Aging and disease

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Targeting Cellular Senescence as a Therapeutic Strategy to Attenuate Pulmonary Fibrosis Associated with Metabolic Syndrome
Michaela Rennerova, Tereza Havrlantova, Igor Simonik, Renata Pavlovicova, Miloslava Cechova, Anna Cinkajzlova, Dan-Diem Thi Le, Jana Klouckova, Jiri Fronek, Filip Thieme, Jiri Neuzil, Lukas Werner, Jan Stursa, Milos Mraz, Martin Haluzik, Sona Stemberkova Hubackova

PDF(1011KB) Supplement

1. Supplementary data.pdf (952KB)

Accepted: 2026-06-24 DOI: 10.14336/AD.2026.0150
Staging of Neuropil Morphological Alterations in Alzheimer’s Disease
Zhi-Yi Zhang, Xin-Meng Wang, Xin Ma, Yi Wang, Shuai-Deng Wang, Yi-Lin Peng, Kun Cheng, Yue-Ru Shen, Guo-Zhang Tang, Chen-Wei Wang, Jiang-Ning Zhou

PDF(2956KB) Supplement

1. Supplementary data.pdf (2496KB)

Accepted: 2026-06-24 DOI: 10.14336/AD.2026.0213
IRG1/Itaconate Inhibits Microglial Senescence-Like Transition by Modulating Mitochondrial Dynamics through Rhoa Alkylation in Subarachnoid Hemorrhage
Zeyu Zhang, Yanlin Chen, Weizhen Gao, Fengchen Zhang, Yichao Jin, Jie Li, Jiaqi Wang, Tao Lv, Feng Jia, Xiaohua Zhang

PDF(2115KB) Supplement

1. Supplementary data.pdf (1650KB)

Accepted: 2026-06-23 DOI: 10.14336/AD.2025.1527
Lifelong Consumption of Freeze-Dried Parabacteroides Distasonis Improves Gut Barrier Integrity and Extends Lifespan and Health Span in Drosophila Melanogaster.
Sarah Shnayder, Vicki Do, Junyue Wang, Luana Machado, Sofia Rosa, Lora Kusaku, Benjamin Kuo, Jill Hutchinson, Grace Ogden, Neja Majeti, Weimin Guo, Samuel Beck, Mitch McVey, Jimmy W. Crott

PDF(716KB) Supplement

1. Supplementary data.pdf (347KB)

Accepted: 2026-06-22 DOI: 10.14336/AD.2025.1584
Rapamycin Attenuates Age-Related Changes in Marmoset Submandibular Gland: A Non-Human Primate Model of Human Oral Aging
Parveez Ahamed Abdul-Azees, Hanzhou Wang, Jerry Chen, Milos Marinkovic, David D. Dean, Xiao-Dong Chen, Adam B. Salmon, Chih-Ko Yeh

PDF(2245KB)

Accepted: 2026-06-22 DOI: 10.14336/AD.2026.0057

Current issue

11 June 2026. VOL 17, ISSUE 4 Previous Issue

Editorial

Unveiling the Relation between Cellular Aging, Epigenetics and Cancer
Pawel Kordowitzki, Arkadiusz Grzeczka

2026, 17 (4): 1756-1763 | DOI: 10.14336/AD.2025.0677

PDF (506KB)

Review

Updates in Intravenous Thrombolysis Treatment for Acute Ischemic Stroke in Asian Populations
Rui Xue, Anni Wang, Ying Zhou, Min Lou

2026, 17 (4): 1764-1785 | DOI: 10.14336/AD.2025.0060

PDF (497KB)
Targeting Ferroptosis to Eliminate Senescent Cells: Mechanisms and Therapeutic Potential
Sanjay Kumar Kureel, Blake B. Rasmussen

2026, 17 (4): 1786-1808 | DOI: 10.14336/AD.2025.0141

PDF (980KB)
Novel Insights into the Mechanism and Treatment of Diabetes-Related Brain Complications: Focusing on the Blood-Brain Barrier Impairment
Caiyi Long, Yueheng Pu, Shunseng Keng, Jiajing Tao, Boxun Zhang, Rensong Yue

2026, 17 (4): 1809-1833 | DOI: 10.14336/AD.2025.0296

PDF (934KB)
The Comorbidity of AD and PD: Exploring Clinical, Pathological, and Biomarker Interactions
Qi-Lei Zhang, Yu Liu, Tian Tu, Xiao-Xin Yan

2026, 17 (4): 1834-1849 | DOI: 10.14336/AD.2025.0301

PDF (1121KB)
Glucose Metabolism, Lactate, Lactylation and Alzheimer’s Disease
Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun

2026, 17 (4): 1850-1867 | DOI: 10.14336/AD.2025.0338

PDF (704KB)
Epigenetic Dysregulation and Osteocyte Senescence: Convergent Drivers of Osteosarcopenia in Aging Bone and Muscle
Shahneela Nusrat, Rahman Ud Din, Muhammad Akram Tariq, Haisheng Yang

2026, 17 (4): 1868-1882 | DOI: 10.14336/AD.2025.0370

PDF (620KB)
Adaptive Immune Dyshomeostasis as a Mediator of Vascular Cognitive Decline: Unraveling Neurovascular Crosstalk
Yating Li, Jinlin Shen, Li Zhang, Yang Luo

2026, 17 (4): 1883-1903 | DOI: 10.14336/AD.2025.0380

PDF (967KB)
Exercise as a Metabolic Regulator: Targeting AMPK/mTOR-Autophagy Crosstalk to Counteract Sarcopenic Obesity
Daoqi Zhang, Congfei Lu, Kai Sang

2026, 17 (4): 1904-1915 | DOI: 10.14336/AD.2025.0419

PDF (512KB)
Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease
Fengwen Jiang, Niya Wang, Qiang Meng

2026, 17 (4): 1916-1931 | DOI: 10.14336/AD.2025.0502

PDF (1030KB)
Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies
Wenjie Cai, Haoyu Zhang, Zhouzhou Li, Mingyun Cai, Shiwen Yu, Peng Chen, Xinyu Song

2026, 17 (4): 1932-1954 | DOI: 10.14336/AD.2025.0503

PDF (1567KB)
Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief
Hong Wu, Jia-Yi Wu, Shao-Jie Gao, Lin Liu, Xin-Yi Dai, Wen-Lu Song, Long-Qing Zhang, Dai-Qiang Liu, Ying-Xin Tang, Ya-Qun Zhou, Wei Mei

2026, 17 (4): 1955-1970 | DOI: 10.14336/AD.2025.0530

PDF (736KB)
Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases
Yuxiang Du, Yong Xia

2026, 17 (4): 1971-1984 | DOI: 10.14336/AD.2025.0542

PDF (553KB)
Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes
Shuxian Huang, Yongling Zhao, Yuanpeng Xin, Ziqi Yao, Yi Deng, Qihui Cai, Junyi Xie, Ruixue Wang, Zhaohong Liao

2026, 17 (4): 1985-2002 | DOI: 10.14336/AD.2025.0549

PDF (6061KB)
Regulatory and Influencing Factors of Digestive Function in Elderly People: Roles of the Gut Microbiota and Nutritional Interventions
Ka Li, Safia Arbab, Qiujing Du, Jiao Zhou, Yuwen Chen, Yali Tian, Li Qijie, Hanif Ullah, Ben Zhang

2026, 17 (4): 2003-2020 | DOI: 10.14336/AD.2025.0565

PDF (833KB)
Effects of Lipid Metabolites and Cross Organ Lipid Metabolism Regulation on Bone Homeostasis
Mengyuan Li, Jiaheng Zhang, Jiaqian Tang, Chang Zhou, Guomin Zhang, Huiping Liu, Xiaoming Lei

2026, 17 (4): 2021-2034 | DOI: 10.14336/AD.2025.0575

PDF (762KB)
Exercise-Induced Short-Chain Fatty Acids: A Novel Therapeutic Target in Type 2 Diabetes Mellitus with Sarcopenia
Fan Shi, Jun Chen

2026, 17 (4): 2035-2052 | DOI: 10.14336/AD.2025.0670

PDF (577KB)
Spinal Cord Injury and Ageing: The Role of Chronic Neuroinflammation
Tianwei Wang, Zhaoyang Zhang, Jian Liu, Liping Zhang, Qingbin Ni, Baoliang Sun, Jingyi Sun

2026, 17 (4): 2053-2074 | DOI: 10.14336/AD.2025.10630

PDF (794KB)
Monocytes/Macrophages in Giant Cell Arteritis-Polymyalgia Rheumatica Spectrum Disease
Junyan Guo, Yanlin He, Fan Yang, Weiqian Chen

2026, 17 (4): 2075-2088 | DOI: 10.14336/AD.2025.0830

PDF (725KB)
Insights into Biomarkers of Alzheimer's Disease: From Core Markers to Emerging Directions
Weiyao Zhu, Yu Wang, Ming Qin, Qinghe Zhao, Lina Feng, Mingquan Li

2026, 17 (4): 2089-2113 | DOI: 10.14336/AD.2025.0761

PDF (947KB)
VCAM-1 in Cognitive Impairment: Mechanisms, Biomarker Potential, and Therapeutic Targeting
Xilong Guan, Xiaoling Zhu, Linan Zha, Wen Yu, Xiuqin Rao, Yanhong Xiong, Yu Jin, Mojiao Zhang, Tao Luo, Xiangfei Huang, Xifeng Wang, Fuzhou Hua, Jing Xu

2026, 17 (4): 2114-2130 | DOI: 10.14336/AD.2025.0675

PDF (961KB)

Original Article

Age-dependent Transcriptional and Circuit Alterations in the brain Underlie Post-Anesthesia Neurobehavioral Dysfunction
Yun Li, Cosar Uzun, Syed Taufiqul Islam, Balaji Krishnamachary, Hangnoh Lee, Zihui Wang, Hui Li, Shaolin Liu, Junfang Wu

2026, 17 (4): 2131-2153 | DOI: 10.14336/AD.2025.0596

PDF (2210KB)
Supplement

1. Supplementary data.pdf (2622KB)
Dynamic CTA-Based Whole-Brain Arterial-Venous Collateral Assessment for Predicting Futile Recanalization in Acute Ischemic Stroke
Ruoyao Cao, Yao Lu, Wei Li, Fan Yu, Shen Hu, Kunpeng Chen, Guoxuan Wang, Chengkan Sun, Qingfeng Ma, Miao Zhang, Juan Chen, Jie Lu

2026, 17 (4): 2154-2165 | DOI: 10.14336/AD.2025.0540

PDF (1018KB)
Supplement

1. Supplementary data.pdf (751KB)
Exploring the Cerebro-Renovascular Link: Implications of Renal Haemodynamics on Intracranial Arterial Calcification
Joseph Amihere Ackah, Xiang-yan Chen, Huixing Zeng, Yiming Liu, Youcheng Rong, Xuelong Li, Ben Yuk-fai Fong, Ximin Pan, Feng Zhang, Jing Cai

2026, 17 (4): 2166-2180 | DOI: 10.14336/AD.2025.0489

PDF (605KB)
Antigen-Specifically Activated CD8+ and Double-Negative T Cells Accumulate in the Brain of Alzheimer’s Disease Mice
Juliane Gellrich, Johanna Ruhnau, Lea Köslich, Stefan Gross, Agnes Flöel, Juliane Schulze, Antje Vogelgesang

2026, 17 (4): 2181-2197 | DOI: 10.14336/AD.2025.0452

PDF (1076KB)
Supplement

1. Supplementary data.pdf (559KB)
Burn Injuries Accelerate Biological Aging and Increase the Epigenetically Inferred Risk of Mortality and Frailty
Fadi Khalaf, Serena Yang, Dalia Barayan, Diana Julia Tedesco, Michael Chong, Guillaume Paré, Marc G. Jeschke

2026, 17 (4): 2198-2212 | DOI: 10.14336/AD.2025.0407

PDF (1019KB)
Supplement

1. Supplementary data.pdf (301KB)
Lars2 Deficiency-Induced Mitochondrial Dysfunction Drives the Emergence of a Pro-Inflammatory Stroke-Specific Microglial Subpopulation
Qing Zou, Jianxin Zhou, Ying Li, Jiaming Shi, Jingying Huang, Cheng Zhuang, Hao Wu, Huanle Hong, Yanan Guo, Qian Li, Robert Chunhua Zhao, Jiao Wang

2026, 17 (4): 2213-2230 | DOI: 10.14336/AD.2025.0387

PDF (1933KB)
Supplement

1. Supplementary data.pdf (2106KB)
Cardiovascular Health, as per Life's Essential 8, and Impaired Lower-Extremity Function in Older Adults
David Gómez-Ángel, Mercedes Sotos-Prieto, David Martínez-Gómez, Auxiliadora Graciani, Esther García-Esquinas, Fernando Rodríguez-Artalejo, Rosario Ortolá

2026, 17 (4): 2231-2240 | DOI: 10.14336/AD.2025.0347

PDF (478KB)
Supplement

1. Supplementary data.pdf (694KB)
GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment
Mark D. Zuppichini, Abbey M. Hamlin, Quan Zhou, Esther Kim, Kayla Wyatt, Noah Reardon, Benjamin M. Hampstead, Thad A. Polk

2026, 17 (4): 2241-2252 | DOI: 10.14336/AD.2025.0334

PDF (829KB)
Supplement

1. Supplementary data.pdf (901KB)
Age-, Sex-, and Ancestry-Specific Prevalence of Hearing Loss in UK Biobank and All of Us Research Program
Jun He, Sharon G. Curhan, Gary C. Curhan, Renato Polimanti

2026, 17 (4): 2253-2259 | DOI: 10.14336/AD.2025.0754

PDF (576KB)
Supplement

1. Supplementary data.pdf (903KB)
Plasma GFAP and Amyloid Pathology Predict Cognitive Response to Multidomain Interventions in MCI
Myung-Hoon Han, Mina Hwang, Hyuk Sung Kwon, So Young Moon, Yoo Kyoung Park, Jee Hyang Jeong, Seong Hye Choi, Seong-Ho Koh

2026, 17 (4): 2260-2272 | DOI: 10.14336/AD.2025.0646

PDF (836KB)
Supplement

1. Supplementary data.pdf (1409KB)