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Aging and Disease    2017, Vol. 8 Issue (2) : 149-161     DOI: 10.14336/AD.2016.0810
Review |
Shining the Light on Senescence Associated LncRNAs
A.R. Ghanam1,2,Qianlan Xu1,Shengwei Ke1,Muhammad Azhar1,Qingyu Cheng1,Xiaoyuan Song1,*
1CAS Key Laboratory of Brain Function and Disease, CAS Center for Excellence in Molecular Cell Science, Collaborative Innovation Center of Chemistry for Life Sciences, School of Life Sciences, University of Science and Technology of China, Hefei 230027, China.
2Collage of Veterinary Medicine, Suez Canal University, Ismailia 41522, Egypt
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Abstract  

Cellular senescence can be described as a complex stress response that leads to irreversible cell cycle arrest. This process was originally described as an event that primary cells go through after many passages of cells during cell culture. More recently, cellular senescence is viewed as a programmed process by which the cell displays a senescence phenotype when exposed to a variety of stresses. Cellular senescence has been implicated in tumor suppression and aging such that senescence may contribute to both tumor progression and normal tissue repair. Here, we review different forms of cellular senescence, as well as current biomarkers used to identify senescent cells in vitro and in vivo. Additionally, we highlight the role of senescence-associated long noncoding RNAs (lncRNAs).

Keywords cellular senescence      lncRNAs      biomarkers     
Corresponding Authors: Xiaoyuan Song   
Issue Date: 01 April 2017
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A.R. Ghanam
Qianlan Xu
Shengwei Ke
Muhammad Azhar
Qingyu Cheng
Xiaoyuan Song
Cite this article:   
A.R. Ghanam,Qianlan Xu,Shengwei Ke, et al. Shining the Light on Senescence Associated LncRNAs[J]. A&D, 2017, 8(2): 149-161.
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http://www.aginganddisease.org/EN/10.14336/AD.2016.0810     OR     http://www.aginganddisease.org/EN/Y2017/V8/I2/149
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