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Aging and Disease    2014, Vol. 5 Issue (4) : 281-291     DOI: 10.14336/AD.2014.0500281
Nothobranchius as a model for aging studies. A review
Alejandro Lucas-Sánchez1, *, Pedro Francisco Almaida-Pagán2, Pilar Mendiola1, Jorge de Costa1
1Department of Physiology. Faculty of Biology. University of Murcia. 30100 Murcia, Spain.
2Institute of Aquaculture, School of Natural Sciences, University of Stirling, Stirling FK9 4LA, UK.
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In recent decades, the increase in human longevity has made it increasingly important to expand our knowledge on aging. To accomplish this, the use of animal models is essential, with the most common being mouse (phylogenetically similar to humans, and a model with a long life expectancy) and Caenorhabditis elegans (an invertebrate with a short life span, but quite removed from us in evolutionary terms). However, some sort of model is needed to bridge the differences between those mentioned above, achieving a balance between phylogenetic distance and life span. Fish of the genus Nothobranchius were suggested 10 years ago as a possible alternative for the study of the aging process. In the meantime, numerous studies have been conducted at different levels: behavioral (including the study of the rest-activity rhythm), populational, histochemical, biochemical and genetic, among others, with very positive results. This review compiles what we know about Nothobranchius to date, and examines its future prospects as a true alternative to the classic models for studies on aging.

Keywords Aging      Fish      killifish      Nothobranchius     
Corresponding Authors: Alejandro Lucas-Sánchez   
Issue Date: 04 November 2014
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Alejandro Lucas-Sánchez
Pedro Francisco Almaida-Pagán
Pilar Mendiola
Jorge de Costa
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Alejandro Lucas-Sánchez,Pedro Francisco Almaida-Pagán,Pilar Mendiola, et al. Nothobranchius as a model for aging studies. A review[J]. Aging and Disease, 2014, 5(4): 281-291.
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Figure 1.  Advantages of Nothobranchius genus as a model for aging studies
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