, Yao Lu, Wei Li, Fan Yu, Shen Hu, Kunpeng Chen, Guoxuan Wang, Chengkan Sun, Qingfeng Ma, Miao Zhang, Juan Chen, Jie Lu
| DOI: 10.14336/AD.2025.0540
Supplement

1. Supplementary data.pdf (751KB)

Astrocytic Glucose Sensing Drives Synaptic Depression under Metabolic Stress
Andrés M. Baraibar, Carlos G. Ardanaz, Susana Mato, Paulo Kofuji, Alfonso Araque, Maite Solas
| DOI: 10.14336/AD.2025.0507
Supplement

1. Supplementary data.pdf (277KB)

Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations
Rui Xue, Anni Wang, Ying Zhou, Min Lou
| DOI: 10.14336/AD.2025.0060
Effective Therapeutic Strategies to Prevent Frailty and Falls in Community-Dwelling Older Adults
Dmitry Tsvetkov, Marleen J. Meyer-Tönnies, Mladen V. Tzvetkov, Werner Weitschies, Stefan Engeli, Anna Lebedeva, Anke Hannemann, Martin C. Jordan, Ulrike Garscha, Luzia Valentini, Daria Antonenko, Lieven N. Kennes, Maik Gollasch
| DOI: 10.14336/AD.2025.0445
The Mitochondrial Foundations of Parkinson’s Disease: Therapeutic Implications
Smijin K. Soman, Micah R. J. Woodruff, Ruben K. Dagda
| DOI: 10.14336/AD.2025.0440
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions
Qi-Lei Zhang, Yu Liu, Tian Tu, Xiao-Xin Yan
| DOI: 10.14336/AD.2025.0301
Exploring the Complex Relationship between Biological Aging and Cancer in a Prospective Italian Population Cohort
Martina Morelli, Antonietta Pepe, Simona Costanzo, Teresa Panzera, Sara Magnacca, Amalia De Curtis, Maria Loreto Muñoz Venegas, Chiara Cerletti, Maria Benedetta Donati, Giovanni de Gaetano, Licia Iacoviello, Alessandro Gialluisi, on behalf of the Moli-sani Study Investigators
| DOI: 10.14336/AD.2025.0204
Supplement

1. Supplementary data.pdf (831KB)

Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle
Shahneela Nusrat, Rahman Ud Din, Muhammad Akram Tariq, Haisheng Yang
| DOI: 10.14336/AD.2025.0370
Effects of Lipid Metabolites and Cross Organ Lipid Metabolism Regulation on Bone Homeostasis
Mengyuan Li, Jiaheng Zhang, Jiaqian Tang, Chang Zhou, Guomin Zhang, Huiping Liu, Xiaoming Lei
| DOI: 10.14336/AD.2025.0575
Novel Insights into the Mechanism and Treatment of Diabetes-Related Brain Complications: Focusing on the Blood-Brain Barrier Impairment
Caiyi Long, Yueheng Pu, Shunseng Keng, Jiajing Tao, Boxun Zhang, Rensong Yue
| DOI: 10.14336/AD.2025.0296
Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity
Daoqi Zhang, Congfei Lu, Kai Sang
| DOI: 10.14336/AD.2025.0419
Microcirculation Dysfunction in Subacute Stroke: The Role of Delayed Capillary Pericyte Loss
Yiya Xu, Chao Chen, Jilin Weng, Ting Chen, Yingchao He, Zhiwei Song, Yinzhou Wang
| DOI: 10.14336/AD.2025.0197
Supplement

1. Supplementary data.pdf (1613KB)

Age-dependent Transcriptional and Circuit Alterations in the brain Underlie Post-Anesthesia Neurobehavioral Dysfunction
Yun Li, Cosar Uzun, Syed Taufiqul Islam, Balaji Krishnamachary, Hangnoh Lee, Zihui Wang, Hui Li, Shaolin Liu, Junfang Wu
| DOI: 10.14336/AD.2025.0596
Supplement

1. Supplementary data.pdf (2622KB)

Advanced Age Worsens Phenotypes of Ocular Hypertension in Mice
Priyamvada M. Pitale, Solomon E. Gibson, Caroline C. Keehn, Arman T. Yazdian, Guofu Shen, Benjamin J. Frankfort
| DOI: 10.14336/AD.2025.0349
Supplement

1. Supplementary data.pdf (316KB)

Blue Zones, an Analysis of Existing Evidence through a Scoping Review
Cristina Candal-Pedreira, Lucía Martín-Gisbert, Ana Teijeiro, Guadalupe García, Alberto Ruano-Ravina, Mónica Pérez-Ríos
| DOI: 10.14336/AD.2025.0461
Supplement

1. Supplementary data.pdf (244KB)

Risk Factors for Oropharyngeal Dysphagia in Older Adults - Evidence from Consorci Sanitari Del Maresme and Mataró University Hospital, Catalonia, Spain
Lucilla Guidotti, Jorge Iván Castañeda-Maldonado, Marta Santiago, Pere Clavé, Omar Ortega
| DOI: 10.14336/AD.2025.0345
A Standardized Protocol for Mouse Longevity Studies in Preclinical Drug Development
Alex Zhavoronkov, Qian Wang, Yujie Liu, Wenbin Hou, Yuelei Shen, Dominika Wilczok, Kristen Fortney, Alex Aliper, Man Zhang, Feng Ren, Richard A. Miller
| DOI: 10.14336/AD.2025.0508
Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
Gudimetla Susmitha Mohan, Rahul Kumar
| DOI: 10.14336/AD.2025.0472
Neutrophil Extracellular Traps Promote AIM2-Dependent Microglial Pyroptosis Following Stroke
Hanze Chen, Linhui Ni, Jinhua Zhang, Xu Zheng, Yigang Chen, Xing Jin, Beibei Hu, Xinxin Xu, Qiwen Tang, Shuang Li, Yonggang Hao, Shilong Sun, Chengbin He, Shuxia Cao, Xingyue Hu
| DOI: 10.14336/AD.2024.1733
Supplement

1. Supplementary data.pdf (1499KB)

RSV Infection and Neurodegenerative Diseases: A Hypothesis of Energy Metabolism Disruption via the Lung-Brain Axis
Zeping Liu, Yan Zhou, Mingming Qi, Fangyuan Ren, Yurong Tan
| DOI: 10.14336/AD.2025.0534
Short-Chain Fatty Acids Improve Hippocampal Atrophy, Ventricular Dilatation and Cognitive Function Decline in Aged Mice
Pei-Ju Lee, Yu-Chun Lo, You-Yin Chen, Chaur-Jong Hu, Yen-Kuang Lin, Quoc Thao Trang Pham, Nicholas Keyi Sim, Chee Kin Then, Shing-Chuan Shen
| DOI: 10.14336/AD.2025.0426
Supplement

1. Supplementary data.pdf (660KB)

The Multimodal Nanomaterials of Phototherapy for Tumor Treatment
Yanan Bao, Wenxin Chou, Yusen Hou, Shanlin Yang, Yi Li, Yuxia Zhao, Hongyou Zhao
| DOI: 10.14336/AD.2025.0448