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2023
Impact Factor
7.0

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 191 results are found
Pericytes in the Development and Progression of Brain Diseases
Qingbin Wu, Xinyi Cui, Xiaochen Yuan, Jianqun Han, Hongwei Li, Ruijuan Xiu
| DOI: 10.14336/AD.2025.0028
Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice
Eok-Cheon Kim, Youlim Son, Seon-Hui Kim, Soo-Ji Kim, So-Young Park, Jae-Ryong Kim
| DOI: 10.14336/AD.2025.1219
Supplement

1. Supplementary data.pdf (448KB)

Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies
Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang
| DOI: 10.14336/AD.2025.0017
Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy
Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu
| DOI: 10.14336/AD.2025.0275
Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments
Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren
| DOI: 10.14336/AD.2025.0175
OPA1 Enhances Microglial Amyloid-β Clearance and Alleviates Cognitive Impairments in an Alzheimer’s Disease Model
Qing Wang, Mengqi Dong, Xue Xia, Xinyu Bao, Mengsha Hu, Lei Ye, Yun Xu
| DOI: 10.14336/AD.2025.0082
Supplement

1. Supplementary data.pdf (802KB)

PCSK9 in Vascular Aging and Age-Related Diseases
Dong Tan, Xin Yang, Jing Yang, Gang Fan, Guozuo Xiong
| DOI: 10.14336/AD.2024.1713
LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
| DOI: 10.14336/AD.2024.1697
Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities
Théodore Decaix, Matthieu Lilamand, Karl Götze, François Mouton-Liger, Emmanuel Cognat, Jacques Hugon, Elodie Bouaziz-Amar, Louise Sindzingre, Julien Dumurgier, Claire Paquet
| DOI: 10.14336/AD.225.0020
NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo
| DOI: 10.14336/AD.2025.0053
Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen
| DOI: 10.14336/AD.2024.1585
Supplement

1. Supplementary data.pdf (158KB)

Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association Between Malnutrition and Cognitive Decline in Disabled Elderly
Runyuan Yu, Lixia Wang, Yifan Liu, Yimeng Hu, Zuncheng Zheng, Xiaoyu Wang, Yuexia Chen, Yulian Liu
| DOI: 10.14336/AD.2025.0337
Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?
Xinxin Zuo*
| DOI: 10.14336/AD.2025.0189
SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
| DOI: 10.14336/AD.2025.0106
Predictive Value of Sarcopenia and Cognitive Decline in Hospitalized Older Adults
Xiaoyan Hu, Peng Sun
| DOI: 10.14336/AD.2025.0418
Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
| DOI: 10.14336/AD.2025.0398
Exploring the Role of RhoA/ROCK Signaling in Pain: A Narrative Review
Nan Chen, Ye Tu, Dai-Qiang Liu, Yi Zhang, Yu-Ke Tian, Ya-Qun Zhou, Shao-Bing Yang*
| DOI: 10.14336/AD.2024.1539
Erratum to “P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy”
Liangliang Huang, Yan Chen, Rui Liu, Binbin Li, Xuan Fei, Xiang Li, Ge Liu, Yunman Li, Baohui Xu, Weirong Fang
| DOI: 10.14336/AD.2025.10326
Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song
| DOI: 10.14336/AD.2025.0277
Association Between Dementia and Optical Coherence Tomography Scan Quality
Reuben Jyong Kiat Foo, Damon Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Leopold Schmetterer, Jacqueline Chua
| DOI: 10.14336/AD.2024.1744
Supplement

1. Supplementary data.pdf (170KB)

Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis
Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong
| DOI: 10.14336/AD.2025.0123
Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research
Wenkang Chen, Hede Zou, Haoran Xu, Rui Cao, Yapeng Zhang, Yongjie Ma, Wei Lin, Hekun Zhang, Jiayou Zhao
| DOI: 10.14336/AD.2025.0070
Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health
Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun
| DOI: 10.14336/AD.2025.10319
Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences
Yu-Xin Li, Kun Liu, Qin Zeng, Wei-Hong Zeng, Jia-Li Li, Qian-Qian Zhang, Xuan Lu, Hong-Wen Deng, Li-Jun Tan
| DOI: 10.14336/AD.2024.1438
Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study
Sapir Kon-Kfir, Tali Cukierman-Yaffe, Haim Krupkin, Ana Belkin, Gadi Shlomai, Jonathan Bleier, Shiri Weinstein, Liora Bruckmayer, Elad Prinz, Alon Kaplan, Michal Goldenberg Shraga, Dana Lev, Shahar Dekel, Noa Shalmon, Nurit Tsarfaty, Niv Reiss, Evelyne Bischof, Avshalom Leibowitz
| DOI: 10.14336/AD.2024.1676
Supplement

1. Supplementary data.pdf (296KB)

The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9
Yuting Li, Linying Huang, Miaochun Fang, Liwen Ye, Haiqing Yang, Weijia Wu, Yuan Yuan, Kun Cao, Hui-ling Zheng, Xuerong Sun, Yun Wu, Xing-Dong Xiong, Xinguang Liu, Shun Xu
| DOI: 10.14336/AD.2024.1715
Supplement

1. Supplementary data.pdf (650KB)

Biological Aging in Combination with Lifestyle Factors in the Blood-Based Methylome: A Biomarker for Colorectal Cancer Susceptibility in African American Women
Su Yon Jung, Matteo Pellegrini, Herbert Yu
| DOI: 10.14336/AD.2025.0099
Supplement

1. Supplementary data.pdf (5098KB)

Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis
Xuexuan Fan, Guangze Chen, Sishu Wang, Xinhong Liu, Sai Huang, Cong Feng, Xiaolei Jiang
| DOI: 10.14336/AD.2024.1080
Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
| DOI: 10.14336/AD.2025.0218
Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi Chen, Zhou Su, Jianxin Xue
| DOI: 10.14336/AD.2025.0061
Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets
Heyang Sun, Qianya Hong, Chenning Li, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo
| DOI: 10.14336/AD.2025.0039
1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases?
Davide Norata, Fioravante Capone, Francesco Motolese, Massimo Marano, Mariagrazia Rossi, Rosalinda Calandrelli, Marta Sacchetti, Flavio Mantelli, Vincenzo Di Lazzaro, Fabio Pilato
| DOI: 10.14336/AD.2024.0573
Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy
Weiyue Zhang, Baoqing Pei, Yifan Zhou, Hui Li, Wei Ma, Bing Zhou, Chen Zhou, Huimin Jiang, Xunming Ji
| DOI: 10.14336/AD.2024.1688
Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways
Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee
| DOI: 10.14336/AD.2025.0025
Supplement

1. Supplementary data.pdf (534KB)

Gut Microbiota Modulation of Dementia Related Complications
Xiaoqing Su, Yinghua Chen, Xingxing Yuan
| DOI: 10.14336/AD.2025.0108
Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis
Yanlei Zhang, Jiachun Song, Yuxuan Li, Quanbo Ji
| DOI: 10.14336/AD.2025.0166
The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
| DOI: 10.14336/AD.2024.1558
Supplement

1. Supplementary data.pdf (378KB)

Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair
MingYu Qiu, YangYang Li, QiSen Wang, XiaoTing Jian, JingWen Huang, WeiChao Gui, Jijie Hu, Hua Liao
| DOI: 10.14336/AD.2024.1501
New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space
Yumeng Cheng, Jiao Liu, Feng Tian, Hanbo Tan, Tianyu Wang, Jiabin Lu, Zeqing Tang, Xinlei Ma, Jingge Lian, Shaoyi Su, Yu Fu, Bin Liu, Yuliang Li, Wanyi Fu, Meng Xu, Hongbin Han
| DOI: 10.14336/AD.2024.1444
Supplement

1. Supplementary data.pdf (878KB)

CD16-CD56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis
Zhenxiang Gong, Li Ba, Zehui Li, Hongyan Hou, Min Zhang
| DOI: 10.14336/AD.2024.1597
Supplement

1. Supplementary data.pdf (805KB)