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Aging and disease    2020, Vol. 11 Issue (1) : 129-140     DOI: 10.14336/AD.2019.0508
Review Article |
Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease
Shijin Xia1, Changxi Zhou2, Bill Kalionis3, Xiaoping Shuang4, Haiyan Ge5,*, Wen Gao6,*
1Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China.
2Department of Respiratory Medicine, The Second Medical Center of PLA General Hospital, Beijing, China.
3Department of Maternal-Fetal Medicine Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women’s Hospital, Parkville, Victoria, Australia.
4Department of Cardiovascular Diseases, Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, Hubei, China.
5Department of Pulmonary Diseases, Huadong Hospital, Fudan University, Shanghai, China.
6Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, China.
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Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.

Keywords chronic obstructive pulmonary disease      oxidative stress      inflammaging      lung mesenchymal stem cells     
Corresponding Authors: Haiyan Ge,Wen Gao   
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These authors contributed equally to this work.

Just Accepted Date: 11 May 2019   Issue Date: 15 January 2020
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Shijin Xia
Changxi Zhou
Bill Kalionis
Xiaoping Shuang
Haiyan Ge
Wen Gao
Cite this article:   
Shijin Xia,Changxi Zhou,Bill Kalionis, et al. Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease[J]. Aging and disease, 2020, 11(1): 129-140.
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Figure 1.  Oxidative stress interacts with airway epithelial cells to participate in the development of COPD. Activators of CFTR, such as pendrin (SLC26A4), SLC26A8 and Ivacaftor, may improve respiratory tract function and delay the process of COPD.
Figure 2.  Effect of SIRT6 and PAI-1 on smoking-induced pulmonary inflammation.
Figure 3.  A new strategy for treatment of elderly patients with COPD; combining antioxidants and anti-inflammaging drugs with improved endogenous/exogenous MSC function.
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