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Aging and Disease    2017, Vol. 8 Issue (5) : 677-684     DOI: 10.14336/AD.2017.0607
Review |
Ovarian Cancer Management in the Oldest Old: Improving Outcomes and Tailoring Treatments
Lucia Tortorella1,Giuseppe Vizzielli1,Domenico Fusco2,William C. Cho3,Roberto Bernabei2,Giovanni Scambia1,Giuseppe Colloca2,*
1Division of Gynecologic Oncology, Catholic University of the Sacred Heart, Rome, Italy.
2Geriartic Department, Fondazione Policlinico A.Gemelli, Rome, Italy
3Department of Clinical Oncology, Queen Elizabeth Hospital, Kowloon, Hong Kong
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Abstract  

Ovarian cancer is the most common cause of death from gynecological cancers in developed countries. It is a common disease of older women at or above 63 years upon diagnosis. Thanks to advance in new treatments, mortality from ovarian cancer has declined in developed countries in the last decade. This decline in mortality rate is unevenly distributed across the age-spectrum. While mortality in younger women has decreased 21.7%, for elderly women it has declined only 2.2%. Even if ovarian cancer is clearly a disease of the elderly, older women are underrepresented in clinical trials, and scant evidence exists for the treatment of women older than 80 years. Moreover, older women are frequently undertreated, receive less chemotherapy and less combination of surgery and chemotherapy, despite the fact that this is considered the optimal treatment modality. This may be mainly due to the lack of evidence and physician’s confidence in the management of elderly women with ovarian cancer. In this review, we focus on the management of older women with ovarian cancer, considering geriatric features tied to this population.

Keywords ovarian cancer      elderly      frailty     
Corresponding Authors: Giuseppe Colloca   
Just Accepted Date: 07 June 2017   Issue Date: 27 September 2017
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Lucia Tortorella
Giuseppe Vizzielli
Domenico Fusco
William C. Cho
Roberto Bernabei
Giovanni Scambia
Giuseppe Colloca
Cite this article:   
Lucia Tortorella,Giuseppe Vizzielli,Domenico Fusco, et al. Ovarian Cancer Management in the Oldest Old: Improving Outcomes and Tailoring Treatments[J]. A&D, 2017, 8(5): 677-684.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0607     OR     http://www.aginganddisease.org/EN/Y2017/V8/I5/677
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