2023
Impact Factor
7.0
Impact Factor
7.0
Special Issue: Strengthening collaborations in ageing
research: impaired resilience from 'bench to bedside'
Deadline for submission of article: October 1, 2024
Ageing is a complex heterogeneous process, both in terms of fundamental mechanisms and clinical manifestations. The 12 'hallmarks of ageing' are recognised as counterparts to the ageing process by discovery and biomedical scientists. However, laboratory studies have commonly been performed in healthy older adults without clinical assessment. Conversely, clinicians involved in the healthcare of older adults may have expertise in the identification of frailty, long-term conditions, and overall holistic management, but commonly do not have expertise in fundamental mechanisms of ageing. Indeed, many clinicians involved in healthcare of older people struggle to understand the relevance of ageing processes to their clinical practice. This leads to a disconnect in terms of how research is conducted, interpreted, and disseminated, which in itself leads to a further cycle of siloed working. In this special issue, we are aiming to publish research that involves collaboration between clinicians, fundamental scientists, physiologists, and/or bioinformaticians. Articles describing any experimental methodology will be considered, but these should relate directly to clinical manifestations of impaired resilience with ageing in the interpretation of results (e.g., frailty, sarcopenia, cognitive spectrum disorders including delirium, falls, outcomes from infection or acute illness). This issue will consider articles including original articles, reviews, and short communications.
Guest Editor
Dr. Carly Welch, MBChB, PhD
Senior Lecturer and Consultant Geriatrician
Department of Twin Research, Kings College London, UK
Email: carly.welch@kcl.ac.uk
Special Issue: Unveiling the relation between cellular aging, epigenetics, and cancer
Deadline for submission of article: 20 December, 2025
Cellular aging describes the process of deterioration and functional decline in cells as they age. Cellular aging refers to the overall process of aging at the cellular level, encompassing various molecular and physiological changes that occur in cells over time. Aging, a universal and inevitable process, has long been a subject of fascination and scientific inquiry. Emerging evidence suggests that the intricate relationship between aging, epigenetics, and cancer holds the key to unraveling the complexities of this natural phenomenon. Epigenetic modifications, such as DNA methylation and histone modifications, have been recognized as crucial mediators in the aging process, influencing gene expression patterns and cellular function. As individuals age, the epigenome undergoes progressive changes, leading to a multitude of age-associated disorders, including cancer. Importantly, the epigenetic clock, a biological measure of age based on DNA methylation patterns, has emerged as a powerful tool in predicting disease prognosis and tracking the aging process. By understanding the dynamic nature of DNA methylation during aging, researchers have uncovered its potential as a 'prophet' of age-related outcomes, including the risk of developing cancer. Notably, the development of epigenetic drugs that target specific pathways involved in age-related diseases, such as cancer, has sparked hope for novel anti-aging strategies.
This special issue invites the submission of Reviews, Mini-Reviews, Perspectives, and Original Articles that provide novel insights into the relationship between aging, epigenetics, and cancer.
Guest Editor:
Prof.UMK, Dr. habil.Dr.med.vet. Pawel Kordowitzki, Dipl. ECAR
University Professor
Department of Basic and Preclinical Sciences
Nicolaus Copernicus University, Torun, Poland
Email: p.kordowitzki@umk.pl
Deadline for submission of article: April 1, 2025
Natural biomaterials and advanced medical devices play a crucial role in addressing age-related diseases within the field of biomedicine. The development and application of these materials offer expanded options and possibilities for the treatment of conditions associated with aging, including osteoporosis, arthritis, Alzheimer's disease, and others. Natural biomaterials, such as polyesters, proteins, and polysaccharides, are utilized to repair damaged tissues, promote cell regeneration, and develop biosensors for monitoring patients' physiological states, thereby potentially slowing the aging process. Advanced medical devices, such as nano-drug carriers, 3D printing scaffolds and microneedle, facilitate precise drug delivery and minimize side effects. The synergy between the biocompatibility of natural materials and the high efficiency and functionality of advanced materials significantly enhances the prevention and treatment of age-related diseases, consequently improving patients' quality of life. Therefore, understanding the pivotal role of natural biomaterials and novel medical devices in geriatric diseases is essential for developing effective treatments.
This special issue invites the submission of Review, Mini-Review and Opinion that provide novel insights into the use of natural biomaterials and innovative medical devices for the treatment of age-related diseases.
Guest Editor,
Dai-Xu Wei, Ph.D.,
Professor,
School of Medicine, Faculty of Life Sciences and Medicine, Northwest University, Xi’an, 710069, China
Email: daviddxwei@163.com
Guest Editor,
Quanbo Ji, Ph.D., M.D.,
Associate Professor,
Department of Orthopaedics, Chinese PLA General Hospital
Beijing, 100853, China
Email: quanbo301@163.com
Deadline for submission of articles: April 1, 2025
Special Issue Information:
Alterations in mitochondrial bioenergetics, biogenesis, mitophagy and oxidative stress originating from mitochondria are closely linked to aging and the development of age-related diseases. Age-related diseases are very complex process, and the various factors involved in its aetiology are not yet completely understood. The main theme of this Special Issue centers on exploring mitochondrial dysfunction in aging and the development of age-related diseases and the signaling pathways associated with mitochondrial bioenergetics, biogenesis, mitophagy, and reactive oxygen species generation. Additionally, we aim to stimulate constructive discussions about mitochondria-targeted therapies under development and shed light on the latest advancements in understanding aging and disease mechanisms, biomarkers, and therapies related to neurodegeneration. We are inviting submissions of review, mini-review, commentary, or perspective articles, and novel communications that delve into the molecular mechanisms underlying the significance of mitochondria in neurodegenerative disease processes.
Guest Editor
Aida Adlimoghaddam PhD, CRQM
Assistant Professor
Neurology Department, SIU School of Medicine
Springfield, IL, USA
Email: aadlimoghaddam72@siumed.edu
Special Issue: Circadian Rhythms, Aging and
Disease
Deadline for submission of articles: July 1 2025
Background:
The field of aging research has benefited greatly in recent years form new understanding that focuses on circadian rhythms as determinants of disease initiation and progression. Our biological clock, or our circadian rhythm, governs many physiological processes and its disruptions have been linked to a collection of age-related diseases such as cardiovascular disease, metabolic syndrome, cancer and neurodegeneration. Understanding the complex relationship between circadian dysfunctions and aging is crucial for developing effective chronotherapeutic and nutritional tools for aging-related disease prevention and treatment.
Aim:
The aim of this special collection is to provide a comprehensive overview of the latest research on the relationship between circadian rhythms, aging-related diseases. By bringing together leading experts in the field, this collection aims to deepen our understanding of the underlying mechanisms and identify potential therapeutic targets for the management of aging-related diseases.
Scope:
This special collection welcome review articles that provide an in-depth analysis of the current state of knowledge on the topic.
The focus will be on the following key areas:
1. The role of circadian rhythms in healthy aging and age-related diseases
2. Mechanisms linking circadian disruptions to disease development
3. Impact of environmental factors on circadian rhythms and aging
4. Advances in Experimental Techniques for Circadian Aging Research
5. Systems biology approaches to understand circadian aging and disease
6. Role of epigenetics in circadian aging and disease
7. Pharmacological interventions to modulate circadian rhythms
8. Lifestyle interventions to improve circadian rhythms and healthspan
9. Clinical implications of circadian-based therapies for age-related diseases
10. Future directions in circadian aging research
Guest Editor
Dr. Peixin Dong, MD, PhD
Department of Obstetrics and Gynecology
Hokkaido University School of Medicine
Hokkaido University
Sapporo, Japan
Email: dongpeix@hotmail.co.jp
Special Issue: 'Recent advances in aging-related diseases: Evidence from molecular mechanisms to interventions and therapies
Deadline for submission of articles: July 30, 2024
Special Issue Information:
Aging is an irreversible pathophysiological process that occurs with a decline in tissue and cell function and a significant increase in the risk of various aging-related diseases, including neurological, cardiovascular, metabolic, and immune system diseases. As aging is one of the major risk factors for most chronic diseases, understanding the aging process is expected to facilitate the identification of therapeutic targets for age-related diseases and the development of suitable pharmacological agents for approved clinical use in the future. Research on aging mechanisms and intervention methods is important in improving human health and increasing lifespan. Currently, great progress has been made in research on the molecular mechanisms of aging, and progress has been made in understanding the biological and genetic mechanisms of the aging process, as well as a deeper understanding of the pathogenesis of aging. However, these findings are still far from being able to delay human aging and reduce the occurrence of aging-related diseases. Considering the aging of the population, anti-aging and healthy aging are undoubtedly important tasks of public health organizations, scientific research units, and drug research development centers. Although there are many challenges to research on aging and aging-related diseases, many questions still need to be addressed. This special issue aims to publish reviews, opinions, commentaries, letters to the editor, and correspondence describing the mechanisms related to pharmacological, non-pharmacological interventions and therapeutic strategies for aging-related diseases.
Guest Editors:
Nasrollah Moradikor, Ph.D.
Research Director and Head of Brain Aging and Dementia Group
Center for Neuroscience Research, 0105 Tbilisi
Georgia
Email: moradikor.nasroallah@yahoo.com
Mahdi Esmaeilzadeh, Ph.D.
Head of Cell and Molecular Biology Department
Center for Neuroscience Research, 0105 Tbilisi
Georgia
Email: mehdi_dna@yahoo.com