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Aging and Disease    2014, Vol. 5 Issue (6) : 419-429     DOI: 10.14336/AD.2014.0500419
Review Article |
Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge?
Vaiserman* Alexander()
D.F. Chebotarev Institute of Gerontology, Kiev, Ukraine
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Abstract  

A growing body of evidence demonstrates that adverse events early in development, and particularly during intrauterine life, may program risks for diseases in adult life. Increasing evidence has been accumulated indicating the important role of epigenetic regulation including DNA methylation, histone modifications and miRNAs in developmental programming. Among the environmental factors which play an important role in programming of chronic pathologies, the endocrine-disrupting chemicals (EDCs) that have estrogenic, anti-estrogenic, and anti-androgenic activity are of specific concern because the developing organism is extremely sensitive to perturbation by substances with hormone-like activity. Among EDCs, there are many substances that are constantly present in the modern human environment or are in widespread use, including dioxin and dioxin-like compounds, phthalates, agricultural pesticides, polychlorinated biphenyls, industrial solvents, pharmaceuticals, and heavy metals. Apart from their common endocrine active properties, several EDCs have been shown to disrupt developmental epigenomic programming. The purpose of this review is to provide a summary of recent research findings which indicate that exposure to EDCs during in-utero and/or neonatal development can cause long-term health outcomes via mechanisms of epigenetic memory.

Keywords endocrine-disrupting chemicals      developmental programming      epigenetics      adult-life disease     
Issue Date: 21 November 2014
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Vaiserman* Alexander
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Vaiserman* Alexander. Early-life Exposure to Endocrine Disrupting Chemicals and Later-life Health Outcomes: An Epigenetic Bridge?[J]. Aging and Disease, 2014, 5(6): 419-429.
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http://www.aginganddisease.org/EN/10.14336/AD.2014.0500419     OR     http://www.aginganddisease.org/EN/Y2014/V5/I6/419
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