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Aging and disease    2019, Vol. 10 Issue (1) : 147-156     DOI: 10.14336/AD.2018.0326
Review |
Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?
Michael G. Flynn1,2,*, Melissa M. Markofski3, Andres E. Carrillo4,5
1HCA South Atlantic Division, Charleston, SC 29492, USA
2College of Charleston, Charleston, SC 29424, USA
3University of Houston, Department of Health and Human Performance, Houston, TX 77204, USA
4Department of Exercise Science, Chatham University, Pittsburgh, PA 15232, USA
5FAME Laboratory, Department of Exercise Science, University of Thessaly, Trikala, Greece
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Age-associated hyper-inflammation or “inflamm-aging” has been linked to the development of chronic diseases and characterized as an unavoidable aspect of aging. However, the inflamm-aging model does not adequately address the potential anti-inflammatory effects of exercise training and the potential for exercise to ameliorate several age-related diseases. In this brief review, we introduce a new paradigm—inflamm-inactivity—that describes a potent counter-measure to age-associated inflammatory illness.

Keywords inflammation      exercise      physical activity      immune system      gerontology     
Corresponding Authors: Flynn Michael G.   
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These authors contributed equally.

Issue Date: 06 January 2018
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Flynn Michael G.
Markofski Melissa M.
Carrillo Andres E.
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Flynn Michael G.,Markofski Melissa M.,Carrillo Andres E.. Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?[J]. Aging and disease, 2019, 10(1): 147-156.
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