Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and disease    2019, Vol. 10 Issue (2) : 463-469     DOI: 10.14336/AD.2018.0329
Short Communications |
Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults
Fabienne Cyprien1,2, Philippe Courtet1,2, Jerome Maller3, Chantal Meslin4, Karen Ritchie1, Marie-Laure Ancelin1, Sylvaine Artero1,*
1INSERM, Univ Montpellier, Neuropsychiatry, Epidemiological and Clinical Research, Montpellier, France.
2CHU Montpellier, F-34095, France.
3Monash Alfred Psychiatry Research Centre, Central Clinical School, Monash University and Alfred Hospital, Melbourne, Australia.
4Centre for Research on Ageing, Health and Wellbeing, Research School of Population Health, ANU College of Medicine, Biology and Environment at the Australian National University, Canberra, Australia.
Download: PDF(404 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Chronic systemic low-grade inflammation is associated with aging, but little is known on whether age-related inflammation affects brain structure, particularly white matter. The current study tested the hypothesis that in older adults without dementia, higher serum levels of high-sensitivity C-reactive protein (hs-CRP) are associated with reduced corpus callosum (CC) areas. French community-dwelling subjects (ESPRIT study) aged 65 and older (N=101) underwent hs-CRP testing and structural magnetic resonance imaging (MRI). Multiple linear regression models were carried out. In the unadjusted model, higher hs-CRP level was significantly associated with smaller anterior, mid, and total midsagittal CC areas, but not with the posterior CC area. These associations were independent of demographic characteristics and intracranial volume. After adjustment for body mass index, diabetes, inflammation-related chronic pathologies and white matter lesions (WML), only the associations between hs-CRP level and smaller anterior and total midsagittal CC areas were still significant, although weaker. These findings suggest that low-grade inflammation is associated with CC structural integrity alterations in older adults independently of physical or neuropsychiatric pathologies.

Keywords corpus callosum      C-reactive protein      magnetic resonance imaging      older people      inflammation     
Corresponding Authors: Artero Sylvaine   
About author:

Currently address: Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai, China

Issue Date: 24 January 2018
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Fabienne Cyprien
Philippe Courtet
Jerome Maller
Chantal Meslin
Karen Ritchie
Marie-Laure Ancelin
Sylvaine Artero
Cite this article:   
Fabienne Cyprien,Philippe Courtet,Jerome Maller, et al. Increased Serum C-reactive Protein and Corpus Callosum Alterations in Older Adults[J]. Aging and disease, 2019, 10(2): 463-469.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2018.0329     OR     http://www.aginganddisease.org/EN/Y2019/V10/I2/463
Demographical/Clinical characteristics
Participants, n101
Women, %54.5
Age, years (mean ± SD [min-max])71.4 ± 4.1 (65-80)
Education level, % (n)
 No formal education or primary school22.8 (23)
 Lower secondary education28.7 (29)
 Higher secondary education24.8 (25)
 University degree23.8 (24)
MMSEa, median (IQR)27 (3)
Depressive symptomatologyb, % (n)22.8 (23)
Current or former smoker, % (n)46.5 (46)
Alcohol consumptionc, % (n)40.6 (41)
Body Mass Indexd, kg/m2 (mean ± SD [range])24.4 ± 3.3 (18.0-32.2)
History of cardiovascular diseasee, % (n)5.0 (5)
Hypertensionf, % (n)45.5 (46)
Diabetesg, % (n)4.0 (4)
Hypercholesterolemiah, % (n)50.5 (51)
Inflammation-related chronic pathologiesi, % (n)29.7 (30)
C-reactive protein, mg/L (mean ± SD [range])2.6 ± 0.2 (0.2-9.2)
Structural imaging
Corpus callosum areas, mm2 (mean ± SD)
 Anterior220.4 ± 4.0
 Mid136.2 ± 3.0
 Posterior237.6 ± 3.9
 Total area594.1 ± 9.5
Intracranial volume, cm3 (mean ± SD)1207.6 ± 14.5
White matter lesions volume, mm3 [median (IQR)]0.90 (2.8)
Table 1  Characteristics of the study population.
Corpus callosum regionmodel 1
model 2
model 3
βStandard errorpβStandard errorpβStandard errorp
Anterior area-0.3020.0010.002-0.3720.0010.001-.3030.0010.003
Mid area-0.2570.0010.010-0.2720.0010.010-.1820.0010.054
Posterior area-0.1370.0010.171-0.1530.0010.151-.0980.0010.291
Mid-sagittal total area-0.268<0.00010.007-0.311<0.00010.004-.228<0.00010.020
Table 2  Association of serum hs-CRP level with corpus callosum area.
Figure 1.  Slopes showing the association between log hs-CRP serum level and the anterior, mid, posterior corpus callosum (CC) areas (unadjusted).
[1] Franceschi C, Campisi J (2014). Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. J Gerontol A Biol Sci Med Sci, 69 Suppl 1:S4-9.
[2] Pearson TA, Mensah GA, Alexander RW, Anderson JL, Cannon RO3rd, Criqui M, et al. (2003). Markers of inflammation and cardiovascular disease: application to clinical and public health practice: A statement for healthcare professionals from the Centers for Disease Control and Prevention and the American Heart Association. Circulation, 107:499-511.
[3] Ridker PM, Buring JE, Cook NR, Rifai N (2003). C-reactive protein, the metabolic syndrome, and risk of incident cardiovascular events: an 8-year follow-up of 14 719 initially healthy American women. Circulation, 107:391-397.
[4] Koyama A, O'Brien J, Weuve J, Blacker D, Metti AL, Yaffe K (2013). The role of peripheral inflammatory markers in dementia and Alzheimer's disease: a meta-analysis. J Gerontol A Biol Sci Med Sci, 68:433-440.
[5] Soysal P, Stubbs B, Lucato P, Luchini C, Solmi M, Peluso R, et al. (2016). Inflammation and frailty in the elderly: A systematic review and meta-analysis. Ageing Res Rev, 31:1-8.
[6] Yang RR, Lu BC, Li T, Du YF, Wang X, Jia YX (2016). The relationship between high-sensitivity C-reactive protein at admission and post stroke depression: a 6-month follow-up study. Int J Geriatr Psychiatry, 31:231-239.
[7] Courtet P, Jaussent I, Genty C, Dupuy AM, Guillaume S, Ducasse D, et al. (2015). Increased CRP levels may be a trait marker of suicidal attempt. Eur Neuropsychopharmacol, 25:1824-1831.
[8] Satizabal CL, Zhu YC, Mazoyer B, Dufouil C, Tzourio C (2012). Circulating IL-6 and CRP are associated with MRI findings in the elderly: the 3C-Dijon Study. Neurology, 78:720-727.
[9] Fleischman DA, Arfanakis K, Kelly JF, Rajendran N, Buchman AS, Morris MC, et al. (2010). Regional brain cortical thinning and systemic inflammation in older persons without dementia. J Am Geriatr Soc, 58:1823-1825.
[10] Jefferson AL, Massaro JM, Wolf PA, Seshadri S, Au R, Vasan RS, et al. (2007). Inflammatory biomarkers are associated with total brain volume: the Framingham Heart Study. Neurology, 68:1032-1038.
[11] Miralbell J, Soriano JJ, Spulber G, Lopez-Cancio E, Arenillas JF, Bargallo N, et al. (2012). Structural brain changes and cognition in relation to markers of vascular dysfunction. Neurobiol Aging, 33:1003 e1009-1017.
[12] Wersching H, Duning T, Lohmann H, Mohammadi S, Stehling C, Fobker M, et al. (2010). Serum C-reactive protein is linked to cerebral microstructural integrity and cognitive function. Neurology, 74:1022-1029.
[13] Arfanakis K, Fleischman DA, Grisot G, Barth CM, Varentsova A, Morris MC, et al. (2013). Systemic inflammation in non-demented elderly human subjects: brain microstructure and cognition. PLoS One, 8:e73107.
[14] Bellani M, Yeh PH, Tansella M, Balestrieri M, Soares JC, Brambilla P (2009). DTI studies of corpus callosum in bipolar disorder. Biochem Soc Trans, 37:1096-1098.
[15] Di Paola M, Di Iulio F, Cherubini A, Blundo C, Casini AR, Sancesario G, et al. (2010). When, where, and how the corpus callosum changes in MCI and AD: a multimodal MRI study. Neurology, 74:1136-1142.
[16] Arnone D, McIntosh AM, Chandra P, Ebmeier KP (2008). Meta-analysis of magnetic resonance imaging studies of the corpus callosum in bipolar disorder. Acta Psychiatr Scand, 118:357-362.
[17] Cyprien F, Courtet P, Poulain V, Maller J, Meslin C, Bonafe A, et al. (2014). Corpus callosum size may predict late-life depression in women: a 10-year follow-up study. J Affect Disord, 165:16-23.
[18] Cyprien F, Courtet P, Malafosse A, Maller J, Meslin C, Bonafe A, et al. (2011). Suicidal behavior is associated with reduced corpus callosum area. Biol Psychiatry, 70:320-326.
[19] Lebel C, Gee M, Camicioli R, Wieler M, Martin W, Beaulieu C (2012). Diffusion tensor imaging of white matter tract evolution over the lifespan. Neuroimage, 60:340-352.
[20] Ritchie K, Artero S, Beluche I, Ancelin ML, Mann A, Dupuy AM, et al. (2004). Prevalence of DSM-IV psychiatric disorder in the French elderly population. Br J Psychiatry, 184:147-152.
[21] Talairach JTP1993. Referentially Oriented Cerebral MRI Anatomy: Atlas of Stereotaxic Anatomical Correlations for Gray and White Matter. New-York: Thieme Medical Publishers Inc.
[22] Sun J, Maller JJ, Daskalakis ZJ, Furtado CC, Fitzgerald PB (2009). Morphology of the corpus callosum in treatment-resistant schizophrenia and major depression. Acta Psychiatr Scand, 120:265-273.
[23] Ryberg C, Rostrup E, Stegmann MB, Barkhof F, Scheltens P, van Straaten EC, et al. (2007). Clinical significance of corpus callosum atrophy in a mixed elderly population. Neurobiol Aging, 28:955-963.
[24] Mortamais M, Reynes C, Brickman AM, Provenzano FA, Muraskin J, Portet F, et al. (2013). Spatial distribution of cerebral white matter lesions predicts progression to mild cognitive impairment and dementia. PLoS One, 8:e56972.
[25] Folstein MF, Folstein SE, McHugh PR (1975). "Mini-mental state". A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res, 12:189-198.
[26] Radloff L (1977). The CES-D Scale: A self report depression scale for research in the general population. Applied Psychological Measurement, 1:385-401.
[27] Bettcher BM, Watson CL, Walsh CM, Lobach IV, Neuhaus J, Miller JW, et al. (2014). Interleukin-6, age, and corpus callosum integrity. PLoS One, 9:e106521.
[28] Mazer SP, Rabbani LE (2004). Evidence for C-reactive protein's role in (CRP) vascular disease: atherothrombosis, immuno-regulation and CRP. J Thromb Thrombolysis, 17:95-105.
[29] Zacho J, Tybjaerg-Hansen A, Jensen JS, Grande P, Sillesen H, Nordestgaard BG (2008). Genetically elevated C-reactive protein and ischemic vascular disease. N Engl J Med, 359:1897-1908.
[30] Lee DY, Fletcher E, Martinez O, Zozulya N, Kim J, Tran J, et al. (2010). Vascular and degenerative processes differentially affect regional interhemispheric connections in normal aging, mild cognitive impairment, and Alzheimer disease. Stroke, 41:1791-1797.
[31] Roth AD, Ramirez G, Alarcon R, Von Bernhardi R (2005). Oligodendrocytes damage in Alzheimer's disease: beta amyloid toxicity and inflammation. Biol Res, 38:381-387.
[1] Ma Linsha, Hu Jingchao, Cao Yu, Xie Yilin, Wang Hua, Fan Zhipeng, Zhang Chunmei, Wang Jinsong, Wu Chu-Tse, Wang Songlin. Maintained Properties of Aged Dental Pulp Stem Cells for Superior Periodontal Tissue Regeneration[J]. Aging and disease, 2019, 10(4): 793-806.
[2] Deng Xu-Xu, Li Shan-Shan, Sun Feng-Yan. Necrostatin-1 Prevents Necroptosis in Brains after Ischemic Stroke via Inhibition of RIPK1-Mediated RIPK3/MLKL Signaling[J]. Aging and disease, 2019, 10(4): 807-817.
[3] Han Rongrong, Liu Zeyue, Sun Nannan, Liu Shu, Li Lanlan, Shen Yan, Xiu Jianbo, Xu Qi. BDNF Alleviates Neuroinflammation in the Hippocampus of Type 1 Diabetic Mice via Blocking the Aberrant HMGB1/RAGE/NF-κB Pathway[J]. Aging and disease, 2019, 10(3): 611-625.
[4] Li Kunyu, Li Jiatong, Zheng Jialin, Qin Song. Reactive Astrocytes in Neurodegenerative Diseases[J]. Aging and disease, 2019, 10(3): 664-675.
[5] Li Xianmei, Lin Siyang, Chen Xiaoli, Huang Wensi, Li Qian, Zhang Hongxia, Chen Xudong, Yang Shaohua, Jin Kunlin, Shao Bei. The Prognostic Value of Serum Cytokines in Patients with Acute Ischemic Stroke[J]. Aging and disease, 2019, 10(3): 544-556.
[6] Chung Hae Young, Kim Dae Hyun, Lee Eun Kyeong, Chung Ki Wung, Chung Sangwoon, Lee Bonggi, Seo Arnold Y., Chung Jae Heun, Jung Young Suk, Im Eunok, Lee Jaewon, Kim Nam Deuk, Choi Yeon Ja, Im Dong Soon, Yu Byung Pal. Redefining Chronic Inflammation in Aging and Age-Related Diseases: Proposal of the Senoinflammation Concept[J]. Aging and disease, 2019, 10(2): 367-382.
[7] Sarkar Saumyendra N., Russell Ashley E., Engler-Chiurazzi Elizabeth B., Porter Keyana N., Simpkins James W.. MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma[J]. Aging and disease, 2019, 10(2): 329-352.
[8] Michael G. Flynn,Melissa M. Markofski,Andres E. Carrillo. Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?[J]. Aging and disease, 2019, 10(1): 147-156.
[9] Wanying Duan, Yuehua Pu, Haiyan Liu, Jing Jing, Yuesong Pan, Xinying Zou, Yilong Wang, Xingquan Zhao, Chunxue Wang, Yongjun Wang, Ka Sing Lawrence Wong, Ling Wei, Liping Liu, . Association between Leukoaraiosis and Symptomatic Intracranial Large Artery Stenoses and Occlusions: the Chinese Intracranial Atherosclerosis (CICAS) Study[J]. Aging and disease, 2018, 9(6): 1074-1083.
[10] Antonina Luca, Carmela Calandra, Maria Luca. Molecular Bases of Alzheimer’s Disease and Neurodegeneration: The Role of Neuroglia[J]. Aging and disease, 2018, 9(6): 1134-1152.
[11] Calvin Pak-Wing Cheng, Sheung-Tak Cheng, Cindy Woon-Chi Tam, Wai-Chi Chan, Winnie Chiu-Wing Chu, Linda Chiu-Wa Lam. Relationship between Cortical Thickness and Neuropsychological Performance in Normal Older Adults and Those with Mild Cognitive Impairment[J]. Aging and disease, 2018, 9(6): 1020-1030.
[12] Ze Teng, Aibo Wang, Peng Wang, Rui Wang, Wei Wang, Hongbin Han. The Effect of Aquaporin-4 Knockout on Interstitial Fluid Flow and the Structure of the Extracellular Space in the Deep Brain[J]. Aging and disease, 2018, 9(5): 808-816.
[13] Yong-Fei Zhao, Qiong Zhang, Jian-Feng Zhang, Zhi-Yin Lou, Hen-Bing Zu, Zi-Gao Wang, Wei-Cheng Zeng, Kai Yao, Bao-Guo Xiao. The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease[J]. Aging and disease, 2018, 9(5): 785-797.
[14] Brandenberger Christina, Kling Katharina Maria, Vital Marius, Christian Mühlfeld. The Role of Pulmonary and Systemic Immunosenescence in Acute Lung Injury[J]. Aging and disease, 2018, 9(4): 553-565.
[15] Chen Yali, Yin Mengmei, Cao Xuejin, Hu Gang, Xiao Ming. Pro- and Anti-inflammatory Effects of High Cholesterol Diet on Aged Brain[J]. Aging and disease, 2018, 9(3): 374-390.
Viewed
Full text


Abstract

Cited

  Shared   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd