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Aging and disease    2017, Vol. 8 Issue (3) : 354-363     DOI: 10.14336/AD.2016.1022
Review |
Geroprotectors: A Unified Concept and Screening Approaches
Moskalev Alexey1,2,3, Chernyagina Elizaveta2, Kudryavtseva Anna1, Shaposhnikov Mikhail3
1Laboratory of postgenomic studies, Engelhardt Institute of Molecular Biology of Russian Academy of Sciences, Moscow, 119991, Russia
2Laboratory of genetics of aging and longevity, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia
3Laboratory of molecular radiobiology and gerontology, Institute of Biology of Komi Science Center of Ural Branch of Russian Academy of Sciences, Syktyvkar, 167982, Russia
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Abstract  

Although the geroprotectors discovery is a new biomedicine trend and more than 200 compounds can slow aging and increase the lifespan of the model organism, there are still no geroprotectors on the market. The reasons may be partly related to the lack of a unified concept of geroprotector, accepted by the scientific community. Such concept as a system of criteria for geroprotector identification and classification can form a basis for an analytical model of anti-aging drugs, help to consolidate the efforts of various research initiatives in this area and compare their results. Here, we review the existing classification and characteristics of geroprotectors based on their effect on the survival of a group of individuals or pharmaceutics classes, according to the proposed mechanism of their geroprotective action or theories of aging. After discussing advantages and disadvantages of these approaches, we offer a new concept based on the maintenance of homeostatic capacity because aging can be considered as exponential shrinkage of homeostatic capacity leading to the onset of age-related diseases and death. Besides, we review the most promising current screening approaches to finding new geroprotectors. Establishing the classification of existing geroprotectors based on physiology and current understanding of the nature of aging is essential for putting the existing knowledge into a single system. This system could be useful to formulate standards for finding and creating new geroprotectors. Standardization, in turn, would allow easier comparison and combination of experimental data obtained by different research groups.

Keywords aging      criteria of geroprotectors      geroprotectors      healthspan      lifespan     
Corresponding Authors: Moskalev Alexey   
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These authors contributed equally to the work.

Issue Date: 01 June 2017
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Moskalev Alexey
Chernyagina Elizaveta
Kudryavtseva Anna
Shaposhnikov Mikhail
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Moskalev Alexey,Chernyagina Elizaveta,Kudryavtseva Anna, et al. Geroprotectors: A Unified Concept and Screening Approaches[J]. Aging and disease, 2017, 8(3): 354-363.
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http://www.aginganddisease.org/EN/10.14336/AD.2016.1022     OR     http://www.aginganddisease.org/EN/Y2017/V8/I3/354
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