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Special Issue: Neurodegenerative disorders and Ageing: Underlying mechanisms and neuroprotective Strategie

Deadline for submission of articles: Feb. 1, 2024

Special Issue Information 

Age-related changes constitute a significant predisposing factor for diverse neurodegenerative disorders. Neurodegeneration constitutes as a common underlying molecular process in various chronic neurological diseases. The aetiology of these disorders can be attributed to multifaceted gene environment interactions, advancing age, or a combination of several other pathological triggers. This spectrum of neurodegenerative disorders encompasses a convergence of pathologies affecting both the central and peripheral nervous systems and includes conditions such as Alzheimer's disease and other forms of dementia, multiple sclerosis and its variants, motor neuron disease, and movement disorders such as Parkinson's disease. These molecular pathological changes may extend to encompass mental health disorders, including but not limited to depression, anxiety, schizophrenia, and autism spectrum disorder. In addition, neural degeneration is known to be associated with disorders like traumatic brain injury and stroke. Furthermore, neurodegeneration exerts influence over sensory nervous systems, giving rise to disease conditions like glaucoma, age-related macular degeneration, retinopathies, and auditory impairments. 

Recent research has unveiled shared molecular pathological traits in multiple neurodegenerative mechanisms. Similar molecular changes have also been observed in ageing underscoring the interconnection of these biological processes. 

Researchers are actively exploring an array of neuroprotective strategies ranging from investigating innate neuroprotective mechanisms to exploring pharmacological agents, peptides, antibodies, or gene manipulation techniques, including gene silencing, gene therapy, and CRISPR-based methodologies. Several interventions are under development to modulate disease progression and intervene at various nodal points within the biochemical networks that govern neurodegenerative mechanisms. 

This Special Issue serves as a focal point for recent advancements in understanding the pathological mechanisms underpinning neurodegenerative disorders and the aging process. Additionally, it delves into the utilization of diverse neuroprotective strategies aimed at ameliorating the course of neurodegenerative disorders and unravelling the intricate mechanisms at play. 

In this context, we extend an invitation for contributions of high-quality original research and comprehensive review articles centred around clinical and preclinical investigations. The scope includes but is not confined to the following domains: 

  • Unravelling the pathological mechanisms intrinsic to neurological disorders intertwined with neurodegenerative processes and ageing 
  • Diagnostic methodologies for age-related and neurodegenerative disorders across various stages of pathological progression 
  • Pharmacological strategies targeting diverse facets of ageing and neurodegenerative conditions, encompassing natural and synthetic compounds, antibodies, peptides, vaccinations, and/ or other biologics 
  • Investigations into lifestyle interventions like exercise, dietary modulation, and innovative drug delivery techniques 
  • Utilization of clinical studies, preclinical animal models and in vitro cell culture systems to dissect the intricacies of neurodegenerative conditions. 

Guest Editor

Prof. Vivek K Gupta, BSc, MSc, PhD, FHEA, FRCPath

NHMRC Dementia Leadership Fellow,  

RD Wright NHMRC Career Development Awardee,  

Fellow of the Higher Education Academy (FHEA),  

Macquarie Medical School, Faculty of Medicine, Health and Human Sciences

Macquarie University | NSW 2109, Australia  


Dr. Nitin Chitranshi, M. Pharma., PhD

Macquarie Medical School,

Faculty of Medicine, Health and Human Sciences |  

Macquarie University | NSW 2109, Australia  



A/Prof. Veer Bala Gupta, BSc, MSc, PhD, G Cert HigherEd. L&T

Associate Professor in Neurobiology

School of Medicine, Faculty of Health

Deakin University

VIC-3216, Australia


Special Issue:  Mitochondrial Dysfunction in Aging and Age-related Disorders

Deadline for submission of articles: Feb. 1, 2024

Special Issue Information:

    Alterations in mitochondrial bioenergetics, biogenesis, mitophagy and oxidative stress originating from mitochondria are closely linked to aging and the development of age-related diseases. Age-related diseases are very complex process, and the various factors involved in its aetiology are not yet completely understood. The main theme of this Special Issue centers on exploring mitochondrial dysfunction in aging and the development of age-related diseases and the signaling pathways associated with mitochondrial bioenergetics, biogenesis, mitophagy, and reactive oxygen species generation. Additionally, we aim to stimulate constructive discussions about mitochondria-targeted therapies under development and shed light on the latest advancements in understanding aging and disease mechanisms, biomarkers, and therapies related to neurodegeneration. We are inviting submissions of review, mini-review, commentary, or perspective articles, and novel communications that delve into the molecular mechanisms underlying the significance of mitochondria in neurodegenerative disease processes.


Guest Editor

Aida Adlimoghaddam PhD, CRQM

Assistant Professor

Neurology Department, SIU School of Medicine

Springfield, IL, USA


Special Issue: AI Innovations in Cancer Management

Deadline for submission of articles: 31 December 2024


Special Issue Information

Cancer remains a formidable challenge in global health, with many cases identified only in advanced stages, leaving few therapeutic options. Traditional chemotherapy, while a staple, comes with drawbacks like non-specific targeting, drug resistance, and numerous side effects. Although newer treatments like immunotherapy have made strides, they do not universally benefit all patients, highlighting the need for more precise treatments. Enter artificial intelligence (AI) with deep learning and machine learning leading the charge, AI is transforming how we manage cancer. Its skill in analyzing images with high precision is key for catching cancer early, understanding tumors in detail, and predicting the risk of spread, which is crucial for planning the right treatment. AI's ability to sift through and make sense of complex omics data is also critical, helping to tailor treatments to each patient's unique situation. This special collection shines a light on AI's vital role in improving cancer care, especially in personalizing chemotherapy. It brings together studies that showcase AI's impact on both cancer diagnosis and treatment, while also considering its limitations and future potential in everything from early detection to treatment prediction.


We invite submissions of original research, with a particular interest in reviews, commentaries, opinions, and editorials. Our scope includes, but is not limited to, the following topics:


l  Exploring AI's impact on cancer therapy development

l  Precision prognosis through AI's multi-omics analysis

l  Improving diagnostics with AI-enhanced imaging and pathology

l  Personalizing treatment with AI and multi-omics insights

l  Addressing AI's limitations and ethical challenges in oncology


Guest Editor


Dr. Peixin Dong, MD, PhD 

Department of Obstetrics and Gynecology 

Hokkaido University School of Medicine 

Hokkaido University 

Sapporo, Japan 



Dr. Lei Huang, MD, PhD

Department of Oncology

Ruijin Hospital, Shanghai Jiao Tong University School of Medicine

Shanghai, China



Dr. Shuihua Wang, PhD

Department of Biological Sciences

Xi'an Jiaotong Liverpool University

Suzhou, China


Special Issue: 'Recent advances in aging-related diseases: Evidence from molecular mechanisms to interventions and therapies


Deadline for submission of articles: July 30, 2024


Special Issue Information:

Aging is an irreversible pathophysiological process that occurs with a decline in tissue and cell function and a significant increase in the risk of various aging-related diseases, including neurological, cardiovascular, metabolic, and immune system diseases. As aging is one of the major risk factors for most chronic diseases, understanding the aging process is expected to facilitate the identification of therapeutic targets for age-related diseases and the development of suitable pharmacological agents for approved clinical use in the future. Research on aging mechanisms and intervention methods is important in improving human health and increasing lifespan. Currently, great progress has been made in research on the molecular mechanisms of aging, and progress has been made in understanding the biological and genetic mechanisms of the aging process, as well as a deeper understanding of the pathogenesis of aging. However, these findings are still far from being able to delay human aging and reduce the occurrence of aging-related diseases. Considering the aging of the population, anti-aging and healthy aging are undoubtedly important tasks of public health organizations, scientific research units, and drug research development centers. Although there are many challenges to research on aging and aging-related diseases, many questions still need to be addressed. This special issue aims to publish reviews, opinions, commentaries, letters to the editor, and correspondence describing the mechanisms related to pharmacological, non-pharmacological interventions and therapeutic strategies for aging-related diseases. 


Guest Editors:


Nasrollah Moradikor, Ph.D.

Research Director and Head of Brain Aging and Dementia Group

Center for Neuroscience Research, 0105 Tbilisi




Mahdi Esmaeilzadeh, Ph.D.

Head of Cell and Molecular Biology Department

Center for Neuroscience Research, 0105 Tbilisi




Pubdate:2021-10-18 Viewed: 12859