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Aging and disease    2020, Vol. 11 Issue (4) : 978-987     DOI: 10.14336/AD.2019.0910
Review |
Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus
Ma Wei-Xing1,2,3, Tang Jing3, Lei Zhi-Wen3, Li Chun-Yan1,4, Zhao Li-Qing3, Lin Chao3, Sun Tao3, Li Zheng-Yi3, Jiang Ying-Hui3, Jia Jun-Tao3, Liang Cheng-Zhu3, Liu Jun-Hong2, Yan Liang-Jun1,*
1Department of Pharmaceutical, University of North Texas Health Science Center, Fort Worth, Texas, USA
2Chemical Engineering Institute, Qingdao University of Science and Technology, Qingdao, Shandong, China
3Technological Center, Qingdao Customs, Qingdao, Shandong, China
4Shantou University Medical College, Shantou, Guangdong, China
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Abstract  

The goal of this review was to summarize current biochemical mechanisms of and risk factors for diabetic brain injury. We mainly summarized mechanisms published in the past three years and focused on diabetes induced cognitive impairment, diabetes-linked Alzheimer’s disease, and diabetic stroke. We think there is a need to conduct further studies with increased sample sizes and prolonged period of follow-ups to clarify the effect of DM on brain dysfunction. Additionally, we also think that enhancing experimental reproducibility using animal models in conjunction with application of advanced devices should be considered when new experiments are designed. It is expected that further investigation of the underlying mechanisms of diabetic cognitive impairment will provide novel insights into therapeutic approaches for ameliorating diabetes-associated injury in the brain.

Keywords diabetes      brain      cognitive impairment      Alzheimer’s disease      stroke     
Corresponding Authors: Yan Liang-Jun   
About author:

These authors contributed equally to this work.

Just Accepted Date: 23 September 2019   Issue Date: 30 July 2020
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Ma Wei-Xing
Tang Jing
Lei Zhi-Wen
Li Chun-Yan
Zhao Li-Qing
Lin Chao
Sun Tao
Li Zheng-Yi
Jiang Ying-Hui
Jia Jun-Tao
Liang Cheng-Zhu
Liu Jun-Hong
Yan Liang-Jun
Cite this article:   
Ma Wei-Xing,Tang Jing,Lei Zhi-Wen, et al. Potential Biochemical Mechanisms of Brain Injury in Diabetes Mellitus[J]. Aging and disease, 2020, 11(4): 978-987.
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http://www.aginganddisease.org/EN/10.14336/AD.2019.0910     OR
Figure 1.  Signaling pathways and risk factors that are potentially involved in development of cognitive impairment induced by diabetes.
Figure 2.  Signaling pathways and risk factors that are potentially involved in diabetic AD.
Figure 3.  Signaling pathways and risk factors potentially involved in diabetic stroke.
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