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Aging and disease    2020, Vol. 11 Issue (1) : 179-190     DOI: 10.14336/AD.2019.0511
Review Article |
The Paradoxical Effect of Deep Brain Stimulation on Memory
Shawn Zheng Kai Tan, Man-Lung Fung, Junhao Koh, Ying-Shing Chan, Lee Wei Lim*
School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong SAR, China
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Abstract  

Deep brain stimulation (DBS) is a promising treatment for many memory-related disorders including dementia, anxiety, and addiction. However, the use of DBS can be a paradoxical conundrum—dementia treatments aim to improve memory, whereas anxiety or addiction treatments aim to suppress maladaptive memory. In this review, the key hypotheses on how DBS affects memory are highlighted. We consolidate the findings and conclusions from the current research on the effects of DBS on memory in attempt to make sense of the bidirectional nature of DBS in disrupting and enhancing memory. Based on the current literature, we hypothesize that the timing of DBS plays a key role in its contradictory effects, and therefore, we propose a consolidated model of how DBS can both disrupt and enhance memory.

Keywords memory      neuromodulation      deep brain stimulation      dementia      anxiety      addiction     
Corresponding Authors: Lee Wei Lim   
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These authors contributed equally to this work.

Just Accepted Date: 21 July 2019   Issue Date: 15 January 2020
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Shawn Zheng Kai Tan
Man-Lung Fung
Junhao Koh
Ying-Shing Chan
Lee Wei Lim
Cite this article:   
Shawn Zheng Kai Tan,Man-Lung Fung,Junhao Koh, et al. The Paradoxical Effect of Deep Brain Stimulation on Memory[J]. Aging and disease, 2020, 11(1): 179-190.
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http://www.aginganddisease.org/EN/10.14336/AD.2019.0511     OR     http://www.aginganddisease.org/EN/Y2020/V11/I1/179
TargetStudyStimulation ParametersParadigmResults
Ventromedial prefrontal cortexLiu et al., 2015 [7]Single 1-h stimulation 30 mins prior to behaviour testingMorris Water Maze, Novel Object RecognitionOnly short-term memory improvement
Daily 1-h stimulation for 4 weeks, 30 mins prior to behaviour testingMorris Water Maze, Novel Object RecognitionLong-lasting benefits to memory
Tan et al., 2019 [57]Single 15-min stimulation during consolidationFear ConditioningDisruption of memory
Forniceal areaSweet et al., 2010 [124]Traumatic Brain Injury (TBI) model (also non-TBI), stimulation 15 min before and during testingDelayed non-match-to-sample swim T-mazeNo significant difference in non-TBI animals
Hescham et al., 2013 [5]6 consecutive sessions with different parameters, 2 mins before and during behaviour testingObject Location Task
Specific memory benefits in certain parameters (did not consider cumulative effects)
Hao et al., 2015 [94]Rett syndrome mice, daily 1-h stimulation for 2 weeks, not stimulated during behaviour daysMorris Water Maze, Contextual FearRescue of impaired memory
Hescham et al., 2016 [43]Single 6-h stimulation, behaviour testing 30 days after stimulationMorris Water MazeImprovement in memory
Entorhinal cortexStone et al., 2011 [41]Single 30 to 120-min stimulation, behaviour testing 10 weeks afterMorris Water MazeImprovement in memory
Xia et al., 2017 [4]Alzheimer's mice model, single 1-h stimulation, behaviour testing 1,3,6 weeks post-stimulationMorris Water Maze, Contextual FearImprovement later at 3 & 6 weeks but not at 1 week
Anterior thalamusHamani et al., 2010 [96]Stimulation during behaviour testingContextual FearImpaired memory
Stimulation immediately after behaviour testing (unknown time)Contextual FearNo significant difference
Hamani et al., 2011 [40]Cortisone-treated rats, single 1-h stimulation, behaviour testing 4/28 days after stimulationNon-Matching-to-SampleRescue of impaired memory
Table 1  Non-exhaustive list of rodent studies looking at the effects of Deep Brain Stimulation on memory.
Figure 1.  Consolidated model on how DBS can disrupt and enhance memory. In this model, DBS is applied to the mPFC, a target previously shown to be ideal for both disruption and enhancement of memory. This results in downstream effects in the hippocampus, including effects on brainwaves, neurotransmitters, and possibly neurogenesis, leading to either disruption or enhancement of memory depending on how and when DBS is applied.
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