Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and Disease    2014, Vol. 5 Issue (3) : 212-217     DOI: 10.14336/AD.2014.0500212
Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging
Chandan Prasad1, *, Victorine Imrhan1, Francesco Marotta2, Shanil Juma1, Parakat Vijayagopal1
1Department of Nutrition and Food Sciences, Texas Woman’s University, Denton, Texas, USA
2ReGenera Research group for Aging Intervention, Milano, Italy
Download: PDF(0 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

Uncontrolled continued exposure to oxidative stress is a precursor to many chronic diseases including cancer, diabetes, degenerative disorders and cardiovascular diseases. Of the many known mediators of oxidative stress, reactive oxygen species (ROS) and advanced glycation end products (AGEs) are the most studied. In the present review, we have summarized current data on the origin of circulating AGEs, discussed issues associated with reliable assessment of its steady state level, and changes in its level with age and select metabolic diseases. Lastly, we have made recommendations about life style changes that may decrease AGEs burden to promote healthy aging.

Keywords Aging      glycation      oxidative stress      reactive nitrogen species      reactive oxygen species     
Corresponding Authors: Chandan Prasad   
Issue Date: 10 May 2014
E-mail this article
E-mail Alert
Articles by authors
Chandan Prasad
Victorine Imrhan
Francesco Marotta
Shanil Juma
Parakat Vijayagopal
Cite this article:   
Chandan Prasad,Victorine Imrhan,Francesco Marotta, et al. Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging[J]. Aging and Disease, 2014, 5(3): 212-217.
URL:     OR
[1] Salganik RI(2001). Apoptosis and other protective mechanisms in cancer patients and the human population. J Am Coll Nutr, 20:464S-472S
[2] Halliwell B, Cutteridge JMC(1969). Free radicals in biology and medicineOxfordOxford University Press
[3] Aims BN, Shinegava MK, Hagen TM(1993). Oxidants, antioxidants and the degenerative diseases. Proc Natl Acad Sci USA, 90:7915-7922
[4] Kerr JFR, Winterfold CM, Harmon BV(1994). Apoptosis, its significance in cancer and cancer therapy. Cancer, 73:2013-2026
[5] Blackstone NW, Green DR(1999). The evolution of a mechanism of cell suicide. BioEssays, 21:84-88
[6] Ghosh MK, Mukhopadhyay M, Chatterjee IB(1997). NADPH-initiated P450-dependent free-iron-dependent microsomal lipid peroxidation: specific prevention by ascorbic acid. Mol Cell Biochem, 166:35-44
[7] Barlovic DP, Soro-Paavonen A, Jandeleit-Dahm KA(2011). RAGE biology, atherosclerosis and diabetes. Clin Science, 121:43-55
[8] Kalousová M, Zima T, Tesař V, Dusilová-Sulková S, Jan Škrha J(2005). Advanced glycooxidation end products in chronic disease—clinical chemistry and genetic background. Mutation Res, 579:37-46
[9] Semba RD, Bandinelli S, Sun K, Guralnik JM, Ferrucci L(2010). Relationship of an advanced glycation end product, plasma carboxymethyl-lysine, with slow walking speed in older adults: the InCHIANTI study. Eur J Appl Physiol, 108:109-115
[10] Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H(2010). Advanced glycation end products in foods and a practical guide to their reduction in the diet. J of the Am Diet Assoc, 110:911-916
[11] Maillard LC(1912). Action des acides amines sur les sucres: formation des melanoidines par voie methodique. C R Acad Sci (Paris)154:66-68
[12] Luevano-Contreras C, Chapman-Novakofski K(2010). Dietary Advanced Glycation End Products and Aging. Nutrients, 2:1247-1265
[13] Prasad A, Bekker P, Tsimikas S(2012). Advanced glycation end products and diabetic cardiovascular disease. Cardiol Rev, 20:177-183
[14] Willett TL, Kandel R, De Croos JNA, Avery NC, MGrynpas MD(2012). Enhanced levels of nonenzymatic glycation and pentosidine crosslinking in spontaneous osteoarthritis progression. Osteoarthritis Cartilage, 20:7736-744
[15] Ulrich P, Cerami A(2001). Protein glycation, diabetes, and aging. Recent Prog Horm Res, 56:1-21
[16] Sparvero LJ, Asafu-Adjei D, Kang R, Tang D, Amin N, Im J, Rutledge R, Lin B, Amoscato AA, Zeh HJ, Lotze MT(2009). RAGE (Receptor for Advanced Glycation Endproducts), RAGE Ligands, and their role in Cancer and Inflammation. J Transl Med, 17:7-17
[17] Ramasamy R, Vannucci SJ, Shi Du Yan S, Herold K, Fang Yan S, Schmidt AM(2005). Advanced glycation end products and RAGE: a common thread in aging, diabetes, neurodegeneration, and inflammation. Glycobiology, 15(7):16R-28R
[18] Raucci A, Cugusi S, Antonelli A, Barabino SM, Monti L, Bierhaus A, Reiss K, Saftig P, Bianchi ME(2008). A soluble form of the receptor for advanced glycation endproducts (RAGE) is produced by proteolytic cleavage of the membrane-bound form by the sheddase a disintegrin and metalloprotease 10 (ADAM10)FASEB J, 22:3716-3727
[19] Kalea AZ, Schmidt AM, Hudson BI(2011). Alternative splicing of RAGE: roles in biology and disease. Frontiers in Bioscience, l16:2756-2770
[20] Ramasamy R, Yan S-F, Schmidt AM(2012). Advanced glycation endproducts: from precursors to RAGE: round and round we go. Amino Acids, 42(4):1151-1161
[21] Fritz G(2011). RAGE a single receptor fits multiple ligands. Trends in Biochem Sci, 36(12):625-632
[22] Vlassara H, Cai W, Goodman S, Pyzik R, Yong A, Chen X, Zhu L, Neade T, Beeri M, Silverman JM, Ferrucci L, Tansman L, Striker GE, Uribarri J(2009). Protection against loss of innate defenses in adulthood by low advanced glycation end products (AGE) intake: Role of the antiinflammatory AGE receptor-1. J Clin Endocrinol Metab, 94:4483-4491
[23] Vlassara H, Striker G(2007). Glycotoxins in the diet promote diabetes and diabetic complications. Curr Diab Rep, 7:235-241
[24] Peppa M, Uribarri J, Vlassara H(2008). Aging and glycoxidant stress. Hormones (Athens)7:123-132
[25] Uribarri J, Cai W, Peppa M, Goodman S, Ferrucci L, Striker G, Vlassara H(2007). Circulating glycotoxins and dietary advanced glycation endproducts: two links to inflammatory response, oxidative stress, and aging. J Gerontol A Biol Sci Med Sci, 62:427-433
[26] Tatone C, Amicarelli F, Carbone MC, Monteleone P, Caserta D, Marci R, Artini PG, Piomboni P, Focarelli R(2008). Cellular and molecular aspects of ovarian follicle ageing. Hum Reprod Update, 14:131-142
[27] Tatone C, Carbone MC, Campanella G, Festuccia C, Artini PG, Talesa V, Focarelli R, Amicarelli F(2010). Female reproductive dysfunction during ageing: role of methylglyoxal in the formation of advanced glycation endproducts in ovaries of reproductively-aged mice. J Biol Regul Homeost Agents, 24:63-72
[28] Lindeman RD(1990). Overview: Renal physiology and pathophysiology of aging. Am J Kidney Dis, 16:275-282
[29] Hofmann SM, Dong HJ, Li Z, Cai W, Altomonte J, Thung SN, Zeng F, Fisher EA, Vlassara H(2002). Improved insulin sensitivity is associated with restricted intake of dietary glycoxidation products in the db/db mouse. Diabetes, 51:2082-2089
[30] Zheng F, He C, Cai W, Hattori M, Steffes M, Vlassara H(2002). Prevention of diabetic nephropathy in mice by a diet low in glycoxidation products. Diabetes Metab Res Rev, 18:224-237
[31] Peppa M, He C, Hattori M, McEvoy R, Zheng F, Vlassara H(2003). Fetal or neonatal low–glycotoxin environment prevents autoimmune diabetes in NOD mice. Diabetes, 52:1441-1448
[32] Sebekova K, Hofmann T, Boor P, Sebekova KJr, Ulicna O, Erbersdobler HF, Baynes JW, Thorpe SR, Heidland A, Somoza V(2005). Renal effects of oral maillard reaction product load in the form of bread crusts in healthy and subtotally nephrectomized rats. Ann N Y Acad Sci, 1043:482-491
[33] Diamanti-Kandarakis E, Piperi C, Korkolopoulou P, Kandaraki E, Levidou G, Papalois A, Patsouris E, Papavassiliou AG(2007). Accumulation of dietary glycotoxins in the reproductive system of normal female rats. J Mol Med, 85:1413-1420
[34] Bengmark S(2006). Impact of nutrition on ageing and disease. Curr Opin Clin Nutr Metab Care, 9:2-7
[35] Davis K, Prasad C, Juma S, Vijayagopal P, Imrhan V(2013). Advanced Glycation End Products, Inflammation, and Chronic Metabolic Diseases: Links in a Chain?. Critical Reviews in Nutrition and Food Science(In Press).
[36] Goldberg T, Cai W, Peppa M, Dardaine V, Baliga BS, Uribarri J, Vlassara H(2004). Advanced glycoxidation end products in commonly consumed foods. J Am Diet Assoc, 104:1287-1291
[37] Uribarri J, Woodruff S, Goodman S, Cai W, Chen X, Pyzik R, Yong A, Striker GE, Vlassara H(2010). Advanced glycation end products in foods and a practical guide to their reduction in the diet. J Am Diet Assoc, 110:911-16
[38] Nicholl ID, Bucala R(1998). Advanced glycation endproducts and cigarette smoking. Cell Mol Biol (Noisy-le-grand)44(7):1025-33
[39] Cerami C, Founds H, Nicholl I, Mitsuhashi T, Giordano D, Vanpatten S, Lee A, Al-Abed Y, Vlassara H, Bucala R, Cerami A(1997). Tobacco smoke is a source of toxic reactive glycation products. Proc Natl Acad Sci U S A, 94(25):13915-20
[1] Feng Tang,Meng-Hao Pan,Yujie Lu,Xiang Wan,Yu Zhang,Shao-Chen Sun. Involvement of Kif4a in Spindle Formation and Chromosome Segregation in Mouse Oocytes[J]. A&D, 2018, 9(4): 623-633.
[2] Fabiana Morroni,Giulia Sita,Agnese Graziosi,Eleonora Turrini,Carmela Fimognari,Andrea Tarozzi,Patrizia Hrelia. Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway[J]. A&D, 2018, 9(4): 605-622.
[3] J. Thomas Mock,Sherilynn G Knight,Philip H Vann,Jessica M Wong,Delaney L Davis,Michael J Forster,Nathalie Sumien. Gait Analyses in Mice: Effects of Age and Glutathione Deficiency[J]. A&D, 2018, 9(4): 634-646.
[4] Jiayu Wu,Weiying Ren,Li Li,Man Luo,Kan Xu,Jiping Shen,Jia Wang,Guilin Chang,Yi Lu,Yiming Qi,Binger Xu,Yuting He,Yu Hu. Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats[J]. A&D, 2018, 9(4): 566-577.
[5] Carmen G Vinagre,Fatima R Freitas,Carlos H de Mesquita,Juliana C Vinagre,Ana Carolina Mariani,Roberto Kalil-Filho,Raul C Maranhão. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects[J]. A&D, 2018, 9(4): 748-754.
[6] Yao-Chih Yang,Cheng-Yen Tsai,Chien-Lin Chen,Chia-Hua Kuo,Chien-Wen Hou,Shi-Yann Cheng,Ritu Aneja,Chih-Yang Huang,Wei-Wen Kuo. Pkcδ Activation is Involved in ROS-Mediated Mitochondrial Dysfunction and Apoptosis in Cardiomyocytes Exposed to Advanced Glycation End Products (Ages)[J]. A&D, 2018, 9(4): 647-663.
[7] Aurore Marie,Johann Meunier,Emilie Brun,Susanna Malmstrom,Veronique Baudoux,Elodie Flaszka,Gaëlle Naert,François Roman,Sylvie Cosnier-Pucheu,Sergio Gonzalez-Gonzalez. N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model[J]. A&D, 2018, 9(4): 664-673.
[8] Jun Zhang,Kaiyin Liu,Omar Elmadhoun,Xunming Ji,Yunxia Duan,Jingfei Shi,Xiaoduo He,Xiangrong Liu,Di Wu,Ruiwen Che,Xiaokun Geng,Yuchuan Ding. Synergistically Induced Hypothermia and Enhanced Neuroprotection by Pharmacological and Physical Approaches in Stroke[J]. A&D, 2018, 9(4): 578-589.
[9] Yali Chen,Mengmei Yin,Xuejin Cao,Gang Hu,Ming Xiao. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain[J]. A&D, 2018, 9(3): 374-390.
[10] Wenzhi Sun,Jiewen Tan,Zhuo Li,Shibao Lu,Man Li,Chao Kong,Yong Hai,Chunjin Gao,Xuehua Liu. Evaluation of Hyperbaric Oxygen Treatment in Acute Traumatic Spinal Cord Injury in Rats Using Diffusion Tensor Imaging[J]. A&D, 2018, 9(3): 391-400.
[11] Changjun Yang,Kelly M. DeMars,Eduardo Candelario-Jalil. Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain[J]. A&D, 2018, 9(2): 322-330.
[12] Meng Zhang,Yong-Ning Deng,Jing-Yi Zhang,Jie Liu,Yan-Bo Li,Hua Su,Qiu-Min Qu. SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway[J]. A&D, 2018, 9(2): 273-286.
[13] Lin-Yuan Zhang,Pan Lin,Jiaji Pan,Yuanyuan Ma,Zhenyu Wei,Lu Jiang,Liping Wang,Yaying Song,Yongting Wang,Zhijun Zhang,Kunlin Jin,Qian Wang,Guo-Yuan Yang. CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain[J]. A&D, 2018, 9(2): 262-272.
[14] Weiming Hu,Junwu Wu,Wenjing Jiang,Jianguo Tang. MicroRNAs and Presbycusis[J]. A&D, 2018, 9(1): 133-142.
[15] Barbara Strasser,Konstantinos Volaklis,Dietmar Fuchs,Martin Burtscher. Role of Dietary Protein and Muscular Fitness on Longevity and Aging[J]. A&D, 2018, 9(1): 119-132.
Full text



Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail:
Powered by Beijing Magtech Co. Ltd