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2025
Impact Factor
9.6

Early Edition

The papers published below have been examined by the peer-review process and accepted for publication in Aging and Disease. A “Just Accepted” paper is published online shortly after its acceptance, which allows authors to make their results available to the research community as soon as possible after acceptance. When the final version appears, the version of early edition is replaced with the final version, and the paper is moved to the appropriate issue on the Aging and Disease website. The paper will no longer appear in the “Just Accepted”. However, all links (the URL) will not change. “Just Accepted” papers are citable from that date they are posted. To cite this manuscript please include its Digital Object Identifier (DOI), which is identical for all formats of publication.
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Total 242 results are found
Hepatic FoxO3 Supports Metabolic Resilience, Attenuates Age-Associated Obesity and Metabolic Dysfunction, and Mitigates Diet-Induced Steatohepatitis
Toshimitsu Komatsu, Seongjoon Park, Sangeun Kim, Hiroko Hayashi, Isao Shimokawa
| DOI: 10.14336/AD.2026.0477
Supplement

1. Supplementary data.pdf (1054KB)

Cognitive Impairment after Aneurysmal Subarachnoid Hemorrhage: Temporal Patterns and Electrophysiological Risk Stratification
Kun Yang, Peng Liu, Oxana Semyachkina-Glushkovskaya, Mingchang Li, Yuxiang Yan, Hongqi Zhang
| DOI: 10.14336/AD.2026.10505
Supplement

1. Supplementary data.pdf (5711KB)

Targeting the Microbiota-Butyrate-BHB Axis As a Potential Metabolic Therapeutic Strategy for Alzheimer’s Disease
Vijay Kumar, Sinae Jang, Yebeen Choi, Sujin Kim, Yunkwon Nam
| DOI: 10.14336/AD.2026.0606
Glial Scar Stiffness Affects NSCs Differentiated Direction via Piezo1 Post-Stroke
Shengju Wu, Yuanyue Song, Yangqianbo Yao, Ze Liu, Yaohui Tang, Wanlu Li, Guo-yuan Yang, Zhijun Zhang
| DOI: 10.14336/AD.2026.0347
Intestinal Organoids from Alzheimer’s Disease Transgenic Mice Reveal Structural and Molecular Gut Pathology
K. Matisse Gilson, Alfredo Fernandez Higueras, Winston M. Walters, Juliana Sanchez-Molano, Vania W. Almeida, Zane Zeier, W. Dalton Dietrich, Helen M. Bramlett, Nadine A. Kerr
| DOI: 10.14336/AD.2026.0233
Functional Imaging in Osteoarthritis: Bridging Mechanistic Insight and Therapeutic Translation
Xiwei Fan, Fumin Yuan, Feng Gao, Chaoshuo Liu, Indira Prasadam, Antonia Rujia Sun, Ross Crawford, Yanping Wang, Siyi Chen, Qichen Long, Xinzhan Mao
| DOI: 10.14336/AD.2026.0304
Aging-Related Metaflammation and Mitochondrial Dysfunction in Neurodegenerative Diseases
Wenting Gao, Hye-Yeon Lee, Kyung-Jin Min
| DOI: 10.14336/AD.2026.0366
From Structure to Function: Cognitive Impairment and Its Heterogeneity in Cerebral Small Vessel Disease
Wei Sun, Aini He, Benke Zhao, Xuefan Yao, Xiao Wu, Haiqing Song
| DOI: 10.14336/AD.2026.0351
Single-Cell RNA Sequencing Characterizes Microglial Phenotypic Heterogeneity Across Different Stroke Subtypes
Yiyan Guo, Tongtong Xu, Chang Liu, Shiyu Deng, Lin Gan, Qianyuan Lian, Jing Ye, Wanlu Li, Zhijun Zhang, Guo-Yuan Yang, Jixian Wang, Yaohui Tang
| DOI: 10.14336/AD.2026.0803
Supplement

1. Supplementary data.pdf (632KB)

Metabolism of Young and Aged Hematopoietic and Acute Myeloid Leukemia Stem Cells: Insights for Rejuvenation and Therapy
Alhomidi Almotiri
| DOI: 10.14336/AD.2026.0302
Chronogeroprotection: Circadian Action Bundles for Healthy Aging
Jasmin Weninger, Shadab Rahman, Mustafa Özcürümez
| DOI: 10.14336/AD.2026.0646
Vitamin C, ACSL4, and Ferro-Aging: Mechanistic Insights and Translational Perspectives from Primate Studies
Chenxi Li, Zhongcheng Gong, Jishi Ye, Yuchen Ni
| DOI: 10.14336/AD.2026.0371
Targeting Cellular Senescence as a Therapeutic Strategy to Attenuate Pulmonary Fibrosis Associated with Metabolic Syndrome
Michaela Rennerova, Tereza Havrlantova, Igor Simonik, Renata Pavlovicova, Miloslava Cechova, Anna Cinkajzlova, Dan-Diem Thi Le, Jana Klouckova, Jiri Fronek, Filip Thieme, Jiri Neuzil, Lukas Werner, Jan Stursa, Milos Mraz, Martin Haluzik, Sona Stemberkova Hubackova
| DOI: 10.14336/AD.2026.0150
Supplement

1. Supplementary data.pdf (952KB)

Staging of Neuropil Morphological Alterations in Alzheimer’s Disease
Zhi-Yi Zhang, Xin-Meng Wang, Xin Ma, Yi Wang, Shuai-Deng Wang, Yi-Lin Peng, Kun Cheng, Yue-Ru Shen, Guo-Zhang Tang, Chen-Wei Wang, Jiang-Ning Zhou
| DOI: 10.14336/AD.2026.0213
Supplement

1. Supplementary data.pdf (2496KB)

IRG1/Itaconate Inhibits Microglial Senescence-Like Transition by Modulating Mitochondrial Dynamics through Rhoa Alkylation in Subarachnoid Hemorrhage
Zeyu Zhang, Yanlin Chen, Weizhen Gao, Fengchen Zhang, Yichao Jin, Jie Li, Jiaqi Wang, Tao Lv, Feng Jia, Xiaohua Zhang
| DOI: 10.14336/AD.2025.1527
Supplement

1. Supplementary data.pdf (1650KB)

Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster.
Sarah Shnayder, Vicki Do, Junyue Wang, Luana Machado, Sofia Rosa, Lora Kusaku, Benjamin Kuo, Jill Hutchinson, Grace Ogden, Neja Majeti, Weimin Guo, Samuel Beck, Mitch McVey, Jimmy W. Crott
| DOI: 10.14336/AD.2025.1584
Supplement

1. Supplementary data.pdf (347KB)

Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging
Parveez Ahamed Abdul-Azees, Hanzhou Wang, Jerry Chen, Milos Marinkovic, David D. Dean, Xiao-Dong Chen, Adam B. Salmon, Chih-Ko Yeh
| DOI: 10.14336/AD.2026.0057
Muscle-Brain Crosstalk in Alzheimer’s Disease: Exercise-Associated FNDC5/Irisin Pathways in Preclinical Models - A Systematic Review
Rafael Aguiar Marschner, Fernanda Marques da Silva, Daisy Crispim, Carlos Alberto Saraiva Gonçalves
| DOI: 10.14336/AD.2026.0427
Extracellular Space Barrier Dysfunction Disrupts Interstitial Fluid Drainage and Is Associated with Memory Heterogeneity in Cognitive Aging
Xin Mao, Rui Wang, Wanyi Fu, Hanbo Tan, Tianzi Gao, Dan Du, Yang Shi, Shufan Yang, Changming Wang, Yu Fu, Shaoyi Su, Meng Xu, Hongbin Han
| DOI: 10.14336/AD.2026.0422
Supplement

1. Supplementary data.pdf (1149KB)

Peripheral Immune Challenge Drives Enteric α-Synuclein and Tau Pathology in LRRK2 G2019S Mice
Carmela Giachino, Federico Bertoli, Cataldo Tirolo, Claudio Giuliano, Marika Mearelli, Meike Jakobi, Nicole Schneiderhan-Marra, Francesca L’Episcopo, Michela Deleidi
| DOI: 10.14336/AD.2026.0342
Supplement

1. Supplementary data.pdf (480KB)

Integrating AI and Causal Genetics to Prioritize Therapeutic Targets for Aging and Age-Related Diseases
Geoffrey H. D. Leung, Jianjiu Chen, I. Aylin Ergun, Evgeny Izumchenko, Alex Aliper, Feng Ren, Frank W. Pun, Alex Zhavoronkov
| DOI: 10.14336/AD.2026.0356
Supplement

1. Supplementary data.pdf (1593KB)

A Biological Alignment Framework for Interpreting Anti-Inflammatory Cardiovascular Trials in Atherosclerosis
Hua Yan, Dong Yi, Bingyin Wang
| DOI: 10.14336/AD.2026.10405
Community-Based Ocular Screening Integrated into Primary Healthcare for Older Adults: Design and 2-Year Follow-Up Results
Gu Zheng, Shiqi Hu, Yiming Zhao, Yanyan Lin, Hairui Jiao, Wanwan He, Tianhao Huang, Shilei Wang, Cong Ye, Meixiao Shen, Ming Li, Jie Chen, Xinting Liu, Fan Lu
| DOI: 10.14336/AD.2026.10331
Supplement

1. Supplementary data.pdf (159KB)

Vascular Aging Across the Cardiovascular-Alzheimer’s Continuum: Hemodynamics and Artificial Intelligence
Ziqiang Zhou, Ruihua Zhang, Jinwen Wang, Yajie Yu, Shepeng Wei, Weiqing Wan
| DOI: 10.14336/AD.2026.0539
Spatiotemporal White Matter Pathology in Chronic Cerebral Hypoperfusion: Insights from the BCAS Mouse Model of Vascular Cognitive Impairment and Dementia
Milton H. Hamblin, Austin C. Boese, Joseph Y. Zhou, Tanvi Bobba, Jean-Pyo Lee
| DOI: 10.14336/AD.2026.0256
Immersive Technologies of Virtual and Augmented Reality (VR/AR) in Patient-Centered Neurorehabilitation
Fahad Somaa, Azka Khan, Mubin Mustafa Kiyani
| DOI: 10.14336/AD.2026.0360
Circadian Rhythms, Metabolic Disorders, and Cardiovascular Aging: Molecular Crosstalk and Clinical Translation
Jing Wang, Qianwen Xu, Dongchen Zhou, Biqi Zhang, Xiaosheng Hu, Ting Chen
| DOI: 10.14336/AD.2026.0314
Supplement

1. Supplementary data.pdf (290KB)

Cognitive Frailty in Older Adults with Ischemic Stroke: Epidemiology, Mechanisms, and Multidimensional Management Strategies
Yang Li, Xiaoxing Lai, Wanchen Song, Kexin Zhang, Donglei Shi, Zhiyuan Zhang
| DOI: 10.14336/AD.2026.0305
Epigenetic Clocks in the Cosmic Silence of a Deep Underground Laboratory: Implications for Aging and Space Exploration
Javier A. Menendez, Carlos Peña-Garay, Tomás Alarcón, Elisabet Cuyàs
| DOI: 10.14336/AD.2026.0468
Mitochondrial Dynamics in Cellular Senescence: Mechanisms, Context Dependence, and Therapeutic Potential
Dan Wu, Shihao Jiang, Chenyang Li, Xianqi Wang, Yuexiang Ma, Peiwen Wang, Yanan Xu, Heliang Fu, Qianmei Wang, Kuo Shen, Rui Zheng, Junjie Li
| DOI: 10.14336/AD.2026.0323
Optimizing Antibody-Based Therapies for Alzheimer’s Disease: From Clinical Limitations to Molecular Engineering Innovations
Qian Liu, Rong-Rong Lin
| DOI: 10.14336/AD.2026.0292
Delphi-derived Framework for Healthspan-Oriented Care: The Cardiometabolic Health Perspective
Marek Postula, & Svjatoslavs Kistkins, Anna Nowak-Szwed, Salvatore DeRosa, Karol Kaminski, Anna Erat, Uģis Klētnieks, Othmar Moser, Dmitrijs Bliznuks, Ilia Stambler, Emīls Sjundjukovs, Jaron Rabinovici, Morten Scheibye-Knudsen, Alex Zhavoronkov, Vadim N. Gladyshev, Steve Horvath, Bruno Vellas, George A. Kuchel, Harald Sourij, Evelyne Bischof, Andreas F.H. Pfeiffer
| DOI: 10.14336/AD.2026.0279
Supplement

1. Supplementary data.pdf (541KB)

Brain Dysfunction in Genetically Determined Accelerated Aging Syndromes
Jelena Vasilevska, Nelli A. Arakelyan, Anastasiya L. Kungurtseva, Alisa V. Vitebskaya, Evgeny I. Rogaev
| DOI: 10.14336/AD.2026.0370
Aging Biomarkers in Osteoporosis: A Systematic Review of Molecular Mechanisms, Biological Aging, and Population Evidence
Miaosen Liu, Su Yon Jung
| DOI: 10.14336/AD.2025.1653
Supplement

1. Supplementary data.pdf (1290KB)

PCSK9 in Brain Health and Disease: Liver-Vascular-Brain Interactions in Aging and Disease
Mengqi Zhang, Neel S. Singhal
| DOI: 10.14336/AD.2026.0209
Astrocytic Ferroptosis: An Integrative Hub Linking Metabolic Dyshomeostasis, Glial Crosstalk, and Neurodegeneration in Alzheimer’s Disease
Zhimin Lu, Chang Meng, Xiaoyan Ren, Shuo Zhang, Xinqing Xu, Shaofei Hao, Qinglu Wang, Daoqing Zhou
| DOI: 10.14336/AD.2026.0328
Melatonin in Circadian Rhythm and Brain Health: Neuroprotective Effects and Therapeutic Potential
Yuxiao Feng, Yanpo Si, Xin Pang, Shuying Feng, Yuewen Zhang, Shujuan Xue, Tao Guo
| DOI: 10.14336/AD.2026.0119
Harnessing Neuronal Autophagy: Bridging Mechanistic Breakthroughs to Therapeutic Interventions
Nuzhat Ahsan, Farheen Badrealam Khan, Jhinuk Basu, Mohd Shariq, Nida Zaidi, Rizwan Hasan Khan, Reshmi Raj, Mohammed Akli Ayoub, Avadhesha Surolia, Ghulam Md Ashraf
| DOI: 10.14336/AD.2025.0804
Cellular Senescence in the Absence of Galactic Cosmic-Ray Muons
Àngela Llop-Hernández, Júlia López, Sara Verdura, Rebecca Hernández-Antolín, Laura Cid-Barrio, Carlos Peña-Garay, Tomás Alarcón, Elisabet Cuyàs, Javier A. Menendez
| DOI: 10.14336/AD.2026.0025
Supplement

1. Supplementary data.pdf (1185KB)

The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting
Juju Zhou, Xiaoqian Zhu, Weihan Chen, Junjuan Tan, Liwei Hong, Lingya Yang, Yonglin Liu, Tiantian Zhai, Kai Chen
| DOI: 10.14336/AD.2025.1506