2022
Impact Factor
7.4
Impact Factor
7.4
Special Issue Information
Age-related changes constitute a significant predisposing factor for diverse neurodegenerative disorders. Neurodegeneration constitutes as a common underlying molecular process in various chronic neurological diseases. The aetiology of these disorders can be attributed to multifaceted gene environment interactions, advancing age, or a combination of several other pathological triggers. This spectrum of neurodegenerative disorders encompasses a convergence of pathologies affecting both the central and peripheral nervous systems and includes conditions such as Alzheimer's disease and other forms of dementia, multiple sclerosis and its variants, motor neuron disease, and movement disorders such as Parkinson's disease. These molecular pathological changes may extend to encompass mental health disorders, including but not limited to depression, anxiety, schizophrenia, and autism spectrum disorder. In addition, neural degeneration is known to be associated with disorders like traumatic brain injury and stroke. Furthermore, neurodegeneration exerts influence over sensory nervous systems, giving rise to disease conditions like glaucoma, age-related macular degeneration, retinopathies, and auditory impairments.
Recent research has unveiled shared molecular pathological traits in multiple neurodegenerative mechanisms. Similar molecular changes have also been observed in ageing underscoring the interconnection of these biological processes.
Researchers are actively exploring an array of neuroprotective strategies ranging from investigating innate neuroprotective mechanisms to exploring pharmacological agents, peptides, antibodies, or gene manipulation techniques, including gene silencing, gene therapy, and CRISPR-based methodologies. Several interventions are under development to modulate disease progression and intervene at various nodal points within the biochemical networks that govern neurodegenerative mechanisms.
This Special Issue serves as a focal point for recent advancements in understanding the pathological mechanisms underpinning neurodegenerative disorders and the aging process. Additionally, it delves into the utilization of diverse neuroprotective strategies aimed at ameliorating the course of neurodegenerative disorders and unravelling the intricate mechanisms at play.
In this context, we extend an invitation for contributions of high-quality original research and comprehensive review articles centred around clinical and preclinical investigations. The scope includes but is not confined to the following domains:
Guest Editor
Prof. Vivek K Gupta, BSc, MSc, PhD, FHEA, FRCPath
NHMRC Dementia Leadership Fellow,
RD Wright NHMRC Career Development Awardee,
Fellow of the Higher Education Academy (FHEA),
Macquarie Medical School, Faculty of Medicine, Health and Human Sciences
Macquarie University | NSW 2109, Australia
Email: vivek.gupta@mq.edu.au
Dr. Nitin Chitranshi, M. Pharma., PhD
Macquarie Medical School,
Faculty of Medicine, Health and Human Sciences |
Macquarie University | NSW 2109, Australia
Email: vivek.gupta@mq.edu.au
A/Prof. Veer Bala Gupta, BSc, MSc, PhD, G Cert HigherEd. L&T
Associate Professor in Neurobiology
School of Medicine, Faculty of Health
Deakin University
VIC-3216, Australia
Email: www.deakin.edu.au
Deadline for submission of articles: Feb. 1, 2024
Special Issue Information:
Alterations in mitochondrial bioenergetics, biogenesis, mitophagy and oxidative stress originating from mitochondria are closely linked to aging and the development of age-related diseases. Age-related diseases are very complex process, and the various factors involved in its aetiology are not yet completely understood. The main theme of this Special Issue centers on exploring mitochondrial dysfunction in aging and the development of age-related diseases and the signaling pathways associated with mitochondrial bioenergetics, biogenesis, mitophagy, and reactive oxygen species generation. Additionally, we aim to stimulate constructive discussions about mitochondria-targeted therapies under development and shed light on the latest advancements in understanding aging and disease mechanisms, biomarkers, and therapies related to neurodegeneration. We are inviting submissions of review, mini-review, commentary, or perspective articles, and novel communications that delve into the molecular mechanisms underlying the significance of mitochondria in neurodegenerative disease processes.
Guest Editor
Aida Adlimoghaddam PhD, CRQM
Assistant Professor
Neurology Department, SIU School of Medicine
Springfield, IL, USA
Email: aadlimoghaddam72@siumed.edu
Special Issue: Vascular Contributions to Healthy Aging and Dementia
This special issue will consider Review, Mini-review, Original Research, Opinion, Commentary, or Perspective articles focused on the link of vascular contributions to aging and dementia, including Alzheimer Disease. This research topic is to promote biomedical research on better understanding age-related changes of vascular and glymphatic systems and to facilitate research exchanges across different fields (e.g., imaging, molecular biology, pathology and clinical correlation and treatments) on this topic.
Guest Editor
Yulin Ge, MD, Professor
Department of Radiology / Center for Biomedical Imaging
NYU Langone Health
New York University School of Medicine
New York, NY 10016
Email: Yulin.Ge@nyulangone.org
Deadline for submission of articles: June 15, 2023
Inflammation is the primary pathological feature of various brain diseases including Alzheimer’s disease, Parkinson’s disease, viral infections, stroke, traumatic brain injury and multiple sclerosis etc. Microglia, astrocytes, and peripheral immune cells are key regulators of inflammatory responses in the central nervous system. The interaction among these cells is also very complicated and important for mediating neuroinflammation. A better understanding of the roles of these cells in inflammation after brain disease is essential for developing effective therapies. This special issue will consider Review, Mini-review, Original Research, Opinion, Commentary, or Perspective articles providing novel insights on glial cells and immune cells mediated neuroinflammation in brain disease.
Guest Editor
Yaohui Tang, Ph.D.
Associate Professor
Department of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai, 200030, China
Email:yaohuitang@sjtu.edu.cn
Special Issue: Mitochondrial DAMPs in inflammaging
Deadline for submission of articles: December 1, 2023
The decline in mitochondrial quality and functional activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Scientific literature has long struggled to explain the cellular and molecular basis of aging. The deterioration of mitochondrial function has been reported as a contributor to the observed age-dependent decline in organ function. Concurrently, the aggravated inflammatory microenvironment of the aging organs like myocardium, kidney, etc. might contribute to mitochondrial structural degradation. Mitochondrial damage might also contribute to peripheral tissue damage by production of ROS or pro-inflammatory signals or through mitochondrial membrane permeabilization.
Mitochondrial damage thus releases the mitochondrial contents to the tissue as DAMPs. The biological correlation of mitochondrial DAMPs with the age-related organ dysfunction is crucial to understand the role of mitochondria in the disease process. The present Special issue entitled as “Mitochondrial DAMPs in inflammaging” would look to understand the mitochondrial DAMPs through reviews, perspectives, commentaries and clinical studies or original research articles.
Guest Editor:
Santanu Rana
Assistant Professor of Zoology
Raja Peary Mohan College
University of Calcutta
West Bengal
India
Co-Lead, Raja Peary Mohan
College Integrated Biological Research Facility (RIBRF)
Central Research Facility
Raja Peary Mohan College
Uttarpara, Hooghly
West Bengal
India