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Aging and Disease    2014, Vol. 5 Issue (4) : 256-262     DOI: 10.14336/AD.2014.0500256
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Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress
Olaoluwa O Okusaga
Department of Psychiatry and Behavioral Sciences, the University of Texas Health Science Center at Houston, Texas, USA
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Abstract  

Several lines of evidence suggest that schizophrenia, a severe mental illness characterized by delusions, hallucinations and thought disorder is associated with accelerated aging. The free radical (oxidative stress) theory of aging assumes that aging occurs as a result of damage to cell constituents and connective tissues by free radicals arising from oxygen-associated reactions. Schizophrenia has been associated with oxidative stress and chronic inflammation, both of which also appear to reciprocally induce each other in a positive feedback manner. The buildup of damaged macromolecules due to increased oxidative stress and failure of protein repair and maintenance systems is an indicator of aging both at the cellular and organismal level. When compared with age-matched healthy controls, schizophrenia patients have higher levels of markers of oxidative cellular damage such as protein carbonyls, products of lipid peroxidation and DNA hydroxylation. Potential confounders such as antipsychotic medication, smoking, socio-economic status and unhealthy lifestyle make it impossible to solely attribute the earlier onset of aging-related changes or oxidative stress to having a diagnosis of schizophrenia. Regardless of whether oxidative stress can be attributed solely to a diagnosis of schizophrenia or whether it is due to other factors associated with schizophrenia, the available evidence is in support of increased oxidative stress-induced cellular damage of macromolecules which may play a role in the phenomenon of accelerated aging presumed to be associated with schizophrenia.

Keywords Schizophrenia      accelerated aging      oxidative stress      free radicals      inflammation     
Corresponding Authors: Olaoluwa O Okusaga   
Issue Date: 10 July 2014
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Olaoluwa O Okusaga. Accelerated Aging in Schizophrenia Patients: The Potential Role of Oxidative Stress[J]. Aging and Disease, 2014, 5(4): 256-262.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500256     OR     http://www.aginganddisease.org/EN/Y2014/V5/I4/256
[1] de Grey AD(2013). The desperate need for a biomedically useful definition of aging. Rejuvenation Res, 16:89-90
[2] Flatt T(2012). A new definition of aging?. Front Genet, 3:148
[3] Rose MR Evolutionary Biology of AgingOxfordOxford University Press1991
[4] Kirkpatrick B, Messias E, Harvey PD, Fernandez-Egea E, Bowie CR(2008). Is Schizophrenia a Syndrome of Accelerated Aging?. Schizophr Bull, 34:1024-1032
[5] Papanastasiou E, Gaughran F, Smith S(2011). Schizophrenia as segmental progeria. J R Soc Med, 104:475-484
[6] Jin K(2010). Modern Biological Theories of Aging. Aging Dis, 1:72-74
[7] Flatow J, Buckley P, Miller BJ(2013). Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry, 74:400-409
[8] Finkel T, Holbrook NJ(2000). Oxidants, oxidative stress and the biology of ageing. Nature, 408:239-247
[9] Laursen TM, Munk-Olsen T, Vestergaard M(2012). Life expectancy and cardiovascular mortality in persons with schizophrenia. Curr Opin Psychiatry, 25:83-88
[10] Andrews AO, Bartels SJ, Xie H, Peacock WJ(2009). Increased risk of nursing home admission among middle aged and older adults with schizophrenia. Am J Geriatr Psychiatry, 17:697-705
[11] Loewenstein DA, Czaja SJ, Bowie CR, Harvey PD(2012). Age-associated differences in cognitive performance in older patients with schizophrenia: a comparison with healthy older adults. Am J Geriatr Psychiatry, 20:29-40
[12] Kochunov P, Glahn DC, Rowland LM, Olvera RL, Winkler A, Yang YH(2013). Testing the hypothesis of accelerated cerebral white matter aging in schizophrenia and major depression. Biol Psychiatry, 73:482-491
[13] Cobia DJ, Smith MJ, Wang L, Csernansky JG(2012). Longitudinal progression of frontal and temporal lobe changes in schizophrenia. Schizophr Res, 139:1-6
[14] Papanastasiou E(2013). The prevalence and mechanisms of metabolic syndrome in schizophrenia: a review. Ther Adv Psychopharmacol, 3:33-51
[15] Fernandez-Egea E, García-Rizo C, Miller B, Parellada E, Justicia A, Bernardo M(2011). Testosterone in newly diagnosed, antipsychotic-naive men with nonaffective psychosis: a test of the accelerated aging hypothesis. Psychosom Med, 73:643-647
[16] Renn JH, Yang NP, Chueh CM, Lin CY, Lan TH, Chou P Bone mass in schizophrenia and normal populations across different decades of life. BMC Musculoskelet Disord, 10:1
[17] Sugawara N, Yasui-Furukori N, Umeda T, Tsuchimine S, Fujii A, Sato Y(2012). Effect of age and disease on bone mass in Japanese patients with schizophrenia. Ann Gen Psychiatry, 11:5
[18] Fernandez-Egea E, Bernardo M, Heaphy CM, Griffith JK, Parellada E, Esmatjes E(2009). Telomere length and pulse pressure in newly diagnosed, antipsychotic-naive patients with nonaffective psychosis. Schizophr Bull, 35:437-442
[19] Maudsley H The Pathology of Mind3rd ed.LondonMacmillan1979
[20] Harman D(1956). Aging: a theory based on free radical and radiation chemistry. J Gerontol, 11:298-300
[21] Halliwell B(1989). Tell me about free radicals, doctor: a review. J R Soc Med, 82:747-752
[22] Martínez MC, Andriantsitohaina R(2009). Reactive nitrogen species: molecular mechanisms and potential significance in health and disease. Antioxid Redox Signal, 11:669-702
[23] McCord JM, Fridovich I(1969). Superoxide dismutase. An enzymic function for erythrocuprein (hemocuprein)J Biol Chem, 244:6049-6055
[24] Kalyanaraman B(2013). Teaching the basics of redox biology to medical and graduate students: Oxidants, antioxidants and disease mechanisms. Redox Biol, 1:244-257
[25] Baker DJ, Wijshake T, Tchkonia T, LeBrasseur NK, Childs BG, van de Sluis B(2012). Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders. Nature, 479:232-236
[26] Ahmed EK, Rogowska-Wrzesinska A, Roepstorff P, Bulteau AL, Friguet B(2010). Protein modification and replicative senescence of WI-38 human embryonic fibroblasts. Aging Cell, 9:252-272
[27] Jeong J, Jung Y, Na S, Jeong J, Lee E, Kim MS(2011). Novel oxidative modifications in redox-active cysteine residues. Mol Cell Proteomics, 10M110.000513.
[28] Giustarini D, Rossi R, Milzani A, Colombo R, Dalle-Donne I(2004). S-glutathionylation: from redox regulation of protein functions to human diseases. J Cell Mol Med, 8:201-212
[29] Hess DT, Matsumoto A, Kim SO, Marshall HE, Stamler JS(2005). Protein S-nitrosylation: purview and parameters. Nat Rev Mol Cell Biol, 6:150-166
[30] Gould N, Doulias PT, Tenopoulou M, Raju K, Ischiropoulos H(2013). Regulation of protein function and signaling by reversible cysteine S-nitrosylation. J Biol Chem, 288:26473-26479
[31] Held JM, Gibson BW(2012). Regulatory control or oxidative damage? Proteomic approaches to interrogate the role of cysteine oxidation status in biological processes. Mol Cell Proteomics, 11R111.013037.
[32] Charles RL, Schröder E, May G, Free P, Gaffney PR, Wait R(2007). Protein sulfenation as a redox sensor: proteomics studies using a novel biotinylated dimedone analogue. Mol Cell Proteomics, 6:1473-1484
[33] Gems D, Doonan R(2009). Antioxidant defense and aging in C. elegans: is the oxidative damage theory of aging wrong?. Cell Cycle, 8:1681-1687
[34] Lapointe J, Hekimi S(2010). When a theory of aging ages badly. Cell Mol Life Sci, 67:1-8
[35] Afanas’ev I(2010). Signaling and Damaging Functions of Free Radicals in Aging-Free Radical Theory, Hormesis, and TOR. Aging Dis, 1:75-88
[36] Liochev SI(2013). Reactive oxygen species and the free radical theory of aging. Free Radic Biol Med, 60:1-4
[37] Yan LJ, Sohal RS(1998). Mitochondrial adenine nucleotide translocase is modified oxidatively during aging. Proc Natl Acad Sci U S A, 95:12896-12901
[38] Korotkova EI, Misini B, Dorozhko EV, Bukkel MV, Plotnikov EV, Linert W(2011). Study of OH Radicals in Human Serum Blood of Healthy Individuals and Those with Pathological Schizophrenia. Int J Mol Sci, 12:401-410
[39] Herken H, Uz E, Ozyurt H, Söğüt S, Virit O, Akyol O(2001). Evidence that the activities of erythrocyte free radical scavenging enzymes and the products of lipid peroxidation are increased in different forms of schizophrenia. Mol Psychiatry, 6:66-73
[40] Dietrich-Muszalska A, Olas B(2009). Modifications of blood platelet proteins of patients with schizophrenia. Platelets, 20:90-96
[41] Sirota P, Gavrieli R, Wolach B(2003). Overproduction of neutrophil radical oxygen species correlates with negative symptoms in schizophrenic patients: Parallel studies on neutrophil chemotaxis, superoxide production and bactericidal activity. Psychiatry Res, 121:123-132
[42] Do KQ, Trabesinger AH, Kirsten-Krüger M, Lauer CJ, Dydak U, Hell D(2000). Schizophrenia: Glutathione deficit in cerebrospinal fluid and prefrontal cortex in vivo. Eur J Neurosci, 12:3721-3728
[43] Yao JK, Leonard S, Reddy RD(2004). Increased nitric oxide radicals in postmortem brain from patients with schizophrenia. Schizophr Bull, 30:923-934
[44] Chowdari KV, Bamne MN, Nimgaonkar VL(2011). Genetic association studies of antioxidant pathway genes and schizophrenia. Antioxid Redox Signal, 15:2037-2045
[45] Berk M, Copolov D, Dean O, Lu K, Jeavons S, Schapkaitz I(2008). N-acetyl cysteine as a glutathione precursor for schizophrenia— a double-blind, randomized, placebo-controlled trial. Biol Psychiatry, 64:361-368
[46] Palaniswamy KS, Vishwanadha VP, Ramalingam Singaravelu S(2013). Fish oil rich in eicosapentaenoic acid protects against oxidative stress-related renal dysfunction induced by TCDD in Wistar rats. Cell Stress Chaperones[Epub ahead of print]
[47] Torrey EF, Davis JM(2012). Adjunct treatments for schizophrenia and bipolar disorder: what to try when you are out of ideas. Clin Schizophr Relat Psychoses, 5:208-216
[48] Miller B, Buckley P, Seabolt W, Mellor A, Kirkpatrick B(2011). Metaanalysis of cytokine alterations in schizophrenia: Clinical status and antipsychotic effects. Biol Psychiatry, 70:663-671
[49] Miller BJ, Gassama B, Sebastian D, Buckley P, Mellor A(2013). Meta-analysis of lymphocytes in schizophrenia: clinical status and antipsychotic effects. Biol Psychiatry, 73:993-999
[50] Bitanihirwe BK, Woo TU(2011). Oxidative stress in schizophrenia: An integrated approach. Neurosci Biobehav Rev, 35:878-893
[51] Sonoda J, Laganière J, Mehl IR, Barish GD, Chong LW, Li X(2007). Nuclear receptor ERR alpha and coactivator PGC-1 beta are effectors of IFN-gamma-induced host defense. Genes Dev, 21:1909-1920
[52] Corda S, Laplace C, Vicaut E, Duranteau J(2001). Rapid reactive oxygen species production by mitochondria in endothelial cells exposed to tumor necrosis factor-alpha is mediated by ceramide. Am J Respir Cell Mol Biol, 24:762-768
[53] Geldhoff M, Mook-Kanamori BB, Brouwer MC, Troost D, Leemans JC, Flavell RA(2013). Inflammasome activation mediates inflammation and outcome in humans and mice with pneumococcal meningitis. BMC Infect Dis, 13:358
[54] Nathan C, Cunningham-Bussel A(2013). Beyond oxidative stress: an immunologist’s guide to reactive oxygen species. Nat Rev Immunol, 13:349-361
[55] Latz E, Xiao TS, Stutz A(2013). Activation and regulation of the inflammasomes. Nat Rev Immunol, 13:397-411
[56] Reuter S, Gupta SC, Chaturvedi MM, Aggarwal BB(2010). Oxidative stress, inflammation, and cancer: how are they linked?. Free Radical Biol Med, 49:1603-1616
[57] Rawdin BJ, Mellon SH, Dhabhar FS, Epel ES, Puterman E, Su Y(2013). Dysregulated relationship of inflammation and oxidative stress in major depression. Brain Behav Immun, 31:143-152
[58] Stadtman ER(2006). Protein oxidation and aging. Free Radical Research, 40:1250-1258
[59] Rucci A, Ensinck MA, Mufarrege N, Cotorruelo C, Borrás SG, Racca L(2010). Modifications of band 3 and oxidation level of membrane proteins in senescent erythrocytes. Clin Biochem, 43:1171-1173
[60] Muteliefu G, Shimizu H, Enomoto A, Nishijima F, Takahashi M, Niwa T(2012). Indoxyl sulfate promotes vascular smooth muscle cell senescence with upregulation of p53, p21, and prelamin A through oxidative stress. Am J Physiol Cell Physiol, 303:C126-134
[61] Dietrich-Muszalska A, Olas B, Rabe-Jablonska J(2005). Oxidative stress in blood platelets from schizophrenic patients. Platelets, 16:386-391
[62] Jorgensen A, Broedbaek K, Fink-Jensen A, Knorr U, Greisen Soendergaard M, Henriksen T(2013). Increased systemic oxidatively generated DNA and RNA damage in schizophrenia. Psychiatry Res, 209:417-23
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