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Aging and Disease    2018, Vol. 9 Issue (4) : 664-673     DOI: 10.14336/AD.2017.0930
Orginal Article |
N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model
Aurore Marie1,Johann Meunier2,Emilie Brun3,Susanna Malmstrom1,Veronique Baudoux1,Elodie Flaszka1,Gaëlle Naert1,François Roman2,Sylvie Cosnier-Pucheu1,Sergio Gonzalez-Gonzalez1,*
1CILcare, Parc Scientifique Agropolis, Montpellier, France
2Amylgen, Montferrier-sur-Lez, France
3Correlative Microscopy and Electron Tomography Platform, Hopital Saint Eloi, Montpellier, France
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Abstract  

Age-related hearing loss (ARHL) is the most common sensory disorder in the elderly population. SAMP8 mouse model presents accelerated senescence and has been identified as a model of gerontological research. SAMP8 displays a progressive age-related decline in brain function associated with a progressive hearing loss mimicking human aging memory deficits and ARHL. The molecular mechanisms associated with SAMP8 senescence process involve oxidative stress leading to chronic inflammation and apoptosis. Here, we studied the effect of N-acetylcysteine (NAC), an antioxidant, on SAMP8 hearing loss and memory to determine the potential interest of this model in the study of new antioxidant therapies. We observed a strong decrease of auditory brainstem response thresholds from 45 to 75 days of age and an increase of distortion product amplitudes from 60 to 75 days in NAC treated group compared to vehicle. Moreover, NAC treated group presented also an increase of memory performance at 60 and 105 days of age. These results confirm that NAC delays the senescence process by slowing the age-related hearing loss, protecting the cochlear hair cells and improving memory, suggesting that antioxidants could be a pharmacological target for age-related hearing and memory loss.

Keywords SAMP8      hearing loss      antioxidant      N-acetylcysteine      aging     
Corresponding Authors: Sergio Gonzalez-Gonzalez   
Issue Date: 01 August 2018
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Aurore Marie
Johann Meunier
Emilie Brun
Susanna Malmstrom
Veronique Baudoux
Elodie Flaszka
Gaëlle Naert
François Roman
Sylvie Cosnier-Pucheu
Sergio Gonzalez-Gonzalez
Cite this article:   
Aurore Marie,Johann Meunier,Emilie Brun, et al. N-acetylcysteine Treatment Reduces Age-related Hearing Loss and Memory Impairment in the Senescence-Accelerated Prone 8 (SAMP8) Mouse Model[J]. A&D, 2018, 9(4): 664-673.
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http://www.aginganddisease.org/EN/10.14336/AD.2017.0930     OR     http://www.aginganddisease.org/EN/Y2018/V9/I4/664
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