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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 216 results are found
Islet Inflammation and Endocrine Function in Aging - Evaluating the Role of Toll-like receptor 4
Julia Jelleschitz, Annette Brandt, Klara Brehm, Vanessa Schnell, Tobias Jung, Ina Bergheim, Annika Höhn
| DOI: 10.14336/AD.2025.1130
Supplement

1. Supplementary data.pdf (403KB)

Phosphorylated Ubiquitin as a Clinical Biomarker for Mitochondrial Damage in Neurodegenerative Diseases
Fabienne C. Fiesel, Jens O. Watzlawik, Michael G. Heckman, Sophia G. Blumenfeld, Michael J. Rigby, Mohammed Kehili, Katja Lohmann, Christine Klein, Derek P. Narendra, Clemens R. Scherzer, Nilufer Ertekin-Taner, Neill R. Graff-Radford, Zbigniew K. Wszolek, Owen A. Ross, Wolfdieter Springer
| DOI: 10.14336/AD.2025.1220
Supplement

1. Supplementary data.pdf (1217KB)

Perspectives on Pathological Crosstalk between Malocclusion and Multi-organ Systems: The Hidden Face of an Iceberg
Thakur Prasad Chaturvedi, Ching-Hsin Chang, Prathap Somu, Navneet Kumar Dubey, Ming-Che Liu
| DOI: 10.14336/AD.2025.1377
Prospects and Challenges in Identifying Genetic Determinants of Age-Related Cerebral Small Vessel Disease
Polina S. Shlapakova, Larisa A. Dobrynina, Elena V. Gnedovskaya, Evgeny I. Rogaev
| DOI: 10.14336/AD.2025.1272
Glucagon Like Peptide-1 Receptor Agonists for Sarcopenia and Muscle Wasting Disorders: A Systematic Review of Efficacy and Mechanisms
Abudureheman Maihemuti, Can Cui, Qianjin Wang, Reziwanguli Amuti, Wai Wang Chau, Senlin Chai, Ning Zhang, Ronald Man Yeung Wong, Ho Ko, Timothy Chi-Yui Kwok, Wing-Hoi Cheung
| DOI: 10.14336/AD.2025.1165
Supplement

1. Supplementary data.pdf (298KB)

Vascular Aging and Multi-Omic Regulation in Ischemic Stroke: Toward Precision Neurorepair
Denisa Floriana Pirscoveanu, Dirk M. Hermann, Mihaela Abuzan, Thorsten R. Doeppner, Liviu Martin, Aurel Popa-Wagner
| DOI: 10.14336/AD.2025.1363
Reduced Blood Choline in Obesity Is Associated with Metabolic and Alzheimer’s Biomarkers
Wendy Winslow, Jessica M. Judd, Savannah Tallino, Geidy E. Serrano, Thomas G. Beach, Lori R. Roust, Eleanna De Filippis, Brooke Brown, Christos Katsanos, Ramon Velazquez
| DOI: 10.14336/AD.2025.1207
Senescence in Aging and Alzheimer’s Disease
Li Sun, Chu Chen
| DOI: 10.14336/AD.2025.1201
Emerging Roles of Skeletal Muscle-Derived Exosomal miRNAs in Metabolic Regulation: A Perspective
Fei Zhang, Ziwen Wang, Zhong Wang
| DOI: 10.14336/AD.2025.1331
The Q4-Mood Framework: A Stratified Movement Intervention Model for Late-Life Depression
Kerui Liu, Zikang Hao, Junqi Lian
| DOI: 10.14336/AD.2025.1208
Supplement

1. Supplementary data.pdf (902KB)

Advancing Immunosenescence Research: Mechanistic Depth, Predictive Models, and Digital Translation for Global Equity
Danrui Cai, Hangyu Fu, Jiancang Ma, Fangshi Xu
| DOI: 10.14336/AD.2025.1151
Male Monocyte-Like Cells are Prone to a Senescence-Induced Pro-inflammatory State
Luan Hernando Samit, Julia Temp, Irene Algarra Flores, Olesya Vakhrusheva, Yury Ladilov, Maria Luisa Barcena
| DOI: 10.14336/AD.2025.0871
Supplement

1. Supplementary data.pdf (356KB)

Adrenal Aging: Region-Specific Vulnerability and Proteostatic Decline - Mechanisms, Biomarkers, and Translational Opportunities
Guanxiong Ding, Yangyang Xu, Ting Guo, Chenchen Feng
| DOI: 10.14336/AD.2025.1296
Long-term Senolytic Treatment Prevents Endothelial Dysfunction in Arterial Aging
Jie Lin, Shilin Chen, Dong Tan, Xin Yang, Weiming Guo, Pengxu Cang, Zhihui Yang, Jinhui Zha, Haihuan Lin, Qingping Zhang, Jing Yang, Gang Fan
| DOI: 10.14336/AD.2025.0976
Supplement

1. Supplementary data.pdf (453KB)

The Multinutrient Fortasyn Connect Influences Gut Microbiota and Intestinal Function in Early Alzheimer’s Disease
Natalia Molinero, Marta Montero-Atalaya, Lucía Méndez, Mikel Roldán, Itziar Palmí Cortés, Sara Ruhland, Begoña Bartolomé, Isabel Medina, M. Victoria Moreno-Arribas
| DOI: 10.14336/AD.2025.1176
Supplement

1. Supplementary data.pdf (1366KB)

Integrative Mechanisms and Emerging Therapies for Lacrimal Gland Aging
Xiaoting Pei, Zhijie Li
| DOI: 10.14336/AD.2025.1144
Visual Dependence in Postural Control Is Increased in Older Adults
Saskia Neumann, Cyrille Mvomo, Deepak K. Ravi, Friederike A. Schulte, Lorenz Assländer, Chris Easthope Awai
| DOI: 10.14336/AD.2025.1119
The Molecular and Metabolic Landscape of Insulin Resistance in Aging-Related Cardiovascular Diseases
Jinyuan Luoqian, Junhong Wu, Lanlan Jia, Zhuorui Ran, Moujiang Wu, Siyuan Yang
| DOI: 10.14336/AD.2025.1108
A Signature of Senescence Based on An Analysis of Selected Markers in Primary Vascular Smooth Muscle Cells Cultured In Vitro and Derived from Atherosclerotic Plaque
Agata Głuchowska, Krzysztof Bojakowski, Dorota Janiszewska, Karolina Staniak, Magdalena Dudkowska, Grażyna Mosieniak
| DOI: 10.14336/AD.2025.0687
Supplement

1. Supplementary data.pdf (871KB)

Rethinking Muscle Aging Through the Lens of Fibro-Adipogenic Progenitors
Feng-Min Zhang, Xian-Zhong Zhang, Zhen Yu, Cheng-Le Zhuang, Li-Li Han
| DOI: 10.14336/AD.2025.1162
Neoadjuvant Immunotherapy in Triple-Negative Breast Cancer: Striking Potential or Need for Caution?
Panni Li, Xianan Guo, Wenhui Ruan, Jing Guo, Wei Wu, Yiding Chen, Yunxiang Zhou
| DOI: 10.14336/AD.2025.1265
Multi-Omics Advances in Major Depressive Disorder for Molecular Insights, Biomarker Discovery, and Therapeutic Development
Abdelbaset Mohamed Elasbali, Mohd Adnan, Ahmed S. Ali, Anas Shamsi, Md. Imtaiyaz Hassan
| DOI: 10.14336/AD.2025.1075
Cross-Tissue Proteomic Mendelian Randomization Identifies Therapeutic Targets for Vascular Dementia
Cheng Wang, Qiu-Han Xu, Jun-Ming Zhu, Jian Shen
| DOI: 10.14336/AD.2025.0538
Hexokinase as a Central Hub in Neurodegeneration: From Metabolic Dysfunction to Therapeutic Innovation
Shiyuan Cai, Yanjun Liu, Bo Liu, Hongli Liao, Ke Li
| DOI: 10.14336/AD.2025.0891
Cisternostomy Facilitates Clearance of Metabolic Waste from Cerebrospinal Fluid in Patients with Severe Brain Injury
Weiwei He, Shuai Gao, Lulu Du, Tangrui Han, Di Yao, Hao Wu, Qiang Li, Feixiang Li, Woo-ping Ge, Yonghong Wang
| DOI: 10.14336/AD.2025.0738
Supplement

1. Supplementary data.pdf (1209KB)

Late Onset Rheumatoid Arthritis
Zhao Peng, Wenjing Liu, BinYu Huang, Qian Wang, Xinping Tian, Sean X. Leng, Lin Kang
| DOI: 10.14336/AD.2025.0898
Erratum to “Aberrantly High FBXO31 Impairs Oocyte Quality in Premature Ovarian Insufficiency”
Feiyan Zhao, Long Yan, Xuehan Zhao, Jiaqi Wu, Ying Fang, Zhimin Xin, Hongmei Wang, Xiaokui Yang
| DOI: 10.14336/AD.2025.10817
Epigenetic Regulation of Regulated Cell Death in Aging-Related Diseases: Clinical Perspectives
Le Liu, Chen Li, Youshuo Liu
| DOI: 10.14336/AD.2025.1098
Lamotrigine Restores Impairments in Theta Rhythms and LTP as Early Biomarkers of Aβ1-42-Induced Hippocampal Network Dysfunction
Maciej Studzian, Bartosz Bobula, M. Bruce MacIver, Renata Bocian, Anna Kobrzycka, Bartosz Caban, Tomasz Kowalczyk, Jacek Grebowski, Sylwia Michlewska, Maciej M. Jankowski, Krzysztof Tokarski, Paulina Kazmierska-Grebowska
| DOI: 10.14336/AD.2025.0796
Supplement

1. Supplementary data.pdf (791KB)

Neuropsychological Diagnostic Tools in Mild Cognitive Impairment: A Systematic Review and Meta-Analysis
Nuria Jerez-Garrido, Ana M. Jiménez-García, David Sánchez-Borda, Natalia Arias
| DOI: 10.14336/AD.2025.0618
Supplement

1. Supplementary data.pdf (419KB)

The Ability of Activity and Cognition in Old Mice to Predict Age of Death
Sreemathi Logan, Kavitha Kurup, Michael Chan, Michelle Ranjo-Bishop, Anthony Masingale, Daniel Owen, William E. Sonntag, Arlan Richardson, Archana Unnikrishnan
| DOI: 10.14336/AD.2025.1056
Supplement

1. Supplementary data.pdf (1199KB)

Emerging Perspectives in Anti-aging Treatments Using Anti-Fibrotic Strategies
Yu Wang, Chenshi Xi, Jiangli Yang, Mingye Wang, Linghui Zeng, Lingxiao Zhang, Chong Gao
| DOI: 10.14336/AD.2025.1204
SIRT1-Mediated Mitochondrial Homeostasis in Cardiac Aging: Molecular Mechanisms and Therapeutic Implications
Sitong Chen, Hanying Xu, Xiaonan Li, Xiaolei Tang, Lan Yang, Jing Lu, Jun Li
| DOI: 10.14336/AD.2025.1128
Potential Risk to Brain Health after Surgical Interventions: Biomarkers to Predict the Occurrence of Cognitive Decline
Julio Rey-Picazo, Jimena Pita, Lucía Peña, Marta Ferraz-Torres, Oscar Martínez-García, Marina Ávila-Villanueva, Gloria Santos-Pérez, David López-Sanz, M. Victoria Moreno-Arribas, Carlos González Perrino, Vicente Muedra, Alfredo Jesús Miñano-Molina, Vicente Hernández-Rabaza, Ulises Gómez-Pinedo, Gonzalo León-Espinosa
| DOI: 10.14336/AD.2025.1105
Microglial Replacement Reverses Age-Associated Epigenetic Modifications Despite Accelerating Epigenetic Age
Maria Arbaizar-Rovirosa, Raúl F. Pérez, Alfonso Peñarroya, Mattia Gallizioli, Mario F. Fraga, Anna M. Planas
| DOI: 10.14336/AD.2025.1066
Supplement

1. Supplementary data.pdf (789KB)

Immunosenescence: Shaping the Hematological Narrative in the Era of Aging
Yajie Wu, Ji Luo, Jiaoya Lin, Shuai Zheng, Yingmiao Wu, Yifei Gao, Jiao Chen, Feifei Che, Ling Zhong
| DOI: 10.14336/AD.2025.0741
Histone H4 Lysine 12 Lactylation Promotes the Senescence of Alveolar Epithelial Type II Cells in Chronic Obstructive Pulmonary Disease by Modulating the CD38-NAD+ Signaling Pathway
Chunxiao Yang, Qi Wang, Yuhan Xiong, Nan Ruan, Jun Yu, Yi Huang, Yu Liu, Cuntai Zhang, Weiwei Yu
| DOI: 10.14336/AD.2025.0291
Cellular Characterization and Neural Electrophysiology in Cerebral Organoid Models of Neurological Disorders
Quankun Zhou, Ling Ma, Bangming Guo, Peng Li, Ye Song
| DOI: 10.14336/AD.2025.0758
The HLA-B*57:01 Haplotype, Genetic Key Linking Innate Immunity and Longevity
Myriam Rahmouni, Cristina Giuliani, Daniela Colucci, Nicolás Mendoza-Mejía, Samuel Hiet, Marco Lamanda, Jean-Louis Spadoni, Sigrid Le Clerc, Taoufik Labib, Matilde Manetti, Maxime Tison, Raissa Medina-Santos, Paolo Garagnani, Alexandre How-Kit, Armand Bensussan, Marianne Nygaard, Kaare Christensen, Almut Nebel, Jean-François Deleuze, Jean-François Zagury
| DOI: 10.14336/AD.2025.1109
The Role of Mitochondria-Associated Endoplasmic Reticulum Membranes in Fibrotic Diseases
Fei Wang, Han Wang, Yun chao Zhang, Cao Dan, Yi Ming Qin, Mei Juan Xie, Xiao Yan Lyu
| DOI: 10.14336/AD.2025.1087