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Aging and Disease    2016, Vol. 7 Issue (4) : 502-513     DOI: 10.14336/AD.2015.1220
Review Article |
Danggui-Shaoyao-San: New Hope for Alzheimer's Disease
Xin Fu1,QiuHong Wang1,ZhiBin Wang1,HaiXue Kuang1,*,Pinghui Jiang2
1School of Pharmacy, Key Laboratory of Chinese Materia Medica, Heilongjiang University of Chinese Medicine, Ministry of Education, Harbin 150040, China.
2College of Electrical and Information Engineering, Heilongjiang Institute of Technology, Harbin 150050, China.
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Abstract  

Danggui-Shaoyao-San (DSS), also called Toki-shakuyaku-san (TJ-23) or Dangguijakyak-san (DJS), is a well-known herbal formula (Angelica sinensis (Oliv.) Diels., Ligusticum chuanxiong Hort., Paeonia lactiflora pall., Poria cocos (Schw.) Wolf, Alisma orientalis (Sam.) Juzep., Atractylodes macrocephala Koidz.), which has been widely used in oriental countries for the treatment of various gynecological diseases. Recent studies show that DSS has an effect on free radical-mediated neurological diseases and exhibits anti-inflammatory and antioxidant activities and reduces cell apoptosis in the hippocampus. In addition, DSS mediates the modulation of central monoamine neurotransmitter systems and ameliorates dysfunction of the central cholinergic nervous system and scopolamine-induced decrease in ACh levels. DSS improves the function of the dopaminergic, adrenergic, and serotonergic nervous systems. Interestingly, DSS can alleviate cognitive dysfunction of Alzheimer's disease (AD) patients, suggesting that it is a useful therapeutic agent for AD. This paper reviews the mechanism of DSS for the treatment of AD.

Keywords Danggui-Shaoyao-San      Alzheimer's disease      anti-inflammation      antioxidant activity      cell apoptosis     
Corresponding Authors: HaiXue Kuang   
Issue Date: 01 August 2016
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Xin Fu
QiuHong Wang
ZhiBin Wang
HaiXue Kuang
Pinghui Jiang
Cite this article:   
Xin Fu,QiuHong Wang,ZhiBin Wang, et al. Danggui-Shaoyao-San: New Hope for Alzheimer's Disease[J]. A&D, 2016, 7(4): 502-513.
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http://www.aginganddisease.org/EN/10.14336/AD.2015.1220     OR     http://www.aginganddisease.org/EN/Y2016/V7/I4/502
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