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Aging and Disease    2017, Vol. 8 Issue (5) : 611-627     DOI: 10.14336/AD.2016.1230
Review |
Cancer and Aging - the Inflammatory Connection
Adar Zinger1,William C Cho2,Arie Ben-Yehuda1,*
1Department of Medicine, Hadassah-Hebrew University Medical Center, Jerusalem, Israel
2Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
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Abstract  

Aging and cancer are highly correlated biological phenomena. Various cellular processes such as DNA damage responses and cellular senescence that serve as tumor suppressing mechanisms throughout life result in degenerative changes and contribute to the aging phenotype. In turn, aging is considered a pro-tumorigenic state, and constitutes the single most important risk factor for cancer development. However, the causative relations between aging and cancer is not straight forward, as these processes carry contradictory hallmarks; While aging is characterized by tissue degeneration and organ loss of function, cancer is a state of sustained cellular proliferation and gain of new functions. Here, we review the molecular and cellular pathways that stand in the base of aging related cancer. Specifically, we deal with the inflammatory perspective that link these two processes, and suggest possible molecular targets that may be exploited to modify their courses.

Keywords aging      cancer      senescence      inflammation      immunosenescence      autophagy     
Corresponding Authors: Arie Ben-Yehuda   
Issue Date: 01 October 2017
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Adar Zinger
William C Cho
Arie Ben-Yehuda
Cite this article:   
Adar Zinger,William C Cho,Arie Ben-Yehuda. Cancer and Aging - the Inflammatory Connection[J]. A&D, 2017, 8(5): 611-627.
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http://www.aginganddisease.org/EN/10.14336/AD.2016.1230     OR     http://www.aginganddisease.org/EN/Y2017/V8/I5/611
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