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Aging and disease    2017, Vol. 8 Issue (6) : 868-886     DOI: 10.14336/AD.2017.0816
Review |
Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic
Liu Ping1, Zhao Haiping1, Luo Yumin1,2,3,*
1Cerebrovascular Diseases Research Institute, and Department of Neurology, Xuanwu Hospital of Capital Medical University, Beijing, China
2Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China
3Beijing Key Laboratory of Translational Medicine for Cerebrovascular Diseases, Beijing, China
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Owing to a dramatic increase in average life expectancy and the Family Planning program of the 1970s - 1990s, China is rapidly becoming an aging society. Therefore, the investigation of healthspan-extending drugs becomes more urgent. Astragalus membranaceus (Huangqi) is a major medicinal herb that has been commonly used in many herbal formulations in the practice of traditional Chinese medicine (TCM) to treat a wide variety of diseases and body disorders, or marketed as life-prolonging extracts for human use in China, for more than 2000 years. The major components of Astragalus membranaceus are polysaccharides, flavonoids, and saponins. Pharmacological research indicates that the extract component of Astragalus membranaceus can increase telomerase activity, and has antioxidant, anti-inflammatory, immunoregulatory, anticancer, hypolipidemic, antihyperglycemic, hepatoprotective, expectorant, and diuretic effects. A proprietary extract of the dried root of Astragalus membranaceus, called TA-65, was associated with a significant age-reversal effect in the immune system. Our review focuses on the function and the underlying mechanisms of Astragalus membranaceus in lifespan extension, anti-vascular aging, anti-brain aging, and anti-cancer effects, based on experimental and clinical studies.

Keywords Astragalus membranaceus      aging      neurodegenerative disease      cancer      immnoregulation     
Corresponding Authors: Luo Yumin   
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these authors contributed equally to this work

Issue Date: 01 December 2017
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Liu Ping,Zhao Haiping,Luo Yumin. Anti-Aging Implications of Astragalus Membranaceus (Huangqi): A Well-Known Chinese Tonic[J]. Aging and disease, 2017, 8(6): 868-886.
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