Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and disease    2020, Vol. 11 Issue (1) : 129-140     DOI: 10.14336/AD.2019.0508
Review Article |
Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease
Shijin Xia1, Changxi Zhou2, Bill Kalionis3, Xiaoping Shuang4, Haiyan Ge5,*, Wen Gao6,*
1Shanghai Institute of Geriatrics, Huadong Hospital, Fudan University, Shanghai, China.
2Department of Respiratory Medicine, The Second Medical Center of PLA General Hospital, Beijing, China.
3Department of Maternal-Fetal Medicine Pregnancy Research Centre and University of Melbourne Department of Obstetrics and Gynaecology, Royal Women’s Hospital, Parkville, Victoria, Australia.
4Department of Cardiovascular Diseases, Xiangyang Hospital of Traditional Chinese Medicine, Xiangyang, Hubei, China.
5Department of Pulmonary Diseases, Huadong Hospital, Fudan University, Shanghai, China.
6Department of Thoracic Surgery, Huadong Hospital, Fudan University, Shanghai, China.
Download: PDF(569 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Chronic Obstructive Pulmonary Disease (COPD) is a worldwide health problem associated with high morbidity and mortality, especially in elderly patients. Aging functions include mitochondrial dysfunction, cell-to-cell information exchange, protein homeostasis and extracellular matrix dysregulation, which are closely related to chronic inflammatory response and oxidation-antioxidant imbalance in the pathogenesis of COPD. COPD displays distinct inflammaging features, including increased cellular senescence and oxidative stress, stem cell exhaustion, alterations in the extracellular matrix, reduced levels of endogenous anti-inflammaging molecules, and reduced autophagy. Given that COPD and inflammaging share similar general features, it is very important to identify the specific mechanisms of inflammaging, which involve oxidative stress, inflammation and lung mesenchymal stem cell function in the development of COPD, especially in elderly COPD patients. In this review, we highlight the studies relevant to COPD progression, and focus on mechanisms associated with inflammaging.

Keywords chronic obstructive pulmonary disease      oxidative stress      inflammaging      lung mesenchymal stem cells     
Corresponding Authors: Haiyan Ge,Wen Gao   
About author:

These authors contributed equally to this work.

Just Accepted Date: 11 May 2019   Issue Date: 15 January 2020
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Shijin Xia
Changxi Zhou
Bill Kalionis
Xiaoping Shuang
Haiyan Ge
Wen Gao
Cite this article:   
Shijin Xia,Changxi Zhou,Bill Kalionis, et al. Combined Antioxidant, Anti-inflammaging and Mesenchymal Stem Cell Treatment: A Possible Therapeutic Direction in Elderly Patients with Chronic Obstructive Pulmonary Disease[J]. Aging and disease, 2020, 11(1): 129-140.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2019.0508     OR     http://www.aginganddisease.org/EN/Y2020/V11/I1/129
Figure 1.  Oxidative stress interacts with airway epithelial cells to participate in the development of COPD. Activators of CFTR, such as pendrin (SLC26A4), SLC26A8 and Ivacaftor, may improve respiratory tract function and delay the process of COPD.
Figure 2.  Effect of SIRT6 and PAI-1 on smoking-induced pulmonary inflammation.
Figure 3.  A new strategy for treatment of elderly patients with COPD; combining antioxidants and anti-inflammaging drugs with improved endogenous/exogenous MSC function.
[1] Mortality GBD, Causes of Death C (2016). Global, regional, and national life expectancy, all-cause mortality, and cause-specific mortality for 249 causes of death, 1980-2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet, 388: 1459-1544
[2] Adeloye D, Chua S, Lee C, Basquill C, Papana A, Theodoratou E, et al. (2015). Global and regional estimates of COPD prevalence: Systematic review and meta-analysis. J Glob Health, 5: 020415
[3] Wang C, Xu J, Yang L, Xu Y, Zhang X, Bai C, et al. (2018). Prevalence and risk factors of chronic obstructive pulmonary disease in China (the China Pulmonary Health [CPH] study): a national cross-sectional study. Lancet, 391: 1706-1717
[4] Srivastava K, Thakur D, Sharma S, Punekar YS (2015). Systematic review of humanistic and economic burden of symptomatic chronic obstructive pulmonary disease. Pharmacoeconomics, 33: 467-488
[5] Sullivan SD, Ramsey SD, Lee TA (2000). The economic burden of COPD. Chest, 117: 5S-9S
[6] Ford ES, Croft JB, Mannino DM, Wheaton AG, Zhang X, Giles WH (2013). COPD surveillance--United States, 1999-2011. Chest, 144: 284-305
[7] Thannickal VJ, Murthy M, Balch WE, Chandel NS, Meiners S, Eickelberg O, et al. (2015). Blue journal conference. Aging and susceptibility to lung disease. Am J Respir Crit Care Med, 191: 261-269
[8] Lourenco J, Serrano A, Santos-Silva A, Gomes M, Afonso C, Freitas P, et al. (2018). Cardiovascular Risk Factors Are Correlated with Low Cognitive Function among Older Adults Across Europe Based on The SHARE Database. Aging Dis, 9: 90-101
[9] Osanai T, Tanaka M, Mikami K, Kitajima M, Tomisawa T, Magota K, et al. (2018). Novel anti-aging gene NM_026333 contributes to proton-induced aging via NCX1-pathway. J Mol Cell Cardiol, 125: 174-184
[10] Franceschi C, Garagnani P, Parini P, Giuliani C, Santoro A (2018). Inflammaging: a new immune-metabolic viewpoint for age-related diseases. Nat Rev Endocrinol, 14: 576-590
[11] Bernardo I, Bozinovski S, Vlahos R (2015). Targeting oxidant-dependent mechanisms for the treatment of COPD and its comorbidities. Pharmacol Ther, 155: 60-79
[12] Mercado N, Ito K, Barnes PJ (2015). Accelerated ageing of the lung in COPD: new concepts. Thorax, 70: 482-489
[13] Liguori I, Russo G, Curcio F, Bulli G, Aran L, Della-Morte D, et al. (2018). Oxidative stress, aging, and diseases. Clin Interv Aging, 13: 757-772
[14] Choudhury G, MacNee W (2017). Role of Inflammation and Oxidative Stress in the Pathology of Ageing in COPD: Potential Therapeutic Interventions. COPD, 14: 122-135
[15] Gopal P, Reynaert NL, Scheijen JL, Schalkwijk CG, Franssen FM, Wouters EF, et al. (2014). Association of plasma sRAGE, but not esRAGE with lung function impairment in COPD. Respir Res, 15: 24
[16] Thomson NC (2018). Targeting oxidant-dependent mechanisms for the treatment of respiratory diseases and their comorbidities. Curr Opin Pharmacol, 40: 1-8
[17] Stanojkovic I, Kotur-Stevuljevic J, Milenkovic B, Spasic S, Vujic T, Stefanovic A, et al. (2011). Pulmonary function, oxidative stress and inflammatory markers in severe COPD exacerbation. Respir Med, 105 Suppl 1: S31-37
[18] Antus B, Harnasi G, Drozdovszky O, Barta I (2014). Monitoring oxidative stress during chronic obstructive pulmonary disease exacerbations using malondialdehyde. Respirology, 19: 74-79
[19] Vaitkus M, Lavinskiene S, Barkauskiene D, Bieksiene K, Jeroch J, Sakalauskas R (2013). Reactive oxygen species in peripheral blood and sputum neutrophils during bacterial and nonbacterial acute exacerbation of chronic obstructive pulmonary disease. Inflammation, 36: 1485-1493
[20] Dianat M, Radan M, Badavi M, Mard SA, Bayati V, Ahmadizadeh M (2018). Crocin attenuates cigarette smoke-induced lung injury and cardiac dysfunction by anti-oxidative effects: the role of Nrf2 antioxidant system in preventing oxidative stress. Respir Res, 19: 58
[21] Montano M, Cisneros J, Ramirez-Venegas A, Pedraza-Chaverri J, Mercado D, Ramos C, et al. (2010). Malondialdehyde and superoxide dismutase correlate with FEV(1) in patients with COPD associated with wood smoke exposure and tobacco smoking. Inhal Toxicol, 22: 868-874
[22] To Y, Ito K, Kizawa Y, Failla M, Ito M, Kusama T, et al. (2010). Targeting phosphoinositide-3-kinase-delta with theophylline reverses corticosteroid insensitivity in chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 182: 897-904
[23] Ahmad T, Sundar IK, Lerner CA, Gerloff J, Tormos AM, Yao H, et al. (2015). Impaired mitophagy leads to cigarette smoke stress-induced cellular senescence: implications for chronic obstructive pulmonary disease. FASEB J, 29: 2912-2929
[24] Sheppard DN, Welsh MJ (1999). Structure and function of the CFTR chloride channel. Physiol Rev, 79: S23-45
[25] Choi HC, Kim CS, Tarran R (2015). Automated acquisition and analysis of airway surface liquid height by confocal microscopy. Am J Physiol Lung Cell Mol Physiol, 309: L109-118
[26] Bodas M, Pehote G, Silverberg D, Gulbins E, Vij N (2019). Autophagy augmentation alleviates cigarette smoke-induced CFTR-dysfunction, ceramide-accumulation and COPD-emphysema pathogenesis. Free Radic Biol Med, 131: 81-97
[27] Courville CA, Tidwell S, Liu B, Accurso FJ, Dransfield MT, Rowe SM (2014). Acquired defects in CFTR-dependent beta-adrenergic sweat secretion in chronic obstructive pulmonary disease. Respir Res, 15: 25
[28] Stankovic M, Nikolic A, Divac A, Tomovic A, Petrovic-Stanojevic N, Andjelic M, et al. (2008). The CFTR M470V gene variant as a potential modifier of COPD severity: study of Serbian population. Genet Test, 12: 357-362
[29] Song Y, Namkung W, Nielson DW, Lee JW, Finkbeiner WE, Verkman AS (2009). Airway surface liquid depth measured in ex vivo fragments of pig and human trachea: dependence on Na+ and Cl- channel function. Am J Physiol Lung Cell Mol Physiol, 297: L1131-1140
[30] Su X, Looney MR, Su HE, Lee JW, Song Y, Matthay MA (2011). Role of CFTR expressed by neutrophils in modulating acute lung inflammation and injury in mice. Inflamm Res, 60: 619-632
[31] Dalli J, Rosignoli G, Hayhoe RP, Edelman A, Perretti M (2010). CFTR inhibition provokes an inflammatory response associated with an imbalance of the annexin A1 pathway. Am J Pathol, 177: 176-186
[32] Sloane PA, Rowe SM (2010). Cystic fibrosis transmembrane conductance regulator protein repair as a therapeutic strategy in cystic fibrosis. Curr Opin Pulm Med, 16: 591-597
[33] Cantin AM, Hanrahan JW, Bilodeau G, Ellis L, Dupuis A, Liao J, et al. (2006). Cystic fibrosis transmembrane conductance regulator function is suppressed in cigarette smokers. Am J Respir Crit Care Med, 173: 1139-1144
[34] Gould NS, Min E, Martin RJ, Day BJ (2012). CFTR is the primary known apical glutathione transporter involved in cigarette smoke-induced adaptive responses in the lung. Free Radic Biol Med, 52: 1201-1206
[35] Pedemonte N, Caci E, Sondo E, Caputo A, Rhoden K, Pfeffer U, et al. (2007). Thiocyanate transport in resting and IL-4-stimulated human bronchial epithelial cells: role of pendrin and anion channels. J Immunol, 178: 5144-5153
[36] Ko SB, Zeng W, Dorwart MR, Luo X, Kim KH, Millen L, et al. (2004). Gating of CFTR by the STAS domain of SLC26 transporters. Nat Cell Biol, 6: 343-350
[37] Shcheynikov N, Ko SB, Zeng W, Choi JY, Dorwart MR, Thomas PJ, et al. (2006). Regulatory interaction between CFTR and the SLC26 transporters. Novartis Found Symp, 273: 177-186; discussion 186-192, 261-174
[38] Fong P (2012). CFTR-SLC26 transporter interactions in epithelia. Biophys Rev, 4: 107-116
[39] Kim D, Huang J, Billet A, Abu-Arish A, Goepp J, Matthes E, et al. (2019). Pendrin Mediates Bicarbonate Secretion and Enhances CFTR Function in Airway Surface Epithelia. Am J Respir Cell Mol Biol
[40] Xia S, Zhang X, Zheng S, Khanabdali R, Kalionis B, Wu J, et al. (2016). An Update on Inflamm-Aging: Mechanisms, Prevention, and Treatment. J Immunol Res, 2016: 8426874
[41] Wu J, Xia S, Kalionis B, Wan W, Sun T (2014). The role of oxidative stress and inflammation in cardiovascular aging. Biomed Res Int, 2014: 615312
[42] Franceschi C, Bonafe M, Valensin S, Olivieri F, De Luca M, Ottaviani E, et al. (2000). Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci, 908: 244-254
[43] Franceschi C, Capri M, Monti D, Giunta S, Olivieri F, Sevini F, et al. (2007). Inflammaging and anti-inflammaging: a systemic perspective on aging and longevity emerged from studies in humans. Mech Ageing Dev, 128: 92-105
[44] Kumar M, Seeger W, Voswinckel R (2014). Senescence-associated secretory phenotype and its possible role in chronic obstructive pulmonary disease. Am J Respir Cell Mol Biol, 51: 323-333
[45] Barnes PJ (2017). Senescence in COPD and Its Comorbidities. Annu Rev Physiol, 79: 517-539
[46] Onodera K, Sugiura H, Yamada M, Koarai A, Fujino N, Yanagisawa S, et al. (2017). Decrease in an anti-ageing factor, growth differentiation factor 11, in chronic obstructive pulmonary disease. Thorax, 72: 893-904
[47] De Martinis M, Franceschi C, Monti D, Ginaldi L (2005). Inflamm-ageing and lifelong antigenic load as major determinants of ageing rate and longevity. FEBS Lett, 579: 2035-2039
[48] Su B, Liu T, Fan H, Chen F, Ding H, Wu Z, et al. (2016). Inflammatory Markers and the Risk of Chronic Obstructive Pulmonary Disease: A Systematic Review and Meta-Analysis. PLoS One, 11: e0150586
[49] Fragoso CA (2016). Epidemiology of Chronic Obstructive Pulmonary Disease (COPD) in Aging Populations. COPD, 13: 125-129
[50] De la Fuente M, Miquel J (2009). An update of the oxidation-inflammation theory of aging: the involvement of the immune system in oxi-inflamm-aging. Curr Pharm Des, 15: 3003-3026
[51] Almawi WY, Melemedjian OK (2002). Molecular mechanisms of glucocorticoid antiproliferative effects: antagonism of transcription factor activity by glucocorticoid receptor. J Leukoc Biol, 71: 9-15
[52] Miller GE, Cohen S, Ritchey AK (2002). Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model. Health Psychol, 21: 531-541
[53] Zhang W, Li J, Suzuki K, Qu J, Wang P, Zhou J, et al. (2015). Aging stem cells. A Werner syndrome stem cell model unveils heterochromatin alterations as a driver of human aging. Science, 348: 1160-1163
[54] Pont AR, Sadri N, Hsiao SJ, Smith S, Schneider RJ (2012). mRNA decay factor AUF1 maintains normal aging, telomere maintenance, and suppression of senescence by activation of telomerase transcription. Mol Cell, 47: 5-15
[55] Liao CY, Kennedy BK (2016). SIRT6, oxidative stress, and aging. Cell Res, 26: 143-144
[56] Mostoslavsky R, Chua KF, Lombard DB, Pang WW, Fischer MR, Gellon L, et al. (2006). Genomic instability and aging-like phenotype in the absence of mammalian SIRT6. Cell, 124: 315-329
[57] Chen Y, Sun T, Wu J, Kalionis B, Zhang C, Yuan D, et al. (2015). Icariin intervenes in cardiac inflammaging through upregulation of SIRT6 enzyme activity and inhibition of the NF-kappa B pathway. Biomed Res Int, 2015: 895976
[58] Takasaka N, Araya J, Hara H, Ito S, Kobayashi K, Kurita Y, et al. (2014). Autophagy induction by SIRT6 through attenuation of insulin-like growth factor signaling is involved in the regulation of human bronchial epithelial cell senescence. J Immunol, 192: 958-968
[59] Takeshita K, Yamamoto K, Ito M, Kondo T, Matsushita T, Hirai M, et al. (2002). Increased expression of plasminogen activator inhibitor-1 with fibrin deposition in a murine model of aging, "Klotho" mouse. Semin Thromb Hemost, 28: 545-554
[60] Murano S, Nakazawa A, Saito I, Masuda M, Morisaki N, Akikusa B, et al. (1997). Increased blood plasminogen activator inhibitor-1 and intercellular adhesion molecule-1 as possible risk factors of atherosclerosis in Werner syndrome. Gerontology, 43 Suppl 1: 43-52
[61] To M, Takagi D, Akashi K, Kano I, Haruki K, Barnes PJ, et al. (2013). Sputum plasminogen activator inhibitor-1 elevation by oxidative stress-dependent nuclear factor-kappaB activation in COPD. Chest, 144: 515-521
[62] Song Y, Lynch SV, Flanagan J, Zhuo H, Tom W, Dotson RH, et al. (2007). Increased plasminogen activator inhibitor-1 concentrations in bronchoalveolar lavage fluids are associated with increased mortality in a cohort of patients with Pseudomonas aeruginosa. Anesthesiology, 106: 252-261
[63] Goolaerts A, Lafargue M, Song Y, Miyazawa B, Arjomandi M, Carles M, et al. (2011). PAI-1 is an essential component of the pulmonary host response during Pseudomonas aeruginosa pneumonia in mice. Thorax, 66: 788-796
[64] Rojas M, Xu J, Woods CR, Mora AL, Spears W, Roman J, et al. (2005). Bone marrow-derived mesenchymal stem cells in repair of the injured lung. Am J Respir Cell Mol Biol, 33: 145-152
[65] Ortiz LA, Dutreil M, Fattman C, Pandey AC, Torres G, Go K, et al. (2007). Interleukin 1 receptor antagonist mediates the antiinflammatory and antifibrotic effect of mesenchymal stem cells during lung injury. Proc Natl Acad Sci U S A, 104: 11002-11007
[66] Kotton DN, Morrisey EE (2014). Lung regeneration: mechanisms, applications and emerging stem cell populations. Nat Med, 20: 822-832
[67] Tong L, Zhou J, Rong L, Seeley EJ, Pan J, Zhu X, et al. (2016). Fibroblast Growth Factor-10 (FGF-10) Mobilizes Lung-resident Mesenchymal Stem Cells and Protects Against Acute Lung Injury. Sci Rep, 6: 21642
[68] Li J, Zhou J, Zhang D, Song Y, She J, Bai C (2015). Bone marrow-derived mesenchymal stem cells enhance autophagy via PI3K/AKT signalling to reduce the severity of ischaemia/reperfusion-induced lung injury. J Cell Mol Med, 19: 2341-2351
[69] Guan XJ, Song L, Han FF, Cui ZL, Chen X, Guo XJ, et al. (2013). Mesenchymal stem cells protect cigarette smoke-damaged lung and pulmonary function partly via VEGF-VEGF receptors. J Cell Biochem, 114: 323-335
[70] Huh JW, Kim SY, Lee JH, Lee JS, Van Ta Q, Kim M, et al. (2011). Bone marrow cells repair cigarette smoke-induced emphysema in rats. Am J Physiol Lung Cell Mol Physiol, 301: L255-266
[71] Weiss DJ, Casaburi R, Flannery R, LeRoux-Williams M, Tashkin DP (2013). A placebo-controlled, randomized trial of mesenchymal stem cells in COPD. Chest, 143: 1590-1598
[72] de Oliveira HG, Cruz FF, Antunes MA, de Macedo Neto AV, Oliveira GA, Svartman FM, et al. (2017). Combined Bone Marrow-Derived Mesenchymal Stromal Cell Therapy and One-Way Endobronchial Valve Placement in Patients with Pulmonary Emphysema: A Phase I Clinical Trial. Stem Cells Transl Med, 6: 962-969
[73] Armitage J, Tan DBA, Troedson R, Young P, Lam KV, Shaw K, et al. (2018). Mesenchymal stromal cell infusion modulates systemic immunological responses in stable COPD patients: a phase I pilot study. Eur Respir J, 51
[74] Stolk J, Broekman W, Mauad T, Zwaginga JJ, Roelofs H, Fibbe WE, et al. (2016). A phase I study for intravenous autologous mesenchymal stromal cell administration to patients with severe emphysema. QJM, 109: 331-336
[75] Kubo H (2012). Concise review: clinical prospects for treating chronic obstructive pulmonary disease with regenerative approaches. Stem Cells Transl Med, 1: 627-631
[76] Ito K, Barnes PJ (2009). COPD as a disease of accelerated lung aging. Chest, 135: 173-180
[77] Yin L, Zheng D, Limmon GV, Leung NH, Xu S, Rajapakse JC, et al. (2014). Aging exacerbates damage and delays repair of alveolar epithelia following influenza viral pneumonia. Respir Res, 15: 116
[78] Yang SR, Park JR, Kang KS (2015). Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxid Med Cell Longev, 2015: 486263
[79] Tsuji T, Aoshiba K, Nagai A (2010). Alveolar cell senescence exacerbates pulmonary inflammation in patients with chronic obstructive pulmonary disease. Respiration, 80: 59-70
[80] Mora AL, Rojas M (2013). Adult stem cells for chronic lung diseases. Respirology, 18: 1041-1046
[81] Bustos ML, Huleihel L, Kapetanaki MG, Lino-Cardenas CL, Mroz L, Ellis BM, et al. (2014). Aging mesenchymal stem cells fail to protect because of impaired migration and antiinflammatory response. Am J Respir Crit Care Med, 189: 787-798
[82] Sepulveda JC, Tome M, Fernandez ME, Delgado M, Campisi J, Bernad A, et al. (2014). Cell senescence abrogates the therapeutic potential of human mesenchymal stem cells in the lethal endotoxemia model. Stem Cells, 32: 1865-1877
[83] Rahman I (2005). The role of oxidative stress in the pathogenesis of COPD: implications for therapy. Treat Respir Med, 4: 175-200
[84] Chilosi M, Carloni A, Rossi A, Poletti V (2013). Premature lung aging and cellular senescence in the pathogenesis of idiopathic pulmonary fibrosis and COPD/emphysema. Transl Res, 162: 156-173
[85] Borodkina A, Shatrova A, Abushik P, Nikolsky N, Burova E (2014). Interaction between ROS dependent DNA damage, mitochondria and p38 MAPK underlies senescence of human adult stem cells. Aging (Albany NY), 6: 481-495
[86] Chau BN, Wang JY (2003). Coordinated regulation of life and death by RB. Nat Rev Cancer, 3: 130-138
[87] Yahata T, Takanashi T, Muguruma Y, Ibrahim AA, Matsuzawa H, Uno T, et al. (2011). Accumulation of oxidative DNA damage restricts the self-renewal capacity of human hematopoietic stem cells. Blood, 118: 2941-2950
[88] Sundar IK, Yao H, Rahman I (2013). Oxidative stress and chromatin remodeling in chronic obstructive pulmonary disease and smoking-related diseases. Antioxid Redox Signal, 18: 1956-1971
[89] Yao H, Chung S, Hwang JW, Rajendrasozhan S, Sundar IK, Dean DA, et al. (2012). SIRT1 protects against emphysema via FOXO3-mediated reduction of premature senescence in mice. J Clin Invest, 122: 2032-2045
[90] Trocme C, Deffert C, Cachat J, Donati Y, Tissot C, Papacatzis S, et al. (2015). Macrophage-specific NOX2 contributes to the development of lung emphysema through modulation of SIRT1/MMP-9 pathways. J Pathol, 235: 65-78
[91] Feng N, Wang Q, Zhou J, Li J, Wen X, Chen S, et al. (2016). Keratinocyte growth factor-2 inhibits bacterial infection with Pseudomonas aeruginosa pneumonia in a mouse model. J Infect Chemother, 22: 44-52
[1] Wenjun Tu, Hong Wang, Song Li, Qiang Liu, Hong Sha. The Anti-Inflammatory and Anti-Oxidant Mechanisms of the Keap1/Nrf2/ARE Signaling Pathway in Chronic Diseases[J]. Aging and disease, 2019, 10(3): 637-651.
[2] Saumyendra N. Sarkar, Ashley E. Russell, Elizabeth B. Engler-Chiurazzi, Keyana N. Porter, James W. Simpkins. MicroRNAs and the Genetic Nexus of Brain Aging, Neuroinflammation, Neurodegeneration, and Brain Trauma[J]. Aging and disease, 2019, 10(2): 329-352.
[3] Lucy A. Murtha, Matthew Morten, Michael J. Schuliga, Nishani S. Mabotuwana, Sean A. Hardy, David W. Waters, Janette K. Burgess, Doan TM. Ngo, Aaron L. Sverdlov, Darryl A. Knight, Andrew J. Boyle. The Role of Pathological Aging in Cardiac and Pulmonary Fibrosis[J]. Aging and disease, 2019, 10(2): 419-428.
[4] Antonina Luca, Carmela Calandra, Maria Luca. Molecular Bases of Alzheimer’s Disease and Neurodegeneration: The Role of Neuroglia[J]. Aging and disease, 2018, 9(6): 1134-1152.
[5] Changhong Ren, Hang Wu, Dongjie Li, Yong Yang, Yuan Gao, Yunneng Jizhang, Dachuan Liu, Xunming Ji, Xuxiang Zhang. Remote Ischemic Conditioning Protects Diabetic Retinopathy in Streptozotocin-induced Diabetic Rats via Anti-Inflammation and Antioxidation[J]. Aging and disease, 2018, 9(6): 1122-1133.
[6] Yong-Fei Zhao, Qiong Zhang, Jian-Feng Zhang, Zhi-Yin Lou, Hen-Bing Zu, Zi-Gao Wang, Wei-Cheng Zeng, Kai Yao, Bao-Guo Xiao. The Synergy of Aging and LPS Exposure in a Mouse Model of Parkinson’s Disease[J]. Aging and disease, 2018, 9(5): 785-797.
[7] Morroni Fabiana, Sita Giulia, Graziosi Agnese, Turrini Eleonora, Fimognari Carmela, Tarozzi Andrea, Hrelia Patrizia. Neuroprotective Effect of Caffeic Acid Phenethyl Ester in A Mouse Model of Alzheimer’s Disease Involves Nrf2/HO-1 Pathway[J]. Aging and disease, 2018, 9(4): 605-622.
[8] Zhang Meng, Deng Yong-Ning, Zhang Jing-Yi, Liu Jie, Li Yan-Bo, Su Hua, Qu Qiu-Min. SIRT3 Protects Rotenone-induced Injury in SH-SY5Y Cells by Promoting Autophagy through the LKB1-AMPK-mTOR Pathway[J]. Aging and disease, 2018, 9(2): 273-286.
[9] Mari L. Sbardelotto,Giulia S. Pedroso,Fernanda T. Pereira,Helen R. Soratto,Stella MS. Brescianini,Pauline S. Effting,Anand Thirupathi,Renata T. Nesi,Paulo CL. Silveira,Ricardo A. Pinho. The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men[J]. A&D, 2017, 8(6): 887-898.
[10] Gao Guofen, Zhang Nan, Wang Yue-Qi, Wu Qiong, Yu Peng, Shi Zhen-Hua, Duan Xiang-Lin, Zhao Bao-Lu, Wu Wen-Shuang, Yan-Zhong Chang. Mitochondrial Ferritin Protects Hydrogen Peroxide-Induced Neuronal Cell Damage[J]. Aging and disease, 2017, 8(4): 458-470.
[11] Zheng Hong, Wu Jinzi, Jin Zhen, Yan Liang-Jun. Potential Biochemical Mechanisms of Lung Injury in Diabetes[J]. Aging and disease, 2017, 8(1): 7-16.
[12] Kim Kyung Soo, Kwak Jin Wook, Lim Su Jin, Park Yong Kyun, Yang Hoon Shik, Kim Hyun Jik. Oxidative Stress-induced Telomere Length Shortening of Circulating Leukocyte in Patients with Obstructive Sleep Apnea[J]. Aging and disease, 2016, 7(5): 604-613.
[13] Gaman Amelia Maria, Uzoni Adriana, Popa-Wagner Aurel, Andrei Anghel, Petcu Eugen-Bogdan. The Role of Oxidative Stress in Etiopathogenesis of Chemotherapy Induced Cognitive Impairment (CICI)-“Chemobrain”[J]. Aging and disease, 2016, 7(3): 307-317.
[14] Zhao Haiping, Han Ziping, Ji Xunming, Luo Yumin. Epigenetic Regulation of Oxidative Stress in Ischemic Stroke[J]. Aging and disease, 2016, 7(3): 295-306.
[15] Ma Liwei, Wang Hongjun, Wang Chunyan, Su Jing, Xie Qi, Xu Lu, Yu Yang, Liu Shibing, Li Songyan, Xu Ye, Li Zhixin. Failure of Elevating Calcium Induces Oxidative Stress Tolerance and Imparts Cisplatin Resistance in Ovarian Cancer Cells[J]. Aging and disease, 2016, 7(3): 254-266.
Viewed
Full text


Abstract

Cited

  Shared   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd