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2023
Impact Factor
7.0

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 160 results are found
Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider
| DOI: 10.14336/AD.2024.1175
Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges
Xiuyun Liu, Hui Zhi, Marek Czosnyka, Chiara Robba, Zofia Czosnyka, Jennifer Lee Summers, Huijie Yu, Xiaoguang Tong, Guoyi Gao, Gelei Xiao, Kai Yu, Yan Xing, Renling Mao, Shaoya Yin, Yangong Chao, Hongliang Li, Ke Pu, Keke Feng, Meijun Pang, Dong Ming
| DOI: 10.14336/AD.2024.1434
Supplement

1. Supplementary data.pdf (321KB)

Oxidative Stress Promotes Axonal Atrophy through Alterations in Microtubules and EB1 Function
Samuel Shields, Emilia Gregory, Oliver Wilkes, IIlana Gozes, Natalia Sanchez-Soriano
| DOI: 10.14336/AD.2024.0839
Supplement

1. Supplementary data.pdf (858KB)

NR1D1 Inhibition Enhances Autophagy and Mitophagy in Alzheimer's Disease Models
Shi-qi Zhang, Zhangming Niu, Alexander Anisimov, Fang Shi, Shenglong Deng, Xianglu Xiao, Shu-qin Cao, Jun-ping Pan, He-Ling Wang, Maria J. Lagartos-Donate, Nihal Gullu Bozbas, Ping-Jie Wang, Ruixue Ai, Yan Li, Guang Yang, Sofie Lautrup, Evandro F. Fang
| DOI: 10.14336/AD.2024.1654
Supplement

1. Supplementary data.pdf (718KB)

Chronic Cerebral Deterioration - A Comprehensive View of Old-Age Cerebral Deterioration
Jan Willem van Dalen
| DOI: 10.14336/AD.2024.1073
Pros and Cons of Human Brain Organoids to Study Alzheimer’s Disease
Andrea Sainz, Fernando Pérez-Cerdá, Alberto Pérez-Samartín, Mitradas Panicker, Asier Ruiz, Carlos Matute
| DOI: 10.14336/AD.2024.1409
Physical Prehabilitation for Older Patients with Cancer before Complex Medical-Surgical Interventions: An Umbrella Review
Dana Loudovici-Krug, Louise André, Heiner Paul Blumensaat, Marion Granger, Laetitia Stefani, Josephine Kühnemund, Christina Lemhöfer, Claire Falandry
| DOI: 10.14336/AD.2024.0957
Targeting Astrogliosis in the Retrotrapezoid Nucleus: A Novel Approach to Ameliorate Respiratory Dysfunction and Alzheimer's Pathology in Mice
Zahid Iqbal, Ahmad El Hamamy, Ngoc Mai Le, Arya Ranjan, YuXing Zhang, Li Qi, Bharti Manwani, Chunfeng Tan, Louise D. McCullough, Jun Li*
| DOI: 10.14336/AD.2024.0523
TBC1D15 Inhibits Autophagy of Microglia through Maintaining the Damaged Swelling Lysosome in Alzheimer’s Disease
You Wu, Yong-ming Zhou, Wei Wu, Wan-rong Jiang, Xin-yuan Zhang, Si-yuan Song, Zhao-hui Yao
| DOI: 10.14336/AD.2024.1373
Supplement

1. Supplementary data.pdf (676KB)

Decoding the Multiple Identities and Crosstalk of Organokines in Obesity-Related Type 2 Diabetes Mellitus
Yu-Qing Ni, Jun-Kun Zhan, You-Shuo Liu
| DOI: 10.14336/AD.2024.1138
Addressing Healthy Aging: Time to Stop a Tsunami of Rising Alzheimer’s Disease
Nobel Chenggong Zong, Yuhan Zhang, Yuanli Huang, Hua Cai
| DOI: 10.14336/AD.2024.1476
Mechanisms Underlying Vascular Inflammaging: Current Insights and Potential Treatment Approaches
Ying Zeng, Francesco Buonfiglio, Jingyan Li, Norbert Pfeiffer, Adrian Gericke
| DOI: 10.14336/AD.2024.0922
Circulating Endocannabinoids and Cognitive Function
in Older Adults
Shiraz Vered, Alexa S. Beiser, Liron Sulimani, Sharon Sznitman, Saptaparni Ghosh, Gil M Lewitus, David Meiri, Sudha Seshadri, Galit Weinstein
| DOI: 10.14336/AD.2024.1427
Supplement

1. Supplementary data.pdf (1170KB)

Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease
Sihang Fang, Mingjun Jiang, Juan Jiao, Hongye Zhao, Dizhi Liu, Danni Gao, Tenger Wang, Ze Yang, Huiping Yuan
| DOI: 10.14336/AD.2024.1253
Fecal Microbiota Transplantation from Young-Trained Donors Improves Cognitive Function in Old Mice Through Modulation of the Gut-Brain Axis
Camila Cerna, Nicole Vidal-Herrera, Francisco Silva-Olivares, Daniela Álvarez, Camila González-Arancibia, Miltha Hidalgo, Pabla Aguirre, José González-Urra, Camila Astudillo-Guerrero, Michel Jara, Omar Porras, Gonzalo Cruz, Christian Hodar, Paola Llanos, Pamela Urrutia, Claudia Ibacache-Quiroga, Yulia Nevzorova, Francisco Javier Cubero, Marco Fuenzalida, Samanta Thomas-Valdés, Gonzalo Jorquera
| DOI: 10.14336/AD.2024.1089
Supplement

1. Supplementary data.pdf (902KB)

Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms
Ling Zhong, Jielin Yang, Jibran Nehal Syed, Yuwei Zhang, Yan Tian, Xianghui Fu
| DOI: 10.14336/AD.2024.1477
Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence
Wenhui Xu, Lei Li, Zhendong Cao, Jinghong Ye, Xuyu Gu
| DOI: 10.14336/AD.2024.1188
Senescent Macrophages and the Lung Cancer Microenvironment: A New Perspective on Tumor Immune Evasion
Lexin Qin, Tingting Liang, Xinyu Zhu, Wentao Hu, Bo Li, Meidan Wei, Jiaxin Zhang, Jianxiang Li*, Jin Wang*
| DOI: 10.14336/AD.2024.1404
Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk
Jianqiong Yin, Wei Peng, Lu Lu, Zhen Hong, Dong Zhou, Jinmei Li
| DOI: 10.14336/AD.2024.1499
Bone Health and Physical Activity - The Complex Mechanism
Alicja Nowak, Małgorzata Ogurkowska
| DOI: 10.14336/AD.2024.1316
Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside
Xiwei Fan, Hong Xu, Indira Prasadam, Antonia Rujia Sun, Xiaoxin Wu, Ross Crawford, Yanping Wang, Xinzhan Mao
| DOI: 10.14336/AD.2024.1538
Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses
Shokofeh Rahimpour, Briana L. Clary, Sanaz Nasoohi, Yohanna S. Berhanu, Candice M. Brown
| DOI: 10.14336/AD.2024.1293
Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective
Zikang Hao, Xinmeng Guo, Jiawen Wu, Guang Yang
| DOI: 10.14336/AD.2024.1560
Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future
Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu
| DOI: 10.14336/AD.2024.1495
Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease
Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang
| DOI: 10.14336/AD.2024.1129
Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization
Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang
| DOI: 10.14336/AD.2024.01213
Neuroinflammation as a Link in Parkinson’s and Alzheimer’s Diseases: A Systematic Review and Meta-Analysis
Anna Tylutka, Piotr Żabiński, Łukasz Walas, Agnieszka Zembron-Lacny
| DOI: 10.14336/AD.2024.1174
Supplement

1. Supplementary data.pdf (444KB)

Multi-Omics Research on Angina Pectoris: A Novel Perspective
Haiyang Chen, Lijun Zhang, Meiyan Liu, Yanwei Li, Yunpeng Chi
| DOI: 10.14336/AD.2024.1298
Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications
Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi
| DOI: 10.14336/AD.2024.1362
Response to Letter to the Editor, “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Dong Tan, Chun Xu, Qing Zhu, Gang Fan, Qing-Tian Luo
| DOI: 10.14336/AD.2024.1262R
Metabolic Dysfunction in Idiopathic Intracranial Hypertension: Current Theories and Updates
Hui Li, Lu Liu, Yifan Zhou, Huimin Jiang, Weiyue Zhang, Chenxia Zhou, Chuanjie Wu, Chen Zhou, Xunming Ji
| DOI: 10.14336/AD.2024.1147
Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis
Yiran Huang, Nan Gao, Boren Liu, Weili Luo, Jianfei Chen, Yan Chen, Yong Bi, Zikai Zhou
| DOI: 10.14336/AD.2024.0835
Supplement

1. Supplementary data.pdf (509KB)

Role of AMPK and Sirtuins in Aging Heart: Basic and Translational Aspects
Maria Luisa Barcena, Muhammad Aslam, Kristina Norman, Christiane Ott, Yury Ladilov
| DOI: 10.14336/AD.2024.1216
Lifelong Glutathione Deficiency in Mice Increased Lifespan and Delayed Age-Related Motor Declines
J. Thomas Mock, Paapa Mensah-Kane, Delaney L. Davis, Jessica M. Wong, Philip H. Vann, Michael J. Forster, Nathalie Sumien
| DOI: 10.14336/AD.2024.1077
Brain Regulates Neuronal Activity Directly through the Heartbeat: A New Pathway of Heart-Brain Interaction
Zhitian Wang, Junjian Zhang, Qing-Guo Ren
| DOI: 10.14336/AD.2024.1083
Harnessing BDNF Signaling to Promote Resilience in Aging
Jamshid Faraji, Gerlinde A. S. Metz
| DOI: 10.14336/AD.2024.0961
APOE ɛ4 and Insulin Resistance Influence Path-Integration-Based Navigation through Distinct Large-Scale Network Mechanisms
Karel M. Lopez-Vilaret, Marina Fernandez-Alvarez, Anne Bierbrauer, Nikolai Axmacher, Jose L. Cantero, Mercedes Atienza
| DOI: 10.14336/AD.2024.0975
Supplement

1. Supplementary data.pdf (329KB)

Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis
Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid, Amaya Puig-Kröger, Manuel D Gahete, Jorge Manzanares, Esther Caparrós, Rubén Francés
| DOI: 10.14336/AD.2024.0932
Supplement

1. Supplementary data.pdf (1052KB)

The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu
| DOI: 10.14336/AD.2024.1223
Histone Methylation, Energy Metabolism, and Alzheimer's Disease
Jiaqi Fu, Li An
| DOI: 10.14336/AD.2024.0899