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Aging and disease    2018, Vol. 9 Issue (1) : 133-142     DOI: 10.14336/AD.2017.0119
Review |
MicroRNAs and Presbycusis
Hu Weiming1, Wu Junwu2,3, Jiang Wenjing1, Tang Jianguo3,*
1Department of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China
2Department of Otolaryngology-Head and Neck Surgery, Yiwu traditional Chinese Medicine Hospital, Yiwu 322000, China
3Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China.
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Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes. It has been identified that various miRNAs are up- or down-regulated during mammalian aging processes in tissue-specific manners. Most miRNAs bind to specific sites on their target messenger-RNAs (mRNAs) and decrease their expression. Germline mutation may lead to dysregulation of potential miRNAs expression, causing progressive hair cell degeneration and age-related hearing loss. Therapeutic innovations could emerge from a better understanding of diverse function of miRNAs in presbycusis. This review summarizes the relationship between miRNAs and presbycusis, and presents novel miRNAs-targeted strategies against presbycusis.

Keywords presbycusis      microRNAs      target gene      progressive hair cell degeneration      aging     
Corresponding Authors: Tang Jianguo   
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These two authors contribute equally to this work

Issue Date: 01 February 2018
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Hu Weiming
Wu Junwu
Jiang Wenjing
Tang Jianguo
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Hu Weiming,Wu Junwu,Jiang Wenjing, et al. MicroRNAs and Presbycusis[J]. Aging and disease, 2018, 9(1): 133-142.
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miRNAExpression with agingPossible targetInference
let-7 familydownregulatedTnfsf10/Caspase3/Birc5Regulate dedifferentiation, promote hair cells regeneration
miRNA-183 familydownregulatedSlc26a5 (prestin)/ Gfi1/ Pitpnm1/ Ocm (oncomodulin) /PtprqPromote hair cell differentiation and maturation.
miRNA-34 familyupregulatedP53/E74ALead to cell-cycle arrest and apoptosis/protect neural cell in the neuro-degenerative disease
miR-200c, miR-29a and miR-17upregulatedPTPN11/IGF-1/PIK3R1Enhance sensory and neural cell survival and differentiation
miR-124downregulatedDicer1Maintain normal neuronal functions and normal audition
miR-376downregulatedphosphoribosyl pyrophosphate synthetase 1 (PRPS1)Regulate the development of the ganglia and sensory epithelia in the embryonic inner ear; keep normal function of spiral ganglion neurons and cells in the cochlear
downregulatedSlc12a2/Cldn12/BdnfRegulate and control inner ear tissue differentiation and maintenance
miR-181adownregulatedP27Result in the production of new hair cells, and play an important role in auditory hair cell proliferation and regeneration
miR-29bupregulatedSIRT1/PGC-1αInduce cochlear hair cell apoptosis
Table1  the miRNAs involved in regulating age-related hearing loss.
[1] Octavia Y, Brunner-La Rocca HP, Moens AL (2012). NADPH oxidase-dependent oxidative stress in the failing heart: From pathogenic roles to therapeutic approach. Free Radic Biol Med, 52: 291-297
[2] Seidman MD, Ahmad N, Bai U (2002). Molecular mechanisms of age-related hearing loss. Ageing Res Rev, 1: 331-343
[3] Seidman MD, Ahmad N, Joshi D, Seidman J, Thawani S, Quirk WS (2004). Age-related hearing loss and its association with reactive oxygen species and mitochondrial DNA damage. Acta oto-laryngologica. Supplementum: 16-24
[4] Mazelova J, Popelar J, Syka J (2003). Auditory function in presbycusis: peripheral vs. central changes. Exp Gerontol, 38: 87-94
[5] Gates GA, Mills JH (2005). Presbycusis. Lancet, 366: 1111-1120
[6] Perez P, Bao J (2011). Why do hair cells and spiral ganglion neurons in the cochlea die during aging? Aging Dis, 2(3):231-41
[7] Fetoni AR, Picciotti PM, Paludetti G, Troiani D (2011). Pathogenesis of presbycusis in animal models: a review. Exp Gerontol, 46: 413-425
[8] Tavanai E, Mohammadkhani G (2016). Role of antioxidants in prevention of age-related hearing loss: a review of literature. Eur Arch Otorhinolaryngol, in press.
[9] Chen H, Tang J (2014). The role of mitochondria in age-related hearing loss. Biogerontology, 15: 13-19
[10] Lee RC, Feinbaum RL, Ambros V (1993). The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell, 75: 843-854
[11] Ushakov K, Rudnicki A, Avraham KB (2013). MicroRNAs in sensorineural diseases of the ear. Front Mol Neurosci, 6: 52
[12] Wienholds E, Kloosterman WP, Miska E, Alvarez-Saavedra E, Berezikov E, de Bruijn E,et al (2005). MicroRNA expression in zebrafish embryonic development. Science, 309: 310-311
[13] Kozomara A, Griffiths-Jones S (2011). miRBase: integrating microRNA annotation and deep-sequencing data. Nucleic Acids Res, 39: D152-157
[14] Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM (2003). bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell, 113: 25-36
[15] Zhang Q, Liu H, McGee J, Walsh EJ, Soukup GA, He DZ (2013). Identifying microRNAs involved in degeneration of the organ of corti during age-related hearing loss. PLoS One, 8: e62786
[16] Tsonis PA, Call MK, Grogg MW, Sartor MA, Taylor RR, Forge A,et al (2007). MicroRNAs and regeneration: Let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt. Biochem Biophys Res Commun, 362: 940-945
[17] Weston MD, Pierce ML, Rocha-Sanchez S, Beisel KW, Soukup GA (2006). MicroRNA gene expression in the mouse inner ear. Brain Res, 1111: 95-104
[18] Friedman LM, Avraham KB (2009). MicroRNAs and epigenetic regulation in the mammalian inner ear: implications for deafness. Mamm Genome, 20: 581-603
[19] Zhang Q, Liu H, Soukup GA, He DZ (2014). Identifying microRNAs involved in aging of the lateral wall of the cochlear duct. PLoS One, 9: e112857
[20] Frucht CS, Santos-Sacchi J, Navaratnam DS (2011). MicroRNA181a plays a key role in hair cell regeneration in the avian auditory epithelium. Neurosci Lett, 493: 44-48
[21] Hermeking H (2010). The miR-34 family in cancer and apoptosis. Cell Death Differ, 17: 193-199
[22] Karali M, Peluso I, Marigo V, Banfi S (2007). Identification and characterization of microRNAs expressed in the mouse eye. Invest Ophthalmol Vis Sci, 48: 509-515
[23] Xu S, Witmer PD, Lumayag S, Kovacs B, Valle D (2007). MicroRNA (miRNA) transcriptome of mouse retina and identification of a sensory organ-specific miRNA cluster. J Biol Chem, 282: 25053-25066
[24] Sacheli R, Nguyen L, Borgs L, Vandenbosch R, Bodson M, Lefebvre P,et al (2009). Expression patterns of miR-96, miR-182 and miR-183 in the development inner ear. Gene Expr Patterns, 9: 364-370
[25] Lewis MA, Quint E, Glazier AM, Fuchs H, De Angelis MH, Langford C,et al (2009). An ENU-induced mutation of miR-96 associated with progressive hearing loss in mice. Nat Genet, 41: 614-618
[26] Mencia A, Modamio-Hoybjor S, Redshaw N, Morin M, Mayo-Merino F, Olavarrieta L,et al (2009). Mutations in the seed region of human miR-96 are responsible for nonsyndromic progressive hearing loss. Nat Genet, 41: 609-613
[27] Goodyear RJ, Legan PK, Wright MB, Marcotti W, Oganesian A, Coats SA,et al (2003). A receptor-like inositol lipid phosphatase is required for the maturation of developing cochlear hair bundles. J Neurosci, 23: 9208-9219
[28] Liu XZ, Ouyang XM, Xia XJ, Zheng J, Pandya A, Li F,et al (2003). Prestin, a cochlear motor protein, is defective in non-syndromic hearing loss. Hum Mol Genet, 12: 1155-1162
[29] Liberman MC, Gao J, He DZ, Wu X, Jia S, Zuo J (2002). Prestin is required for electromotility of the outer hair cell and for the cochlear amplifier. Nature, 419: 300-304
[30] Wallis D, Hamblen M, Zhou Y, Venken KJ, Schumacher A, Grimes HL,et al (2003). The zinc finger transcription factor Gfi1, implicated in lymphomagenesis, is required for inner ear hair cell differentiation and survival. Development, 130: 221-232
[31] Sakaguchi N, Henzl MT, Thalmann I, Thalmann R, Schulte BA (1998). Oncomodulin is expressed exclusively by outer hair cells in the organ of Corti. J Histochem Cytochem, 46: 29-40
[32] Zhu Y, Zong L, Mei L, Zhao HB (2015). Connexin26 gap junction mediates miRNA intercellular genetic communication in the cochlea and is required for inner ear development. Sci Rep, 5: 15647
[33] Solda G, Robusto M, Primignani P, Castorina P, Benzoni E, Cesarani A,et al (2012). A novel mutation within the MIR96 gene causes non-syndromic inherited hearing loss in an Italian family by altering pre-miRNA processing. Hum Mol Genet, 21: 577-585
[34] Liu N, Landreh M, Cao K, Abe M, Hendriks GJ, Kennerdell JR,et al (2012). The microRNA miR-34 modulates ageing and neurodegeneration in Drosophila. Nature, 482: 519-523
[35] Maes OC, Sarojini H, Wang E (2009). Stepwise up-regulation of microRNA expression levels from replicating to reversible and irreversible growth arrest states in WI-38 human fibroblasts. J Cell Physiol, 221: 109-119
[36] Li N, Bates DJ, An J, Terry DA, Wang E (2011). Up-regulation of key microRNAs, and inverse down-regulation of their predicted oxidative phosphorylation target genes, during aging in mouse brain. Neurobiol Aging, 32: 944-955
[37] Ibanez-Ventoso C, Yang M, Guo S, Robins H, Padgett RW, Driscoll M (2006). Modulated microRNA expression during adult lifespan in Caenorhabditis elegans. Aging Cell, 5: 235-246
[38] Christoffersen NR, Shalgi R, Frankel LB, Leucci E, Lees M, Klausen M,et al (2010). p53-independent upregulation of miR-34a during oncogene-induced senescence represses MYC. Cell Death Differ, 17: 236-245
[39] Huang C, Xiong C, Kornfeld K (2004). Measurements of age-related changes of physiological processes that predict lifespan of Caenorhabditis elegans. Proc Natl Acad Sci U S A, 101: 8084-8089
[40] Yang J, Chen D, He Y, Melendez A, Feng Z, Hong Q,et al (2013). MiR-34 modulates Caenorhabditis elegans lifespan via repressing the autophagy gene atg9. Age (Dordr), 35: 11-22
[41] Salminen A, Kaarniranta K (2009). SIRT1: regulation of longevity via autophagy. Cell Signal, 21: 1356-1360
[42] Hansen M, Chandra A, Mitic LL, Onken B, Driscoll M, Kenyon C (2008). A role for autophagy in the extension of lifespan by dietary restriction in C. elegans. PLoS Genet, 4: e24
[43] Yamakuchi M, Ferlito M, Lowenstein CJ (2008). miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A, 105: 13421-13426
[44] Kuma A, Matsui M, Mizushima N (2007). LC3, an autophagosome marker, can be incorporated into protein aggregates independent of autophagy: caution in the interpretation of LC3 localization. Autophagy, 3: 323-328
[45] Yamamoto H, Kakuta S, Watanabe TM, Kitamura A, Sekito T, Kondo-Kakuta C,et al (2012). Atg9 vesicles are an important membrane source during early steps of autophagosome formation. J Cell Biol, 198: 219-233
[46] Pang J, Xiong H, Yang H, Ou Y, Xu Y, Huang Q,et al (2016). Circulating miR-34a levels correlate with age-related hearing loss in mice and humans. Exp Gerontol, 76: 58-67
[47] Xiong H, Pang J, Yang H, Dai M, Liu Y, Ou Y,et al (2015). Activation of miR-34a/SIRT1/p53 signaling contributes to cochlear hair cell apoptosis: implications for age-related hearing loss. Neurobiol Aging, 36: 1692-1701
[48] Corney DC, Flesken-Nikitin A, Godwin AK, Wang W, Nikitin AY (2007). MicroRNA-34b and MicroRNA-34c are targets of p53 and cooperate in control of cell proliferation and adhesion-independent growth. Cancer Res, 67: 8433-8438
[49] Chang TC, Wentzel EA, Kent OA, Ramachandran K, Mullendore M, Lee KH,et al (2007). Transactivation of miR-34a by p53 broadly influences gene expression and promotes apoptosis. Mol Cell, 26: 745-752
[50] Bommer GT, Gerin I, Feng Y, Kaczorowski AJ, Kuick R, Love RE,et al (2007). p53-mediated activation of miRNA34 candidate tumor-suppressor genes. Curr Biol, 17: 1298-1307
[51] Simon AF, Shih C, Mack A, Benzer S (2003). Steroid control of longevity in Drosophila melanogaster. Science, 299: 1407-1410
[52] Aw S, Cohen SM (2012). Time is of the essence: microRNAs and age-associated neurodegeneration. Cell Res, 22: 1218-1220
[53] Morimoto RI (2008). Proteotoxic stress and inducible chaperone networks in neurodegenerative disease and aging. Genes Dev, 22: 1427-1438
[54] Jiang H, Talaska AE, Schacht J, Sha SH (2007). Oxidative imbalance in the aging inner ear. Neurobiol Aging, 28: 1605-1612
[55] Sha SH, Chen FQ, Schacht J (2009). Activation of cell death pathways in the inner ear of the aging CBA/J mouse. Hear Res, 254: 92-99
[56] Guthrie OW (2008). Aminoglycoside induced ototoxicity. Toxicology, 249: 91-96
[57] Wang Z, Liu Y, Han N, Chen X, Yu W, Zhang W,et al (2010). Profiles of oxidative stress-related microRNA and mRNA expression in auditory cells. Brain Res, 1346: 14-25
[58] Sanchez-Calderon H, Rodriguez-de la Rosa L, Milo M, Pichel JG, Holley M, Varela-Nieto I (2010). RNA microarray analysis in prenatal mouse cochlea reveals novel IGF-I target genes: implication of MEF2 and FOXM1 transcription factors. PLoS One, 5: e8699
[59] Kersigo J, D'Angelo A, Gray BD, Soukup GA, Fritzsch B (2011). The role of sensory organs and the forebrain for the development of the craniofacial shape as revealed by Foxg1-cre-mediated microRNA loss. Genesis, 49: 326-341
[60] Friedman LM, Dror AA, Mor E, Tenne T, Toren G, Satoh T,et al (2009). MicroRNAs are essential for development and function of inner ear hair cells in vertebrates. Proc Natl Acad Sci U S A, 106: 7915-7920
[61] Yan D, Xing Y, Ouyang X, Zhu J, Chen ZY, Lang H,et al (2012). Analysis of miR-376 RNA cluster members in the mouse inner ear. Int J Exp Pathol, 93: 450-457
[62] Palakodeti D, Smielewska M, Graveley BR (2006). MicroRNAs from the Planarian Schmidtea mediterranea: a model system for stem cell biology. RNA, 12: 1640-1649
[63] Taylor RR, Forge A (2005). Hair cell regeneration in sensory epithelia from the inner ear of a urodele amphibian. J Comp Neurol, 484: 105-120
[64] Stone JS, Cotanche DA (2007). Hair cell regeneration in the avian auditory epithelium. Int J Dev Biol, 51: 633-647
[65] Warchol ME, Corwin JT (1996). Regenerative proliferation in organ cultures of the avian cochlea: identification of the initial progenitors and determination of the latency of the proliferative response. J Neurosci, 16: 5466-5477
[66] Lee KH, Cotanche DA (1996). Localization of the hair-cell-specific protein fimbrin during regeneration in the chicken cochlea. Audiol Neurootol, 1: 41-53
[67] Saunders SS, Salvi RJ (1995). Pure tone masking patterns in adult chickens before and after recovery from acoustic trauma. J Acoust Soc Am, 98: 1365-1371
[68] Gale JE, Meyers JR, Periasamy A, Corwin JT (2002). Survival of bundleless hair cells and subsequent bundle replacement in the bullfrog's saccule. J Neurobiol, 50: 81-92
[69] Navaratnam DS, Su HS, Scott SP, Oberholtzer JC (1996). Proliferation in the auditory receptor epithelium mediated by a cyclic AMP-dependent signaling pathway. Nat Med, 2: 1136-1139
[70] Montcouquiol M, Corwin JT (2001). Brief treatments with forskolin enhance s-phase entry in balance epithelia from the ears of rats. J Neurosci, 21: 974-982
[71] Wang X, Gocek E, Liu CG, Studzinski GP (2009). MicroRNAs181 regulate the expression of p27Kip1 in human myeloid leukemia cells induced to differentiate by 1,25-dihydroxyvitamin D3. Cell Cycle, 8: 736-741
[72] Lowenheim H, Furness DN, Kil J, Zinn C, Gultig K, Fero ML,et al (1999). Gene disruption of p27(Kip1) allows cell proliferation in the postnatal and adult organ of corti. Proc Natl Acad Sci U S A, 96: 4084-4088
[73] Frucht CS, Uduman M, Duke JL, Kleinstein SH, Santos-Sacchi J, Navaratnam DS (2010). Gene expression analysis of forskolin treated basilar papillae identifies microRNA181a as a mediator of proliferation. PLoS One, 5: e11502
[74] Xue T, Wei L, Zha DJ, Qiu JH, Chen FQ, Qiao L,et al (2016). miR-29b overexpression induces cochlear hair cell apoptosis through the regulation of SIRT1/PGC-1alpha signaling: Implications for age-related hearing loss. Int J Mol Med
[75] Falah M, Najafi M, Houshmand M, Farhadi M (2016). Expression levels of the BAK1 and BCL2 genes highlight the role of apoptosis in age-related hearing impairment. Clinical interventions in aging, 11: 1003-1008
[76] Dong Y, Li M, Liu P, Song H, Zhao Y, Shi J (2014). Genes involved in immunity and apoptosis are associated with human presbycusis based on microarray analysis. Acta oto-laryngologica, 134: 601-608
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