Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and Disease    2015, Vol. 6 Issue (1) : 17-26     DOI: 10.14336/AD.2014.0514
Effect of Aging in the Perception of Health-Related Quality of Life in End-Stage Renal Disease Patients under Online-Hemodiafiltration
Alexandra Moura1, José Madureira2, Pablo Alija2, João Carlos Fernandes3, José Gerardo Oliveira4, Martin Lopez5, Madalena Filgueiras6, Leonilde Amado7, Maria Sameiro-Faria7, Vasco Miranda7, Alice Santos-Silva8, 9, Elísio Costa8, 9, *
1Instituto de Ciências da Saúde, Universidade Católica Portuguesa, Porto, Portugal
2Clínica de Hemodiálise NefroServe, Barcelos, Portugal
3Clínica de Hemodiálise NefroServe, Viana do Castelo, Portugal
4Centro Hospitalar do Porto, Porto, Portugal
5Clínica de Hemodiálise de Felgueira, Felgueiras, Portugal
6Clínica de Hemodiálise de Gondomar, Gondomar, Portugal
7Clínica de Hemodiálise NephroCare, Maia, Portugal
8Laboratório de Bioquímica, Departamento de Ciências Biológicas, Faculdade de Farmácia, Universidade do Porto, Portugal
9Instituto de Biologia Molecular e Celular, Universidade do Porto, Portugal.
Download: PDF(928 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

This work aimed to evaluate how aging could influence patients’ perception of health quality of life (HRQOL), as well as, the effect of aging on dialysis adequacy and in hematological, iron status, inflammatory and nutritional markers. In this transversal study were enrolled 305 ESRD patients under online-hemodiafiltration (OL-HDF) (59.67% males; 64.9 ± 14.3 years old). Data about comorbidities, hematological data, iron status, dialysis adequacy, nutritional and inflammatory markers were collected from patient’s records. Moreover, HRQOL score, by using the Kidney Disease Quality of Life-Short Form (KDQOL-SF), was assessed. Analyzing the results according to quartiles of age, significant differences were found for some parameters evaluated by the KDQOL-SF instrument, namely for work status, physical functioning and role-physical, which decreased with increasing age. We also found a higher proportion of diabetic patients, a decrease in creatinine, iron, albumin serum levels, transferrin saturation and nPCR, with increasing age. Moreover, significant negative correlations were found between age and mean cell hemoglobin concentration, iron, transferrin saturation, albumin, nPCR, work status, physical functioning and role-physical. In conclusion, our results showed that aging is associated with a decreased work status, physical functioning and role-physical, with a decreased dialysis adequacy, iron availability and nutritional status, and with an increased proportion of diabetic patients and of patients using central venous catheter, as the vascular access. The knowledge of these changes associated with aging, which have impact in the quality of life of the patients, could be useful in their management.

Keywords Health-related quality of life      on-line hemodiafiltration      aging      gender      dialysis adequacy      iron availability      nutritional status     
Corresponding Authors: Elísio Costa   
Issue Date: 01 February 2015
E-mail this article
E-mail Alert
Articles by authors
Alexandra Moura
José Madureira
Pablo Alija
João Carlos Fernandes
José Gerardo Oliveira
Martin Lopez
Madalena Filgueiras
Leonilde Amado
Maria Sameiro-Faria
Vasco Miranda
Alice Santos-Silva
Elísio Costa
Cite this article:   
Alexandra Moura,José Madureira,Pablo Alija, et al. Effect of Aging in the Perception of Health-Related Quality of Life in End-Stage Renal Disease Patients under Online-Hemodiafiltration[J]. Aging and Disease, 2015, 6(1): 17-26.
URL:     OR
[1] Vollmer WM, Wahl PW, Blagg CR(1983). Survival with dialysis and transplantation in patients with end-stage renal disease. N Eng J Med, 308:1553-1558
[2] Held PJ, Brunner F, Odaka M, Garcia JR, Port FK, Gaylin DS(1990). Five-year survival for end-stage renal disease patients in the United States, Europe, and Japan, 1982 to 1987. Am J Kidney Dis, 15:451-457
[3] Jager KJ, Lindholm B, Goldsmith D, Fliser D, Wiecek A, Suleymanlar G(2011). Cardiovascular and non-cardiovascular mortality in dialysis patients: where is the link. Kidney Int, 1(suppl 1):21-23
[4] Foley RN, Parfrey PS, Sarnak MJ(1998). Clinical epidemiology of cardiovascular disease in chronic renal disease. Am J Kidney Dis, 32(suppl 3):S112-119
[5] Mazairac HA, de Wit GA, Grooteman MPC(2012). Clinical Performance Targets and Quality of Life in Hemodialysis Patients. Blood Purif, 33:73-79
[6] Mapes DL, Lopes AA, Satayathum S(2003). Health-related quality of life as a predictor of mortality and hospitalization: the Dialysis Outcomes and Practice Patterns Study (DOPPS)Kidney Int, 64:339-349
[7] Lowrie EG, Curtin RB, Lepain N, Schatell D(2003). Medical outcomes study short form-36: a consistent and powerful predictor of morbidity and mortality in dialysis patients. Am J Kidney Dis, 41:1286-1292
[8] Knight EL, Ofsthun N, Teng M, Lazarus JM, Curhan GC(2003). The association between mental health, physical function, and hemodialysis mortality. Kidney Int, 63:1843-1851
[9] Germin-Petrović D, Mesaros-Devcić I, Lesac A, Mandić M, Soldatić M, Vezmar D, Petrić D, Vujicić B, Basić-Jukić N, Racki S(2011). Original scientific paper Health-related Quality of Life in the Patients on Maintenance Hemodialysis: The Analysis of Demographic and Clinical Factors Antropol, 35:687-693
[10] Gibbons E, Fitzpatrick R(2010). A Structured review of patient-reported outcome measures for people with chronic kidney disease. Report to the Department of Health and NHS Kidney CareUniversity of Oxford
[11] Schmid H, Schiffl H(2012). Hemodiafiltration and survival of end-stage renal disease patients: the long journey goes on. Int Urol Nephrol, 44:1435-1440
[12] Maduell F, Moreso F, Pons M, Ramos R, Mora-Macià J, Carreras J, Soler J, Torres F, Campistol JM, Martinez-Castelao Afor the ESHOL Study Group2013). High-Efficiency Postdilution Online Hemodiafiltration Reduces All-Cause Mortality in Hemodialysis Patients. J Am Soc Nephrol, 24:487-497
[13] Mazairac AH, de Wit GA, Grooteman MP(2013). Effect of hemodiafiltration on quality of life over time. Clin J Am Soc Nephrol, 8:82-89
[14] Franco MR, Fernandes NM(2013). Diálise no paciente idoso: um desafio do século XXI – revisão narrativa. J Bras Nefrol, 35:132-141
[15] Laudański K, Nowak Z, Niemczyk S(2013). Age-related differences in the quality of life in end-stage renal disease in patients enrolled in hemodialysis or continuous peritoneal dialysis. Med Sci Monit, 19:378-385
[16] Rebollo P, Ortega F, Baltar JM(1998). Health-related quality of life HRQOL in end stage renal disease ESRD patients over 65 years. Geriatr Nephrol Urol, 8:85-94
[17] Hays RD, Kallich JD, Mapes DL, Coons SJ, Carter WB(1994). Development of the kidney disease quality of life (KDQOL) instrument. Qual Life Res, 3:329-338
[18] Mapes DL, Bragg-Gresham JL, Bommer J(2004). Health-related quality of life in the Dialysis Outcomes and Practice Patterns Study (DOPPS)Am J Kidney Dis, 44(suppl 2):54-60
[19] Unruh M, Benz R, Greene T(2004). Effects of hemodialysis dose and membrane flux on health-related quality of life in the HEMO Study. Kidney Int, 66:355-366
[20] Ferreira PL, Anes EJ(2010). Medição da qualidade de vida de insuficientes renais crónicos: criação da versão portuguesa do KDQOL-SF. Rev Port Sau Pub, 28:31-39
[21] Lessan-Pezeshki M, Rostami Zohreh(2009). Contributing Factors in Health-Related Quality of Life Assessment of ESRD Patients: A Single Center Study. Int J Nephrol Urol, 1:129-136
[22] Anees M, Hameed F, Mumtaz A, Ibrahim M, Saeed Khan MN(2011). Dialysis-Related Factors Affecting Quality of Life in Patients on Hemodialysis. Iran J Kidney Dis, 5:9-14
[23] Knight EL, Ofsthun N, Teng M, Lazarus JM, Curhan GC(2003). The association between mental health, physical function and hemodialysis mortality. Kidney Int, 63:1843-1851
[24] Simmons RG, Abress L(1990). Quality-of-life issues for end-stage renal disease patients. Am J Kidney Dis, 15:201-208
[25] Kalantar-Zadeh K, Fouque D, Kopple JD(2004). Outcome research, nutrition, and reverse epidemiology in maintenance dialysis patients. J Ren Nutr, 14:64-71
[26] Schiffl H(2007). Prospective randomized cross-over long-term comparison of online haemodiafiltration and ultrapure high-flux haemodialysis. Eur J Med Res, 12:26-33
[27] Cuevas X, García F, Martín-Malo A, Fort J, Lladós F, Lozano J, Pérez-García R(2011). Risk Factors Associated with Cardiovascular Morbidity and Mortality in Spanish Incident Hemodialysis Patients: Two-Year Results from the ANSWER Study. Blood Purif, 33:21-29
[28] Yen TH, Lin JL, Lin-Tan DT, Hsu CW(2010). Association between body mass and mortality in maintenance hemodialysis patients. Ther Apher Dial, 14:400-408
[29] Tanner RM, Brown TM, Muntner P(2012). Epidemiology of Obesity, the Metabolic Syndrome, and Chronic Kidney Disease. Curr Hypertens Rep, 14:152-159
[30] Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horwich TB(2005). Survival advantages of obesity in dialysis patients. Am J Clin Nutr, 81:543-554
[31] Kalender B, Ozdemir AC, Dervisoglu E, Ozdemir O(2007). Quality of life in chronic kidney disease: effects of treatment modality, depression, malnutrition and inflammation. Int J Clin Pract, 61:569-576
[32] Tanner RM, Brown TM, Muntner P(2012). Epidemiology of Obesity, the Metabolic Syndrome, and Chronic Kidney Disease. Curr Hypertens Rep, 14:152-159
[33] Kalantar-Zadeh K, Abbott KC, Salahudeen AK, Kilpatrick RD, Horwich TB(2005). Survival advantages of obesity in dialysis patients. Am J Clin Nutr, 81:543-554
[34] Costa E, Fernandes J, Ribeiro S, Sereno J, Garrido P, Rocha-Pereira P, Coimbra S, Catarina C, Belo L, Bronze-da-Rocha E, Vala H, Alves R, Reis F, Santos-Silva A(2014). Aging is Associated with Impaired Renal Function, INF-gamma Induced Inflammation and with Alterations in Iron Regulatory Proteins Gene Expression. Aging Disin press
[35] Seica A, Segall L, Verzan C(2009). Factors affecting the quality of life of haemodialysis patients from Romania: a multicentric study. Nephrol Dial Transplant, 24:626-629
[36] Mapes DL, Bragg-Gresham JL, Bommer J(2004). Health-related quality of life in the Dialysis Outcomes and Practice Patterns Study (DOPPS)Am J Kidney Dis, 44(suppl 2):54-60
[37] Astor BC, Coresh J, Powe NR, Eustace JA, Klag MJ(2000). Relation between gender and vascular access complications in hemodialysis patients. Am J Kidney Dis, 36:1126-1134
[38] Stehman-Breen CO, Sherrard DJ, Gillen D, Caps M(2000). Determinants of type and timing of initial permanent hemodialysis vascular access. Kidney Int, 57:639-645
[39] Astor BC, Eustace JA, Powe NR, Klag MJ, Sadler JH, Fink NE, Coresh J(2001). Timing of nephrologist referral and arteriovenous access use. The CHOICE Study. Am J Kidney Dis, 38:494-501
[40] Ng YY, Wu SC, Hung YN, Ko PJ(2009). Effect of demographic characteristics and timing of vascular access maturation on patency in Chinese incident haemodialysis patients. Nephrol Dial Transplant, 11:3447-3453
[41] van Blijderveen JC, Straus SM, Zietse R, Stricker BH, Sturkenboom MC, Verhamme KM(2013). A population-based study on the prevalence and incidence of chronic kidney disease in the Netherlands. Int Urol Nephrol, 46:583-592
[42] Shoji T, Emoto M, Shinohara K, Kakiya R, Tsujimoto Y, Kishimoto H, Ishimura E, Tabata T, Nishizawa Y(2001). Diabetes mellitus, aortic stiffness, and cardiovascular mortality in end-stage renal disease. J Am Soc Nephrol, 12:2117-2124
[1] Feng Tang,Meng-Hao Pan,Yujie Lu,Xiang Wan,Yu Zhang,Shao-Chen Sun. Involvement of Kif4a in Spindle Formation and Chromosome Segregation in Mouse Oocytes[J]. A&D, 2018, 9(4): 623-633.
[2] J. Thomas Mock,Sherilynn G Knight,Philip H Vann,Jessica M Wong,Delaney L Davis,Michael J Forster,Nathalie Sumien. Gait Analyses in Mice: Effects of Age and Glutathione Deficiency[J]. A&D, 2018, 9(4): 634-646.
[3] Jiayu Wu,Weiying Ren,Li Li,Man Luo,Kan Xu,Jiping Shen,Jia Wang,Guilin Chang,Yi Lu,Yiming Qi,Binger Xu,Yuting He,Yu Hu. Effect of Aging and Glucagon-like Peptide 2 on Intestinal Microbiota in SD Rats[J]. A&D, 2018, 9(4): 566-577.
[4] Carmen G Vinagre,Fatima R Freitas,Carlos H de Mesquita,Juliana C Vinagre,Ana Carolina Mariani,Roberto Kalil-Filho,Raul C Maranhão. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects[J]. A&D, 2018, 9(4): 748-754.
[5] Aurore Marie,Johann Meunier,Emilie Brun,Susanna Malmstrom,Veronique Baudoux,Elodie Flaszka,Gaëlle Naert,François Roman,Sylvie Cosnier-Pucheu,Sergio Gonzalez-Gonzalez. N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model[J]. A&D, 2018, 9(4): 664-673.
[6] Yali Chen,Mengmei Yin,Xuejin Cao,Gang Hu,Ming Xiao. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain[J]. A&D, 2018, 9(3): 374-390.
[7] Wenzhi Sun,Jiewen Tan,Zhuo Li,Shibao Lu,Man Li,Chao Kong,Yong Hai,Chunjin Gao,Xuehua Liu. Evaluation of Hyperbaric Oxygen Treatment in Acute Traumatic Spinal Cord Injury in Rats Using Diffusion Tensor Imaging[J]. A&D, 2018, 9(3): 391-400.
[8] Changjun Yang,Kelly M. DeMars,Eduardo Candelario-Jalil. Age-Dependent Decrease in Adropin is Associated with Reduced Levels of Endothelial Nitric Oxide Synthase and Increased Oxidative Stress in the Rat Brain[J]. A&D, 2018, 9(2): 322-330.
[9] Lin-Yuan Zhang,Pan Lin,Jiaji Pan,Yuanyuan Ma,Zhenyu Wei,Lu Jiang,Liping Wang,Yaying Song,Yongting Wang,Zhijun Zhang,Kunlin Jin,Qian Wang,Guo-Yuan Yang. CLARITY for High-resolution Imaging and Quantification of Vasculature in the Whole Mouse Brain[J]. A&D, 2018, 9(2): 262-272.
[10] Weiming Hu,Junwu Wu,Wenjing Jiang,Jianguo Tang. MicroRNAs and Presbycusis[J]. A&D, 2018, 9(1): 133-142.
[11] Barbara Strasser,Konstantinos Volaklis,Dietmar Fuchs,Martin Burtscher. Role of Dietary Protein and Muscular Fitness on Longevity and Aging[J]. A&D, 2018, 9(1): 119-132.
[12] Huaqin Liu,Zhui Yu,Ying Li,Bin Xu,Baihui Yan,Wulf Paschen,David S Warner,Wei Yang,Huaxin Sheng. Novel Modification of Potassium Chloride Induced Cardiac Arrest Model for Aged Mice[J]. A&D, 2018, 9(1): 31-39.
[13] Fangyu Peng,Fang Xie,Otto Muzik. Alteration of Copper Fluxes in Brain Aging: A Longitudinal Study in Rodent Using 64CuCl2-PET/CT[J]. A&D, 2018, 9(1): 109-118.
[14] Nathalie K Zgheib,Fatima Sleiman,Lara Nasreddine,Mona Nasrallah,Nancy Nakhoul,Hussain Isma’eel,Hani Tamim. Short Telomere Length is Associated with Aging, Central Obesity, Poor Sleep and Hypertension in Lebanese Individuals[J]. A&D, 2018, 9(1): 77-89.
[15] Mari L. Sbardelotto,Giulia S. Pedroso,Fernanda T. Pereira,Helen R. Soratto,Stella MS. Brescianini,Pauline S. Effting,Anand Thirupathi,Renata T. Nesi,Paulo CL. Silveira,Ricardo A. Pinho. The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men[J]. A&D, 2017, 8(6): 887-898.
Full text



Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail:
Powered by Beijing Magtech Co. Ltd