Aging and disease

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Layer-Specific Colocalization of Microglia with Amyloid Plaques in the Middle Temporal Gyrus Predicts Cognitive Decline in Alzheimer's Disease
Wellydo Kesllowd Marinho Escarião, Guilherme Henrique Viana da Silva, Hellen Suzane Clemente de Castro, Sayonara Pereira da Silva, Nelyane Nayara Martins de Santana, Ramon Hypolito Lima, Felipe Porto Fiuza

PDF(2124KB) Supplement

1. Supplementary data.pdf (459KB)

Accepted: 2025-05-19 DOI: 10.14336/AD.2025.0409
Spatial Insights in Cardiovascular Aging
Zhongling Dai, Huiqin Ding, Quan Zhang, Liyao Fu, Shi Tai

PDF(946KB)

Accepted: 2025-05-19 DOI: 10.14336/AD.2025.0272
Anillin Recedes in p53-Dependent Senescence of Tumor Cells and Reappears in Cells Escaping from Senescence
Tomasz Buko, Karolina Staniak, Magdalena Dudkowska, Dorota Janiszewska, Dominika Dębowska, Agnieszka Gadecka, Anna Bielak-Zmijewska

PDF(984KB) Supplement

1. Supplementary data.pdf (899KB)

Accepted: 2025-05-16 DOI: 10.14336/AD.2025.0402
Tumor Immunosenescence Driven by Chronic Inflammation: Mechanisms, Microenvironment Remodeling and Therapeutic Strategies
Yiran Liu, Yang Yu, Yuanyuan Chen, Jing Zhuang, Changgang Sun

PDF(1626KB)

Accepted: 2025-05-15 DOI: 10.14336/AD.2025.0471
Associations of Elevated Red Cell Distribution Width (RDW) with Decreased Physical and Cognitive Function in Older Adults, and The Potential Mediation by Mitochondrial Energetics: The Study of Muscle, Mobility and Aging (SOMMA)
Kyoung Min Kim, Li-Yung Lui, Theresa Mau, Paul M. Coen, Steven R Cummings

PDF(721KB) Supplement

1. Supplementary data.pdf (278KB)

Accepted: 2025-05-15 DOI: 10.14336/AD.2024.1724

Current issue

01 April 2025. VOL 16, ISSUE 2 Previous Issue

Perspective

Chronobiology of the Tumor Microenvironment: Implications for Therapeutic Strategies and Circadian-Based Interventions
Dengxiong Li, Qingxin Yu, Ruicheng Wu, Zhouting Tuo, Weizhen Zhu, Jie Wang, Fanglin Shao, Luxia Ye, Xing Ye, Koo Han Yoo, Mang Ke, Yubo Yang, Wuran Wei, Dechao Feng

2025, 16 (2): 645-657 | DOI: 10.14336/AD.2024.0327

PDF (801KB)

Review

Amyloid-β and Phosphorylated Tau are the Key Biomarkers and Predictors of Alzheimer’s Disease
Jangampalli Adi Pradeepkiran, Javaria Baig, Md Ariful Islam, Sudhir Kshirsagar, P. Hemachandra Reddy

2025, 16 (2): 658-682 | DOI: 10.14336/AD.2024.0286

PDF (1120KB)
Vascular Calcification Heterogeneity from Bench to Bedside: Implications for Manifestations, Pathogenesis, and Treatment Considerations
Kuo-Cheng Lu, Kuo-Chin Hung, Min-Tser Liao, Li-Jane Shih, Chia-Ter Chao

2025, 16 (2): 683-692 | DOI: 10.14336/AD.2024.0289

PDF (410KB)
Drug Screening and Validation Targeting TDP-43 Proteinopathy for Amyotrophic Lateral Sclerosis
Jiaqi Xin, Sen Huang, Jing Wen, Yunhao Li, Ang Li, Senthil Kumaran Satyanarayanan, Xiaoli Yao, Huanxing Su

2025, 16 (2): 693-713 | DOI: 10.14336/AD.2024.0440

PDF (669KB)
Age-Related Dysfunction in Balance: A Comprehensive Review of Causes, Consequences, and Interventions
Jixian Wang, Yongfang Li, Guo-Yuan Yang, Kunlin Jin

2025, 16 (2): 714-737 | DOI: 10.14336/AD.2024.0124-1

PDF (451KB)
Endogenous Retroviruses Unveiled: A Comprehensive Review of Inflammatory Signaling/Senescence-Related Pathways and Therapeutic Strategies
Xin-ran Zhao, Jia-bin Zong, Yu-xiao Liu, Tuersun Aili, Min Qiu, Jie-hong Wu, Bo Hu

2025, 16 (2): 738-756 | DOI: 10.14336/AD.2024.0123-1

PDF (1101KB)
Assessing the Influence of Maternal Age in Bovine Embryos and Oocytes: A Model for Human Reproductive Aging
Aleksander Franciszek Butkiewicz, Ana Amaral, Marta Cerveira-Pinto, Pawel Kordowitzki

2025, 16 (2): 757-768 | DOI: 10.14336/AD.2024.0305

PDF (626KB)
The Role of Liquid-Liquid Phase Separation in the Accumulation of Pathological Proteins: New Perspectives on the Mechanism of Neurodegenerative Diseases
Xingyu Lu, Jiongtong Lu, Shengnan Li, Sifan Feng, Yan Wang, Lili Cui

2025, 16 (2): 769-786 | DOI: 10.14336/AD.2024.0209

PDF (830KB)
Cell-Free DNA As Peripheral Biomarker of Alzheimer’s Disease
Sachi Khemka, Ujala Sehar, Pulak R Manna, Sudhir Kshirsagar, P. Hemachandra Reddy

2025, 16 (2): 787-803 | DOI: 10.14336/AD.2024.0329

PDF (899KB)
Repurposing Ketamine in the Therapy of Depression and Depression-Related Disorders: Recent Advances and Future Potential
Qianting Deng, Emily Parker, Chongyun Wu, Ling Zhu, Timon Cheng-Yi Liu, Rui Duan, Luodan Yang

2025, 16 (2): 804-840 | DOI: 10.14336/AD.2024.0239

PDF (1703KB)
Role of Serotonylation and SERT Posttranslational Modifications in Alzheimer's Disease Pathogenesis
Arubala P. Reddy, Priyanka Rawat, Nicholas Rohr, Razelle Alvir, Jasbir Bisht, Mst Anika Bushra, Jennifer Luong, Aananya P. Reddy

2025, 16 (2): 841-858 | DOI: 10.14336/AD.2024.0328

PDF (864KB)
Inflammatory Markers Associated with Physical Frailty and Cognitive Impairment
Yiming Pan, Lina Ma

2025, 16 (2): 859-875 | DOI: 10.14336/AD.2024.0258

PDF (616KB)
Exosomal Proteomics: Unveiling Novel Insights into Lung Cancer
Guanhua Yi, Haixin Luo, Yalin Zheng, Wenjing Liu, Denian Wang, Yong Zhang

2025, 16 (2): 876-900 | DOI: 10.14336/AD.2024.0409

PDF (885KB)
Skin-brain axis in Alzheimer's disease - Pathologic, diagnostic, and therapeutic implications: A Hypothetical Review
Hyeon soo Kim, Haram Jung, Yong Ho Park, Su-Hak Heo, Sujin Kim, Minho Moon

2025, 16 (2): 901-916 | DOI: 10.14336/AD.2024.0406

PDF (639KB)
Disulfidptosis, A Novel Cell Death Pathway: Molecular Landscape and Therapeutic Implications
Qiuyang Gu, Yumei An, Mingyuan Xu, Xinqi Huang, Xueshi Chen, Xianzhe Li, Haiyan Shan, Mingyang Zhang

2025, 16 (2): 917-945 | DOI: 10.14336/AD.2024.0083

PDF (1129KB)
Revolutionizing Diabetic Foot Ulcer Care: The Senotherapeutic Approach
Guiqin Zhang, Priyadarshani Nadeeshika Samarawickrama, Li Gui, Yuan Ma, Mei Cao, Hong Zhu, Wei Li, Honglin Yang, Kecheng Li, Yang Yang, Enfang Zhu, Wen Li, Yonghan He

2025, 16 (2): 946-970 | DOI: 10.14336/AD.2024.0065

PDF (1049KB)
Expert Consensus on Prevention and Treatment of Aging-Related Gonadal Dysfunction
Xi Wang, Li Ma, Sheng Jiang, Junping Wen, Zhaoli Yan, Long Tian, Shan Deng, Boxian Huang, Ilia Stambler, Calogero Caruso, Kyung-Jin Min, Huanxing Su, Kunlin Jin, Jiangfeng Mao, Xueyan Wu, Qin Han, Robert Chunhua Zhao

2025, 16 (2): 971-979 | DOI: 10.14336/AD.2024.0004

PDF (608KB)
Aging Gut Microbiome in Healthy and Unhealthy Aging
Yangyanqiu Wang, Zhanbo Qu, Jian Chu, Shuwen Han

2025, 16 (2): 980-1002 | DOI: 10.14336/AD.2024.0331

PDF (1158KB)
Aging-Related Sarcopenia: Metabolic Characteristics and Therapeutic Strategies
Yonglian Chen, Jinhui Wu

2025, 16 (2): 1003-1022 | DOI: 10.14336/AD.2024.0407

PDF (635KB)
Navigating the Complex Terrain of Dysregulated Microglial Function in Depressive Disorders: Insights, Challenges and Future Directions
Yuling Zhang, Chaozhi Tang

2025, 16 (2): 1023-1035 | DOI: 10.14336/AD.2024.0326

PDF (691KB)
Current Understanding of Marginal Grafts in Liver Transplantation
Ze Xiang, Jiarui Li, Huixuan Zeng, Xiaonan Xiang, Fengqiang Gao, Kai Wang, Xuyong Wei, Shusen Zheng, Xiao Xu

2025, 16 (2): 1036-1058 | DOI: 10.14336/AD.2024.0214

PDF (740KB)

Original Article

Adiponectin mRNA Conjugated with Lipid Nanoparticles Specifically Targets the Pathogenesis of Type 2 Diabetes
Rady E. El-Araby, Qisheng Tu, Ying Xie, Tarek Aboushousha, Zhongyu Li, Xiaoyang Xu, Zoe X. Zhu, Lily Q. Dong, Jake Chen

2025, 16 (2): 1059-1079 | DOI: 10.14336/AD.2024.0162

PDF (2552KB)
Supplement

1. Supplementary data.pdf (275KB)
m⁶A Reader HNRNPC Facilitates Adipogenesis by Regulating Cytoskeletal Remodeling through Enhanced Lcp1 mRNA Stability
Wenhua Xie, Yewei Cui, Lingzhi Yue, Ting Zhang, Chenglong Huang, Xinyu Yu, Dan Ma, Dongfang Liu, Rui Cheng, Xueya Zhao, Xi Li

2025, 16 (2): 1080-1098 | DOI: 10.14336/AD.2024.0132

PDF (1811KB)
Supplement

1. Supplementary data.pdf (900KB)
Progressive Disruption of Sphingosine-1-Phosphate Receptor 1 Correlates with Blood-Brain Barrier Leakage in A Rat Model of Chronic Hypoxic Hypoperfusion
Jeffrey Thompson, Yirong Yang, Kelsey Duval, Michael Griego, Haojie Chen, Karen SantaCruz, Haoran Deng, Carlos Perez, Sean Maez, Sasha Hobson, Theodore Li, Halima Akter, Michel Torbey, Yi Yang

2025, 16 (2): 1099-1119 | DOI: 10.14336/AD.2024.0098

PDF (2025KB)
The NRF2/ID2 Axis in Vascular Smooth Muscle Cells: Novel Insights into the Interplay between Vascular Calcification and Aging
Mulin Xu, Xiuxian Wei, Jinli Wang, Yi Li, Yi Huang, Anying Cheng, Fan He, Le Zhang, Cuntai Zhang, Yu Liu

2025, 16 (2): 1120-1140 | DOI: 10.14336/AD.2024.0075

PDF (2657KB)
Supplement

1. Supplementary data.pdf (1137KB)
Association between Body Iron Status and Cognitive Task Performance in a Nationally Representative Sample of Older Adults
Jianying Peng, Buyun Liu, Wei Tan, Shouzhang Hu, Benchao Li, Jin Zhou, Guifeng Xu, Yangbo Sun, Linda G. Snetselaar, Robert B. Wallace, Shuang Rong, Wei Bao

2025, 16 (2): 1141-1148 | DOI: 10.14336/AD.2019.0064

PDF (400KB)
Supplement

1. Supplementary data.pdf (382KB)
Hypermethylation of Bmp2 and Fgfr2 Promoter Regions in Bone Marrow Mesenchymal Stem Cells Leads to Bone Loss in Prematurely Aged Mice
Yao Wang, Lin Sun, Tianyou Kan, Wendong Xue, Han Wang, Ping Xu, Lei Zhang, Mengning Yan, Hanjun Li, Zhifeng Yu

2025, 16 (2): 1149-1168 | DOI: 10.14336/AD.2024.0324

PDF (2807KB)
Supplement

1. Supplementary data.pdf (651KB)
Inferior Frontal Sulcal Hyperintensity on Fluid-Attenuated Inversion Recovery Is Related to Cerebrospinal Fluid Clearance via Putative Meningeal Lymphatics
Ziyu Zhou, Ying Zhou, Wang Ran, Shenqiang Yan, Xiao Zhu, Zhongyu Luo, Huihong Ke, Kemeng Zhang, Mengmeng Fang, Jianzhong Sun, Min Lou

2025, 16 (2): 1169-1179 | DOI: 10.14336/AD.2024.0415

PDF (848KB)
Supplement

1. Supplementary data.pdf (322KB)
Fecal Microbiota Transplantation Attenuates Frailty via Gut-Muscle Axis in Old Mice
Mengpei Zhu, Yumei Huang, Ziwen Wang, Ze Jin, Jiali Cao, Qiangqiang Zhong, Zhifan Xiong

2025, 16 (2): 1180-1198 | DOI: 10.14336/AD.2024.0321

PDF (1623KB)
Supplement

1. Supplementary data.pdf (500KB)
Nogo-A Drives Alzheimer’s Disease Progression by Inducing Tauopathy Vulnerability
Zijian Wang, Jun-ping Pan, Jiayuan Geng, Shijie Lv, Guisi Chen, Nian Fang, Zheng Zhang, Junliang Li, Xinke Xu, Rui Wang, Qing Zheng, Li Yan, Guobing Chen, Fei Xiao

2025, 16 (2): 1199-1215 | DOI: 10.14336/AD.2024.0053

PDF (2025KB)
Supplement

1. Supplementary data.pdf (888KB)