Editorial
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Aging as a Networked Process: Systems, Signals, and Interventions Across the Lifespan
Zaid Nathani, Zaid Qaddura, Kunlin Jin
Perspective
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Decoding the Multiple Identities and Crosstalk of Organokines in Obesity-Related Type 2 Diabetes Mellitus
Yu-Qing Ni, Jun-Kun Zhan, You-Shuo Liu
Review
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Nanozyme-Based Strategies in Cancer Immunotherapy: Overcoming Resistance to Enhance Therapeutic Efficacy
Guangjian Hou, Yukun Xu, Chunhua Wang, Can Lu, Abhimanyu Thakur, Kui Zhang, Wei Li, Zhijie Xu
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Unveiling the Therapeutic Promise of Epigenetics in Vascular Cognitive Impairment and Vascular Dementia
Sharmelee Selvaraji, Jasmine Mosberger, David Y. Fann, Mitchell KP. Lai, Christopher Li Hsian Chen, Thiruma V. Arumugam
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The Role of Hypoxia in Longevity
Ayesha Nisar, Sawar Khan, Yongzhang Pan, Li Hu, Pengyun Yang, Naheemat Modupeola Gold, Zhen Zhou, Shengjie Yuan, Meiting Zi, Sardar Azhar Mehmood, Yonghan He
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Decoding Microglial Polarization and Metabolic Reprogramming in Neurodegenerative Diseases: Implications for Disease Progression and Therapy
Ran Gao, Ya Gao, Wenting Su, Renxi Wang
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Revisiting the Role of Mitochondrial DNA Mutations in Aging: Bridging Theoretical Expectations with Empirical Observations
Runyu Liang, Qiang Tang, Jia Chen, Yongyin Huang, Luwen Zhu
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Ovarian Aging: The Silent Catalyst of Age-Related Disorders in Female Body
Xingyu Liu, Yuanqu Zhao, Yanzhi Feng, Shixuan Wang, Aiyue Luo, Jinjin Zhang
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Interconnected Pathways of Alzheimer's Disease and Osteoporosis: A Review of Genetic, Hormonal, and Environmental Influences
Yu-Xin Li, Kun Liu, Qin Zeng, Wei-Hong Zeng, Jia-Li Li, Qian-Qian Zhang, Xuan Lu, Hong-Wen Deng, Li-Jun Tan
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Advancing Hydrocephalus Management: Pathogenesis Insights, Therapeutic Innovations, and Emerging Challenges
Xiuyun Liu, Hui Zhi, Marek Czosnyka, Chiara Robba, Zofia Czosnyka, Jennifer Lee Summers, Huijie Yu, Xiaoguang Tong, Guoyi Gao, Gelei Xiao, Kai Yu, Yan Xing, Renling Mao, Shaoya Yin, Yangong Chao, Hongliang Li, Ke Pu, Keke Feng, Meijun Pang, Dong Ming
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A Connection Between the Gut Microbiome and Epigenetic Modification in Age-Related Cancer: A Narrative Review
Florida Owens, Joseph Souchak, Valeria Nazaire, Juliet Akkaoui, Rajib Shil, Candy Carbajal, Kingshuk Panda, David Caraballo Delgado, Inge Claassen, Santiago Moreno, Samantha Yi, Yishu Dong, Nirbachita Adrita, Lee-Seng Lau, Nazira El-Hage
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Capsaicin and TRPV1: A Novel Therapeutic Approach to Mitigate Vascular Aging
Xing-Yu Cui, Jun-Kun Zhan
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Exploiting the Fractionation of Stable Isotopes in Biochemical Processes for Medical Diagnosis: A Narrative Review
Markus A. Hobert, Niklas Helle, Christopher Siebert, Anton Eisenhauer, Martha Gledhill, Walter Maetzler
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Cerebral Small Vessel Disease: Current and Emerging Therapeutic Strategies
Yuewen Sun, Xiaoqian Song, Chenyang Jin, Yilong Peng, Jing Zhou, Xueping Zheng
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Unraveling the ROS-Inflammation-Immune Balance: A New Perspective on Aging and Disease
Sihang Fang, Mingjun Jiang, Juan Jiao, Hongye Zhao, Dizhi Liu, Danni Gao, Tenger Wang, Ze Yang, Huiping Yuan
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Circadian Rhythms and Lung Cancer in the Context of Aging: A Review of Current Evidence
Wenhui Xu, Lei Li, Zhendong Cao, Jinghong Ye, Xuyu Gu
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Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair
MingYu Qiu, YangYang Li, QiSen Wang, XiaoTing Jian, JingWen Huang, WeiChao Gui, Jijie Hu, Hua Liao
Original Article
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Age-Associated Activation of the cGAS-STING Pathway and Impairment of DNA Damage Repair in Human Primary Alveolar Type II Cells
Chih-Ru Lin, Hassan Hayek, Hannah Simborio, Loukmane Karim, Karim Bahmed, Sudhir Bolla, Nathaniel Marchetti, Gerard J. Criner, Ying Tian, Beata Kosmider
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Parental Alcohol Use Disrupts Offspring Mitochondrial Activity, Promoting Susceptibility to Toxicant-Induced Liver Cancer
Alison Basel, Sanat S. Bhadsavle, Katherine Z. Scaturro, Grace K. Parkey, Yava Jones-Hall, Michael C. Golding
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Cd16-Cd56bright NK Cells: A Protective NK Cell Subset for Progression and Prognosis in Amyotrophic Lateral Sclerosis
Zhenxiang Gong, Li Ba, Zehui Li, Hongyan Hou, Min Zhang
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The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila
Ricardo Aparicio, Anna M. Salazar, Edward T. Schmid, Armen Khanbabaei, Arun Rajgopal, R. Keith Randolph, David W. Walker
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AI-Driven Robotics Laboratory Identifies Pharmacological TNIK Inhibition as a Potent Senomorphic Agent
Qiuqiong Tang, Deyong Xiao, Alexander Veviorskiy, Ying Xin, Sarah W.Y. Lok, Fadi E. Pulous, Peiran Zhang, Yunfeng Zhu, Yongming Ma, Xiao Hu, Shoulai Gu, Chenting Zong, Sabina Mukba, Mikhail Korzinkin, Frank W. Pun, Man Zhang, Alex Aliper, Lijuan Wu, Feng Ren, Li Zhang, Alex Zhavoronkov
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New Insight into the Mechanism of Neurochemical Imbalance in Multiple Sclerosis: Abnormal Transportation of Brain Extracellular Space
Yumeng Cheng, Jiao Liu, Feng Tian, Hanbo Tan, Tianyu Wang, Jiabin Lu, Zeqing Tang, Xinlei Ma, Jingge Lian, Shaoyi Su, Yu Fu, Bin Liu, Yuliang Li, Wanyi Fu, Meng Xu, Hongbin Han
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Enhanced Chondrogenic Potential and Osteoarthritis Treatment Using Cyaonoside A-Induced MSC Delivered via a Hyaluronic Acid-Based Hydrogel System
Xingyan An, Qirong Zhou, Shihao Sheng, Anfu Deng, Han Liu, Xiuhui Wang, Qin Zhang, Yingying Jing, Ke Xu, Chongru He, Robert Chunhua Zhao, Jiacan Su
Review
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Gut Microbiota Modulation of Dementia Related Complications
Xiaoqing Su, Yinghua Chen, Xingxing Yuan
Original Article
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Profile for Brain Disease Research Infrastructure for Data Gathering and Exploration (BRIDGE) Platform
Sujung Oh, Hee-Young Sohn, Junwoo Seo, Eunjee Kang, Jae Kyung Park, So Young Moon, Hee Jin Kim, Na-Yeon Jung, Sun Min Lee, Bo Kyoung Cheon, Hyemin Jang, Sung Hoon Kang, Sarang Kang, Kyu Yeong Choi, Sang-Won Yoo, Yun Joong Kim, Juhee Cho, Eun-Joo Kim, Sang Won Seo, Kun Ho Lee, Joong-Seok Kim, Young Ho Koh, Chi-Hun Kim, Munjin Kwon, Danbee Kang
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Circulating Endocannabinoids and Cognitive Function in Older Adults
Shiraz Vered, Alexa S. Beiser, Liron Sulimani, Sharon Sznitman, Saptaparni Ghosh, Gil M Lewitus, David Meiri, Sudha Seshadri, Galit Weinstein
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Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways
Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee
Orignal Article
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Unveiling Lipid Droplet Transport Dynamics as Biomarkers of Senescence Using Label-Free, Time-Lapse Holotomography
Amarnath Singam, Nikita Gopakumar, Apoorva Chauhan, Kimberly Ramirez, Jeong Hee Kim, Chandrabali Bhattacharya, Jingchun Chen, Deok-Ho Kim, Seungman Park
Original Article
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Association Between Dementia and Optical Coherence Tomography Scan Quality
Reuben Jyong Kiat Foo, Damon Wong, Nur Fidyana Binte Abdul Gani, Bingyao Tan, Munirah Binte Ismail, Gerhard Garhöfer, Laetitia Hinterhuber, Narayanaswamy Venketasubramanian, Christopher Li-Hsian Chen, Leopold Schmetterer, Jacqueline Chua
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Sarcopenia and Cognitive Decline in Hospitalized Older Adults from a Prospective Study
Sapir Kon-Kfir, Tali Cukierman-Yaffe, Haim Krupkin, Ana Belkin, Gadi Shlomai, Jonathan Bleier, Shiri Weinstein, Liora Bruckmayer, Elad Prinz, Alon Kaplan, Michal Goldenberg Shraga, Dana Lev, Shahar Dekel, Noa Shalmon, Nurit Tsarfaty, Niv Reiss, Evelyne Bischof, Avshalom Leibowitz
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Anti-Müllerian Hormone Concentrations in Women of Different Reproductive Age and the Chances of IVF Outcome: A Paradigm Shift is needed
Jakub Wyroba, Joanna Kochan, Liam Kelley, Sharif Iqbal, Paweł Kordowitzki
