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Aging and Disease    2017, Vol. 8 Issue (3) : 314-333     DOI: 10.14336/AD.2016.1101
Review |
Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases
Yiwei Cao,Rui-Hong Wang
Faculty of Health Science, University of Macau, Macau, China
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Abstract  

Accumulating epidemiological studies have implicated a strong link between age associated metabolic diseases and cancer, though direct and irrefutable evidence is missing. In this review, we discuss the connection between Warburg effects and tumorigenesis, as well as adaptive responses to environment such as circadian rhythms on molecular pathways involved in metabolism. We also review the central role of the sirtuin family of proteins in physiological modulation of cellular processes and age-associated metabolic diseases. We also provide a macroscopic view of how the circadian rhythm affects metabolism and may be involved in cell metabolism reprogramming and cancer pathogenesis. The aberrations in metabolism and the circadian system may lead to age-associated diseases directly or through intermediates. These intermediates may be either mutated or reprogrammed, thus becoming responsible for chromatin modification and oncogene transcription. Integration of circadian rhythm and metabolic reprogramming in the holistic understanding of metabolic diseases and cancer may provide additional insights into human diseases.

Keywords Age-associated diseases      circadian rhythm      metabolic reprogramming      sirtuin      tumorigenesis      Warburg effect     
Corresponding Authors: Rui-Hong Wang   
Issue Date: 01 June 2017
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Yiwei Cao
Rui-Hong Wang
Cite this article:   
Yiwei Cao,Rui-Hong Wang. Associations among Metabolism, Circadian Rhythm and Age-Associated Diseases[J]. A&D, 2017, 8(3): 314-333.
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http://www.aginganddisease.org/EN/10.14336/AD.2016.1101     OR     http://www.aginganddisease.org/EN/Y2017/V8/I3/314
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