Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?
Michael G. Flynn1,2,*, Melissa M. Markofski3, Andres E. Carrillo4,5
1HCA South Atlantic Division, Charleston, SC 29492, USA 2College of Charleston, Charleston, SC 29424, USA 3University of Houston, Department of Health and Human Performance, Houston, TX 77204, USA 4Department of Exercise Science, Chatham University, Pittsburgh, PA 15232, USA 5FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
Age-associated hyper-inflammation or “inflamm-aging” has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm—inflamm-inactivity—that describes a potent counter-measure to age-associated inflammatory illness.
Flynn Michael G.,Markofski Melissa M.,Carrillo Andres E.. Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?[J]. Aging and disease,
2019, 10(1): 147-156.
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