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Aging and disease    2015, Vol. 6 Issue (2) : 109-120     DOI: 10.14336/AD.2014.0305
Review Article |
Metabolic Syndrome, Aging and Involvement of Oxidative Stress
Bonomini Francesca*(), Rodella Luigi Fabrizio, Rezzani Rita
Division of Anatomy and Physiopathology, Department of Clinical and Experimental Sciences, University of Brescia, Brescia, Italy
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The prevalence of the metabolic syndrome, a cluster of cardiovascular risk factors associated with obesity and insulin resistance, is dramatically increasing in Western and developing countries. This disorder consists of a cluster of metabolic conditions, such as hypertriglyceridemia, hyper-low-density lipoproteins, hypo-high-density lipoproteins, insulin resistance, abnormal glucose tolerance and hypertension, that-in combination with genetic susceptibility and abdominal obesity-are risk factors for type 2 diabetes, vascular inflammation, atherosclerosis, and renal, liver and heart diseases. One of the defects in metabolic syndrome and its associated diseases is excess of reactive oxygen species. Reactive oxygen species generated by mitochondria, or from other sites within or outside the cell, cause damage to mitochondrial components and initiate degradative processes. Such toxic reactions contribute significantly to the aging process. In this article we review current understandings of oxidative stress in metabolic syndrome related disease and its possible contribution to accelerated senescence.

Keywords metabolic syndrome      aging      accelerated senescence      oxidative stress     
Corresponding Authors: Bonomini Francesca     E-mail:
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present address: Kunming Biomed International, Kunming, Yunnan, 650500, China

Issue Date: 25 March 2015
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Bonomini Francesca
Rodella Luigi Fabrizio
Rezzani Rita
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Bonomini Francesca,Rodella Luigi Fabrizio,Rezzani Rita. Metabolic Syndrome, Aging and Involvement of Oxidative Stress[J]. Aging and disease, 2015, 6(2): 109-120.
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Figure 1.  Schematic relationship between ROS production, accelerated senescence and metabolic syndrome.
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