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Aging and Disease    2018, Vol. 9 Issue (3) : 358-373     DOI: 10.14336/AD.2017.0701
Orginal Article |
Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology
Jiao Lu1,2,Xuefeng Duan1,Wenming Zhao1,Jing Wang1,2,Haoyu Wang3,1,Kai Zhou1,Min Fang1,4,*
1CAS Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China.
2University of Chinese Academy of Sciences, Beijing, China
3Institute of Health Sciences, Anhui University, Hefei, China
4International College, University of Chinese Academy of Sciences, Beijing, China
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Abstract  

Immune responses are a double-edged sword. Effective and appropriate immune responses capable of controlling viral infection while also largely preserving tissue integrity, are critical for host survival. Too strong immune responses might result in immune pathology, while too weak immune responses might cause viral persistence. Physiologic ageing is accompanied with a decline in the normal functioning of the immune system, which is termed as "immunosenescence". We show that aged mice (16-19 months old) are more resistant to influenza A virus (IAV) infection than the young mice. Strong immune responses in the young mice after IAV infection result in faster clearance of virus, but also cause severe lung injury and higher mortality rate. While in the aged mice, the delayed and milder immune responses contribute to reduced pulmonary damage, and are still capable to clear the infection even with a slower kinetics, displaying a more resistant phenotype during IAV infection. Hence, our work demonstrates that moderate immune responses as a decline with ageing in the aged mice balance the immune pathology and viral clearance, might be beneficial for the host during certain circumstances. Our results provide important insight to our basic knowledge of immunosenescence and immune defenses to invading pathogens. Further, our results indicate that age factors should be considered when investigating the vaccination and therapeutic strategies for severe IAV infection.

Keywords ageing      immunosenescence      cellular immunology      IAV infection      inflammation      lung pathology     
Corresponding Authors: Min Fang   
Issue Date: 05 June 2018
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Jiao Lu
Xuefeng Duan
Wenming Zhao
Jing Wang
Haoyu Wang
Kai Zhou
Min Fang
Cite this article:   
Jiao Lu,Xuefeng Duan,Wenming Zhao, et al. Aged Mice are More Resistant to Influenza Virus Infection due to Reduced Inflammation and Lung Pathology[J]. A&D, 2018, 9(3): 358-373.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0701     OR     http://www.aginganddisease.org/EN/Y2018/V9/I3/358
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