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Aging and Disease    2014, Vol. 5 Issue (2) : 109-113     DOI: 10.14336/AD.2014.0500109
Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA)
Peter M Nilsson
Department of Clinical Sciences, Lund University, Skane University Hospital, Sweden
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An increase in peripheral vascular resistance at rest is not routinely observed in healthy older persons, but often associated with increased stiffness of central elastic arteries, as hallmarks of aging effects on the vasculature, referred to as early vascular aging (EVA). In clinical practice, the increased arterial stiffness translates into increased brachial and central systolic blood pressure and corresponding pulse pressure in subjects above 50 years of age, as well as increased carotid-femoral pulse wave velocity (c-f PWV), a marker of arterial stiffness. A c-f PWV value ≥ 10 m/s is currently defined as a threshold for increased cardiovascular risk, based on consensus statement from 2012. Prevention and treatment strategies include a healthy lifestyle and the control of risk factors via appropriate drug therapy to achieve vascular protection related to EVA. New drugs are under development for vascular protection, for example the selective Angiotensin II (AT2) receptor agonist called compound 21. One target group for early intervention could be members of risk families including subjects with early onset cardiovascular disease.

Keywords aging      arterial stiffness      cardiac      blood pressure      haemodynamic      vasculature     
Corresponding Authors: Peter M Nilsson   
Issue Date: 12 November 2014
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Peter M Nilsson
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Peter M Nilsson. Hemodynamic Aging as the Consequence of Structural Changes Associated with Early Vascular Aging (EVA)[J]. Aging and Disease, 2014, 5(2): 109-113.
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Age-related changes in brachial BP
Isolated systolic hypertension (ISH)
Elevated pulse pressure (PP)
Age-related changes in central BP
Increased central systolic BP and PP
Increased BP variability
Linked to arterial stiffness
Decreased heart rate variability
Linked to arterial stiffness
Impaired endothelial function
Less vasodilation, linked to arterial stiffness
Impaired baroreceptor function, orthostatic hypotension
Linked to arterial stiffness
Table 1.  Features of hemodynamic ageing and its relationship to arterial stiffness
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