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Aging and disease    2015, Vol. 6 Issue (5) : 400-405     DOI: 10.14336/AD.2015.0617
Review Article |
Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer’s Disease
Amandine E. Bonnet1, Yannick Marchalant2,*()
1 CNRS, NICN UMR 7259 Aix-Marseille University, 13344 Marseille, France.
2 Department of Psychology/Neuroscience program, Central Michigan University, MI 48859, USA
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Abstract  

Aging can lead to decline in cognition, notably due to neurodegenerative processes overwhelming the brain over time. As people live longer, numerous concerns are rightfully raised toward long-term slowly incapacitating diseases with no cure, such as Alzheimer’s disease. Since the early 2000’s, the role of neuroinflammation has been scrutinized for its potential role in the development of diverse neurodegenerative diseases notably because of its slow onset and chronic nature in aging. Despite the lack of success yet, treatment of chronic neuroinflammation could help alleviate process implicated in neurodegenerative disease. A growing number of studies including our own have aimed at the endocannabinoid system and unfolded unique effects of this system on neuroinflammation, neurogenesis and hallmarks of Alzheimer’s disease and made it a reasonable target in the context of normal and pathological brain aging.

Keywords Cannabinoids      Neuroinflammation      Neurogenesis      Aging      Alzheimer’s disease     
Corresponding Authors: Yannick Marchalant     E-mail: march1y@cmich.edu
About author:

present address: Kunming Biomed International, Kunming, Yunnan, 650500, China

Issue Date: 01 October 2015
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Amandine E. Bonnet,Yannick Marchalant. Potential Therapeutical Contributions of the Endocannabinoid System towards Aging and Alzheimer’s Disease[J]. Aging and disease, 2015, 6(5): 400-405.
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http://www.aginganddisease.org/EN/10.14336/AD.2015.0617     OR     http://www.aginganddisease.org/EN/Y2015/V6/I5/400
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