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Aging and Disease    2015, Vol. 6 Issue (2) : 109-120     DOI: 10.14336/AD.2014.0305
Review Article |
Metabolic Syndrome, Aging and Involvement of Oxidative Stress
Francesca Bonomini(),Luigi Fabrizio Rodella,Rita Rezzani
Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
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The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

Keywords metabolic syndrome      aging      accelerated senescence      oxidative stress     
Corresponding Authors: Francesca Bonomini     E-mail:
Issue Date: 25 March 2015
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Francesca Bonomini
Luigi Fabrizio Rodella
Rita Rezzani
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Francesca Bonomini,Luigi Fabrizio Rodella,Rita Rezzani. Metabolic Syndrome, Aging and Involvement of Oxidative Stress[J]. A&D, 2015, 6(2): 109-120.
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[5] Carmen G Vinagre,Fatima R Freitas,Carlos H de Mesquita,Juliana C Vinagre,Ana Carolina Mariani,Roberto Kalil-Filho,Raul C Maranhão. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects[J]. A&D, 2018, 9(4): 748-754.
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[7] Yali Chen,Mengmei Yin,Xuejin Cao,Gang Hu,Ming Xiao. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain[J]. A&D, 2018, 9(3): 374-390.
[8] Wenzhi Sun,Jiewen Tan,Zhuo Li,Shibao Lu,Man Li,Chao Kong,Yong Hai,Chunjin Gao,Xuehua Liu. Evaluation of Hyperbaric Oxygen Treatment in Acute Traumatic Spinal Cord Injury in Rats Using Diffusion Tensor Imaging[J]. A&D, 2018, 9(3): 391-400.
[9] Changjun Yang,Kelly M. DeMars,Eduardo Candelario-Jalil. Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain[J]. A&D, 2018, 9(2): 322-330.
[10] Meng Zhang,Yong-Ning Deng,Jing-Yi Zhang,Jie Liu,Yan-Bo Li,Hua Su,Qiu-Min Qu. SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway[J]. A&D, 2018, 9(2): 273-286.
[11] Lin-Yuan Zhang,Pan Lin,Jiaji Pan,Yuanyuan Ma,Zhenyu Wei,Lu Jiang,Liping Wang,Yaying Song,Yongting Wang,Zhijun Zhang,Kunlin Jin,Qian Wang,Guo-Yuan Yang. CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain[J]. A&D, 2018, 9(2): 262-272.
[12] Weiming Hu,Junwu Wu,Wenjing Jiang,Jianguo Tang. MicroRNAs and Presbycusis[J]. A&D, 2018, 9(1): 133-142.
[13] Barbara Strasser,Konstantinos Volaklis,Dietmar Fuchs,Martin Burtscher. Role of Dietary Protein and Muscular Fitness on Longevity and Aging[J]. A&D, 2018, 9(1): 119-132.
[14] Huaqin Liu,Zhui Yu,Ying Li,Bin Xu,Baihui Yan,Wulf Paschen,David S Warner,Wei Yang,Huaxin Sheng. Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice[J]. A&D, 2018, 9(1): 31-39.
[15] Fangyu Peng,Fang Xie,Otto Muzik. Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT[J]. A&D, 2018, 9(1): 109-118.
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