Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and Disease    2014, Vol. 5 Issue (2) : 114-125     DOI: 10.14336/AD.2014.0500114
|
Vascular Hyperpermeability and Aging
Ryan Oakley, Binu Tharakan
Department of Surgery, Texas A&M University Health Science Center College of Medicine & Baylor Scott & White Healthcare, Temple, Texas, USA
Download: PDF(0 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Vascular hyperpermeability, the excessive leakage of fluid and proteins from blood vessels to the interstitial space, commonly occurs in traumatic and ischemic injuries. This hyperpermeability causes tissue vasogenic edema, which often leads to multiple organ failure resulting in patient death. Vascular hyperpermeability occurs most readily in small blood vessels as their more delicate physical constitution makes them an easy target for barrier dysfunction. A single layer of endothelial cells, linked to one another by cell adhesion molecules, covers the interior surface of each blood vessel. The cell adhesion molecules play a key role in maintaining barrier functions like the regulation of permeability. Aging is a major risk factor for microvascular dysfunction and hyperpermeability. Apart from age-related remodeling of the vascular wall, endothelial barrier integrity and function declines with the advancement of age. Studies that address the physiological and molecular basis of vascular permeability regulation in aging are currently very limited. There have been many cellular and molecular mechanisms proposed to explain aging-related endothelial dysfunction but their true relationship to barrier dysfunction and hyperpermeability is not clearly known. Among the several mechanisms that promote vascular dysfunction and hyperpermeability, the following are considered major contributors: oxidative stress, inflammation, and the activation of apoptotic signaling pathways. In this review we highlighted (a) the physiological, cellular and molecular changes that occur in the vascular system as a product of aging; (b) the potential mechanisms by which aging leads to barrier dysfunction and vascular hyperpermeability in the peripheral and the blood-brain barrier; (c) the mechanisms by which the age-related increases in oxidative stress, inflammatory markers and apoptotic signaling etc. cause endothelial dysfunction and their relationship to hyperpermeability; and (d) the relationship between aging, vascular permeability and traumatic injuries.

Keywords aging      vascular hyperpermeability      vascular endothelium      permeability regulation     
Corresponding Authors: Binu Tharakan   
Issue Date: 10 March 2014
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Ryan Oakley
Binu Tharakan
Cite this article:   
Ryan Oakley,Binu Tharakan. Vascular Hyperpermeability and Aging[J]. Aging and Disease, 2014, 5(2): 114-125.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2014.0500114     OR     http://www.aginganddisease.org/EN/Y2014/V5/I2/114
[1] Bonetti PO, Lerman LO, Lerman A(2003). Endothelial dysfunction: a marker of atherosclerotic risk. Arterioscler Thromb Vasc Biol, 23:168-175
[2] Widlansky ME, Gokce N, Keaney JFJr, Vita JA(2003). The clinical implications of endothelial dysfunction. J Am Coll Cardiol, 42:1149-1160
[3] Michel CC(2004). Fluid exchange in the microcirculation. J PhysiolJun15pt 3)557:701-2
[4] Dejana E, Bazzone G, Lampugnani MG(1999). Vascular endothelial (VE)-cadherin: only an intercellular glue?. Exp Cell Res, 252:13-19
[5] Childs EW, Tharakan B, Hunter FA, Tinsley JH, Cao X(2007). Apoptotic signaling induces hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol, 292:H3179-89
[6] Tharakan B, Hellman J, Sawant DA, Tinsley JH, Parrish AR, Hunter FA, Smythe WR, Childs EW(2012). β-Catenin dynamics in the regulation of microvascular endothelial cell hyperpermeability. Shock, 37:306-11
[7] Kumar P, Shen Q, Pivetti CD, Lee ES, Wu MH, Yuan SY(2009). Molecular mechanisms of endothelial hyperpermeability: implications in inflammation. Expert Rev Mol Med3011:e19
[8] Tharakan B, Chowdhury I, Bhat GK(2011). Fundamental mechanisms and implications of neuronal cell apoptosis. Schmid CJ, Wolfe JL Neuronal Cell ApoptosisNew YorkNova Scientific Publishers143-166
[9] Sawant DA, Tharakan B, Adekanbi A, Hunter FA, Smythe WR, Childs EW(2011). Inhibition of VE-cadherin proteasomal degradation attenuates microvascular hyperpermeability. Microcirculation, 18:46-55
[10] Krouwer VJ, Hekking LH, Langelaar-Makkinje M, Regan-Klapisz E, Post JA(2012). Endothelial cell senescence is associated with disrupted cell-cell junctions and increased monolayer permeability. Vasc Cell284:12
[11] Pelegrí C, Canudas AM, del Valle J(2007). Increased permeability of blood-brain barrier on the hippocampus of a murine model of senescence. Mech Ageing Dev, 128:522-528
[12] Blau CW, Cowley TR, O’Sullivan J(2012). The age-related deficit in LTP is associated with changes in perfusion and blood-brain barrier permeability. Neurobiol Aging, 33:1005
[13] Luissint AC, Artus C, Glacial F, Ganeshamoorthy K, Couraud PO(2012). Tight junctions at the blood brain barrier: physiological architecture and disease-associated dysregulation. Fluids Barriers CNS, 9:23
[14] Lakatta EG, Levy D(2003). Arterial and cardiac aging: major shareholders in cardiovascular disease enterprises: Part I: aging arteries: a ‘set up’ for vascular disease. Circulation, 107:139-146
[15] Brandes RP, Fleming I, Busse R(2005). Endothelial aging. Cardiovasc Res, 66:286-294
[16] Shalaby F, Rossant J, Yamaguchi TP, Gertsenstein M, Wu XF(1995). Failure of bloodisland formation and vasculogenesis in Flk-1-deficient mice. Nature, 376:62-66
[17] Neufeld G, Cohen T, Gengrinovitch S, Poltorak Z(1999). Vascular endothelial growth factor (VEGF) and its receptors. FASEB J, 13:9-22
[18] Geary GG, Buchholz JN(2003). Selected contribution: effects of aging on cerebrovascular tone and [Ca2+]i. J Appl Physiol, 95:1746-54
[19] Muller-Delp JM, Spier SA, Ramsey MW, Delp MD(2002). Aging impairs endothelium-dependent vasodilation in rat skeletal muscle arterioles. Am J Physiol, Heart Circ Physiol, 283:H1662-72
[20] Csiszar A, Ungvari Z, Koller A, Edwards JG, Kaley G(2003). Aging-induced proinflammatory shift in cytokine expression profile in coronary arteries. FASEB J, 17:1183-1185
[21] Yoon HJ, Cho SW, Ahn BW, Yang SY(2010). Alterations in the activity and expression of endothelial NO synthase in aged human endothelial cells. Mech Ageing Dev, 131:119-123
[22] Durán WN, Breslin JW, Sánchez FA(2010). The NO cascade, eNOS location, and microvascular permeability. Cardiovasc Res, 87:254-61
[23] Tanabe T, Maeda S, Miyauchi T, Iemitsu M, Takanashi M(2003). Exercise training improves ageing-induced decrease in eNOS expression of the aorta. Acta Physiol Scand, 178:3-10
[24] Zhang Y, Zhao S, Gu Y, Lewis DF, Alexander JS, Wang Y(2005). Effects of peroxynitrite and superoxide radicals on endothelial monolayer permeability: potential role of peroxynitrite in preeclampsia. J Soc Gynecol Investig, 12:586-92
[25] Davis ME, Cai H, Drummond GR, Harrison DG(2001). Shear stress regulates endothelial nitric oxide synthase expression through c-Src by divergent signaling pathways. Circ Res, 89:1073-1080
[26] Kleinert H, Wallerath T, Euchenhofer C, Ihrig-Biedert I, Li H(1998). Estrogens increase transcription of the human endothelial NO synthase gene: analysis of the transcription factors involved. Hypertension, 31:582-588
[27] Bouloumie A, Schini-Kerth VB, Busse R(1999). Vascular endothelial growth factor up-regulates nitric oxide synthase expression in endothelial cells. Cardiovasc Res, 41:773-780
[28] Shah GN, Mooradian AD(1997). Age-related changes in the blood-brain barrier. Exp Gerontol, 32:501-19
[29] Tharakan B, Hunter FA, Smythe WR, Childs EW(2008). Alpha-lipoic acid attenuates hemorrhagic shock-induced apoptotic signaling and vascular hyperpermeability. Shock, 30:571-7
[30] Shen Q, Wu MH, Yuan SY(2009). Endothelial contractile cytoskeleton and microvascular permeability. Cell Health Cytoskelet, 2009:43-50
[31] Tinsley JH, Teasdale NR, Yuan SY(2004). Myosin light chain phosphorylation and pulmonary endothelial cell hyperpermeability in burns. Am J Physiol Lung Cell Mol Physiol, 286:L841-7
[32] Rigor RR, Shen Q, Pivetti CD, Wu MH, Yuan SY(2013). Myosin light chain kinase signaling in endothelial barrier dysfunction. Med Res Rev, 33:911-33
[33] Curry FE, Clark JF, Adamson RH(2012). Erythrocyte-derived sphingosine-1-phosphate stabilizes basal hydraulic conductivity and solute permeability in rat microvessels. Am J Physiol Heart Circ Physiol, 303:H825-34
[34] Mitschelen M, Garteiser P, Carnes BA, Farley JA, Doblas S, Demoe JH, Warrington JP, Yan H, Nicolle MM, Towner R, Sonntag WE(2009). Basal and hypercapnia-altered cerebrovascular perfusion predict mild cognitive impairment in aging rodents. 164:918-28
[35] Stone DK, Reynolds AD, Mosley RL, Gendelman HE(2009). Innate and adaptive immunity for the pathobiology of Parkinson’s disease. Antioxid. Redox Signal, 11:2151-2166
[36] Schindowski K, Eckert A, Peters J(2007). Increased T-cell reactivity and elevated levels of CD8_ memory T-cells in Alzheimer’s disease-patients and T-cell hyporeactivity in an Alzheimer’s diseasemouse model: implications for immunotherapy. Neuromol Med, 9:340-354
[37] Togo T, Akiyama H, Iseki E(2002). Occurrence of T cells in the brain of Alzheimer’s disease and other neurological diseases. J Neuroimmunol, 124:83-92
[38] Popescu BO, Toescu EC, Popescu LM, Bajenaru O, Muresanu DF, Schultzberg M, Bogdanovic N(2009). Blood-brain barrier alterations in ageing and dementia. J Neurol Sci, 283:99-106
[39] Simpson JE, Wharton SB, Cooper J, Gelsthorpe C, Baxter L, Forster G, Shaw PJ, Savva G, Matthews FE, Brayne C, Ince PG(2010). Alterations of the blood-brain barrier in cerebral white matter lesions in the ageing brain. Neurosci Lett, 486:246-51
[40] Viggars AP, Wharton SB, Simpson JE, Matthews FE, Brayne C, Savva GM, Garwood C, Drew D, Shaw PJ, Ince PG(2011). Alterations in the blood brain barrier in ageing cerebral cortex in relationship to Alzheimer-type pathology: a study in the MRC-CFAS population neuropathology cohort. 505:25-30
[41] Lee P, Kim J, Williams R, Sandhir R, Gregory E, Brooks WM, Berman NE(2012). Effects of aging on blood brain barrier and matrix metalloproteases following controlled cortical impact in mice. Exp Neurol, 234:50-61
[42] Childs EW, Tharakan B, Byrge N, Tinsley JH, Hunter FA, Smythe WR(2008). Angiopoietin-1 inhibits intrinsic apoptotic signaling and vascular hyperpermeability following hemorrhagic shock. Am J Physiol Heart Circ Physiol, 294:H2285-95
[43] Tharakan B, Whaley JG, Hunter FA, Smythe WR, Childs EW(2010(-)-Deprenyl inhibits vascular hyperpermeability after hemorrhagic shock. Shock, 33:56-63
[44] Stagg HW, Bowen KA, Sawant DA, Rodriguez M, Tharakan B, Childs EW(2013). Tumor necrosis factor-related apoptosis-inducing ligand promotes microvascular endothelial cell hyperpermeability through phosphatidylinositol 3-kinase pathway. Am J Surg, 205:419-25
[45] Finkel T, Holbrook NJ(2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408:239-47
[46] Harman D(2003). The free radical theory of aging. Antioxid Redox Signal, 5:557-61
[47] Hamilton CA, Brosnan MJ, Mcintyre M, Graham D, Dominiczak AF(2011). Superoxide excess in hypertension and aging: a common cause of endothelial dysfunction. Hypertension, 37:529-34
[48] Gorlach A, Brandes RP, Nguyen K, Amidi M, Dehghani F, Busse R(2000). A gp91phox containing NADPH oxidase selectively expressed in endothelial cells is a major source of oxygen radical generation in the arterial wall. Circ Res, 87:26-32
[49] Jung O, Schreiber JG, Geiger H, Pedrazzini T, Busse R, Brandes RP(2004). gp91phox-containing NADPH oxidase mediates endothelial dysfunction in renovascular hypertension. Circulation, 109:1795-1801
[50] Csiszar A, Ungvari Z, Edwards JG, Kaminski P, Wolin MS(2002). Aging-induced phenotypic changes and oxidative stress impair coronary arteriolar function. Circ Res, 90:1159-1166
[51] Francia P, delli Gatti C, Bachschmid M, Martin-Padura I, Savoia C, Migliaccio E, Pelicci PG, Schiavoni M, Luscher TF, Volpe M, Cosentino F(2004). Deletion of p66shc gene protects against age-related endothelial dysfunction. Circulation, 110:2889-2895
[52] Furumoto K, Inoue E, Nagao N, Hiyama E, Miwa N(1998). Age-dependent telomere shortening is slowed down by enrichment of intracellular vitamin C via suppression of oxidative stress. Life Sci, 63:935-948
[53] Haendeler J, Hoffmann J, Diehl JF, Vasa M, Spyridopoulos I(2004). Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res, 94:768-775
[54] Tharakan B, Hunter FA, Smythe WR, Childs EW(2010). Curcumin inhibits reactive oxygen species formation and vascular hyperpermeability following haemorrhagic shock. Clin Exp Pharmacol Physiol, 37:939-44
[55] Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM(2003). Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest, 111:1201-9
[56] Chung HY, Song SH, Kim HJ, Ikeno Y, Yu BP(1999). Modulation of renalxanthine oxidoreductase in aging: gene expression and reactive oxygen species generation. J Nutr Health Aging, 3:19-23
[57] Deshpande SS, Qi B, Park YC, Irani K(2003). Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence. Arterioscler Thromb Vasc Biol, 23:e1-6
[58] Geiszt M, Kopp JB, Varnai P, Leto TL(2000). Identification of renox, an NAD(P)H oxidase in kidney. Proc Natl Acad Sci USA, 97:8010-4
[59] Mazza F, Goodman A, Lombardo G, Vanella A, Abraham NG(2003). Heme oxygenase-1 gene expression attenuates angiotensin II-mediatedDNA damage in endothelial cells. Exp Biol Med (Maywood)228:576-83
[60] Atkinson J(1995). Effect of aging and chronic angiotensin I converting enzyme inhibition on the endothelial function of the mesenteric arterial bed of the rat. Am J Cardiol, 76:19E-23E
[61] Tousoulis D, Charakida M, Stefanadis C(2006). Endothelial function and inflammation in coronary artery disease. Heart, 92:441-444
[62] Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon ROIII, Criqui M, Fadl YY, Fortmann SP, Hong Y, Myers GL(2003). Markers of inflammation and cardiovascular disease: application to clinical and public health practice: a statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107:499-511
[63] Sawant DA, Tharakan B, Wilson RL, Stagg HW, Hunter FA, Childs EW(2013). Regulation of tumor necrosis factor-α-induced microvascular endothelial cell hyperpermeability by recombinant B-cell lymphoma-extra large. J Surg Res, 184:628-37
[64] Donato AJ, Eskurza I, Silver AE, Levy AS, Pierce GL, Gates PE, Seals DR(2007). Direct evidence of endothelial oxidative stress with aging in humans: relation to impaired endothelium-dependent dilation and upregulation of nuclear factor-kappaB. Circ Res, 100:1659-66
[65] Donato AJ, Black AD, Jablonski KL, Gano LB, Seals DR(2008). Aging is associated with greater nuclear NF kappa B, reduced I kappa B alpha, and increased expression of proinflammatory cytokines in vascular endothelial cells of healthy humans. Aging Cell, 7:805-12
[66] Bruunsgaard H, Pedersen M, Pedersen BK(2001). Review Aging and proinflammatory cytokines. Curr Opin Hematol, 8:131-6
[67] Arenas IA, Armstrong SJ, Xu Y, Davidge ST(2006). Tumor necrosis factor-α and vascular angiotensin II in estrogen-deficient rats. Hypertension, 48:497-503
[68] Csiszar A, Labinskyy N, Smith K, Rivera A, Orosz Z, Ungvari Z(2007). Vasculoprotective effects of anti-tumor necrosis factor-α treatment in aging. Am J Pathol, 170:388-398
[69] Csiszar A, Wang M, Lakatta EG, Ungvari Z(2008). Inflammation and endothelial dysfunction during aging: role of NF-κB. J. Appl Physiol, 105:1333-1341
[70] Dieterich LC, Seidel CD, Detmar M Lymphatic vessels: new targets for the treatment of inflammatory diseases. Angiogenesis, 2013Nov9[Epub ahead of print]
[71] Chatterjee V, Gashev AA Aging-associated shifts in functional status of mast cells located by adult and aged mesenteric lymphatic vessels. Am J Physiol Heart Circ Physiol, 2012Sep15303(6):H693-702 Epub 2012 Jul 13
[72] Chowdhury I, Tharakan B, Bhat GK(2006). Current concepts in apoptosis: the physiological suicide program revisited. 11:506-25
[73] Chowdhury I, Tharakan B, Bhat GK(2008). Caspases - an update. Comp Biochem Physiol B Biochem Mol Biol, 151:10-27
[74] Green DR, Evan GI(2002). A matter of life and death. Cancer Cell, 1:19-30
[75] Kim R, Emi M, Tanabe K(2005). Role of mitochondria as the gardens of cell death. Cancer Chemother Pharmacol, 57:1-9
[76] Kuwana T, Bouchier-Hayes L, Chipuk JE, Bonzon C, Sullivan BA, Green DR, Newmeyer DD(2005). BH3 domains of BH3-only proteins differentially regulate Bax-mediated mitochondrial membrane permeabilization both directly and indirectly. Mol Cell, 17:525-535
[77] Newmeyer DD, Ferguson-Miller S(2003). Mitochondria: releasing power for life and unleashing the machineries of death. Cell, 112:481-490
[78] Desagher S, Osen-Sand A, Nichols A, Eskes R, Montessuit S, Lauper S, Maundrell K, Antonsson B, Martinou JC(1999). Bid-induced conformational change of Bax is responsible for mitochondrial cytochrome c release during apoptosis. J Cell Biol, 144:891-901
[79] Asai K, Kudej RK, Shen YT, Yang GP, Takagi G, Kudej AB, Geng YJ, Sato N, Nazareno JB, Vatner DE(2000). Peripheral vascular endothelial dysfunction and apoptosis in old monkeys. Arterioscler Thromb Vasc Biol, 20:1493-1499
[80] Tharakan B, Corprew R, Hunter FA, Whaley JG, Smythe WR, Childs EW(2009). 17beta-estradiol mediates protection against microvascular endothelial cell hyperpermeability. Am J Surg, 197:147-54
[81] Childs EW, Tharakan B, Hunter FA, Smythe WR 17beta-estradiol mediated protection against vascular leak after hemorrhagic shock: role of estrogen receptors and apoptotic signaling. Shock, 34:229-35
[82] Mendelsohn ME(2000). Mechanisms of estrogen action in the cardiovascular system. J Steroid Biochem Mol Biol, 74:337-343
[83] Gavin KM, Seals DR, Silver AE, Moreau KL(2009). Vascular endothelial estrogen receptor α is modulated by estrogen status and related to endothelial function and endothelial nitric oxide synthase in healthy women. J Clin Endocrinol Metab, 94:3513-3520
[84] Sandoval KE, Witt KA(2011). Age and 17β-estradiol effects on blood-brain barrier tight junction and estrogen receptor proteins in ovariectomized rats. Microvasc Res, 81:198-205
[85] Driver JA, Djousse L, Logroscino G, Gaziano JM, Kurth T(2008). Incidence of cardiovascular disease and cancer in advanced age: prospective cohort study. BMJ, 337:a2467
[86] Kelly-Hayes M(2010). Influence of age and health behaviors on stroke risk: lessons from longitudinal studies. J Am Geriatr Soc, 2:S325-328
[87] Lakatta EG(2002). Age-associated cardiovascular changes in health: impact on cardiovascular disease in older persons. Heart Fail Rev, 7:29-49
[88] Gutierrez G, Reines HD, Wulf-Gutierrez ME Z(2004). Clinical review: hemorrhagic shock. Crit Care, 8:373-81
[89] Mees ST, Gwinner M, Marx K, Faendrich F, Schroeder J, Haier J, Kahlke V(2008). Influence of sex and age on morphological organ damage after hemorrhagic shock. 29:670-4
[90] Jian B, Yang S, Chen D, Chaudry I, Raju R(2011). Influence of aging and hemorrhage injury on Sirt1 expression: possible role of myc-Sirt1 regulation in mitochondrial function. Biochim Biophys Acta, 1812:1446-51
[91] Lufrano M, Jacob A, Zhou M, Wang P(2013). Sphingosine kinase-1 mediates endotoxemia-induced hyperinflammation in aged animals. Mol Med Rep, 8:645-9
[92] Saito H, Sherwood ER, Varma TK, Evers BM(2003). Effects of aging on mortality, hypothermia, and cytokine induction in mice with endotoxemia or sepsis. Mech Ageing Dev, 124:1047-58
[93] Tucsek Z, Gautam T, Sonntag WE(2013). Aging exacerbates microvascular endothelial damage induced by circulating factors present in the serum of septic patients. J Gerontol A Biol Sci Med Sci, 68:652-60
[94] Zhou M, Wu R, Dong W, Leong J, Wang P(2010). Accelerated apoptosis contributes to aging-related hyperinflammation in endotoxemia. Int J Mol Med, 25:929-35
[95] Sawant DA, Tharakan B, Tobin RP(2013). Inhibition of Fas-Fas ligand interaction attenuates microvascular hyperpermeability following hemorrhagic shock. Shock, 39:161-7
[96] Grant EJ(2013). Preventing burns in the elderly: a guide for home healthcare professionals. Home Healthc Nurse, 31:561-73
[97] Whaley JG, Tharakan B, Smith B, Hunter FA, Childs EW(2009(−)-Deprenyl inhibits thermal injury-induced apoptotic signaling and hyperpermeability in microvascular endothelial cells. J Burn Care Res, 30:1018-27
[98] Nomellini V, Brubaker AL, Mahbub S(2012). Dysregulation of neutrophil CXCR2 and pulmonary endothelial icam-1 promotes age-related pulmonary inflammation. Aging Dis, 3:234-47
[99] Stagg HW, Whaley JG, Tharakan B(2013). Doxycycline attenuates burn-induced microvascular hyperpermeability. J Trauma Acute Care Surg, 75:1040-6
[1] Feng Tang,Meng-Hao Pan,Yujie Lu,Xiang Wan,Yu Zhang,Shao-Chen Sun. Involvement of Kif4a in Spindle Formation and Chromosome Segregation in Mouse Oocytes[J]. A&D, 2018, 9(4): 623-633.
[2] J. Thomas Mock,Sherilynn G Knight,Philip H Vann,Jessica M Wong,Delaney L Davis,Michael J Forster,Nathalie Sumien. Gait Analyses in Mice: Effects of Age and Glutathione Deficiency[J]. A&D, 2018, 9(4): 634-646.
[3] Jiayu Wu,Weiying Ren,Li Li,Man Luo,Kan Xu,Jiping Shen,Jia Wang,Guilin Chang,Yi Lu,Yiming Qi,Binger Xu,Yuting He,Yu Hu. Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats[J]. A&D, 2018, 9(4): 566-577.
[4] Carmen G Vinagre,Fatima R Freitas,Carlos H de Mesquita,Juliana C Vinagre,Ana Carolina Mariani,Roberto Kalil-Filho,Raul C Maranhão. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects[J]. A&D, 2018, 9(4): 748-754.
[5] Aurore Marie,Johann Meunier,Emilie Brun,Susanna Malmstrom,Veronique Baudoux,Elodie Flaszka,Gaëlle Naert,François Roman,Sylvie Cosnier-Pucheu,Sergio Gonzalez-Gonzalez. N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model[J]. A&D, 2018, 9(4): 664-673.
[6] Yali Chen,Mengmei Yin,Xuejin Cao,Gang Hu,Ming Xiao. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain[J]. A&D, 2018, 9(3): 374-390.
[7] Wenzhi Sun,Jiewen Tan,Zhuo Li,Shibao Lu,Man Li,Chao Kong,Yong Hai,Chunjin Gao,Xuehua Liu. Evaluation of Hyperbaric Oxygen Treatment in Acute Traumatic Spinal Cord Injury in Rats Using Diffusion Tensor Imaging[J]. A&D, 2018, 9(3): 391-400.
[8] Changjun Yang,Kelly M. DeMars,Eduardo Candelario-Jalil. Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain[J]. A&D, 2018, 9(2): 322-330.
[9] Lin-Yuan Zhang,Pan Lin,Jiaji Pan,Yuanyuan Ma,Zhenyu Wei,Lu Jiang,Liping Wang,Yaying Song,Yongting Wang,Zhijun Zhang,Kunlin Jin,Qian Wang,Guo-Yuan Yang. CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain[J]. A&D, 2018, 9(2): 262-272.
[10] Weiming Hu,Junwu Wu,Wenjing Jiang,Jianguo Tang. MicroRNAs and Presbycusis[J]. A&D, 2018, 9(1): 133-142.
[11] Barbara Strasser,Konstantinos Volaklis,Dietmar Fuchs,Martin Burtscher. Role of Dietary Protein and Muscular Fitness on Longevity and Aging[J]. A&D, 2018, 9(1): 119-132.
[12] Huaqin Liu,Zhui Yu,Ying Li,Bin Xu,Baihui Yan,Wulf Paschen,David S Warner,Wei Yang,Huaxin Sheng. Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice[J]. A&D, 2018, 9(1): 31-39.
[13] Fangyu Peng,Fang Xie,Otto Muzik. Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT[J]. A&D, 2018, 9(1): 109-118.
[14] Nathalie K Zgheib,Fatima Sleiman,Lara Nasreddine,Mona Nasrallah,Nancy Nakhoul,Hussain Isma’eel,Hani Tamim. Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals[J]. A&D, 2018, 9(1): 77-89.
[15] Mari L. Sbardelotto,Giulia S. Pedroso,Fernanda T. Pereira,Helen R. Soratto,Stella MS. Brescianini,Pauline S. Effting,Anand Thirupathi,Renata T. Nesi,Paulo CL. Silveira,Ricardo A. Pinho. The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men[J]. A&D, 2017, 8(6): 887-898.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd