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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 198 results are found
A Signature of Senescence Based on An Analysis of Selected Markers in Primary Vascular Smooth Muscle Cells Cultured In Vitro and Derived from Atherosclerotic Plaque
Agata Głuchowska, Krzysztof Bojakowski, Dorota Janiszewska, Karolina Staniak, Magdalena Dudkowska, Grażyna Mosieniak
| DOI: 10.14336/AD.2025.0687
Supplement

1. Supplementary data.pdf (871KB)

Rethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors
Feng-Min Zhang, Xian-Zhong Zhang, Zhen Yu, Cheng-Le Zhuang, Li-Li Han
| DOI: 10.14336/AD.2025.1162
Neoadjuvant Immunotherapy in Triple-Negative Breast Cancer: Striking Potential or Need for Caution?
Panni Li, Xianan Guo, Wenhui Ruan, Jing Guo, Wei Wu, Yiding Chen, Yunxiang Zhou
| DOI: 10.14336/AD.2025.1265
Multi-Omics Advances in Major Depressive Disorder for Molecular Insights, Biomarker Discovery, and Therapeutic Development
Abdelbaset Mohamed Elasbali, Mohd Adnan, Ahmed S. Ali, Anas Shamsi, Md. Imtaiyaz Hassan
| DOI: 10.14336/AD.2025.1075
Cross-Tissue Proteomic Mendelian Randomization Identifies Therapeutic Targets for Vascular Dementia
Cheng Wang, Qiu-Han Xu, Jun-Ming Zhu, Jian Shen
| DOI: 10.14336/AD.2025.0538
Hexokinase as a Central Hub in Neurodegeneration: From Metabolic Dysfunction to Therapeutic Innovation
Shiyuan Cai, Yanjun Liu, Bo Liu, Hongli Liao, Ke Li
| DOI: 10.14336/AD.2025.0891
Cisternostomy Facilitates Clearance of Metabolic Waste from Cerebrospinal Fluid in Patients with Severe Brain Injury
Weiwei He, Shuai Gao, Lulu Du, Tangrui Han, Di Yao, Hao Wu, Qiang Li, Feixiang Li, Woo-ping Ge, Yonghong Wang
| DOI: 10.14336/AD.2025.0738
Supplement

1. Supplementary data.pdf (1209KB)

Late Onset Rheumatoid Arthritis
Zhao Peng, Wenjing Liu, BinYu Huang, Qian Wang, Xinping Tian, Sean X. Leng, Lin Kang
| DOI: 10.14336/AD.2025.0898
Erratum to “Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency”
Feiyan Zhao, Long Yan, Xuehan Zhao, Jiaqi Wu, Ying Fang, Zhimin Xin, Hongmei Wang, Xiaokui Yang
| DOI: 10.14336/AD.2025.10817
Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives
Le Liu, Chen Li, Youshuo Liu
| DOI: 10.14336/AD.2025.1098
Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ1-42-Induced Hippocampal Network Dysfunction
Maciej Studzian, Bartosz Bobula, M. Bruce MacIver, Renata Bocian, Anna Kobrzycka, Bartosz Caban, Tomasz Kowalczyk, Jacek Grebowski, Sylwia Michlewska, Maciej M. Jankowski, Krzysztof Tokarski, Paulina Kazmierska-Grebowska
| DOI: 10.14336/AD.2025.0796
Supplement

1. Supplementary data.pdf (791KB)

Neuropsychological Diagnostic Tools in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
Nuria Jerez-Garrido, Ana M. Jiménez-García, David Sánchez-Borda, Natalia Arias
| DOI: 10.14336/AD.2025.0618
Supplement

1. Supplementary data.pdf (419KB)

The Ability of Activity and Cognition in Old Mice to Predict Age of Death
Sreemathi Logan, Kavitha Kurup, Michael Chan, Michelle Ranjo-Bishop, Anthony Masingale, Daniel Owen, William E. Sonntag, Arlan Richardson, Archana Unnikrishnan
| DOI: 10.14336/AD.2025.1056
Supplement

1. Supplementary data.pdf (1199KB)

Emerging Perspectives in Anti-aging Treatments Using Anti-Fibrotic Strategies
Yu Wang, Chenshi Xi, Jiangli Yang, Mingye Wang, Linghui Zeng, Lingxiao Zhang, Chong Gao
| DOI: 10.14336/AD.2025.1204
SIRT1-Mediated Mitochondrial Homeostasis in Cardiac Aging: Molecular Mechanisms and Therapeutic Implications
Sitong Chen, Hanying Xu, Xiaonan Li, Xiaolei Tang, Lan Yang, Jing Lu, Jun Li
| DOI: 10.14336/AD.2025.1128
Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline
Julio Rey-Picazo, Jimena Pita, Lucía Peña, Marta Ferraz-Torres, Oscar Martínez-García, Marina Ávila-Villanueva, Gloria Santos-Pérez, David López-Sanz, M. Victoria Moreno-Arribas, Carlos González Perrino, Vicente Muedra, Alfredo Jesús Miñano-Molina, Vicente Hernández-Rabaza, Ulises Gómez-Pinedo, Gonzalo León-Espinosa
| DOI: 10.14336/AD.2025.1105
Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age
Maria Arbaizar-Rovirosa, Raúl F. Pérez, Alfonso Peñarroya, Mattia Gallizioli, Mario F. Fraga, Anna M. Planas
| DOI: 10.14336/AD.2025.1066
Supplement

1. Supplementary data.pdf (789KB)

Immunosenescence: Shaping the Hematological Narrative in the Era of Aging
Yajie Wu, Ji Luo, Jiaoya Lin, Shuai Zheng, Yingmiao Wu, Yifei Gao, Jiao Chen, Feifei Che, Ling Zhong
| DOI: 10.14336/AD.2025.0741
Histone H4 Lysine 12 Lactylation Promotes the Senescence of Alveolar Epithelial Type II Cells in Chronic Obstructive Pulmonary Disease by Modulating the CD38-NAD+ Signaling Pathway
Chunxiao Yang, Qi Wang, Yuhan Xiong, Nan Ruan, Jun Yu, Yi Huang, Yu Liu, Cuntai Zhang, Weiwei Yu
| DOI: 10.14336/AD.2025.0291
Cellular Characterization and Neural Electrophysiology in Cerebral Organoid Models of Neurological Disorders
Quankun Zhou, Ling Ma, Bangming Guo, Peng Li, Ye Song
| DOI: 10.14336/AD.2025.0758
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity
Myriam Rahmouni, Cristina Giuliani, Daniela Colucci, Nicolás Mendoza-Mejía, Samuel Hiet, Marco Lamanda, Jean-Louis Spadoni, Sigrid Le Clerc, Taoufik Labib, Matilde Manetti, Maxime Tison, Raissa Medina-Santos, Paolo Garagnani, Alexandre How-Kit, Armand Bensussan, Marianne Nygaard, Kaare Christensen, Almut Nebel, Jean-François Deleuze, Jean-François Zagury
| DOI: 10.14336/AD.2025.1109
The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes in Fibrotic Diseases
Fei Wang, Han Wang, Yun chao Zhang, Cao Dan, Yi Ming Qin, Mei Juan Xie, Xiao Yan Lyu
| DOI: 10.14336/AD.2025.1087
Metabolic-Inflammatory Syndrome: Decoding the Metabolic-Immune Axis for Precision Intervention
Simin Li, Yawei Shi, Chongge You
| DOI: 10.14336/AD.2025.1125
Advancing Single-Cell Transcriptomic Analysis to Reveal Age-Related Skeletal Muscle Changes: A Systematic Review
Chaoran Liu, Hei Yuet Wong, Ranyang Tao, Baoqi Li, Pui Yan Wong, Chun Ho Tam, Ning Zhang, Ling Qin, Jiankun Xu, Gustavo Duque, Christoph Brochhausen, Wing Hoi Cheung, Ronald Man Yeung Wong
| DOI: 10.14336/AD.2025.0701
Supplement

1. Supplementary data.pdf (631KB)

Sphingosine Kinase 2 Inhibition Ameliorates Neuroinflammation in Diet-Induced Obese Mice
Lotte Vanherle, Cecilia Skoug, Lisa Teresa Porschen, Fátima Gimeno-Ferrer, Frank Matthes, João M. N. Duarte, Anja Meissner
| DOI: 10.14336/AD.2025.0636
Supplement

1. Supplementary data.pdf (841KB)

Correlations between Aging, Telomeres, and Natural Compounds
Katarzyna Rakoczy, Laura Wojdyło, Sara Suwała, Karolina Klasen, Jacek Kuźnicki, Marek Ziętek, Julita Kulbacka
| DOI: 10.14336/AD.2025.0853
Annexin A5 in Ischemic Stroke: Molecular Mechanisms and Translational Therapy Strategies
Zhanwei Zhu, Jiachen He, Qi Liu, Jiaqi Guo, Jingbei Liu, Shuaili Xu, Xi Chen, Di Wu
| DOI: 10.14336/AD.2025.1021
Optimal Evaluation and Treatment of Cardiac Rehabilitation for Patients Following TAVR: A Personalized Program Based on The Five Prescriptions
Xue-Song Han, Gang Wang, Yong Miao, Zhi-Yuan Tian, Yong-Chao Zhang, Zong-Yan Li, Xiao-Jia Sun, Qiang Hu
| DOI: 10.14336/AD.2025.0716
Impairment of astrocyte homeostasis and lysosomal function in Alzheimer’s disease pathogenesis
Jenelle M. Collier, Mary McFarland, Sanjana Krishna, Pallavi Kurella, Christian Calderon Pinon, Dandan Sun
| DOI: 10.14336/AD.2025.0694
Aβ Deposition in Extracellular Space Disrupts Glial-Neuron Communication and Triggers Alzheimer's Disease
Ying Chen, Ling Ding, Ziqi Gu, Zixi Tian, Tingting Gao, Feiyan Zhou, Shouzi Zhang, Zhiqian Tong
| DOI: 10.14336/AD.2025.0873
Aging-Related Mechanisms Underlying Carcinogenesis: Therapeutic Opportunities.
Ana Guijarro, Giulia Allavena, Livia Pisciotta, Alessio Nencioni, Irene Caffa
| DOI: 10.14336/AD.2025.0861
Enhancing Mitochondrial Matrix Antioxidant SOD2 in Astrocytes Mitigates Cellular Senescence and Cognitive Impairment in Aging
Matthew P Baier, Sophia I Sharum, Jenna L Wilson, Sanjit Narasimhan, Chinnu Salim, Sreemathi Logan
| DOI: 10.14336/AD.2025.0760
Supplement

1. Supplementary data.pdf (584KB)

Global Burden of Chronic Obstructive Pulmonary Disease and Heart Failure Comorbidity in Older Adults: An Analysis of the Global Burden of Disease Study
Jian Kang, Huiqing Xu, Xiaojing Deng, Yeping Bian, Tianrui Deng, Yunting Xu, Guofeng Ao, Jian Xu, Fei Xu
| DOI: 10.14336/AD.2025.1044
Supplement

1. Supplementary data.pdf (720KB)

Stroke-Induced Retinal Dysfunction: Mechanisms, Diagnostics, and Future Directions
Ting Wang, Zirun Feng, Jin Yang, Cuiying Liu, Heng Zhao, Sheng Huang
| DOI: 10.14336/AD.2025.0451
Early-Life Red Light Exposure Extends Lifespan in C. elegans through ROS-AMPK-Driven Mitochondrial Reprogramming
Yao Zhu, Xin Lin, Huiting Wang, Mingming Song, Tao Yang, Yi Jiao, Chang Liu
| DOI: 10.14336/AD.2025.0791
Supplement

1. Supplementary data.pdf (1495KB)

Diversity of Brain Microvascular Endothelial Cell Functions: Physiology, Ischemia/Hypoxia, and Underlying Protection
Mingxuan Cao, Jia Liu, Xunming Ji
| DOI: 10.14336/AD.2025.0664
Neuronal Necroptosis Drives Neuroinflammation and Cognitive Decline Independent of Neuronal Cell Death
Nidheesh Thadathil, Nicholas A Wolf, Roman Wolf, Carlos Manlio Díaz-García, Sreemathi Logan, Daniel B Owen, Kevin Pham, Willard M Freeman, Arlan Richardson
| DOI: 10.14336/AD.2025.0805
Supplement

1. Supplementary data.pdf (911KB)

Monocytes/Macrophages in Giant Cell Arteritis-Polymyalgia Rheumatica Spectrum Disease
Junyan Guo, Yanlin He, Fan Yang, Weiqian Chen
| DOI: 10.14336/AD.2025.0830
Progress in Disease-Modifying Therapies for Parkinson's Disease
Shuyuan Zhang, Gang Shao, Bin Wu, Liang Xia, Lei Wang, Liwen Li, Kai Jin, Yangfan Zou, Caixing Sun
| DOI: 10.14336/AD.2025.0627
Therapeutic Promise of Exosomal CD73 for Diabetic Bone Disorders: Addressing Mechanistic and Translational Challenges
Jing Lu, DuJiang Yang, Canhao Lai, Xiaoyu Chen, Ruichen Li, GuoYou Wang
| DOI: 10.14336/AD.2025.1154