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Aging and Disease    2017, Vol. 8 Issue (5) : 519-530     DOI: 10.14336/AD.2017.0710
Original Article |
Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats
Mengxiong Pan1,2,Peng Wang1,Chengcai Zheng1,Hongxia Zhang2,Siyang Lin1,Bei Shao1,Qichuan Zhuge1,Kunlin Jin1,2,*
1Zhejiang Provincial Key Laboratory of Aging and Neurological Disorder Research, the First Affiliated Hospital, Wenzhou Medical University, Wenzhou, Zhejiang 325000, China
2Institute for Healthy Aging, University of North Texas Health Science Center, Fort Worth, Texas 76107, USA
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Abstract  

Compelling evidence indicates that factors in the blood can profoundly reverse aging-related impairments, as exposure of aged mice to young blood rejuvenates adult stem cell function, improves cognition, and ameliorates cardiac hypertrophy. Systemic factors from mice can also extend the life span of a partner exposed to a lethal treatment or disease. These findings suggest that the systemic milieu of a healthy young partner may be beneficial for an aged organism. However, it is unknown whether a healthy young systemic milieu can improve functional recovery after ischemic stroke. Intraperitoneal administration of young plasma into aged rats after ischemic stroke induced by distal middle cerebral artery occlusion (dMCAO) reduced infarct volume and motor impairment, compared with vehicle group. On the contrary, intraperitoneal administration of plasma from aged rats into young ischemic rats worsened brain injury and motor deficits. Using a proteomic approach, we found that haptoglobin levels were significantly increased in serum of aged rats and that intraperitoneal administration of haptoglobin impaired outcome after ischemic stroke in young rats. Our data suggest that the aging systemic milieu plays a critical role in functional outcome after ischemic stroke.

Keywords ischemic stroke      systemic milieu      outcome      plasma      haptoglobin     
Corresponding Authors: Kunlin Jin   
Issue Date: 01 October 2017
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Mengxiong Pan
Peng Wang
Chengcai Zheng
Hongxia Zhang
Siyang Lin
Bei Shao
Qichuan Zhuge
Kunlin Jin
Cite this article:   
Mengxiong Pan,Peng Wang,Chengcai Zheng, et al. Aging Systemic Milieu Impairs Outcome after Ischemic Stroke in Rats[J]. A&D, 2017, 8(5): 519-530.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0710     OR     http://www.aginganddisease.org/EN/Y2017/V8/I5/519
[1] Ramirez-Lassepas M (1998). Stroke and the aging of the brain and the arteries. Geriatrics, 53: S44-48.
[2] Villeda SA, Plambeck KE, Middeldorp J, Castellano JM, Mosher KI, Luo J, et al. (2014). Young blood reverses age-related impairments in cognitive function and synaptic plasticity in mice. Nat Med, 20: 659-663
[3] Loffredo FS, Steinhauser ML, Jay SM, Gannon J, Pancoast JR, Yalamanchi P, et al. (2013). Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell, 153: 828-839
[4] Conboy IM, Conboy MJ, Wagers AJ, Girma ER, Weissman IL, Rando TA (2005). Rejuvenation of aged progenitor cells by exposure to a young systemic environment. Nature, 433: 760-764
[5] Brack AS, Conboy MJ, Roy S, Lee M, Kuo CJ, Keller C, et al. (2007). Increased Wnt signaling during aging alters muscle stem cell fate and increases fibrosis. Science, 317: 807-810
[6] Villeda SA, Luo J, Mosher KI, Zou B, Britschgi M, Bieri G, et al. (2011). The ageing systemic milieu negatively regulates neurogenesis and cognitive function. Nature, 477: 90-94
[7] Conboy MJ, Conboy IM, Rando TA (2013). Heterochronic parabiosis: historical perspective and methodological considerations for studies of aging and longevity. Aging Cell, 12: 525-530
[8] Nawashiro H, Martin D, Hallenbeck JM (1997). Inhibition of tumor necrosis factor and amelioration of brain infarction in mice. J Cereb Blood Flow Metab, 17: 229-232
[9] Won SJ, Xie L, Kim SH, Tang H, Wang Y, Mao X, et al. (2006). Influence of age on the response to fibroblast growth factor-2 treatment in a rat model of stroke. Brain Res, 1123: 237-244
[10] Pang C, Cao L, Wu F, Wang L, Wang G, Yu Y, et al. (2015). The effect of trans-resveratrol on post-stroke depression via regulation of hypothalamus-pituitary-adrenal axis. Neuropharmacology, 97: 447-456
[11] Wang LQ, Lin ZZ, Zhang HX, Shao B, Xiao L, Jiang HG, et al. (2014). Timing and dose regimens of marrow mesenchymal stem cell transplantation affect the outcomes and neuroinflammatory response after ischemic stroke. CNS Neurosci Ther, 20: 317-326
[12] Swanson RA, Morton MT, Tsao-Wu G, Savalos RA, Davidson C, Sharp FR (1990). A semiautomated method for measuring brain infarct volume. J Cereb Blood Flow Metab, 10: 290-293
[13] Wang X, Mao X, Xie L, Greenberg DA, Jin K (2009). Involvement of Notch1 signaling in neurogenesis in the subventricular zone of normal and ischemic rat brain in vivo. J Cereb Blood Flow Metab, 29: 1644-1654
[14] Ohlsson AL, Johansson BB (1995). Environment influences functional outcome of cerebral infarction in rats. Stroke, 26: 644-649
[15] Bu Y, Kwon S, Kim YT, Kim MY, Choi H, Kim JG, et al. (2010). Neuroprotective effect of HT008-1, a prescription of traditional Korean medicine, on transient focal cerebral ischemia model in rats. Phytother Res, 24: 1207-1212
[16] Puurunen K, Jolkkonen J, Sirvio J, Haapalinna A, Sivenius J (2001). An alpha(2)-adrenergic antagonist, atipamezole, facilitates behavioral recovery after focal cerebral ischemia in rats. Neuropharmacology, 40: 597-606
[17] Hoyman L, Weese GD, Frommer GP (1979). Tactile discrimination performance deficits following neglect-producing unilateral lateral hypothalamic lesions in the rat. Physiol Behav, 22: 139-147
[18] Schallert T, Whishaw IQ (1984). Bilateral cutaneous stimulation of the somatosensory system in hemidecorticate rats. Behav Neurosci, 98: 518-540
[19] d’Avila JC, Lam TI, Bingham D, Shi J, Won SJ, Kauppinen TM, et al. (2012). Microglial activation induced by brain trauma is suppressed by post-injury treatment with a PARP inhibitor. Journal of neuroinflammation, 9: 31
[20] Schallert T, Upchurch M, Wilcox RE, Vaughn DM (1983). Posture-independent sensorimotor analysis of inter-hemispheric receptor asymmetries in neostriatum. Pharmacol Biochem Behav, 18: 753-759
[21] Hua Y, Schallert T, Keep RF, Wu J, Hoff JT, Xi G (2002). Behavioral tests after intracerebral hemorrhage in the rat. Stroke, 33: 2478-2484
[22] Zhang L, Schallert T, Zhang ZG, Jiang Q, Arniego P, Li Q, et al. (2002). A test for detecting long-term sensorimotor dysfunction in the mouse after focal cerebral ischemia. J Neurosci Methods, 117: 207-214
[23] Spagnuolo MS, Maresca B, Mollica MP, Cavaliere G, Cefaliello C, Trinchese G, et al. (2014). Haptoglobin increases with age in rat hippocampus and modulates Apolipoprotein E mediated cholesterol trafficking in neuroblastoma cell lines. Front Cell Neurosci, 8: 212
[24] Holme I, Aastveit AH, Hammar N, Jungner I, Walldius G (2009). Haptoglobin and risk of myocardial infarction, stroke, and congestive heart failure in 342,125 men and women in the Apolipoprotein MOrtality RISk study (AMORIS). Ann Med, 41: 522-532
[25] Brea D, Sobrino T, Blanco M, Fraga M, Agulla J, Rodriguez-Yanez M, et al. (2009). Usefulness of haptoglobin and serum amyloid A proteins as biomarkers for atherothrombotic ischemic stroke diagnosis confirmation. Atherosclerosis, 205: 561-567
[26] Staals J, Pieters BM, Knottnerus IL, Rouhl RP, van Oostenbrugge RJ, Delanghe JR, et al. (2008). Haptoglobin polymorphism and lacunar stroke. Curr Neurovasc Res, 5: 153-158
[27] Wassdal I, Myrset AH, Helgeland L (1991). A simple and rapid method for purification of rat haptoglobin for production of antiserum. Scand J Clin Lab Invest, 51: 565-569
[28] Ferro JM, Crespo M (1994). Prognosis after transient ischemic attack and ischemic stroke in young adults. Stroke, 25: 1611-1616
[29] Hankey GJ (2013). Stroke in young adults: implications of the long-term prognosis. JAMA, 309: 1171-1172
[30] Varona JF, Bermejo F, Guerra JM, Molina JA (2004). Long-term prognosis of ischemic stroke in young adults. Study of 272 cases. J Neurol, 251: 1507-1514
[31] Sinha M, Jang YC, Oh J, Khong D, Wu EY, Manohar R, et al. (2014). Restoring systemic GDF11 levels reverses age-related dysfunction in mouse skeletal muscle. Science, 344: 649-652
[32] Ding J, Kopchick JJ (2011). Plasma biomarkers of mouse aging. Age (Dordr), 33: 291-307
[33] Hansson LO, Kjellman NI, Ludvigsson J, Lundh B, Tibbling G (1983). Haptoglobin concentrations in children aged 9-10 years and its correlation to indirect parameters of erythrocyte turnover. Scand J Clin Lab Invest, 43: 367-370
[34] Ratanasopa K, Chakane S, Ilyas M, Nantasenamat C, Bulow L (2013). Trapping of human hemoglobin by haptoglobin: molecular mechanisms and clinical applications. Antioxid Redox Signal, 18: 2364-2374
[35] Chamoun V, Zeman A, Blennow K, Fredman P, Wallin A, Keir G, et al. (2001). Haptoglobins as markers of blood-CSF barrier dysfunction: the findings in normal CSF. Journal of the neurological sciences, 182: 117-121
[36] Johnson G, Brane D, Block W, van Kammen DP, Gurklis J, Peters JL, et al. (1992). Cerebrospinal fluid protein variations in common to Alzheimer’s disease and schizophrenia. Appl Theor Electrophor, 3: 47-53
[37] Arguelles S, Venero JL, Garcia-Rodriguez S, Tomas-Camardiel M, Ayala A, Cano J, et al. (2010). Use of haptoglobin and transthyretin as potential biomarkers for the preclinical diagnosis of Parkinson’s disease. Neurochemistry international, 57: 227-234
[38] Huang YC, Wu YR, Tseng MY, Chen YC, Hsieh SY, Chen CM (2011). Increased prothrombin, apolipoprotein A-IV, and haptoglobin in the cerebrospinal fluid of patients with Huntington’s disease. PLoS One, 6: e15809
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