Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and Disease    2015, Vol. 6 Issue (3) : 180-187     DOI: 10.14336/AD.2014.0621
Original Article |
Analysis of Vertebral Bone Strength, Fracture Pattern, and Fracture Location: A Validation Study Using a Computed Tomography-Based Nonlinear Finite Element Analysis
Kazuhiro Imai()
Department of Life Sciences, Graduate School of Arts and Sciences, The University of Tokyo, Tokyo, Japan
Download: PDF(390 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Finite element analysis (FEA) is an advanced computer technique of structural stress analysis developed in engineering mechanics. Because the compressive behavior of vertebral bone shows nonlinear behavior, a nonlinear FEA should be utilized to analyze the clinical vertebral fracture. In this article, a computed tomography-based nonlinear FEA (CT/FEA) to analyze the vertebral bone strength, fracture pattern, and fracture location is introduced. The accuracy of the CT/FEA was validated by performing experimental mechanical testing with human cadaveric specimens. Vertebral bone strength and the minimum principal strain at the vertebral surface were accurately analyzed using the CT/FEA. The experimental fracture pattern and fracture location were also accurately simulated. Optimization of the element size was performed by assessing the accuracy of the CT/FEA, and the optimum element size was assumed to be 2 mm. It is expected that the CT/FEA will be valuable in analyzing vertebral fracture risk and assessing therapeutic effects on osteoporosis.

Keywords vertebral fracture      bone strength      finite element analysis      osteoporosis     
Issue Date: 01 June 2015
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Kazuhiro Imai
Cite this article:   
Kazuhiro Imai. Analysis of Vertebral Bone Strength, Fracture Pattern, and Fracture Location: A Validation Study Using a Computed Tomography-Based Nonlinear Finite Element Analysis[J]. A&D, 2015, 6(3): 180-187.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2014.0621     OR     http://www.aginganddisease.org/EN/Y2015/V6/I3/180
[1] Brekelmans WA, Poort HW, Slooff TJ (1972). A new method to analyse the mechanical behaviour of skeletal parts. ActaOrthopScand, 43: 301-317.
[2] Huiskes R, Chao EY (1983). A survey of finite element analysis in orthopedic biomechanics: the first decade. J Biomech, 16: 385-409.
[3] Faulkner KG, Cann CE, Hasegawa BH (1991). Effect of bone distribution on vertebral strength: assessment with patient-specific nonlinear finite element analysis. Radiology, 179: 669-674.
[4] Silva MJ, Keaveny TM, Hayes WC (1998). Computed tomography-based finite element analysis predicts failure loads and fracture patterns for vertebral sections. J Orthop Res, 16: 300-308.
[5] Martin H, Werner J, Andresen R, Schober HC, Schmitz KP (1998). Noninvasive assessment of stiffness and failure load of human vertebrae from CT-data. Biomed Tech, 43: 82-88.
[6] Liebschner MA, Kopperdahl DL, Rosenberg WS, Keaveny TM (2003). Finite element modeling of the human thoracolumbar spine. Spine, 28: 559-565.
[7] Crawford RP, Cann CE, Keaveny TM (2003). Finite element models predict in vitro vertebral body compressive strength better than quantitative computed tomography. Bone, 33: 744-750.
[8] Keaveny TM, Wachtel EF, Ford CM, Hayes WC (1994). Differences between the tensile and compressive strengths of bovine tibial trabecular bone depend on modulus. J Biomech, 27: 1137-1146.
[9] Kopperdahl DL, Keaveny TM (1998). Yield strain behavior of trabecular bone. J Biomech, 31: 601-608.
[10] Morgan EF, Keaveny TM (2001). Dependence of yield strain of human trabecular bone on anatomic site. J Biomech, 34: 569-577.
[11] Silva MJ, Wang C, Keaveny TM, Hayes WC (1994). Direct and computed tomography thickness measurements of the human, lumbar vertebral shell and endplate. Bone, 15: 409-414.
[12] Vesterby A, Mosekilde L, Gundersen HJ,et al (1991). Biologically meaningful determinants of the in vitro strength of lumbar vertebrae. Bone, 12: 219-224.
[13] Mosekilde L (1993). Vertebral structure and strength in vivo and in vitro. Calcif Tissue Int, 53: S121-S126.
[14] Dougherty G, Newman D (1999). Measurement of thickness and density of thin structures by computed tomography: a simulation study. Med Phys, 26: 1341-1348.
[15] Prevrhal S, Engelke K, KalenderWA (1999). Accuracy limits for the determination of cortical width and density: the influence of object size and CT imaging parameters. Phys Med Biol, 44: 751-764.
[16] Imai K, Ohnishi I, Bessho M, Nakamura K (2006). Nonlinear finite element model predicts vertebral bone strength and fracture site. Spine, 31: 1789-1794.
[17] Imai K, Ohnishi I, Yamamoto S, Nakamura K (2008). In vivo assessment of lumbar vertebral strength in elderly women using CT-based nonlinear finite element model. Spine, 33: 27-32.
[18] Keyak JH, Rossi SA, Jones KA, Skinner HB (1998). Prediction of femoral fracture load using automated finite element modeling. J Biomech, 31: 125-133.
[19] JensenKS, Mosekilde L (1990). A model of vertebral trabecular bone architecture and its mechanical properties. Bone, 11: 417-423.
[20] Rho JY, Tsui TY, Pharr GM (1997). Elastic properties of human cortical and trabecular lamellar bone measured by nanoindentation. Biomaterials, 18: 1325-1330.
[21] Hou FJ, Lang SM, Hoshaw SJ, Reimann DA, Fyhrie DP (1998). Human vertebral body apparent and hard tissue stiffness. J Biomech, 31: 1009-1015.
[22] Ladd AJ, Kinney JH, Haupt DL, Goldstein SA (1998). Finite-element modeling of trabecular bone: comparison with mechanical testing and determination of tissue modulus. J Orthop Res, 16: 622-628.
[23] Overaker DW, Langrana NA, Cuitino AM (1999). Finite element analysis of vertebral body mechanics with a nonlinear microstructural model for the trabecular core. J Biomech Eng, 121: 542-550.
[24] Rockoff SD, Sweet E, Bleustein J (1969). The relative contribution of trabecular and cortical bone to the strength of human lumbar vertebrae. Calcif Tissue Res, 3: 163-175.
[25] Ito M (2005). Assessment of bone quality using micro-computed tomography (micro-CT) and synchrotron micro-CT. J Bone Miner Metab, 23: S115-S121.
[26] Matsumoto T, Ohnishi I, Bessho M, Imai K, Ohashi S, Nakamura K (2009). Prediction of vertebral strength under loading conditions occurring in activities of daily living using a computed tomography-based nonlinear finite element method. Spine, 34: 1464-1469.
[27] Imai K, Ohnishi I, Matsumoto T, Yamamoto S, Nakamura K (2009). Assessment of vertebral fracture risk and therapeutic effects of alendronate in postmenopausal women using a quantitative computed tomography-based nonlinear finite element method. OsteoporosInt, 20: 801-810.
[28] Imai K (2011). Vertebral fracture risk and alendronate effects on osteoporosis assessed by a computed tomography-based nonlinear finite element method. J Bone Miner Metab, 29: 645-651.
[1] Jiao Li,Xingyu Liu,Bin zuo,Li Zhang. The Role of Bone Marrow Microenvironment in Governing the Balance between Osteoblastogenesis and Adipogenesis[J]. A&D, 2016, 7(4): 514-525.
[2] Tetsuro Hida,Atsushi Harada,Shiro Imagama,Naoki Ishiguro. Managing Sarcopenia and Its Related-Fractures to Improve Quality of Life in Geriatric Populations[J]. Aging and Disease, 2014, 5(4): 226-237.
[3] James D. Dolbow,David R. Dolbow,Ashraf S. Gorgey,Robert A. Adler,David R. Gater. The Effects of Aging and Electrical Stimulation Exercise on Bone after Spinal Cord Injury[J]. Aging and Disease, 2013, 4(3): 141-153.
[4] Matti D. Allen,S. Jared McMillan,Cliff S. Klein,Charles L. Rice,Greg D. Marsh. Differential Age-related Changes in Bone Geometry between the Humerus and the Femur in Healthy Men[J]. Aging and Disease, 2012, 3(2): 156-163.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd