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Aging and Disease    2015, Vol. 6 Issue (5) : 369-379     DOI: 10.14336/AD.2015.0616
Review Article |
Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders
José H. Cararo1,Emilio L. Streck2,Patricia F. Schuck1,Gustavo da C. Ferreira3,*()
1 Laboratório de Erros Inatos do Metabolismo, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
2 Laboratório de Bioenergética, Programa de Pós-Graduação em Ciências da Saúde, Universidade do Extremo Sul Catarinense, Criciúma, SC, Brazil
3 Laboratório de Bioenergética, Instituto de Bioquímica Médica Leopoldo de Meis, Universidade Federal do Rio de Janeiro, Rio de Janeiro, RJ, Brazil
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Abstract  

Imidazole dipeptides (ID), such as carnosine (β-alanyl-L-histidine), are compounds widely distributed in excitable tissues of vertebrates. ID are also endowed of several biochemical properties in biological tissues, including antioxidant, bivalent metal ion chelating, proton buffering, and carbonyl scavenger activities. Furthermore, remarkable biological effects have been assigned to such compounds in age-related human disorders and in patients whose activity of serum carnosinase is deficient or undetectable. Nevertheless, the precise biological role of ID is still to be unraveled. In the present review we shall discuss some evidences from clinical and basic studies for the utilization of ID as a drug therapy for age-related human disorders.

Keywords imidazole dipeptides      biological activity      aging      children      serum carnosinase deficiency     
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Corresponding Authors: Gustavo da C. Ferreira     E-mail: gustavo.ferreira@bioqmed.ufrj.br
About author: * Correspondence should be addressed to: Gustavo da Costa Ferreira, PhD. Universidade Federal do Rio de Janeiro, Cidade Universita?ria - Ilha do Fundão, RJ, Brazil. Email: gustavo.ferreira@bioqmed.ufrj.br
Issue Date: 01 October 2015
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José
Emilio L. Streck
Patricia F. Schuck
Gustavo da C. Ferreira
Cite this article:   
José,Emilio L. Streck,Patricia F. Schuck, et al. Carnosine and Related Peptides: Therapeutic Potential in Age-Related Disorders[J]. A&D, 2015, 6(5): 369-379.
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http://www.aginganddisease.org/EN/10.14336/AD.2015.0616     OR     http://www.aginganddisease.org/EN/Y2015/V6/I5/369
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