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2025
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9.6

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 225 results are found
Exercise, Dynamic Functional Connectivity, and Sex in Alzheimer’s Disease: A Hypothesis-Generating Framework for the Sex-Dependent Dynamic Reconstitution Model
Zehui Gong, Zhaobing Xiang, Liang Xiang, Jianrong Yuan
| DOI: 10.14336/AD.2026.1096
Aging Intestinal Niche: Regulation of Stem Cells and Disease
Hang Zhou, Ya-dong Qi, Ya-Ru Liu, Ya-Wen Zhang, Shu-Jie Chen
| DOI: 10.14336/AD.2026.0844
Supplement

1. Supplementary data.pdf (145KB)

Sympathetic Regulation of Bone Metabolism: Mechanisms across Homeostasis, Aging and Disease
Lingxuan Deng, Yiwei Liu, Zhenjia Che, Qiyun Chen, Chenye Zhuang, Xuan Si, Yusheng Li, Ming Cai, Qi Sun
| DOI: 10.14336/AD.2026.0886
Supplement

1. Supplementary data.pdf (166KB)

Baseline Physical Frailty Predicts Clinical Outcomes During Lecanemab Therapy in Early Alzheimer's Disease: A Prospective Real-World Cohort Study
Jaemin Shin, Yu Jeong Park, Seungyun Lee, Jimin Kang, Seongin Lee, Eun Seong Lee, Hye Na Jung, Inseon Ryoo, Su Jin Chung, Jae Seon Eo, Sang-Il Suh, Kyungmi Oh, Seong-Beom Koh, Sung Hoon Kang
| DOI: 10.14336/AD.2026.0978
Supplement

1. Supplementary data.pdf (397KB)

Effects of Spermidine Supplementation on Vascular Brain Health in Older Individuals with Subjective Cognitive Decline - An Exploratory MRI Analysis
Claudia Schwarz, Katharina Wurdack, Stefan Hetzer, Andrea Dell’Orco, Silke M. Wortha, Daria Antonenko, Gloria S. Benson, Nora Horn, Ulrike Grittner, Sebastian J. Hofer, Tobias Eisenberg, Stephan J. Sigrist, Dietmar Schmitz, Miranka Wirth, Frank Madeo, Agnes Flöel
| DOI: 10.14336/AD.2026.0559
Mitochondria Beyond Bioenergetics: Canonical and Non-Canonical Functions in Ischemic Stroke and Aging
Paweł Berezka, Natalia Piekarczyk, Jan Jacek Kaczor
| DOI: 10.14336/AD.2026.0679
GDF15 Induces Weight Loss with Diet- and Age-Dependent Metabolic Effects Across Tissues in Mice
Laura Salmón-Gómez, Victoria Catalán, Beatriz Ramírez, Maite Aguas-Ayesa, Amaia Rodríguez, Sara Becerril, Gema Frühbeck, Javier Gómez-Ambrosi
| DOI: 10.14336/AD.2026.0702
Supplement

1. Supplementary data.pdf (2738KB)

Senescence and SASP in the Stromal Microenvironment of Breast Cancer: Dual Role in Progression and Therapeutic Options
Maria Bogachek, David Sergeevichev, Anastasia Leonteva, Alevtina Pinova, Vladimir Richter, Anna Nushtaeva
| DOI: 10.14336/AD.2026.0869
Supplement

1. Supplementary data.pdf (172KB)

Neuroimmune State Configurations at the Amyloid-Tau Interface in Alzheimer’s Disease: A Testable Framework
Kai Zhang, Yuanyuan Zhang, Xindi Jiang, Xiu Chen
| DOI: 10.14336/AD.2026.0888
Aging as a Potential Modulator of Extramedullary Hematopoiesis: A Hypothesis-Generating Niche-HSPC Competence-Trigger Model
Zoe Bezirgiannidou, Iliana Stamatiou, Konstantinos Liapis, Emmanouil Spanoudakis, Evdokia Mandala, Ioannis Kotsianidis, Timoleon-Achilleas Vyzantiadis, Efthymia Vlachaki
| DOI: 10.14336/AD.2026.0896
Biomarker-Guided, Stage-Specific Senotherapy for Metabolic Dysfunction-Associated Steatotic Liver Disease
Yunhang Chu, Wenqi Jin, Weigeng She, Qi Meng, Liwei Sun, Yan Leng
| DOI: 10.14336/AD.2026.1114
A Clearance-Repair-Activation Framework for Alzheimer's Disease: A Perspective and Validation Roadmap
Yujia Yang, Xiufeng Zhang, Xiang Zan, Chenlong Niu, Xiangyu Wei, Pengcheng Feng, Guopeng Li, Ming Gao
| DOI: 10.14336/AD.2026.1040
Passive Blood Flow Restriction as a Countermeasure Against Disuse-Induced Muscle Atrophy: Physiological Mechanisms and Translational Evidence
Chenghao Feng
| DOI: 10.14336/AD.2026.0439
Ginkgolide B as a Candidate Gerotherapeutic: Evidence, Evidentiary Limits, and Translational Requirements
Joanna Y. Yang, Doris T. Tu, Yun-Lin Chen, Oscar K. Lee
| DOI: 10.14336/AD.2026.0894
Extracellular Vesicle-Mediated microRNA Signaling in Osteosarcopenia: Emerging Insights into Age-Related Bone-Muscle Crosstalk
Srijan Chatterjee, Jae Gyu Kim, Yeon-Hee Lee, Seungyi Cha, Minwook Kim, Chiranjib Chakraborty, Hongsik Cho, Sang-Soo Lee
| DOI: 10.14336/AD.2026.1034
Lysosomal Competence in Skeletal Muscle Aging: Autophagic Flux, Measurement Gaps, and Human Translation
Oyungerel Dogsom, Jae Gyu Kim, Yeon-Hee Lee, Holger Jahr, Sang-Soo Lee
| DOI: 10.14336/AD.2026.1047
Mouse Models for Aging Research: Mechanistic Utility, Translational Relevance, and Practical Model Selection
Cassandra Coleman, Holly Thomas, Shenfeng Qiu, E. Angela Murphy, Daping Fan
| DOI: 10.14336/AD.2026.0565
Functional Hemodynamic Assessment in Intracranial Atherosclerotic Disease: From Anatomical Stenosis to μQFR-Guided Precision Medicine
Kangjie Fan, Shanshan Cao, Yandi Qiao, Zhenhua Zhang, Qiang Li
| DOI: 10.14336/AD.2026.0793
Loss of Newborn Neuron Function Promotes Aβ Accumulation in an Alzheimer’s Disease Mouse Model
Risako Tamura, Riki Kawabata, Chenxu Lei, Haowei Li, Daiki Hayashi, Masashide Seki, Yutaka Suzuki, Tatsuhiro Hisatsune
| DOI: 10.14336/AD.2026.0713
Supplement

1. Supplementary data.pdf (432KB)

Lipid Networks in Osteoarthritis: Context-Dependent Drivers, Hallmarks of Aging, and Clinical Translation
Nijiao Qin, Xiwei Fan, Yaxin Tan, Miao He, Indira Prasadam, Antonia Rujia Sun, Xiaoxin Wu, Ross Crawford, Yanping Wang, Qichen Long, Guozhi Xiao, Xinzhan Mao
| DOI: 10.14336/AD.2026.0752
Lower Epigenetic Age Acceleration in Older Adults with Preserved Global Cognitive Performance
Felipe Salech, Carlos Marquez, Paulina Correa-Burrows, Rodrigo Saguez, Daniela P Ponce, Carol San Martin, Christian Gonzalez-Billault, María Isabel Behrens, Cecilia Albala
| DOI: 10.14336/AD.2026.0311
Supplement

1. Supplementary data.pdf (238KB)

Gut Microbial Function and Immune Aging: An Evidence-Graded Framework Linking Microbial Metabolites to Healthspan and Age-Related Disease
Dong-Sheng He, Fei Liao, Hai-Lin Chen, Qi Zhang, Min-Xue Wei, Dong-Ming Guo
| DOI: 10.14336/AD.2026.0884
Targeting isoD7 Neoepitope in Aβ for Alzheimer's Disease Immunotherapy
Irina L Grigorova, Kseniya B Varshavskaya, Elena V Kuzubova, Lidiia A Koltunova, Elizaveta A Kolobova, Alexandra I Radchenko, Kirill D Chaprov, Viktor V Grishchenko, Irina Yu Petrushanko, Mikhail V Korokin, Vladimir A Mitkevich, Olga I Kechko, Alexander A Makarov
| DOI: 10.14336/AD.2026.0695
Repurposing MitoQ10 as a Therapeutic for Established Alzheimer's Disease Pathology
Mohit Kumar, Sudipta Ray, Susmita Sil
| DOI: 10.14336/AD.2026.0946
Supplement

1. Supplementary data.pdf (1425KB)

Acute Myocardial Infarction and Ischemic Stroke as Systemic Accelerators of Atherosclerotic Plaque Inflammation and Vulnerability
Jiang-ming Yu, Yu-Xiao Liu, Qin Li, Jia-Bin Zong, Tuersun Aili, Xin-Ran Zhao, Bo Hu, Jie-Hong Wu
| DOI: 10.14336/AD.2026.1495
Extreme Longevity Areas: Redefining the Need for A Transparent and Standardized Framework
José María Faílde Garrido, María Dolores Dapía Conde, Alberto Ruano-Ravina, Mónica Pérez-Ríos, Guadalupe García
| DOI: 10.14336/AD.2026.0673
Ubiquitin-Dependent Protein Quality Control in Polyglutamine Diseases
Matthew V. Prifti, Kristin Richardson, Sokol V. Todi
| DOI: 10.14336/AD.2026.0887
The IGF/IGFR System During Chronic Liver Disease: Role in Neurocognitive Complications and Aging
Ani Gasparyan, Esther Caparrós, Rubén Francés
| DOI: 10.14336/AD.2026.0576
A Pathology-Trained Lipid Aging Clock Reveals Accelerated Aging and Prognostic Sphingolipid Signatures in Pancreatic Disease
Maximilian Unfried, Amaury Cazenave-Gassiot, Evelyne Bischof, Michal Holcapek, Morten Scheibye-Knudsen, Markus R. Wenk, Jan Gruber, Brian K. Kennedy
| DOI: 10.14336/AD.2026.0300
Supplement

1. Supplementary data.pdf (717KB)

Motor System Neurodegeneration in Aging and Synucleinopathies: Circuit Vulnerability and Neuroimaging Biomarkers
Jiaqi Wen, Xiaojun Xu, Yulin Ge
| DOI: 10.14336/AD.2026.0457
Context-Dependent Roles of p53 in Cellular Senescence and Fibrosis
Asish K Ghosh, Karim Ullah, Cian O’Donnell, Rishi Arora
| DOI: 10.14336/AD.2026.0543
The Glymphatic and Meningeal Lymphatic Systems: Gatekeepers of Brain Health in Aging and Neurodegeneration
Tayyab Iqbal, Sana Tabassum, Muhammad Imran, Shilong Tang, Pengyu Xiao, Ting Wei, Dilizhawaer Hailaiti, Ping Fan, Weitian Lu, Haiyu Li, Juan Huang
| DOI: 10.14336/AD.2026.0009
Myo-Inositol Dampens Apathetic Symptoms in Aged Mice and Is Associated with Sex-Specific Synapse Remodelling
Chiara D’Amelio, Francesca Natale, Sara Autelitano, Nicola Locci, Ida Nifo Sarrapochiello, Nicoletta Garofalo, Marco Rinaudo, Salvatore Fusco, Claudio Grassi
| DOI: 10.14336/AD.2026.0255
Supplement

1. Supplementary data.pdf (585KB)

Endocrine Factors in Sarcopenia: Lifestyle-Based Approaches with Nutrition, Exercise, and Circadian Health
Sihyung Lee, Choon Young Kim
| DOI: 10.14336/AD.2026.0483
Supplement

1. Supplementary data.pdf (1305KB)

Senolytic Treatment Triggered by Carotid Occlusion Confers Protection Against Later Acute Ischemic Stroke in Aged Rats
Szilvia Kecskés, Péter Makra, Tamás Monostori, Zoltán Veréb, Ferenc Bari, Ákos Menyhárt, Eszter Farkas
| DOI: 10.14336/AD.2026.0537
Supplement

1. Supplementary data.pdf (230KB)

Longitudinal Profiling Reveals Divergent Kidney and Brain Immune Responses during Metabolic Syndrome
Laura Van der Taelen, Sara M.P. Lambrichts, Lieve Temmerman, Romaysa El Ajjouri, Marion J. Gijbels, Nicole Bitsch, Jean Scheijen, Marjo van de Waarenburg, Martina Kutmon, Thomas Unger, Julie Staals, Casper G. Schalkwijk, Ana M. Briones, Robert J. van Oostenbrugge, Sébastien Foulquier
| DOI: 10.14336/AD.2026.0557
Supplement

1. Supplementary data.pdf (505KB)

Sex as a Missing Moderator in the Dual-Pathway Neuroprotection Hypothesis
Zehui Gong, Liang Xiang, Jianrong Yuan, Zhaobing Xiang
| DOI: 10.14336/AD.2026.0914
Single-Nucleus RNA-Seq of Human and Rat Cardiomyocytes Identifies Shared and Distinct Regulators and Features of Aging and Disease
Samaneh Ekhteraei-Tousi, Rosa Doñate Puertas, Mohamad Youness, Onne A.H.O. Ronda, Magnus Aronsen, Emil K. S. Espe, Arne Olav Melleby, Ida Marie Hauge-Iversen, Ella Cutsforth, Lirong Li, Emma L. Robinson, Einar Sjaastad Nordén, Mani Sadredini, Filip Rega, Kenneth C. Bedi Jr, Kenneth B. Margulies, Karin R. Sipido, Ivar Sjaastad, H. Llewelyn Roderick
| DOI: 10.14336/AD.2026.0357
Supplement

1. Supplementary data.pdf (4898KB)

KDM4C inhibition reinforces NK cell cytotoxicity through the cGAS-STING pathway in TP53-mutated AML
Xinyi Zhang, Huilan Liu, Liangquan Geng, Panpan Huang, Mengqing Gao, Qian Fan, Kaishuang Jiang, Na Zhao, Xuxu Zhao, Huaiping Zhu, Cihangir Duy, Haiming Wei, Dongyao Wang
| DOI: 10.14336/AD.2026.0432
Supplement

1. Supplementary data.pdf (3881KB)

Old Hosts, Young Models: Rethinking Cancer Immune Evasion in Aging
Nigar Karimova, Leyla Karimova, Bayram Bayramov, Rena Karimova
| DOI: 10.14336/AD.2026.0738