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Aging and Disease    2017, Vol. 8 Issue (5) : 519-530     DOI: 10.14336/AD.2017.0710
Original Article |
Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Mengxiong Pan1,2,Peng Wang1,Chengcai Zheng1,Hongxia Zhang2,Siyang Lin1,Bei Shao1,Qichuan Zhuge1,Kunlin Jin1,2,*
1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
2Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
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Compelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates cardiac hypertrophy. Systemic factors from mice can also extend the life span of a partner exposed to a lethal treatment or disease. These findings suggest that the systemic milieu of a healthy young partner may be beneficial for an aged organism. However, it is unknown whether a healthy young systemic milieu can improve functional recovery after ischemic stroke. Intraperitoneal administration of young plasma into aged rats after ischemic stroke induced by distal middle cerebral artery occlusion (dMCAO) reduced infarct volume and motor impairment, compared with vehicle group. On the contrary, intraperitoneal administration of plasma from aged rats into young ischemic rats worsened brain injury and motor deficits. Using a proteomic approach, we found that haptoglobin levels were significantly increased in serum of aged rats and that intraperitoneal administration of haptoglobin impaired outcome after ischemic stroke in young rats. Our data suggest that the aging systemic milieu plays a critical role in functional outcome after ischemic stroke.

Keywords ischemic stroke      systemic milieu      outcome      plasma      haptoglobin     
Corresponding Authors: Kunlin Jin   
Issue Date: 01 October 2017
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Mengxiong Pan
Peng Wang
Chengcai Zheng
Hongxia Zhang
Siyang Lin
Bei Shao
Qichuan Zhuge
Kunlin Jin
Cite this article:   
Mengxiong Pan,Peng Wang,Chengcai Zheng, et al. Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats[J]. A&D, 2017, 8(5): 519-530.
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