Editorial
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Biological Age Should Anchor Age-Related Disease Research
Hanin Shakeel, Dana Jin, Kunlin Jin
Letter to the Editor
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Predictive Value of Sarcopenia and Cognitive Decline in Hospitalized Older Adults
Xiaoyan Hu, Peng Sun
Review
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Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy
Mi Chen, Zhou Su, Jianxin Xue
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Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis
Yanlei Zhang, Jiachun Song, Yuxuan Li, Quanbo Ji
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(Dys)regulation of the Immune System in Parkinson’s Disease: Methodologies, Techniques, and Key Findings from Human Studies
Christina M. Lill, Alessia di Flora, Leonardo A. Sechi, Frederico C. Pereira, Nicoleta Moisoi, Neda Nikolovski, Mustafa Aktekin, Yasemin Gursoy-Ozdemir, Laura Deecke, Davide Cossu, Jan Homann, Elena R. Simula, Elif Nedret Keskinoz, Devrim Oz-Arslan, Nuray Bayar Muluk, Milene Gonçalves, Elenamaria Pirovano, Cristoforo Comi, Franca Marino
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Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy
Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu
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PCSK9 in Vascular Aging and Age-Related Diseases
Dong Tan, Xin Yang, Jing Yang, Gang Fan, Guozuo Xiong
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Green Tea Mitigates the Hallmarks of Aging and Age-Related Multisystem Deterioration
Yusuf Yilmaz
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SLC7A11 in Fibrosis: Molecular Mechanisms and Future Prospects
Juntong Chen, Yanjie He, Ru Chen, Zhiyong Yang, Xiaomeng Luo, Fan Yang
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Dual Challenges in the Context of Healthy Aging: A Comprehensive Exploration of the Association between Malnutrition and Cognitive Decline in Disabled Elderly
Runyuan Yu, Lixia Wang, Yifan Liu, Yimeng Hu, Zuncheng Zheng, Xiaoyu Wang, Yuexia Chen, Yulian Liu
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Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets
Heyang Sun, Qianya Hong, Chenning Li, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo
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Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy
Weiyue Zhang, Baoqing Pei, Yifan Zhou, Hui Li, Wei Ma, Bing Zhou, Chen Zhou, Huimin Jiang, Xunming Ji
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Metabolic Rewiring and Post-Translational Modifications: Unlocking the Mechanisms of Bone Turnover in Osteoporosis
Yuanyuan Li, Qilin Li, Kehan Zhang, Yaxin Wu, Gaoshaer Nuerlan, Xiangyao Wang, Yuxiao Zhang, Ahsawle Ozathaley, Jing Mao, Yan Liu, Shiqiang Gong
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Exploring the Mechanisms of Testicular Aging: Advances in Biomarker Research
Wenkang Chen, Hede Zou, Haoran Xu, Rui Cao, Yapeng Zhang, Yongjie Ma, Wei Lin, Hekun Zhang, Jiayou Zhao
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Lactylation: A Novel Epigenetic Regulator of Cellular Senescence
Caiyu Sun, Jiaxuan Li, Lei Dong, Yakui Mou, Bei Zhang, Xicheng Song
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Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies
Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu
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Inflammatory Bridges: Interconnections Between Alzheimer’s Disease and Bone Health
Hengrui Li, Wendi Wang, Liping Zhang, Tianwei Wang, Jian Liu, Jingguo Wu, Qingbin Ni, Baoliang Sun, Jingyi Sun
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Exploring the Role of RhoA/ROCK Signaling in Pain: A Narrative Review
Nan Chen, Ye Tu, Dai-Qiang Liu, Yi Zhang, Yu-Ke Tian, Ya-Qun Zhou, Shao-Bing Yang
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NK Cell Senescence in Cancer: From Molecular Mechanisms to Therapeutic Opportunities
Zilin Qiu, Zhengrui Li, Cangang Zhang, Qun Zhao, Zaoqu Liu, Quan Cheng, Jian Zhang, Anqi Lin, Peng Luo
Original Article
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The Flip Side of the Coin: METTL3 Serves as a Novel Cellular Senescence Accelerator via Negative Regulation of ITGA9
Yuting Li, Linying Huang, Miaochun Fang, Liwen Ye, Haiqing Yang, Weijia Wu, Yuan Yuan, Kun Cao, Hui-ling Zheng, Xuerong Sun, Yun Wu, Xing-Dong Xiong, Xinguang Liu, Shun Xu
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Biological Aging in Combination with Lifestyle Factors in the Blood-Based Methylome: A Biomarker for Colorectal Cancer Susceptibility in African American Women
Su Yon Jung, Matteo Pellegrini, Herbert Yu
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Plasma Interferon-gamma is Associated with Poor Treatment Response in Neovascular Age-Related Macular Degeneration
Alexander Kai Thomsen, Maria Abildgaard Steffensen, Jenni Martinez Villarruel Hinnerskov, Amalie Thomsen Nielsen, Henrik Vorum, Bent Honoré, Mogens Holst Nissen, Torben Lykke Sørensen
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Unraveling Homocysteine's Role in Dementia: No Specific Association with Alzheimer's Disease, but a Connection to White Matter Hyperintensities
Théodore Decaix, Matthieu Lilamand, Karl Götze, François Mouton-Liger, Emmanuel Cognat, Jacques Hugon, Elodie Bouaziz-Amar, Louise Sindzingre, Julien Dumurgier, Claire Paquet
Original Articles
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OPA1 Enhances Microglial Amyloid-β Clearance and Alleviates Cognitive Impairments in an Alzheimer’s Disease Model
Qing Wang, Mengqi Dong, Xue Xia, Xinyu Bao, Mengsha Hu, Lei Ye, Yun Xu
Original Article
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Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments
Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren
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Soluble Epoxide Hydrolase Inhibition Improves Alzheimer’s Disease Hallmarks: Correlation with Peripheral Inflammation and Gut Microbiota Modulation
Júlia Jarne-Ferrer, Christian Griñán-Ferré, Beatrice Jora, Sandra Codony, Lluïsa Miró, Cristina Rosell-Cardona, David Miñana-Galbis, Anna Pérez-Bosque, Santiago Vazquez, Mercè Pallàs
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LLMs and AI Life Models for Traditional Chinese Medicine-derived Geroprotector Formulation
Fedor Galkin, Feng Ren, Alex Zhavoronkov
