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2024
Impact Factor
6.9

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 208 results are found
Extension of Lifespan and Amelioration of Alzheimer’s Disease Phenotypes by Genetic Manipulation of Mitochondrial NAD+/NADH Ratio
Suman Rimal, Jae-Hyuk Lee, Yanzi He, Bingwei Lu
| DOI: 10.14336/AD.2026.0011
Supplement

1. Supplementary data.pdf (229KB)

InflammAging and Human Diversity: Expanding Horizons in Age-Related Chronic Disease
José M. Izquierdo
| DOI: 10.14336/AD.2026.0077
The Role of Macrophage Senescence in Coronary Artery Disease: Underlying Mechanisms and Therapeutic Targets
Yi Xiao, Zhenjie Li, Zipeng Li, Weilin Li, Feiyang Xue, Qiong Liu
| DOI: 10.14336/AD.2025.1562
Dietary Interventions for Healthy Aging: An Epigenetic Perspective
Xinyu Zhang, Ziyue Xie, Huimin Bian, Yu Li, Ruigong Zhu, Jia Sun
| DOI: 10.14336/AD.2026.0333
Fine-Tuning Autophagy in Skeletal Muscle: From Homeostasis to Muscle Wasting Disorders
Qian Gou, Shi Chee Ong, Wen Xing Lee, Priya D. Gopal Krishnan, Hong-Wen Tang
| DOI: 10.14336/AD.2026.0170
The Lung-Brain Axis in Cognitive Impairment and Dementia: Mechanisms and Therapeutic Prospects
Liying Zhang, Abigail Dove, Juan Du, Dan Yang, Qiaoli Su, Xiaoli Huang, Jiao Wang, Jirong Yue
| DOI: 10.14336/AD.2026.0095
Clock and the Cleaner: Circadian Rhythms and Autophagy Coupling in Alzheimer's Disease
Liyun Ma, Zhenxiang Gong, Rong Gao, Lina Zhu, Liru Wu, Min Zhang, Li Ba
| DOI: 10.14336/AD.2025.1496
MAMs as a promising therapeutic strategy for age-related neurodegenerative diseases
Giacoma Galizzi
| DOI: 10.14336/AD.2025.1342
Microbiome-Linked Metabolic Architecture of Accelerated Biological Aging in Humans
Mitsuru Yagi, Ryo Mizukoshi, Keitaro Ito, Norihiro Isogai, Haruki Funao, Retsu Fujita
| DOI: 10.14336/AD.2026.0237
Supplement

1. Supplementary data.pdf (644KB)

Spinal cord changes in Neurodegenerative and Neuroinflammatory Diseases
Rongfan Peng, Ziting Cui, Zhao Chen, Hong Jiang, Zhe Long
| DOI: 10.14336/AD.2025.1555
The Interplay Between Physical Exercise, Nutritional Strategies, and Brain-Derived Neurotrophic Factor in Promoting Cognitive Performance
Jacopo Givralli, Tatiana Moro, Tõnis Timmusk, Antonio Paoli
| DOI: 10.14336/AD.2025.1456
Dopamine-Induced L-Lactate Production in Cortical Astrocytes Cross-Reacts with β1-Adrenoceptor-Mediated cAMP Signalling
Keita Sugiyama, Anemari Horvat, Klemen Dolinar, Sergej Pirkmajer, Borut Furlani, Jernej Jorgačevski, Nina Vardjan, Robert Zorec
| DOI: 10.14336/AD.2025.1442
Supplement

1. Supplementary data.pdf (583KB)

Extracellular Vesicles as Key SASP Carriers Driving Cellular Senescence, Inflammaging, and Therapeutic Opportunities in Aging and Age-Related Diseases
Syeda Warisha Aamir, Jen-Wei Huang, Abdul Qadeer, Khalid J. Alzahrani, Khalaf F. Alsharif, Fuad M. Alzahrani, Sumbal Zaheen, Abdulwahab Abuderman, Chien-Chin Chen, Shahid Hussain
| DOI: 10.14336/AD.2026.0134
SIRT2 Delays Vulnerable Plaque Progression by Modulating Vascular Smooth Muscle Cell Senescence
Leli Zhang, Pengrong Guo, Yue Wang, Zhenbai Qin, Yi Zou, Wenxin Zhao, Xiaofan Wu
| DOI: 10.14336/AD.2026.0063
Supplement

1. Supplementary data.pdf (742KB)

Recent Progress in Endothelial Senescence and Thrombosis: From Molecular Pathways to Therapeutic Prospects
Tianyi Lin, Shiqi Tang, Jianqiu Pei
| DOI: 10.14336/AD.2025.1460
Prolonged Mild Sleep Restriction Changes Epigenome-Wide DNA Methylation in Peripheral Blood Cells: A Randomized Crossover Trial
Rocio Barragán, Christian K. Dye, Brooke Aggarwal, Sanja Jelic, Oscar Coltell, Dolores Corella, Marie-Pierre St-Onge
| DOI: 10.14336/AD.2025.1261
Supplement

1. Supplementary data.pdf (1513KB)

The Microglial Lactate-Lactylation Axis as a Metabolic-Epigenetic Driver of Alzheimer’s Disease
Zhaoxie Yu, Hanzhang Li, Yao Wang, Yanan Li, Feng Shen, Yanchun Wang
| DOI: 10.14336/AD.2025.1487
Fundamental Cell-Intrinsic Mechanism Underlying Age-Dependent Accumulation of Senescent Cells
Pavel I. Deryabin, Aleksandra V. Borodkina
| DOI: 10.14336/AD.2026.0137
Systemic Cytokine Alterations in Periodontitis Independent of Comorbidities: A Systematic Review and Meta-Analysis
Elin Kindstedt, Magnus Wänman, Wendy Yi-Ying Wu, Klara Hofer-Mattsson, Anna Lövgren, Pernilla Lundberg
| DOI: 10.14336/AD.2026.0110
Supplement

1. Supplementary data.pdf (1803KB)

Cellular Senescence in Gastric Cancer: Molecular Mechanisms, Microenvironment Remodeling and Therapeutic Implications
Zhiyuan Shi, Zhao Sun, Yuan Liu, Yuping Ge, Ning Jia, Yuwei Hua, Lin Zhao, Xiang Wang, Yi Ba
| DOI: 10.14336/AD.2025.1571
Epigenetic Noise and Regulatory Entropy in Aging: A Quantitative Systems-Level Framework
Hamilton Ribeiro Correia, Tomás Balseiro, Lucas Caramujo, Sandra Balseiro
| DOI: 10.14336/AD.2026.0215
Critical Considerations for Mesenchymal Stem Cell-based Therapies in Osteoarthritis and Spinal Cord Injury: A Narrative Review
Shaolong Li, Chenxi Zhao, Wei Wang, Wenhan An, Xinyu Liu, Hengxing Zhou, Xiaohong Kong, David D. Dean, Shiqing Feng, Xiao-Dong Chen
| DOI: 10.14336/AD.2026.0003
Ethical Considerations for Clinical Research in Persons with a Terminal Illness
Caroline R. Morehouse, Christine Grady, Benjamin E. Berkman, Robert Steel, David S. Wendler, Saskia Hendriks
| DOI: 10.14336/AD.2026.0099
Targeting the Gut-Retina Axis in Age-Related Retinopathies: Microbiome-Immunometabolic Pathways and Gerotherapeutic Perspectives
Zhihui Feng, Kexin Wang, Xiaosu Wang, Bizhu Zhao, Zixu Huang, Shenao Ding, Jiehao Zhang, Mengli Sun, Meiqi Ma, Yameng Zhao, Yongheng Cui, Zongming Song, Ye Tao
| DOI: 10.14336/AD.2025.1248
The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions
Sarah M. Antonevich, Kate M. Miller, Shasa Hu, Monica Rodriguez-Silva, Carlos T. Moraes, Ivan Jozic
| DOI: 10.14336/AD.2025.1585
Quantum Sensing for Precision Organ Aging Assessment
Jingyi Niu, Ya Peng, Lin Yin, Minghua Wu
| DOI: 10.14336/AD.2025.1500
Peakspan: Defining, Quantifying and Extending the Boundaries of Peak Productive Lifespan
Authors: Alex Zhavoronkov, Kejun Ying, Dominika Wilczok
| DOI: 10.14336/AD.2026.0080
Anti-Tumor Immunotherapy of Scutellaria Baicalensis-Derived Vesicles on Immune Checkpoint Modulation in Colorectal Cancer
Dianxin Cui, Weilin Qiao, Weixuan Chen, Peng Li, Shengpeng Wang, Fengyun Liao, Fei Li, Kewei Wang, Yitao Wang, Huanxing Su, Zhangfeng Zhong
| DOI: 10.14336/AD.2026.0040
Dissecting the Impact of α-MSH-MC1R-cAMP Signaling on UVA-Induced Stress in Fibroblasts - Implications for Regulation of Cutaneous Photoaging
Markus Böhm, Agatha Stegemann, Agnieszka Wolnicka-Głubisz, Bartlomiej Olajossy, Nicole Schäfer, Stephan Niland, Johannes Eble, Verena Raker, Kerstin Steinbrink, Susanne Grässel, Lionel Larue
| DOI: 10.14336/AD.2025.1518
Supplement

1. Supplementary data.pdf (655KB)

Danggui-Shaoyao San Promotes Microglia-Mediated Oligodendrocyte Maturation and White Matter Repair After Stroke
Fang Tong, Yihan Liu, Nan Deng, Yong Yang, Sijie Li, Ziping Han, Jingfei Shi, Xunming Ji, Changhong Ren
| DOI: 10.14336/AD.2026.10202
Supplement

1. Supplementary data.pdf (154KB)

Spatial Transcriptomic Analysis Reveals Dysregulated Pro-Inflammatory Signaling in the Aged Lung
Brianna M. Doratt, Ethan G. Napier, Mahdi Eskandarian Boroujeni, Michael H. Davies, Christine F. Brainson, Eliot R. Spindel, Ilhem Messaoudi
| DOI: 10.14336/AD.2025.1317
Supplement

1. Supplementary data.pdf (1768KB)

Receptor-Specific Adenosine Signalling Governs Astrocyte Glycogen Homeostasis
Kaja Belko Parkel, Živa Tajda Gržina, Robert Zorec, Marko Kreft
| DOI: 10.14336/AD.2025.1389
Supplement

1. Supplementary data.pdf (175KB)

Dual effect of Vascular Calcification in Abdominal Aortic Aneurysm Progression: A Narrative Review from Multi-Scales
Kexin Zhao, Weichang Zhang, Chang Shu
| DOI: 10.14336/AD.2025.1422
Aging of the Blood-Brain Barrier and Altered Permeability to Peripheral Immune Cells: Implications for Central Nervous System Disorders
Yu Gu, Liting Zhang, Zixin Du, Caiyun Wang, Wenyuan Deng, Yong U Liu, Beisha Tang
| DOI: 10.14336/AD.2026.0013
Longevity vs. Healthy Longevity: Different Outcomes Underlain by Different Mechanisms
Daria Kashtanova, Aleksandra Mamchur, Maria Bruttan, Veronika Daniel, Mikhail Ivanov, Elena Zelenova, Irina Dzhumaniiazova, Lorena Matkava, Mikhail Terekhov, Antonina Rumyantzeva, Konstantin Grammatikati, Sergey Mitrofanov, Vladimir Yudin, Valentina Maksyutina, Ekaterina Maralova, Aleksey Ivashechkin, Aleksandra Nekrasova, Irina Strazhesko, Valentin Makarov, Anton Keskinov, Olga Tkacheva, Sergey Yudin, Veronika Skvortsova
| DOI: 10.14336/AD.2025.0828
Supplement

1. Supplementary data.pdf (495KB)

Dysregulated Lipid Metabolism and Neurovascular Unit Dysfunction: Novel Mechanisms Linking Alzheimer’s Disease and Vascular Dementia
MengGe Li, HuiYue Wang, ZhenYan Tang, ShuSheng Yang, Li Lin
| DOI: 10.14336/AD.2025.1464
Health Related Quality of Life in Adults with 13 Chronic Diseases before Age 65 and after Age 65 Using Fuzzy Rough Analysis of SF-36 Domains
Marlena Krawczyk-Suszek, Zofia Matusiewicz, Teresa Mroczek, Andrzej Kleinrok
| DOI: 10.14336/AD.2025.0928
The Effects of Aging and Anti-Aging Dietary Restriction on Brain Glutathione and Thioredoxin Redox Systems
Leah E. Jamerson, Patrick C. Bradshaw
| DOI: 10.14336/AD.2025.1505
Supplement

1. Supplementary data.pdf (513KB)

Neuroinflammation and Cellular Senescence in Brain Aging and Neurodegeneration
Linlin Zhang, longtu Li, Xin Wang, Liang Ma, Li Yan, Qian Xiang, Yimin Cui, Zhiyan Liu
| DOI: 10.14336/AD.2025.1538
Cuproptosis and Aging: Molecular Mechanisms and Therapeutic Implications
Jingyan Hong, Yaxin Liu, Quan Peng, Zhigang Mei, Guozuo Wang
| DOI: 10.14336/AD.2025.1305