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Aging and Disease    2015, Vol. 6 Issue (1) : 56-75     DOI: 10.14336/AD.2014.0209
The Intricate Interplay between Mechanisms Underlying Aging and Cancer
Amanda Piano, Vladimir I. Titorenko
Department of Biology, Concordia University, Montreal, Quebec, Canada
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Age is the major risk factor in the incidence of cancer, a hyperplastic disease associated with aging. Here, we discuss the complex interplay between mechanisms underlying aging and cancer as a reciprocal relationship. This relationship progresses with organismal age, follows the history of cell proliferation and senescence, is driven by common or antagonistic causes underlying aging and cancer in an age-dependent fashion, and is maintained via age-related convergent and divergent mechanisms. We summarize our knowledge of these mechanisms, outline the most important unanswered questions and suggest directions for future research.

Keywords aging      cancer      cell cycle      cellular senescence      cell death      cellular signaling     
Corresponding Authors: Vladimir I. Titorenko   
Issue Date: 01 February 2015
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Amanda Piano
Vladimir I. Titorenko
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Amanda Piano,Vladimir I. Titorenko. The Intricate Interplay between Mechanisms Underlying Aging and Cancer[J]. Aging and Disease, 2015, 6(1): 56-75.
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