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Aging and Disease    2014, Vol. 5 Issue (3) : 212-217     DOI: 10.14336/AD.2014.0500212
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Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Chandan Prasad1, *, Victorine Imrhan1, Francesco Marotta2, Shanil Juma1, Parakat Vijayagopal1
1Department of Nutrition and Food Sciences, Texas Woman’s University, Denton, Texas, USA
2ReGenera Research group for Aging Intervention, Milano, Italy
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Abstract  

Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.

Keywords Aging      glycation      oxidative stress      reactive nitrogen species      reactive oxygen species     
Corresponding Authors: Chandan Prasad   
Issue Date: 04 November 2014
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Chandan Prasad
Victorine Imrhan
Francesco Marotta
Shanil Juma
Parakat Vijayagopal
Cite this article:   
Chandan Prasad,Victorine Imrhan,Francesco Marotta, et al. Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging[J]. Aging and Disease, 2014, 5(3): 212-217.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500212     OR     http://www.aginganddisease.org/EN/Y2014/V5/I3/212
Figure 1.  Relationship between oxidation, modification of essential macromolecules and age-related diseases.
[1] Salganik RI(2001). Apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr, 20:464S-472S
http://dx.doi.org/10.1080/07315724.2001.10719185
[2] Halliwell B, Cutteridge JMC(1969). Free radicals in biology and medicineOxfordOxford University Press
[3] Aims BN, Shinegava MK, Hagen TM(1993). Oxidants, antioxidants and the degenerative diseases. Proc Natl Acad Sci USA, 90:7915-7922
http://dx.doi.org/10.1073/pnas.90.17.7915
[4] Kerr JFR, Winterfold CM, Harmon BV(1994). Apoptosis, its significance in cancer and cancer therapy. Cancer, 73:2013-2026
http://dx.doi.org/10.1002/1097-0142(19940415)73:8<2013::AID-CNCR2820730802>3.0.CO;2-J
[5] Blackstone NW, Green DR(1999). The evolution of a mechanism of cell suicide. BioEssays, 21:84-88
http://dx.doi.org/10.1002/(SICI)1521-1878(199901)21:1<84::AID-BIES11>3.0.CO;2-0
[6] Ghosh MK, Mukhopadhyay M, Chatterjee IB(1997). NADPH-initiated P450-dependent free-iron-dependent microsomal lipid peroxidation: specific prevention by ascorbic acid. Mol Cell Biochem, 166:35-44
http://dx.doi.org/10.1023/A:1006841228483
[7] Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA(2011). RAGE biology, atherosclerosis and diabetes. Clin Science, 121:43-55
http://dx.doi.org/10.1042/CS20100501
[8] Kalousová M, Zima T, Tesař V, Dusilová-Sulková S, Jan Škrha J(2005). Advanced glycooxidation end products in chronic disease—clinical chemistry and genetic background. Mutation Res, 579:37-46
http://dx.doi.org/10.1016/j.mrfmmm.2005.03.024
[9] Semba RD, Bandinelli S, Sun K, Guralnik JM, Ferrucci L(2010). Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study. Eur J Appl Physiol, 108:109-115
[10] Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H(2010). Advanced glycation end products in foods and a practical guide to their reduction in the diet. J of the Am Diet Assoc, 110:911-916
http://dx.doi.org/10.1016/j.jada.2010.03.018
[11] Maillard LC(1912). Action des acides amines sur les sucres: formation des melanoidines par voie methodique. C R Acad Sci (Paris)154:66-68
[12] Luevano-Contreras C, Chapman-Novakofski K(2010). Dietary Advanced Glycation End Products and Aging. Nutrients, 2:1247-1265
http://dx.doi.org/10.3390/nu2121247
[13] Prasad A, Bekker P, Tsimikas S(2012). Advanced glycation end products and diabetic cardiovascular disease. Cardiol Rev, 20:177-183
http://dx.doi.org/10.1097/CRD.0b013e318244e57c
[14] Willett TL, Kandel R, De Croos JNA, Avery NC, MGrynpas MD(2012). Enhanced levels of nonenzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthritis Cartilage, 20:7736-744
[15] Ulrich P, Cerami A(2001). Protein glycation, diabetes, and aging. Recent Prog Horm Res, 56:1-21
http://dx.doi.org/10.1210/rp.56.1.1
[16] Sparvero LJ, Asafu-Adjei D, Kang R, Tang D, Amin N, Im J, Rutledge R, Lin B, Amoscato AA, Zeh HJ, Lotze MT(2009). RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation. J Transl Med, 17:7-17
[17] Ramasamy R, Vannucci SJ, Shi Du Yan S, Herold K, Fang Yan S, Schmidt AM(2005). Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology, 15(7):16R-28R
http://dx.doi.org/10.1093/glycob/cwi053
[18] Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME(2008). A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)FASEB J, 22:3716-3727
http://dx.doi.org/10.1096/fj.08-109033
[19] Kalea AZ, Schmidt AM, Hudson BI(2011). Alternative splicing of RAGE: roles in biology and disease. Frontiers in Bioscience, l16:2756-2770
[20] Ramasamy R, Yan S-F, Schmidt AM(2012). Advanced glycation endproducts: from precursors to RAGE: round and round we go. Amino Acids, 42(4):1151-1161
http://118.145.16.217/magsci/article/article?id=17464787
[21] Fritz G(2011). RAGE a single receptor fits multiple ligands. Trends in Biochem Sci, 36(12):625-632
http://118.145.16.217/magsci/article/article?id=15397260
[22] Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J(2009). Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: Role of the antiinflammatory AGE receptor-1. J Clin Endocrinol Metab, 94:4483-4491
http://dx.doi.org/10.1210/jc.2009-0089
[23] Vlassara H, Striker G(2007). Glycotoxins in the diet promote diabetes and diabetic complications. Curr Diab Rep, 7:235-241
http://118.145.16.217/magsci/article/article?id=16379815
[24] Peppa M, Uribarri J, Vlassara H(2008). Aging and glycoxidant stress. Hormones (Athens)7:123-132
[25] Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H(2007). Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci, 62:427-433
http://dx.doi.org/10.1093/gerona/62.4.427
[26] Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R(2008). Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update, 14:131-142
http://dx.doi.org/10.1093/humupd/dmm048
[27] Tatone C, Carbone MC, Campanella G, Festuccia C, Artini PG, Talesa V, Focarelli R, Amicarelli F(2010). Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice. J Biol Regul Homeost Agents, 24:63-72
[28] Lindeman RD(1990). Overview: Renal physiology and pathophysiology of aging. Am J Kidney Dis, 16:275-282
http://dx.doi.org/10.1016/S0272-6386(12)80002-3
[29] Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H(2002). Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes, 51:2082-2089
http://dx.doi.org/10.2337/diabetes.51.7.2082
[30] Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H(2002). Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev, 18:224-237
http://dx.doi.org/10.1002/dmrr.283
[31] Peppa M, He C, Hattori M, McEvoy R, Zheng F, Vlassara H(2003). Fetal or neonatal low–glycotoxin environment prevents autoimmune diabetes in NOD mice. Diabetes, 52:1441-1448
http://dx.doi.org/10.2337/diabetes.52.6.1441
[32] Sebekova K, Hofmann T, Boor P, Sebekova KJr, Ulicna O, Erbersdobler HF, Baynes JW, Thorpe SR, Heidland A, Somoza V(2005). Renal effects of oral maillard reaction product load in the form of bread crusts in healthy and subtotally nephrectomized rats. Ann N Y Acad Sci, 1043:482-491
http://dx.doi.org/10.1196/annals.1333.055
[33] Diamanti-Kandarakis E, Piperi C, Korkolopoulou P, Kandaraki E, Levidou G, Papalois A, Patsouris E, Papavassiliou AG(2007). Accumulation of dietary glycotoxins in the reproductive system of normal female rats. J Mol Med, 85:1413-1420
http://118.145.16.217/magsci/article/article?id=16568150
[34] Bengmark S(2006). Impact of nutrition on ageing and disease. Curr Opin Clin Nutr Metab Care, 9:2-7
http://dx.doi.org/10.1097/01.mco.0000171129.29278.26
[35] Davis K, Prasad C, Juma S, Vijayagopal P, Imrhan V(2013). Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?. Critical Reviews in Nutrition and Food Science(In Press).
[36] Goldberg T, Cai W, Peppa M, Dardaine V, Baliga BS, Uribarri J, Vlassara H(2004). Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc, 104:1287-1291
http://dx.doi.org/10.1016/j.jada.2004.05.214
[37] Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H(2010). Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc, 110:911-16
http://dx.doi.org/10.1016/j.jada.2010.03.018
[38] Nicholl ID, Bucala R(1998). Advanced glycation endproducts and cigarette smoking. Cell Mol Biol (Noisy-le-grand)44(7):1025-33
[39] Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, Lee A, Al-Abed Y, Vlassara H, Bucala R, Cerami A(1997). Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A, 94(25):13915-20
http://dx.doi.org/10.1073/pnas.94.25.13915
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