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Aging and disease    2017, Vol. 8 Issue (5) : 590-610     DOI: 10.14336/AD.2017.0430
Review |
Age-related Impairment of Vascular Structure and Functions
Xu Xianglai1,2,*, Wang Brian2, Ren Changhong2,4, Hu Jiangnan2, Greenberg David A.5, Chen Tianxiang6, Xie Liping3,*, Jin Kunlin2,*
1Zhongshan Hospital, Fudan University, Shanghai 200032, China.
2Department of Pharmacology and Neuroscience, University of North Texas Health Science Center at Fort Worth, TX 76107, USA.
3Department of Urology, the First Affiliated Hospital, Zhejiang University, Zhejiang Province, China.
4Institute of Hypoxia Medicine, Xuanwu Hospital, Capital Medical University. Beijing, China.
5Buck Institute for Research on Aging, Novato, CA 94945, USA.
6Department of Thoracic Surgery, Shanghai Chest Hospital, Shanghai Jiaotong University, Shanghai, China.
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Among age-related diseases, cardiovascular and cerebrovascular diseases are major causes of death. Vascular dysfunction is a key characteristic of these diseases wherein age is an independent and essential risk factor. The present work will review morphological alterations of aging vessels in-depth, which includes the discussion of age-related microvessel loss and changes to vasculature involving the capillary basement membrane, intima, media, and adventitia as well as the accompanying vascular dysfunctions arising from these alterations.

Keywords vascular aging      vascular remodeling      endothelial dysfunction      arterial stiffness     
Corresponding Authors: Xu Xianglai,Xie Liping,Jin Kunlin   
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These authors contribute equally to the manuscript

Issue Date: 01 October 2017
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Xu Xianglai
Wang Brian
Ren Changhong
Hu Jiangnan
Greenberg David A.
Chen Tianxiang
Xie Liping
Jin Kunlin
Cite this article:   
Xu Xianglai,Wang Brian,Ren Changhong, et al. Age-related Impairment of Vascular Structure and Functions[J]. Aging and disease, 2017, 8(5): 590-610.
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Figure 1.  Illustrated histology of the normal vessel and histological alterations of vascular aging and atherosclerosis

Cross sectional view of the arterial wall. (A) Normal artery. (B) Aged artery. It is characterized by a thickened vessel wall, thickened subendothelial layer, elastin fragments, VSMCs migration and invasion. (C) Atherosclerosis. It is characterized by the accumulation of plaque and the invasion of macrophages and foam cells.

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