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Aging and Disease    2014, Vol. 5 Issue (3) : 212-217     DOI: 10.14336/AD.2014.0500212
Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Chandan Prasad1, *, Victorine Imrhan1, Francesco Marotta2, Shanil Juma1, Parakat Vijayagopal1
1Department of Nutrition and Food Sciences, Texas Woman’s University, Denton, Texas, USA
2ReGenera Research group for Aging Intervention, Milano, Italy
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Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.

Keywords Aging      glycation      oxidative stress      reactive nitrogen species      reactive oxygen species     
Corresponding Authors: Chandan Prasad   
Issue Date: 04 November 2014
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Chandan Prasad
Victorine Imrhan
Francesco Marotta
Shanil Juma
Parakat Vijayagopal
Cite this article:   
Chandan Prasad,Victorine Imrhan,Francesco Marotta, et al. Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging[J]. Aging and Disease, 2014, 5(3): 212-217.
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Figure 1.  Relationship between oxidation, modification of essential macromolecules and age-related diseases.
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