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Aging and Disease    2018, Vol. 9 Issue (1) : 133-142     DOI: 10.14336/AD.2017.0119
Review |
MicroRNAs and Presbycusis
Weiming Hu1,Junwu Wu2,3,Wenjing Jiang1,Jianguo Tang3,*
1Department of Otolaryngology-Head and Neck Surgery, Zhejiang Provincial People’s Hospital, People’s Hospital of Hangzhou Medical College, Hangzhou 310014, China
2Department of Otolaryngology-Head and Neck Surgery, Yiwu traditional Chinese Medicine Hospital, Yiwu 322000, China
3Department of Otolaryngology-Head and Neck Surgery, Sir Run Run Shaw Hospital, Medical College of Zhejiang University, Hangzhou 310016, China.
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Abstract  

Presbycusis (age-related hearing loss) is the most universal sensory degenerative disease in elderly people caused by the degeneration of cochlear cells. Non-coding microRNAs (miRNAs) play a fundamental role in gene regulation in almost every multicellular organism, and control the aging processes. It has been identified that various miRNAs are up- or down-regulated during mammalian aging processes in tissue-specific manners. Most miRNAs bind to specific sites on their target messenger-RNAs (mRNAs) and decrease their expression. Germline mutation may lead to dysregulation of potential miRNAs expression, causing progressive hair cell degeneration and age-related hearing loss. Therapeutic innovations could emerge from a better understanding of diverse function of miRNAs in presbycusis. This review summarizes the relationship between miRNAs and presbycusis, and presents novel miRNAs-targeted strategies against presbycusis.

Keywords presbycusis      microRNAs      target gene      progressive hair cell degeneration      aging     
Corresponding Authors: Jianguo Tang   
Issue Date: 01 February 2018
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Weiming Hu
Junwu Wu
Wenjing Jiang
Jianguo Tang
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Weiming Hu,Junwu Wu,Wenjing Jiang, et al. MicroRNAs and Presbycusis[J]. A&D, 2018, 9(1): 133-142.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0119     OR     http://www.aginganddisease.org/EN/Y2018/V9/I1/133
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