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Aging and disease    2017, Vol. 8 Issue (6) : 691-707     DOI: 10.14336/AD.2017.0410
Review |
Emerging Roles of Ganoderma Lucidum in Anti-Aging
Wang Jue1,2, Cao Bin1, Zhao Haiping2,*, Feng Juan1,*
1Department of Neurology, Shengjing Hospital, China Medical University, Shenyang, 110004, China
2Cerebrovascular Diseases Research Institute, Xuanwu Hospital of Capital Medical University, Beijing, 100053, China
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Ganoderma lucidum is a white-rot fungus that has been viewed as a traditional Chinese tonic for promoting health and longevity. It has been revealed that several extractions from Ganoderma lucidum, such as Ethanol extract, aqueous extract, mycelia extract, water soluble extract of the culture medium of Ganoderma lucidum mycelia, Ganodermasides A, B, C, D, and some bioactive components of Ganoderma lucidum, including Reishi Polysaccharide Fraction 3, Ganoderma lucidum polysaccharides I, II, III, IV, Ganoderma lucidum peptide, Ganoderma polysaccharide peptide, total G. lucidum triterpenes and Ganoderic acid C1 could exert lifespan elongation or related activities. Although the use of Ganoderma lucidum as an elixir has been around for thousands of years, studies revealing its effect of lifespan extension are only the tip of the iceberg. Besides which, the kinds of extractions or components being comfrimed to be anti-aging are too few compared with the large amounts of Ganoderma lucidum extractions or constituients being discovered. This review aims to lay the ground for fully elucidating the potential mechanisms of Ganoderma lucidum underlying anti-aging effect and its clinical application.

Keywords Ganoderma lucidum      anti-aging      antioxidant      immunomodulation      anti-neurodegeneration     
Corresponding Authors: Zhao Haiping,Feng Juan   
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These authors contributed equally to the development of manunscript.

Issue Date: 01 December 2017
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Wang Jue
Cao Bin
Zhao Haiping
Feng Juan
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Wang Jue,Cao Bin,Zhao Haiping, et al. Emerging Roles of Ganoderma Lucidum in Anti-Aging[J]. Aging and disease, 2017, 8(6): 691-707.
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Ethanol extract of Ganoderma lucidum (EGL)Fruit bodyLifespan elongation activityInhibit ROS production, lipid peroxidation, advanced oxidation protein products;
Increase production of mitochondrial electron transport complexes, Mn-SOD, CAT, GSH and GSH-Px, DPPH and ABTS radical scavenger activities and FRAP
[20-24, 26]
Immunomodulatory effectIncrease expressions of TLR4 and MyD88[28]
Antioxidant activityIncrease expression and phosphorylation of Nrf2 to induce the upregulation of HO-1[29, 34]
Ganoderma lucidum aqueous extract (GLA)Fruit bodyAntioxidant activityIncrease radical scavenging activity and ferric reducing antioxidant power[38]
Anti-neurodegenerationInhibit synaptophysin transportation, JNK and p38 signaling pathway to antagonize neuronal apoptosis[39]
Ganoderma lucidum mycelia extractMyceliaNeuronal differentiation promoting effectInduce Erk1/2 and CREB phosphorylation
Increase the secretion of non-amyloidogenic protein secretion (sAPPα) and expression of the amyloid precursor protein (APP)
[40, 41, 43]
Water soluble extract of the culture medium of Ganoderma lucidum mycelia (MAK)MyceliaAntioxidant activityInhibit lipid peroxidation and ROS production
Increase SOD, CAT and GSH productions
Ganodermasides A, B, C and DSporesLifespan elongation activityIncrease expression of Skn7 to induce production of UTH1[50]
Table 1  The origin, function and mechanisms of Ganoderma lucidum extracts in anti-aging or anti-aging related effects.
Figure 1.  The structure of Ganodermasides

A, B, C and D. 1 represents A, 2 represents B, 3 represents C, 4 represents D; 1: R1=H, R2=OH, R3=H; 2: R1=H, R2=H, R3=OH; 3: R1=OH, R2, R3=O; 4: R1=OH, R2=H, R3=H.

SampleCompositionMolar ratio
GLPIAra, Rha, Xyl, Man, Glu4.66: 1.23: 3.14: 0.61: 1.29
GLPIIAra, Xyl, Glu2.82: 1.33: 0.87
GLPIIIAra, Rha, Xyl, Gal, Man, Glu5.09: 0.52: 1.07: 1.29: 0.48: 2.76
GLPIVAra, Rha, Fuc, Xyl, Man, Glu4.73: 0.65: 0.72: 2.27: 0.52: 0.92
Table 2  Monosaccharide composition of GLPI, GLPII, GLPIII and GLPIV.
FunctionMechanismBioactive componentsOriginReferences
Lifespan extensionBinding to TIR-1 and activating the rab-1/pmk-1 signaling pathway to induce the expression of DAF-2RF3Fruit body[61]
Antioxidant activityIncrease hydroxyl and DPPH radical scavenging activities as well as metal chelating activityG. lucidum polysaccharides I, II, III, IVMycelia[64-66]
Increase scavenging of hydroxyl radicals, reactions with free oxygen species or ROOH and increase metal chelating activityGLPFruit body[67, 69]
Increase the production of NADPH, SOD, Mn-SOD, CAT, GSH and GSH-Px; protect the mitochondria in macrophages against t-BOOH induced injury; increase the oxidation of LDLGLPPFruit body[70-72]
Induce the productions of SOD, CAT, GPx and GSH and inhibit protein and lipid peroxidationTotal G. lucidum triterpenesFruit body[73]
Immunomodulatory effectIncrease the production of IL-1, IL-2 and IFN-γ; increase the numbers of CD14+CD26+ monocyte/macrophage, CD83+CD1a+ dendritic cells and CD16+CD56+ NK cells; increase the cytotoxicity of CD56+ NK cellsRF3Fruit body[74, 75]
Increase the proliferation of macrophages and their activation through increase in the production of NOG. lucidum polysaccharides I, II, III, IVMycelia[64]
Activate NF-κB pathway to decrease the production of IL-8 and MCP-1GLPPFruit body[76]
Inhibit the production of TNF-a, INF-γ and the secretion of IL-17aGAC1Fruit body[59, 77]
Promotion of stem/progenitor cell survivalIncrease the expression of CAM, IL-1, MCP-1, MIP-1, RANTES; Increase the secretion of BMP-2, IL-11 and aggrecan; Boost TPO- and GM-CSF-like functionsRF3Fruit body[81]
Table 3  Function, mechanism and origin of bioactive components of Ganoderma lucidum with anti-aging or anti-aging related properties.
Figure 2.  The structure of Reishi Polysaccharide fraction 3 (RF3) with different glycol backbone

A) The structure of RF3 with β-glucan backbone. B) The structure of RF3 with α-mannan backbone.

Figure 3.  The structure of Ganoderic acid C1 (GAC1).
Bioactive componentsOriginFunctionMechanismRefs.
Aqueous extracts of G lucidum and G. neo-japonicumFruit bodies of G lucidum and G. neo-japonicumNeuroprotectionPromote neuritogenesis through the MEK/ERK1/2 and PI3K/Akt signaling pathways[82, 83]
Methanolic extract of G. lucidum, G. lucidum antler and G. tsugaeFruit bodies of G. lucidum, G. lucidum antler and G. tsugaeAntioxidant activityStrong DPPH scavenging effect and ferrous ion chelating activity[84]
G. atrum polysaccharide (PSG-1)Fruit body of G. atrumLifespan extensionDecrease oxidative stress in aged mice; Relieve immune dysfunction through upregulation of serum IL-2 level and increasing lymphocyte proliferation[86, 87]
Antioxidant activityIncrease the production of SOD, CAT, GSH and GPx; decrease the level of MDA and ROS[92, 93, 94]
ImmunomodulationInduce production of IL-2 and increase activation of spleen lymphocytes through Ca2+/calcineurin/nuclear factor of activated T cells (NFAT) pathway or protein kinase C (PKC)/NFAT pathway; Induce the release of TNF-α during macrophage activation through the TLR4/ROS/PI3K/Akt/MAPKs/NF-κB pathway[95, 96, 97]
Polysaccharide from submerged fermentation culturing mycelium powder of G. capenseCulturing mycelium powder of G. capensePromotion of neuronal differentiationStrong 1-diphenyl-2-picryl-hydrazyl (DPPH•) and hydroxyl radical-scavenging abilities[99, 100]
Anti-glycation activityInhibit the formation of advanced glycation end products[101]
Table 4  The origin, function and mechanisms of extractions or bioactive components from other Ganoderma species exerting potential anti-aging effects.
Figure 4.  The structures of polysaccharides from submerged fermentation culturing mycelium powder of Ganoderma capense (GCPB-1b and GCPB-2)

A) The chemical structure of GCPB-1b. B) The chemical structure of GCPB-2.

[1] Yun TK (1999). Asian studies on cancer chemoprevention. Ann N Y Acad Sci, 889, 157-192.
[2] Mau JL, Lin HC, Chen CC (2002). Antioxidant properties of several medicinal mushrooms. J Agric Food Chem, 50: 6072-7.
[3] Boh B, Berovic M, Zhang J, Zhi-Bin L (2007). Ganoderma lucidum and its pharmaceutically active compounds. Biotechnol Annu Rev, 13: 265-301.
[4] Harman D (1992). Free radical theory of ageing. Mutat Res, 275: 257-66.
[5] Kayali R, Cakatay U, Akcay T, Altug T (2006). Effect of alpha-lipoic acid supplementation on markers of protein oxidation in post-mitotic tissues of ageing rat. Cell Biochem Funct, 24: 79-85.
[6] Suh JH, Shigeno ET, Morrow JD, Cox B, Rocha AE, Frei B, et al. (2001). Oxidative stress in the aging rat heart is reversed by dietary supplementation with (R)-(alpha)-lipoic acid. FASEB J, 15: 700-6.
[7] Muscari C, Giaccari A, Giorano E, Clo C, Guarnieri C, Caldarera CM (1996). Role of reactive oxygen species in cardiovascular ageing. Mol Cell Biochem, 160-161:159-66.
[8] Trushina E, McMurray CT (2007). Oxidative stress and mitochondrial dysfunction in neurodegenerative diseases. Neurosci, 145: 1223-48.
[9] Vulevic J, Drakoularakou A, Yaqoob P, Tzortzis G, Gibson GR (2008). Modulation of the fecal microflora profile and immune function by a novel trans-galactooligosaccharide mixture (B-GOS) in healthy elderly volunteers. Am J Clin Nutr, 88: 1438-46.
[10] Keller JN (2006). Age-related neuropathology, cognitive decline, and Alzheimer's disease. Ageing Res Rev, 5: 1-13.
[12] Butterfield DA, Howard B, Yatin S, Koppal T, Drake J, Hensley K, et al. (1999). Elevated oxidative stress in models of normal brain aging and Alzheimer's disease. Life Sci, 65:1883-92.
[13] Wang W, Li S, Dong HP, Lv S, Tang YY (2009). Differential impairment of spatial and nonspatial cognition in a mouse model of brain aging. Life Sci, 85:127-35.
[14] Lavrik IN, Eils R, Fricker N, Pforr C, Krammer PH (2009). Understanding apoptosis by systems biology approaches. Mol Biosyst, 5:1105-11.
[15] Jang KJ, Han MH, Lee BH, Kim BW, Kim CH, Yoon HM, et al. (2010). Induction of apoptosis by ethanol extracts of Ganoderma lucidum in human gastric carcinoma cells. J Acupunct Meridian Stud, 3: 24-31.
[16] Jouihan HA, Cobine PA, Cooksey RC, Hoagland EA, Boudina S, Abel ED, et al (2008). Iron-mediated inhibition of mitochondrial manganese uptake mediates mitochondrial dysfunction in a mouse model of hemochromatosis. Mol Med, 14: 98-108.
[17] Sitte N, Merker K, Von ZT, Davies KJ, Grune T (2004). Protein oxidation and degeneration during cellular senescence of human BJ fibroblast: partII-aging of non- dividing cells. FASEB J, 14:503-10.
[18] Cortopassi GA, Shibata D, Soong NW, Arnheim N (1992). A pattern of accumulation of a somatic deletion of mitochondrial DNA in aging human tissues. Proc Natl Acad Sci USA, 89:7370-4.
[19] Sudheesh NP, Ajith TA, Ramnath V, Janardhanan KK (2010). Therapeutic potential of Ganoderma lucidum (Fr.) P. Karst. against the declined antioxidant status in the mitochondria of post-mitotic tissues of aged mice. Clin Nutr, 29: 406-12.
[20] Dringen R, Gutterer JM, Hirrlinger J (2000). Glutathione metabolism in brain metabolic interaction between astrocytes and neurons in the defense against reactive oxygen species. Eur J Biochem, 267:4912-6.
[21] Yu PB (1994). Cellular defenses against damage from reactive oxygen species. Physiol Rev, 74:134-62.
[22] Alderman CJ, Shah S, Foreman JC, Chain BM, Katz DR (2002). The role of advanced oxidation protein products in regulation of dendritic cell function. Free Radic Biol Med, 32: 377-85.
[23] Cakatay U, Kayali R, Sivas A, Tekeli F (2005). Prooxidant activities of alpha-lipoicacid on oxidative protein damage in the aging rat heart muscle. Arch Gerontol Geriatr, 40: 231-40.
[24] Savitha S, Panneerselvam C (2006). Carnitine and lipoic acid alleviates protein oxidation in heart mitochondria during aging process. Biogerontology, 7: 101-9.
[25] Ajith TA, Sudheesh NP, Roshny D, Abishek G, Janardhanan KK (2009). Effect of Ganoderma lucidum on the activities of mitochondrial dehydrogenases and complex I and II of electron transport chain in the brain of aged rats. Exp Gerontol, 44: 219-23.
[26] Sudheesh NP, Ajith TA, Janardhanan KK (2009). Ganoderma lucidum (Fr.) P. Karst enhances activities of heart mitochondrial enzymes and respiratory chain complexes in the aged rat. Biogerontology, 10: 627-36.
[27] Giovannini MG, Scali C, Prosperi C, Bellucci A, Pepeu G, Casamenti G (2003). Experimental brain inflammation and neurodegeneration as model of Alzheimer's disease: protective effects of selective COX-2 inhibitors. Int J Immunopathol Pharmacol, 16: 31-40.
[28] Yoon HM1, Jang KJ, Han MS, Jeong JW, Kim GY, Lee JH, et al. (2013). Ganoderma lucidum ethanol extract inhibits the inflammatory response by suppressing the NF-κB and toll-like receptor pathways in lipopolysaccharide stimulated BV2 microglial cells. Exp Ther Med, 5: 957-63.
[29] Sakata Y, Zhuang H, Kwansa H, Koehler RC, Dore S (2010). Resveratrol protects against experimental stroke: putative neuroprotective role of heme oxygenase 1. Exp Neurol, 224:325-9.
[30] Zhang Y, Gordon GB (2004). A strategy for cancer prevention: stimulation of the Nrf2-ARE signaling pathway. Mol Cancer Ther, 3: 885-93.
[31] Ishii T, Itoh K, Takahashi S, Sato H, Yanagawa T, Katoh Y, et al. (2000). Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages. J Biol Chem, 275: 16023-9.
[32] Katori M, Anselmo DM, Busuttil RW, Kupiec-Weglinski JW (2009). A novel strategy against ischemia and reperfusion injury: cytoprotection with heme oxygenase system. Transpl Immunol, 9: 227-33.
[33] Scapagnini G, Butterfield DA, Colombrita C, Sultana R, Pascale A, Calabrese V (2004). Ethyl ferulate, a lipophilic polyphenol, induces HO-1 and protects rat neurons against oxidative stress. Antioxid Redox Signal, 6: 811-8.
[34] Lee YH, Kim JH, Song CH, et al. (2016). Ethanol extract of Ganoderma lucidum augments ceiilular antioxidant defense through activation of Nrf2/HO-1. J Pharmacopuncture, 19: 59-69.
[35] Oluba OM, Olusola AO, Fagbohunka BS, Onyeneke E (2012). Antimalarial and hepatoprotective effects of crude ethanolic extract of Lingzhi or Reishimedicinal mushroom, Ganoderma lucidum (W. Curt.: Fr.) P. Karst. (higher Basidiomycetes), in Plasmodium berghei-infected mice. Int J Med Mushrooms, 14: 459-66.
[36] Liu YW, Gao JL, Guan J, Qian ZM, Feng K, Li SP (2009). Evaluation of antiproliferative activities and action mechanisms of extracts from two species of Ganoderma on tumor cell lines. J Agric Food Chem, 57: 3087-93.
[37] Fang X, Chang RCC, Yuen WH, Zee SY (2005). Immune modulatory effects of Prunella vulgaris L. Int J Mol Med, 15: 491-6.
[38] Rani P, Lal MR, Maheshwari U, Krishnan S (2015). Antioxidant Potential of Lingzhi or Reishi Medicinal Mushroom, Ganoderma lucidum (Higher Basidiomycetes) Cultivated on Artocarpus heterophyllus Sawdust Substrate in India. Int J Med Mushrooms, 17: 1171-7.
[39] Lai CS, Yu MS, Yuen WH, So KF, Zee SY, Chang RC (2008). Antagonizing beta-amyloid peptide neurotoxicity of the anti-aging fungus Ganoderma lucidum. Brain Res, 1190: 215-24.
[40] Phan CW, David P, Naidu M, Wong KH, Sabaratnam V (2015). Therapeutic potential of culinary-medicinal mushrooms for the management of neurodegenerative diseases: diversity, metabolite, and mechanism. Crit Rev Biotechnol, 35: 355-68.
[41] Cheung WM, Hui WS, Chu PW, Chiu SW, Ip NY (2000). Ganoderma extract activates MAP kinases and induces the neuronal differentiation of rat pheochromocytoma PC12 cells. FEBS Lett, 486: 291-6.
[42] Mayford M, Kandel ER (1999). Genetic approaches to memory storage. Trends Genet, 15: 463-70.
[43] Pinweha S, Wanikiat P, Sanvarinda Y, Supavilai P (2008).The signaling cascades of Ganoderma Lucidum extracts in stimulating non-amyloidegenic protein secretion in human neuroblastoma SH-SY5Y cell lines. Neurosci Lett, 448: 62-6.
[44] Loffler J, Huber G (1992). Beta-amyloid precursor protein isoforms in various rat brain regions and during brain development. J Neurochem, 59: 1316-24.
[45] Chen CW, Boiteau RM, Lai WF, Barger SW, Cataldo AM (2006). sAPP enhances the transdifferentiation of adult bone marrowprogenitor cells to neuronal phenotypes. Curr Alzheimer Res, 3: 63-70.
[46] Matsuzaki H, Shimizu Y, Iwata N, Kamiuchi S, Suzuki F, Iizuka H, et al. (2013). Antidepressant-like effects of a water-soluble extract from the culture medium of Ganodermalucidum mycelia in rats. BMC Complement Altern Med, 13: 370.
[47] Okazaki M, Tanaka A, Hatta Y, Kawahara Y, Kamiuchi S, Iwata N, et al. (2008). Antioxidant properties of a water-soluble extract from culture medium of Ganoderma lucidum (Rei-shi) mycelia and antidiabetic effects in streptozotocin-treated mice. Jpn J Compl Altern Med, 5: 209-18.
[48] Iwata N, Okazaki M, Kasahara C, Kamiuchi S, Suzuki F, Iizuka H, et al. (2008). Protective effects of a water-soluble extract from culture medium of Ganoderma lucidum mycelia against neuronal damage after cerebral ischemia/reperfusion in diabetic rats. J Jpn Soc Nutr Food Sci, 61:119-27.
[49] Okazaki M, Iwata N, Horiuchi S, Kamiuchi S, Suzuki F, Iizuka H, et al. (2008). Protective effects of a water-soluble extract from culture medium of Ganoderma lucidum mycelia against neuronal damage after hypoxia-ischemia in mice. Jpn J Compl Altern Med, 5: 153-62.
[50] Weng Y, Xiang L, Matsuura A, Zhang Y, Huang Q, Qi J (2009). Ganodermasides A and B, two novel anti-aging ergosterols from spores of a medicinal mushroom Ganoderma lucidum on yeast via UTH1 gene. Bioorg Med Chem, 18: 999-1002.
[51] Camougrand N, Kissová I, Velours G, Manon S (2004). Uth1p: a yeast mitochondrial protein at the crossroads of stress, degradation and cell death. FEMS Yeast Res, 5: 133-40.
[52] Sun J, He H, Xie BJ (2004). Novel antioxidant peptides from fermented mushroom Ganoderma lucidum. J Agric Food Chem, 52: 6646-52.
[53] Chen HS, Tsai YF, Lin S, Lin CC, Khoo KH, Lin CH, Wong CH (2004). Studies on the immuno-modulating and anti-tumor activities of Ganoderma lucidum (Reishi) polysaccharides. Bioorg Med Chem, 12: 5595-601.
[54] Lee BJ, Hendricks DG (1997). Antioxidant effects of L-carnosine on liposomes and beef homogenates. J Food Sci, 62: 931-34.
[55] Cao QZ, Lin ZB (2004). Antitumor and anti-angiogenic activity of Ganoderma lucidum polysaccharides peptide. Acta Pharmacol Sin, 25, 833-38.
[56] Wu GS, Lu JJ, Guo JJ, Li YB, Tan W, Dang YY, et al (2012). Ganoderic acid DM, a natural triterpenoid, induces DNA damage, G1 cell cycle arrest and apoptosis in human breast cancer cells. Fitoterapia, 83: 408-14.
[57] Que Z, Zou F, Zhang A, Zheng Y, Bi L, Zhong J, et al. (2014). Ganoderic acid Me induces Ganoderic acid Me induces the apoptosis of competent T cells and increases the proportion of Treg cells through enhancing the expression and activation of indoleamine 2,3-dioxygenase in mouse lewis lung cancer cells. Int Immunopharmacol. 23: 192-204.
[58] Liu RM, Li YB, Liang XF, Liu HZ, Xiao JH, Zhong JJ (2015). Structurally related ganoderic acids induce apoptosis in human cervical cancer HeLa cells: Involvement of oxidative stress and antioxidant protective system. Chem Biol Interact, 240:134-44.
[59] Liu C, Yang N, Song Y, Wang L, Zi J, Zhang S, et al (2015). Ganoderic acid C1 isolated from the anti-asthma formula, ASHMI™ suppresses TNF-α production by mouse macrophages and peripheral blood mononuclear cells from asthma patients. Int Immunopharmacol, 27: 224-31.
[60] Mylonakis E, Aballay A (2005). Worms and flies as genetically tractable animal models to study host-pathogen interactions. Infect Immun, 73: 3833-41.
[61] Chuang MH, Chiou SH, Huang CH, Yang WB, Wong CH (2009). The lifespan-promoting effect of acetic acid and Reishi polysaccharide. Bioorg Med Chem, 17: 7831-40.
[62] Yuan JF, Zhang ZQ, Fan ZC, Yang JX (2008). Antioxidant effects and cytotoxicity of three purified polysaccharides from Ligusticum chuanxiong Hort. Carbohydrate Polymers, 74: 822-7.
[63] Dean RT, Fu S, Stocker R, Davies MJ (1997). Biochemistry and pathology of radical-mediated protein oxidation. Biochem J, 324: 1-18.
[64] Shi M, Zhang Z, Yang Y (2013). Antioxidant and immunoregulatory activity of Ganoderma lucidum polysaccharide (GLP). Carbohydr Polym, 95: 200-6.
[65] Lei LS, Lin ZB (1993). Effects of Ganoderma polysaccharides on the activity of DNA polymerase alpha of splenocytes and immune function in aged mice. Yao Xue Xue Bao, 28: 577-82.
[66] Ershler WB, Moore AL, Roessner K, Ranges GE (1985). Interleukin-2 and aging: Decreased interleukin-2 production in healthy older people does not correlate with reduced helper cell numbers or antibody response to influenza vaccine and is not corrected in vitro by thymosin alpha 1. Immunopharmacology, 10:11-7.
[67] Thyagarajan A, Jiang J, Hopf A, Adamec J, Sliva D (2006). Inhibition of oxidative stress-induced invasiveness of cancer cells by Ganoderma lucidum is mediated through the suppression of interleukin-8 secretion. Int J Mol Med, 18: 657-64.
[68] Namiki M (1990). Antioxidants/antimutagens in foods. Crit ReV Food Sci Nutr, 29: 273-300.
[69] Sun J, He H, Xie BJ (2004). Novel antioxidant peptides from fermented mushroomGanoderma lucidum. J Agric Food Chem, 52: 6646-52.
[70] You YH, Lin ZB (2002). Protective effects of Ganoderma lucidum polysaccharides peptide on injury of macrophages induced by reactive oxygen species. Acta Pharmacol Sin, 23: 787-91.
[71] Zhong D, Wang H, Liu M, Li X, Huang M, Zhou H, et al (2015). Ganoderma lucidum polysaccharide peptide prevents renal ischemia reperfusion injury via counteracting oxidative stress. Sci Rep, 5: 16910.
[72] You YH, Lin ZB (2003). Antioxidant effect of Ganoderma polysaccharide peptide. Yao Xue Xue Bao, 38: 85-8.
[73] Smina TP, Joseph J, Janardhanan KK (2016). Ganoderma lucidum total triterpenes prevent γ-radiation induced oxidative stress in Swiss albino mice in vivo. Redox Rep, 5: 1-8.
[74] Wang YY, Khoo KH, Chen ST, Lin CC, Wong CH, Lin CH (2002). Studies on the immuno-modulating and antitumor activities of Ganoderma lucidum (Reishi) polysaccharides: functional and proteomic analyses of a fucose-containing glycoprotein fraction responsible for the activities. Bioorg Med Chem, 10:1057-62.
[75] Chien CM, Cheng JL, Chang WT, Tien MH, Tsao CM, Chang YH (2004). Polysaccharides of Ganoderma lucidum alter cell immunophenotypic expression and enhance CD56+ NK-cell cytotoxicity in cord blood. Bioorg Med Chem, 12: 5603-9.
[76] Loetscher P, Dewald B, Baggiolini M, Seitz M (1994). Monocyte chemoattractant protein 1 and interleukin 8 production by rheumatoid synoviocytes. Effects of anti-rheumatic drugs. Cytokine, 6: 162-70.
[77] Liu C, Dunkin D, Lai J, Song Y, Ceballos C, et al. (2015). Anti-inflammatory Effects of Ganoderma lucidum Triterpenoid in Human Crohn's Disease Associated with Downregulation of NF-κB Signaling. Inflamm Bowel Dis, 21: 1918-25.
[78] Brynskov J, Foegh P, Pedersen G, Ellervik C, Kirkegaard T, Bingham A, et al. (2002). Tumor necrosis factor alpha converting enzyme (TACE) activity in the colonic mucosa of patients with inflammatory bowel disease. Gut, 51: 37-43.
[79] Choy EH, Panayi GS (2001). Cytokine pathways and joint inflammation in rheumatoid arthritis. N Engl J Med, 344: 907-16.
[80] Brightling C, Berry M, Amrani Y (2008). Targeting TNF-alpha: a novel therapeutic approach for asthma. J Allergy Clin Immunol, 121: 5-10.
[81] Chen WY1, Yang WB, Wong CH, Shih DT (2010). Effect of Reishi polysaccharides on human stem/progenitor cell. Bioorg Med Chem, 18: 8583-91.
[82] Ling-Sing Seow S, Naidu M, David P, Wong KH, Sabaratnam V (2013). Potentiation of neuritogenic activity of medicinal mushrooms in rat pheochromocytoma cells. BMC Complement Altern Med, 13: 157.
[83] D’Ambrosi N, Cavaliere F, Merlo D, Milazzo L, Mercanti D, Volonte C (2000). Antagonists of P2 receptor prevent NGF-dependent neuritogenesis in PC12 cells. Neuropharmacology, 39:1083-94.
[84] Kanlaya R, Khamchun S, Kapincharanon C, Thongboonkerd V (2016). Protective effect of epigallocatechin-3-gallate (EGCG) via Nrf2 pathway against oxalate-induced epithelial mesenchymal transition (EMT) of renal tubular cells. Sci Rep, 6: 30233.
[85] Chen Y, Xie MY, Nie SP, Li C, Wang YX (2008). Purification, composition analysis and antioxidant activity of a polysaccharide from the fruiting bodies of Ganoderma atrum. Food Chem, 107:231-41.
[86] Li WJ, Nie SP, Peng XP, Liu XZ, Li C, Chen Y, et al (2012). Ganoderma atrum polysaccharide improves age-related oxidative stress and immune impairment in mice. J Agric Food Chem, 60: 1413-8.
[87] Li WJ, Nie SP, Xie MY, Yu Q, Chen Y, He M (2011). Ganoderma atrum polysaccharide attenuates oxidative stress induced by d-galactose in mousebrain. Life Sci, 88: 713-8.
[88] Hadi SM, Bhat SH, Azmi AS, Hanif S, Shamim U, Ullah MF (2007). Oxidative breakage of cellular DNA by plant polyphenols: a putative mechanism for anticancer properties. Semin. Cancer Biol, 17: 370-6.
[89] Arbogast S, Ferreiro A (2010). Selenoproteins and protection against oxidative stress: selenoprotein N as a novel player at the crossroads of redox signaling and calcium homeostasis. Antioxid Redox Signal, 2:893-904.
[90] Arranz L, De Castro NM, Baeza I, Maté I, Viveros MP, De la Fuente M (2010). Environmental enrichment improves age-related immune system impairment: long-term exposure since adulthood increases life span in mice. Rejuvenation Res, 13: 415-28.
[91] Ren Z, Pae M, Dao MC, Smith D, Meydani SN, Wu D (2010). Dietary supplementation with tocotrienols enhances immune function in C57BL/6 mice. J Nutr, 140: 1335-41.
[92] Li WJ, Nie SP, Yao YF, Liu XZ, Shao DY, Gong DM, et al. (2015). Ganoderma atrum Polysaccharide Ameliorates Hyperglycemia-Induced Endothelial Cell Death via a Mitochondria-ROS Pathway. J Agric Food Chem, 63: 8182-91.
[93] Zhu KX, Nie SP, Li C, Gong D, Xie MY (2014). Ganoderma atrum polysaccharide improves aortic relaxation in diabetic rats via PI3K/Akt pathway. Carbohydr Polym, 103: 520-7.
[94] Zhu KX, Nie SP, Tan LH, Li C, Gong DM, Xie MY (2016). A Polysaccharide from Ganoderma atrum Improves Liver Function in Type 2 Diabetic Rats via Antioxidant Action and Short-Chain Fatty Acids Excretion. J Agric Food Chem, 64: 1938-44.
[95] Yu Q, Nie SP, Wang JQ, Huang DF, Li WJ, Xie MY (2015). Signaling pathway involved in the immunomodulatory effect of Ganoderma atrum polysaccharide in spleen lymphocytes. J Agric Food Chem, 63: 2734-40.
[96] Yu Q, Nie SP, Wang JQ, Yin PF, Huang DF, Li WJ, et al (2014). Toll-like receptor 4-mediated ROS signaling pathway involved in Ganoderma atrumpolysaccharide-induced tumor necrosis factor-α secretion during macrophage activation. Food Chem Toxicol, 66: 14-22.
[97] Yu Q, Nie SP, Wang JQ, Huang DF, Li WJ, Xie MY (2015). Toll-like receptor 4 mediates the antitumor host response induced by Ganoderma atrumpolysaccharide. J Agric Food Chem, 63: 517-25.
[98] Chen Y, Zhang H, Wang Y, Nie S, Li C, Xie M (2014). Structural characterization and antioxidant activity of a novel heteropolysaccharide from the submerged fermentation mycelia of Ganoderma capense. Food Chem, 186: 231-8.
[99] Huang Y, Li N2, Wan JB, Zhang D, Yan C (2015). Structural characterization and antioxidant activity of a novel heteropolysaccharide from the submerged fermentation mycelia of Ganoderma capense. Carbohydr Polym, 134: 752-60.
[100] Jiang J, Kong F, Li N, Zhang D, Yan C, Lv H (2016). Purification, structural characterization and in vitro antioxidant activity of a novel polysaccharide from Boshuzhi. Carbohydr Polym, 147: 365-71.
[101] Yan C, Kong F, Zhang D, Cui J (2013). Anti-glycated and antiradical activities in vitro of polysaccharides from Ganoderma capense. Pharmacogn Mag, 9: 23-7.
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