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Aging and Disease    2018, Vol. 9 Issue (4) : 748-754     DOI: 10.14336/AD.2017.1003
Short Communication |
Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects
Carmen G Vinagre1,2,Fatima R Freitas1,Carlos H de Mesquita3,Juliana C Vinagre1,Ana Carolina Mariani2,Roberto Kalil-Filho1,Raul C Maranhão1,4,*
1Heart Institute (InCor) of Medical School Hospital, University of São Paulo, São Paulo, Brazil.
2University of Santo Amaro, São Paulo, Brazil
3Institute of Nuclear Research, University of São Paulo, São Paulo, Brazil
4Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil
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Dietary fats absorbed in the intestine are transported in the circulation as chylomicrons and remnants that have atherogenic potential. Although postprandial lipidemia is increased in older subjects, the specific chylomicron metabolism has not been explored in older subjects nor compared to young subjects, which is the focus of this study. After a 12 h fast, artificially-made emulsions similar to lymph chylomicrons and doubly labeled with radioactive cholesteryl esters and triglycerides were intravenously injected in 23 older (66±4 years) and 20 young (24±3 years) subjects. Sequential blood samples were collected to determine fractional clearance rates (FCR, in min-1) by compartmental analysis. Older subjects had higher LDL-cholesterol (p<0.001) and triglycerides (p<0.0001) than young subjects; HDL-cholesterol presented no difference. The emulsion cholesteryl-ester FCR was lower in older subjects compared to the young (p=0.0001). The emulsion triglyceride FCR did not differ in the two groups. Tested in vitro, however, the lipolysis of the emulsion triglycerides was less intense in the older than in the young subjects. As delayed removal of remnants, indicated by the pronouncedly smaller cholesteryl ester FCR, is related to the presence of cardiovascular diseases, this can be a risk factor which could accelerate atherogenic complications occurring in aged subjects

Keywords Aging and atherosclerosis      chylomicron remnants      cholesterol and aging      triglyceride      emulsions     
Corresponding Authors: Raul C Maranhão   
Issue Date: 01 August 2018
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Carmen G Vinagre
Fatima R Freitas
Carlos H de Mesquita
Juliana C Vinagre
Ana Carolina Mariani
Roberto Kalil-Filho
Raul C Maranhão
Cite this article:   
Carmen G Vinagre,Fatima R Freitas,Carlos H de Mesquita, et al. Removal of Chylomicron Remnants from the Bloodstream is Delayed in Aged Subjects[J]. A&D, 2018, 9(4): 748-754.
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