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Aging and Disease    2014, Vol. 5 Issue (2) : 126-136     DOI: 10.14336/AD.2014.0500126
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Sepsis in Old Age: Review of Human and Animal Studies
Marlene E Starr1, 3, Hiroshi Saito1, 2, 3, *
1Department of Surgery, Lexington, KY 40536, USA
2Department of Physiology, Lexington, KY 40536, USA
3Markey Cancer Center University of Kentucky, Lexington, KY 40536, USA
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Abstract  

Sepsis is a serious problem among the geriatric population as its incidence and mortality rates dramatically increase with advanced age. Despite a large number of ongoing clinical and basic research studies, there is currently no effective therapeutic strategy that rescues elderly patients with severe sepsis. Recognition of this problem is relatively low as compared to other age-associated diseases. The disparity between clinical and basic studies is a problem, and this is likely due, in part, to the fact that most laboratory animals used for sepsis research are not old while the majority of sepsis cases occur in the geriatric population. The objective of this article is to review recent epidemiological studies and clinical observations, and compare these with findings from basic laboratory studies which have used aged animals in experimental sepsis.

Keywords aging      animal models      coagulation      elderly      inflammation      sepsis     
Corresponding Authors: Hiroshi Saito   
Issue Date: 12 November 2014
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Marlene E Starr,Hiroshi Saito. Sepsis in Old Age: Review of Human and Animal Studies[J]. Aging and Disease, 2014, 5(2): 126-136.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500126     OR     http://www.aginganddisease.org/EN/Y2014/V5/I2/126
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