Aging and disease

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Decentralizing Pulmonary Screening for China’s Aging Population: From Hospitals to Communities
Leiwen Fu, Wei Shu, Yuxian Sun, Liang Li, Jian Du

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Accepted: 2025-08-27 DOI: 10.14336/AD.2025.1027
Recent Advances in Autophagy and Immunotherapy for the Clearance of Aggregated α-Synuclein in Parkinson’s Disease
Khoshnur Jannat, Sang-Bong Lee, Hong-Ryeol Jung, Rengasamy Balakrishnan, Yon-Suk Kim, Mujeeb Ur Rahman, Dong-Kug Choi

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Accepted: 2025-08-20 DOI: 10.14336/AD.2025.0642
Apelin: A Promising Therapeutic Target for Degenerative Diseases of the Musculoskeletal System
Jinkun Xu, Hengzhen Li, Jianfeng Sun, Gaoming Liu, Yuming Yao, Dongliang Yuan, Wenfeng Xiao, Yusheng Li

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Accepted: 2025-08-15 DOI: 10.14336/AD.2025.0555
Mechanisms and Pathogenesis of Diabetic Cognitive Impairment: A Comprehensive Review
Change Qi, Ming Qin, Yu Wang, Cong Li, Huiying Yan, Lina Feng, Mingquan Li

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Accepted: 2025-08-14 DOI: 10.14336/AD.2025.0769
Homeostatic DNMT3a Activity Is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer’s Disease
Yanzhi Liu, Chi Him Poon, Long Sum Rachel Tse, Jaydeep Roy, Charlotte Theodora So, Benjamin Chun-Kit Tong, Kwok-Ming Yao, George Lim Tipoe, Harry Steinbusch, Luca Aquili, Allan Kalueff, King-Ho Cheung, Man-Lung Fung, Lee Wei Lim

PDF(3362KB) Supplement

1. Supplementary data.pdf (757KB)

Accepted: 2025-08-14 DOI: 10.14336/AD.2025.0283

Current issue

12 August 2025. VOL 16, ISSUE 5 Previous Issue

Letter to the Editor

Brain Regulates Neuronal Activity Directly through the Heartbeat: A New Pathway of Heart-Brain Interaction
Zhitian Wang, Junjian Zhang, Qing-Guo Ren

2025, 16 (5): 2483-2487 | DOI: 10.14336/AD.2024.1083

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Comment on: “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Hirofumi Rokutan

2025, 16 (5): 2488-2488 | DOI: 10.14336/AD.2024.1262

PDF (239KB)
Response to Letter to the Editor, “Senolytic Treatment Improve Small Intestine Regeneration in Aging”
Dong Tan, Chun Xu, Qing Zhu, Gang Fan, Qing-Tian Luo

2025, 16 (5): 2489-2492 | DOI: 10.14336/AD.2024.1262R

PDF (397KB)
Spiritual Rejuvenation: An Alternative Way to Healthy Aging
Dalmacito A. Cordero

2025, 16 (5): 2493-2494 | DOI: 10.14336/AD.2024.1375

PDF (295KB)

Editorial

Mitochondrial Dysfunction in Aging and Age-related Disorders
Aida Adlimoghaddam

2025, 16 (5): 2495-2497 | DOI: 10.14336/AD.2025.10731

PDF (311KB)

Commentary

Enhancing Efficiency with an AI-Augmented Clinician in Neurology
Krish Kapadia, Sanskriti Ruwali, Tanvi Malav, Sridhar Seshadri, Abraham Seidmann, Daniel Z. Press, Vijaya B. Kolachalama

2025, 16 (5): 2498-2503 | DOI: 10.14336/AD.2024.1249

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Excitotoxicity, Oxytosis/Ferroptosis, and Neurodegeneration: Emerging Insights into Mitochondrial Mechanisms
Sameera Khan, Nargis Bano, Shakir Ahamad, Urmilla John, Nawab John Dar, Shahnawaz Ali Bhat

2025, 16 (5): 2504-2543 | DOI: 10.14336/AD.2024.0125-1

PDF (1706KB)
Supplement

1. Supplementary data.pdf (290KB)

Perspective

Time and Tissue Windows in Futile Reperfusion after Ischemic Stroke
Zhe Cheng, Hongrui Wang, Xiaokun Geng, Gary B. Rajah, Omar Elmadhoun, Guangge Peng, Yuchuan Ding

2025, 16 (5): 2544-2552 | DOI: 10.14336/AD.2024.1024

PDF (630KB)

Opinion

Impairment of Tricarboxylic Acid Cycle (TCA) Cycle in Alzheimer's Disease: Mechanisms, Implications, and Potential Therapies
Gudimetla Susmitha Mohan, Rahul Kumar

2025, 16 (5): 2553-2574 | DOI: 10.14336/AD.2025.0472

PDF (735KB)

Review

Mitochondrial Dysfunction: A Roadmap for Understanding and Tackling Cardiovascular Aging
Han Zhang, Mairedan Muhetarijiang, Ryan J. Chen, Xiaosheng Hu, Jie Han, Liangrong Zheng, Ting Chen

2025, 16 (5): 2575-2614 | DOI: 10.14336/AD.2024.0058

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Brain Iron Dyshomeostasis and Ferroptosis in Alzheimer’s Disease Pathophysiology: Two Faces of the Same Coin
Mariarosa Mezzanotte, Serena Stanga

2025, 16 (5): 2615-2640 | DOI: 10.14336/AD.2024.0094

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The Role of Protein S-Nitrosylation in Mitochondrial Quality Control in Central Nervous System Diseases
Fang Qiu, Yuqiang Liu, Zhiheng Liu

2025, 16 (5): 2641-2658 | DOI: 10.14336/AD.2024.0099

PDF (812KB)
Early Life Interventions: Impact on Aging and Longevity
Rong Yuan, Aida Adlimoghaddam, Yun Zhu, Xiuqi Han, Andrzej Bartke

2025, 16 (5): 2659-2673 | DOI: 10.14336/AD.202.0516

PDF (505KB)
Mitochondrial Imbalance in Down Syndrome: A Driver of Accelerated Brain Aging?
Xinxin Zuo

2025, 16 (5): 2674-2694 | DOI: 10.14336/AD.2025.0189

PDF (855KB)
The Mitochondrial Foundations of Parkinson’s Disease: Therapeutic Implications
Smijin K. Soman, Micah R. J. Woodruff, Ruben K. Dagda

2025, 16 (5): 2695-2720 | DOI: 10.14336/AD.2025.0440

PDF (1028KB)
Metabolic Dysregulation in Parkinson’s Disease: Non-Oxidative Phosphorylation and Its Role in Brain Energy Metabolism
Marta Pokotylo, Norbert Brüggemann, Jannik Prasuhn

2025, 16 (5): 2721-2738 | DOI: 10.14336/AD.2025.0619

PDF (899KB)
Axonal Energy Crisis and Calcium Phosphate Dysregulation as Pathogenesis of Optic Disc Drusen
Shweta Modgil, Tazbir Ahmed, Yaping Joyce Liao

2025, 16 (5): 2739-2751 | DOI: 10.14336/AD.2024.0459

PDF (692KB)
The Management of Sarcopenic Dysphagia: A Multidisciplinary Approach Leveraging Emerging Technologies
Wei Deng, Xiao-Feng Zeng, Li-Ying Zhang, Ji-Rong Yue, Xiao-Li Huang

2025, 16 (5): 2752-2769 | DOI: 10.14336/AD.2024.0741

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Systemic Modulators: Potential Mechanism for the 5-HT System to Mediate Exercise Amelioration in Alzheimer's Disease
Qingxu Wu, Qiang He, Xianliang Zhang, Si Chen, Xiangli Xue

2025, 16 (5): 2770-2802 | DOI: 10.14336/AD.2024.0834

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The Impact of Aging on Ocular Diseases: Unveiling Complex Interactions
Luling You, Yumeng Lin, Yizhuo Zheng, Zhongyu Han, Liuzhi Zeng, Haoran Chen

2025, 16 (5): 2803-2830 | DOI: 10.14336/AD.2024.0850

PDF (1167KB)
Histone Methylation, Energy Metabolism, and Alzheimer's Disease
Jiaqi Fu, Li An

2025, 16 (5): 2831-2858 | DOI: 10.14336/AD.2024.0899

PDF (1161KB)
Physical Prehabilitation for Older Patients with Cancer before Complex Medical-Surgical Interventions: An Umbrella Review
Dana Loudovici-Krug, Louise André, Heiner Paul Blumensaat, Marion Granger, Laetitia Stefani, Josephine Kühnemund, Christina Lemhöfer, Claire Falandry

2025, 16 (5): 2859-2869 | DOI: 10.14336/AD.2024.0957

PDF (770KB)
The Double-Edged Effects of Substance P in the Pathology of Alzheimer’s Disease
Zihan Lin, Shuyao Yu, Yuling Yang, Hongyu Mu, Yidan Hu, Weihua Yu, Yang Lü

2025, 16 (5): 2870-2889 | DOI: 10.14336/AD.2024.0960

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Mechanisms of the Mitochondrial Unfolded Protein Response in Caenorhabditis elegans and Mammals and Its Roles in Striated Muscles
Tongxiao Luan, Song Hu, Weihong Nie, Jia Liu, Li Jia, Shan Wang, Jing Zhou, Nina An, Yuting Duan, Aohua Wang, Mengru Xu, Yongjun Mao

2025, 16 (5): 2890-2907 | DOI: 10.14336/AD.2024.1019

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Ischemic Stroke and the Biological Hallmarks of Aging
Fangyuan Cheng, Bo Yan, Pan Liao, Han Gao, Zhenyu Yin, Dai Li, Ping Lei

2025, 16 (5): 2908-2936 | DOI: 10.14336/AD.2024.1059

PDF (1094KB)
The Expanding Burden of Neurodegenerative Diseases: An Unmet Medical and Social Need
Shu Wang, Yin Jiang, Anchao Yang, Fangang Meng, Jianguo Zhang

2025, 16 (5): 2937-2952 | DOI: 10.14336/AD.2024.1071

PDF (1253KB)
The Impact of Aging on Neurological Diseases in the Elderly: Molecular Mechanisms and Therapeutic Perspectives
Dan Zhou, Yumeng Lin, Zhongyu Han, Zhuyun Zhang, Le Lin, Shichong Lin, Qianke Yang

2025, 16 (5): 2953-2978 | DOI: 10.14336/AD.2024.1085

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Bidirectional Crosstalk between the Heart and Brain in Alzheimer's Disease
Zhitian Wang, Lv Zhou, Na Zhao, Zhijun Zhang, Junjian Zhang, Qing-Guo Ren

2025, 16 (5): 2979-2998 | DOI: 10.14336/AD.2024.1132

PDF (697KB)
The Organ-Joint Axes in Osteoarthritis: Significant Pathogenesis and Therapeutic Targets
Dinglong Yang, Yujing Chen, Junfei Guo, Xin Xu, Mingyi Yang, Jiale Xie, Ke Xu, Peng Xu

2025, 16 (5): 2999-3021 | DOI: 10.14336/AD.2024.1223

PDF (876KB)

Original Article

C. elegans Presenilin Mediates Inter-Organelle Contacts and Communication that Is Required for Lysosome Activity
Kerry C. Ryan, Zahra Ashkavand, Jocelyn T. Laboy, Ling Wang, Margarida Barroso, Kenneth R. Norman

2025, 16 (5): 3022-3039 | DOI: 10.14336/AD.2024.0228

PDF (1624KB)
Supplement

1. Supplementary data.pdf (434KB)
Exercise Types: Physical Activity Mitigates Cardiac Aging and Enhances Mitochondrial Function via PKG-STAT3-Opa1 Axis
Reka Szekeres, Daniel Priksz, Mariann Bombicz, Beata Pelles-Tasko, Anna Szilagyi, Brigitta Bernat, Aniko Posa, Balazs Varga, Rudolf Gesztelyi, Sandor Somodi, Zoltan Szabo, Zoltan Szilvassy, Bela Juhasz

2025, 16 (5): 3040-3054 | DOI: 10.14336/AD.2024.0959

PDF (1261KB)
Circulating Ketone Bodies, Pyruvate, and Citrate and Risk of Cognitive Decline, Structural Brain Abnormalities, and Dementia
Laia Gutierrez-Tordera, Kristine F. Moseholm, Marta Trius-Soler, Mònica Bulló, Annette Fitzpatrick, Margery A. Connelly, Oscar L. Lopez, Majken K. Jensen, Marta Guasch-Ferré, Kenneth J. Mukamal

2025, 16 (5): 3055-3068 | DOI: 10.14336/AD.2024.0754

PDF (713KB)
Supplement

1. Supplementary data.pdf (534KB)
Brain Resident Ly6C^hi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis
Yiran Huang, Nan Gao, Boren Liu, Weili Luo, Jianfei Chen, Yan Chen, Yong Bi, Zikai Zhou

2025, 16 (5): 3069-3088 | DOI: 10.14336/AD.2024.0835

PDF (2331KB)
Supplement

1. Supplementary data.pdf (509KB)
Impairment of the trans-Golgi-Lysosomal Pathway Accelerates Dopaminergic Neuronal Senescence in LRRK2^R1627P Rats
Qiumei Yang, Shimin Pang, Chunsong Zhao, Yanyan Wang, Jing Lu, Zhenyu Yue, Piu Chan

2025, 16 (5): 3089-3111 | DOI: 10.14336/AD.2024.0883

PDF (3982KB)
Supplement

1. Supplementary data.pdf (2507KB)
Aging Deteriorates Blood Brain Barrier Function and Polarizes Adaptive T Cell Expansion Contributing to Neurocognitive Damage in Experimental Cirrhosis
Sebastián Martínez-López, María Salud García-Gutiérrez, Francisco Navarrete, Isabel Gómez-Hurtado, Pedro Zapater, Enrique Ángel, Oriol Juanola, Juan L López-Cánovas, Paula Boix, Manel C Hadid, Amaya Puig-Kröger, Manuel D Gahete, Jorge Manzanares, Esther Caparrós, Rubén Francés

2025, 16 (5): 3112-3127 | DOI: 10.14336/AD.2024.0932

PDF (1758KB)
Supplement

1. Supplementary data.pdf (1052KB)
Plasma Neurodegenerative Biomarkers in Cognitively Preserved Nonagenarians
Estrella Gómez-Tortosa, Pablo Agüero-Rabes, Alicia Ruiz-González, Sonia Wagner, Raquel Téllez, Ignacio Mahillo, Andrea Ruiz-Calvo, María José Sainz, Anna Lena Nystrom, Lucía Cremades-Jimeno, Teodoro del Ser, Pascual Sánchez-Juan

2025, 16 (5): 3128-3136 | DOI: 10.14336/AD.2024.1260

PDF (472KB)
Differential Roles of Astrocytic CSF1 in Alzheimer's Disease and Cerebral Amyloid Angiopathy: Insights from Transcriptomic Analysis
Chunyuan Li, Yashuang Chen, Shiqi Luo, Yan Yang, Xinnan Liu, Sijie Li, Wei Ge, Cong Han

2025, 16 (5): 3137-3153 | DOI: 10.14336/AD.2024.10530

PDF (2214KB)
Supplement

1. Supplementary data.pdf (973KB)
APOE ɛ4 and Insulin Resistance Influence Path-Integration-Based Navigation through Distinct Large-Scale Network Mechanisms
Karel M. Lopez-Vilaret, Marina Fernandez-Alvarez, Anne Bierbrauer, Nikolai Axmacher, Jose L. Cantero, Mercedes Atienza

2025, 16 (5): 3154-3179 | DOI: 10.14336/AD.2024.0975

PDF (3224KB)
Supplement

1. Supplementary data.pdf (329KB)
Modulation of Mitochondrial Dynamics by the Angiotensin System in Dopaminergic Neurons and Microglia
Aloia Quijano, Ana I. Rodriguez-Perez, María Alicia Costa-Besada, Andrea Lopez-Lopez, María J. Guerra, Jose Luis Labandeira-Garcia, Rita Valenzuela

2025, 16 (5): 3180-3203 | DOI: 10.14336/AD.2024.0981

PDF (2323KB)
Supplement

1. Supplementary data.pdf (130KB)
Normal Bone Matrix Mineralization but Altered Growth Plate Morphology in the Lmna^G609G/G609G Mouse Model of Progeria
Stéphane Blouin, Markus A. Hartmann, Nadja Fratzl-Zelman, Phaedra Messmer, Daniel Whisenant, Michael R. Erdos, Francis S. Collins, Maria Eriksson, Charlotte Strandgren, Wayne A. Cabral, Thomas Dechat

2025, 16 (5): 3204-3218 | DOI: 10.14336/AD.2024.1094

PDF (1447KB)
Supplement

1. Supplementary data.pdf (1010KB)

Cover Illustration

12 August 2025. VOL 16, ISSUE 5
**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.

[Detail]

Cover Illustration

**Impact of HOMA-IR and APOE genotype on intracortical myelin. (A)** Differences in intracortical myelin, as derived from the T1w/T2w ratio, between APOE ?4 carriers (?4⁺) and non-carriers (?4^-). Regions in red indicate decreased intracortical myelin in APOE ?4 carriers compared to noncarriers. (B) Association between intracortical myelin content and HOMA-IR. Regions in red indicate a positive association with HOMA-IR. Statistical results are summarized in Table 10.