Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and disease
Orginal Article |
Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis
Wangxiao Bao, Yun Sun, Tianfang Zhang, Liliang Zou, Xiaohong Wu, Daming Wang, Zuobing Chen*
Department of Rehabilitation Medicine, First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, China
Download: PDF(1299 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    

Sarcopenia is an age-related condition that is characterized by progressive and generalized loss of muscle mass and function. Exercise treatment has been the most commonly used intervention among elderly populations. We performed a systematic review and meta-analysis to evaluate the available literature related to the effects of exercise interventions/programs on muscle mass, muscle strength and physical performance in older adults with sarcopenia. We searched PubMed, EMBASE, MEDLINE and the Web of Science for randomized controlled trials and controlled clinical trials exploring exercise in older adults with sarcopenia published through July 2019 without any language restrictions. Pooled analyses were conducted using Review Manager 5.3, with standardized mean differences (SMDs) and fixed-effect models. A total of 3898 titles and abstracts were initially identified, and 22 studies (1041 individuals, 80.75% females, mean age ranged from 60.51 to 85.90 years) were included in the meta-analysis. The exercise programs in the studies consisted of 30 to 80 min of training, with 1 to 5 training sessions weekly for 6 to 36 weeks. Muscle strength (grip strength [SMD 0.57, 95 % CI 0.42 to 0.73, P <0.00001] and timed five chair stands [SMD -0.56, 95 % CI -0.85 to -0.28, P < 0.0001]) and physical performance (gait speed [SMD 0.44, 95 % CI 0.26 to 0.61, P < 0.00001] and the timed up and go test [SMD -0.97, 95 % CI -1.22 to -0.72, P < 0.00001]) showed significant improvement following exercise treatment, while no differences in muscle mass (ASM [SMD 0.15, 95 % CI -0.05 to 0.36, P = 0.15] and ASM/height2 [SMD 0.21, 95 % CI -0.05 to 0.48, P = 0.12]) were detected. Exercise programs showed overall significant positive effects on muscle strength and physical performance but not on muscle mass in sarcopenic older adults.

Keywords Sarcopenia      exercise      elderly      meta-analysis      muscle      physical     
Corresponding Authors: Zuobing Chen   
About author:

These authors contributed equally to this work.

Just Accepted Date: 23 October 2019  
E-mail this article
E-mail Alert
Articles by authors
Wangxiao Bao
Yun Sun
Tianfang Zhang
Liliang Zou
Xiaohong Wu
Daming Wang
Zuobing Chen
Cite this article:   
Wangxiao Bao,Yun Sun,Tianfang Zhang, et al. Exercise Programs for Muscle Mass, Muscle Strength and Physical Performance in Older Adults with Sarcopenia: A Systematic Review and Meta-Analysis[J]. Aging and disease, 10.14336/AD.2019.1012
URL:     OR
RefsNAgeSex (F, %)BMIDiagnostic CriteriaPeriodWeekly (times)Intervention
[27]141668.47±2.780.00%23.37±1.91ASM/Height2 < 10.75 kg.m-28w310 min warm-up, 45 min resistance training.
[23]8884.30±5.3758.93%21.90±3.01AWGS12w25 min warm-up, 20 min resistance exercise program and 5 min cool down.
[26]403773.39±6.9275.32%18.85±2.04AWGS24w15-10 min warm up and cool down routine,
20-30 min chair-based resistance exercises using Thera-Bands, and 20-min aerobic exercises.
[33]353769.95±2.73100.00%24.80±0.91EWGSOP36w25 min warm-up, 20 min muscular districts with low weight loads
[18]333179.90±7.8050.00%25.00±3.39SMM/Weight < 37.15% for men and < 32.26% for women12w260-min warm-up, muscle resistance training
and relaxation stage.
[25]111781.75±6.9630.72%31.28±6.44SMM/Weight ≤ 0.93 for men and ≤ 0.57 for women12w35 min warm-up, 20-30 min resistance exercises with workload and 5 min cool down.
[34]361872.87±7.0287.30%22.72±2.45EWGSOP12w260 min comprehensive progressive group exercise
program or home therapeutic exercises
[17]171667.48±4.29100.00%N.A.AWGS8w260 min progressive resistance training
[36]332367.35±5.23100.00%28.05±3.77SMM/Weight < 27.6 %12w310 min warm up, 40 min elastic resistance exercises and 5 min cool down.
[22]252574.10±6.15100.00%27.30±1.74SMM/Weight < 25.1 %24w550-80 min of combined aerobic and resistance
[32]252167.32±5.20100.00%27.72±3.30EWGSOP12w35 min warm up, 35-40 min resistance training exercises and cool down routine.
[24]151568.83±3.3683.33%27.83±3.80SMM/Weight ≤ 32.5% for men and
≤25.7% for women
8w260 min progressive resistance load training using weight-training equipment at 60-70% of one repetition maximum.
[35]602075.75±5.4270.00%23.84±3.01ASM/Height2 < 8.87 kg.m-2 for men and 6.42 kg.m-2 for women12w3Whole-body vibration training with 14,400 vertical vibrations
[31]7860.51±2.40100.00%19.47±1.52EWGSOP6w260 min training program comprised five exercises (squats, front lunges, side lunges, calf raises, and toe raises).
[38]181769.20±4.94100.00%28.11±3.66SMM/Weight < 27.6 %12w310 min warm up, 40 min elastic resistance exercises and 5 min cool down.
[37]141472.00±4.05100.00%32.50±2.62Handgrip strength≤21 kg10w260 min progressive resistance exercise program
[21]353481.25±4.68100.00%25.20±2.63SMM/Height2 < 5.67 kg.m-212w260 min warm-up, weight/machine training, stationary bicycle aerobic exercise, and chair/standing exercise.
[29]202185.90±7.5064.44%29.09±4.52EWGSOP24w260 min progressive resistance and balance training.
[30]261468.96±5.7655.77%20.09±1.81AWGS24wvaryinghome exercise programs, combining walking with lower limb resistance exercises.
[28]191679.90±4.9227.69%24.92±3.55ASM/Height2 < 10.75 kg.m-2 for men and 6.75 kg.m-2 for women12w210 min warm up, 30 min resistance exercises using Thera-Bands, and 10 min cool-down.
[20]323268.60±5.54100.00%N.A.ASM/Height2 < 6.42 kg/m212w260 min of stretching, muscle strengthening,
balance and gait training.
[19]393978.85±2.84100.00%18.85±1.85ASM/Height2 < 6.42 kg/m212w25 min warm up, 30 min strengthening exercise, 20 min balance and gait training and 5 min cool down.
Table 1  Characteristics of the included studies.
Figure 1.  Flow diagram of studies search, selection and inclusion process.
Figure 2.  Effects of exercise programs on the muscle mass in older adults with sarcopenia. Forest plot of difference in mean change from baseline in ASM (A) and ASM/height2 (B) after the intervention. ASM, Appendicular skeletal muscle mass. CI confidence interval, IV, inverse variance, Std, standardized.
Figure 3.  Effects of exercise programs on the muscle strength in older adults with sarcopenia. Forest plot of difference in mean change from baseline in grip strength (A) and five chair stands time (B) after the intervention. CI confidence interval, IV, inverse variance, Std, standardized.
Figure 4.  Effects of different exercise programs on the grip strength in older adults with sarcopenia. Forest Forest plot of difference in mean change from baseline for grip strength in sarcopenic individuals after (A) resistance training, (B) weight training, (C) aerobic training. CI confidence interval, IV, inverse variance, Std, standardized.
Figure 5.  Effects of exercise programs on the physical performance in older adults with sarcopenia. Forest plot of difference in mean change from baseline in gait speed (A) and TUG test (B) after the intervention. CI confidence interval, IV, inverse variance, Std, standardized.
Figure 6.  Assessment of risk of bias based on the Cochrane risk-of-bias tool. (A) Risk of bias graph; (B) risk of bias summary.
[1] Anker SD, Morley JE, von Haehling S (2016). Welcome to the ICD-10 code for sarcopenia. J Cachexia Sarcopenia Muscle, 7:512-514.
[2] Cruz-Jentoft AJ, Baeyens JP, Bauer JM, Boirie Y, Cederholm T, Landi F, et al. (2010). Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People. Age Ageing, 39:412-423.
[3] Chen LK, Liu LK, Woo J, Assantachai P, Auyeung TW, Bahyah KS, et al. (2014). Sarcopenia in Asia: consensus report of the Asian Working Group for Sarcopenia. J Am Med Dir Assoc, 15:95-101.
[4] Fielding RA, Vellas B, Evans WJ, Bhasin S, Morley JE, Newman AB, et al. (2011). Sarcopenia: an undiagnosed condition in older adults. Current consensus definition: prevalence, etiology, and consequences. International working group on sarcopenia. J Am Med Dir Assoc, 12:249-256.
[5] Cruz-Jentoft AJ, Sayer AA (2019). Sarcopenia. Lancet, 393:2636-2646.
[6] Hida T, Harada A, Imagama S, Ishiguro N (2014). Managing sarcopenia and its related-fractures to improve quality of life in geriatric populations. Aging Dis, 5:226-237.
[7] Cruz-Jentoft AJ, Bahat G, Bauer J, Boirie Y, Bruyere O, Cederholm T, et al. (2019). Sarcopenia: revised European consensus on definition and diagnosis. Age Ageing, 48:16-31.
[8] Kim KM, Jang HC, Lim S (2016). Differences among skeletal muscle mass indices derived from height-, weight-, and body mass index-adjusted models in assessing sarcopenia. Korean J Intern Med, 31:643-650.
[9] Leong DP, Teo KK, Rangarajan S, Lopez-Jaramillo P, Avezum A, Jr., Orlandini A, et al. (2015). Prognostic value of grip strength: findings from the Prospective Urban Rural Epidemiology (PURE) study. Lancet, 386:266-273.
[10] Syddall HE, Westbury LD, Dodds R, Dennison E, Cooper C, Sayer AA (2017). Mortality in the Hertfordshire Ageing Study: association with level and loss of hand grip strength in later life. Age Ageing, 46:407-412.
[11] Heymsfield SB, Gonzalez MC, Lu J, Jia G, Zheng J (2015). Skeletal muscle mass and quality: evolution of modern measurement concepts in the context of sarcopenia. Proc Nutr Soc, 74:355-366.
[12] Jung HW, Jang IY, Lee CK, Yu SS, Hwang JK, Jeon C, et al. (2018). Usual gait speed is associated with frailty status, institutionalization, and mortality in community-dwelling rural older adults: a longitudinal analysis of the Aging Study of Pyeongchang Rural Area. Clin Interv Aging, 13:1079-1089.
[13] Liao Y, Peng Z, Chen L, Zhang Y, Cheng Q, Nussler AK, et al. (2019). Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia. Aging Dis, 10:157-173.
[14] Akune T, Muraki S, Oka H, Tanaka S, Kawaguchi H, Nakamura K, et al. (2014). Exercise habits during middle age are associated with lower prevalence of sarcopenia: the ROAD study. Osteoporos Int, 25:1081-1088.
[15] Cruz-Jentoft AJ, Landi F, Schneider SM, Zuniga C, Arai H, Boirie Y, et al. (2014). Prevalence of and interventions for sarcopenia in ageing adults: a systematic review. Report of the International Sarcopenia Initiative (EWGSOP and IWGS). Age Ageing, 43:748-759.
[16] Moher D, Liberati A, Tetzlaff J, Altman DG, Group P (2009). Preferred reporting items for systematic reviews and meta-analyses: the PRISMA statement. J Clin Epidemiol, 62:1006-1012.
[17] Chen HT, Wu HJ, Chen YJ, Ho SY, Chung YC (2018). Effects of 8-week kettlebell training on body composition, muscle strength, pulmonary function, and chronic low-grade inflammation in elderly women with sarcopenia. Exp Gerontol, 112:112-118.
[18] Chiu SC, Yang RS, Yang RJ, Chang SF (2018). Effects of resistance training on body composition and functional capacity among sarcopenic obese residents in long-term care facilities: a preliminary study. BMC Geriatr, 18:21.
[19] Kim HK, Suzuki T, Saito K, Yoshida H, Kobayashi H, Kato H, et al. (2012). Effects of exercise and amino acid supplementation on body composition and physical function in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial. J Am Geriatr Soc, 60:16-23.
[20] Kim H, Suzuki T, Saito K, Yoshida H, Kojima N, Kim M, et al. (2013). Effects of exercise and tea catechins on muscle mass, strength and walking ability in community-dwelling elderly Japanese sarcopenic women: a randomized controlled trial. Geriatr Gerontol Int, 13:458-465.
[21] Kim H, Kim M, Kojima N, Fujino K, Hosoi E, Kobayashi H, et al. (2016). Exercise and Nutritional Supplementation on Community-Dwelling Elderly Japanese Women With Sarcopenic Obesity: A Randomized Controlled Trial. J Am Med Dir Assoc, 17:1011-1019.
[22] Park J, Kwon Y, Park H (2017). Effects of 24-Week Aerobic and Resistance Training on Carotid Artery Intima-Media Thickness and Flow Velocity in Elderly Women with Sarcopenic Obesity. J Atheroscler Thromb, 24:1117-1124.
[23] Yamada M, Kimura Y, Ishiyama D, Nishio N, Otobe Y, Tanaka T, et al. (2019). Synergistic effect of bodyweight resistance exercise and protein supplementation on skeletal muscle in sarcopenic or dynapenic older adults. Geriatr Gerontol Int.
[24] Chen HT, Chung YC, Chen YJ, Ho SY, Wu HJ (2017). Effects of Different Types of Exercise on Body Composition, Muscle Strength, and IGF-1 in the Elderly with Sarcopenic Obesity. J Am Geriatr Soc, 65:827-832.
[25] Cebria IIMA, Balasch-Bernat M, Tortosa-Chulia MA, Balasch-Parisi S (2018). Effects of Resistance Training of Peripheral Muscles Versus Respiratory Muscles in Older Adults With Sarcopenia Who are Institutionalized: A Randomized Controlled Trial. J Aging Phys Act, 26:637-646.
[26] Zhu LY, Chan R, Kwok T, Cheng KC, Ha A, Woo J (2018). Effects of exercise and nutrition supplementation in community-dwelling older Chinese people with sarcopenia: a randomized controlled trial. Age Ageing.
[27] Mafi F, Biglari S, Ghardashi Afousi A, Gaeini AA (2019). Improvement in Skeletal Muscle Strength and Plasma Levels of Follistatin and Myostatin Induced by an 8-Week Resistance Training and Epicatechin Supplementation in Sarcopenic Older Adults. J Aging Phys Act:1-8.
[28] Shahar S, Kamaruddin NS, Badrasawi M, Sakian NI, Abd Manaf Z, Yassin Z, et al. (2013). Effectiveness of exercise and protein supplementation intervention on body composition, functional fitness, and oxidative stress among elderly Malays with sarcopenia. Clin Interv Aging, 8:1365-1375.
[29] Hassan BH, Hewitt J, Keogh JW, Bermeo S, Duque G, Henwood TR (2016). Impact of resistance training on sarcopenia in nursing care facilities: A pilot study. Geriatr Nurs, 37:116-121.
[30] Maruya K, Asakawa Y, Ishibashi H, Fujita H, Arai T, Yamaguchi H (2016). Effect of a simple and adherent home exercise program on the physical function of community dwelling adults sixty years of age and older with pre-sarcopenia or sarcopenia. J Phys Ther Sci, 28:3183-3188.
[31] Hamaguchi K, Kurihara T, Fujimoto M, Iemitsu M, Sato K, Hamaoka T, et al. (2017). The effects of low-repetition and light-load power training on bone mineral density in postmenopausal women with sarcopenia: a pilot study. BMC Geriatr, 17:102.
[32] Liao CD, Tsauo JY, Lin LF, Huang SW, Ku JW, Chou LC, et al. (2017). Effects of elastic resistance exercise on body composition and physical capacity in older women with sarcopenic obesity: A CONSORT-compliant prospective randomized controlled trial. Medicine (Baltimore), 96:e7115.
[33] Piastra G, Perasso L, Lucarini S, Monacelli F, Bisio A, Ferrando V, et al. (2018). Effects of Two Types of 9-Month Adapted Physical Activity Program on Muscle Mass, Muscle Strength, and Balance in Moderate Sarcopenic Older Women. Biomed Res Int, 2018:5095673.
[34] Tsekoura M, Billis E, Tsepis E, Dimitriadis Z, Matzaroglou C, Tyllianakis M, et al. (2018). The Effects of Group and Home-Based Exercise Programs in Elderly with Sarcopenia: A Randomized Controlled Trial. J Clin Med, 7.
[35] Wei N, Pang MY, Ng SS, Ng GY (2017). Optimal frequency/time combination of whole body vibration training for developing physical performance of people with sarcopenia: a randomized controlled trial. Clin Rehabil, 31:1313-1321.
[36] Liao CD, Tsauo JY, Huang SW, Ku JW, Hsiao DJ, Liou TH (2018). Effects of elastic band exercise on lean mass and physical capacity in older women with sarcopenic obesity: A randomized controlled trial. Sci Rep, 8:2317.
[37] Vasconcelos KS, Dias JM, Araujo MC, Pinheiro AC, Moreira BS, Dias RC (2016). Effects of a progressive resistance exercise program with high-speed component on the physical function of older women with sarcopenic obesity: a randomized controlled trial. Braz J Phys Ther, 20:432-440.
[38] Huang SW, Ku JW, Lin LF, Liao CD, Chou LC, Liou TH (2017). Body composition influenced by progressive elastic band resistance exercise of sarcopenic obesity elderly women: a pilot randomized controlled trial. Eur J Phys Rehabil Med, 53:556-563.
[39] Vlietstra L, Hendrickx W, Waters DL (2018). Exercise interventions in healthy older adults with sarcopenia: A systematic review and meta-analysis. Australas J Ageing, 37:169-183.
[40] Denison HJ, Cooper C, Sayer AA, Robinson SM (2015). Prevention and optimal management of sarcopenia: a review of combined exercise and nutrition interventions to improve muscle outcomes in older people. Clin Interv Aging, 10:859-869.
[41] Landi F, Marzetti E, Martone AM, Bernabei R, Onder G (2014). Exercise as a remedy for sarcopenia. Curr Opin Clin Nutr Metab Care, 17:25-31.
[42] Kemmler W, von Stengel S, Engelke K, Haberle L, Mayhew JL, Kalender WA (2010). Exercise, body composition, and functional ability: a randomized controlled trial. Am J Prev Med, 38:279-287.
[43] Villareal DT, Aguirre L, Gurney AB, Waters DL, Sinacore DR, Colombo E, et al. (2017). Aerobic or Resistance Exercise, or Both, in Dieting Obese Older Adults. N Engl J Med, 376:1943-1955.
[44] Ashworth NL, Chad KE, Harrison EL, Reeder BA, Marshall SC (2005). Home versus center based physical activity programs in older adults. Cochrane Database Syst Rev:CD004017.
[45] Borde R, Hortobagyi T, Granacher U (2015). Dose-Response Relationships of Resistance Training in Healthy Old Adults: A Systematic Review and Meta-Analysis. Sports Med, 45:1693-1720.
[46] Ferrari R, Fuchs SC, Kruel LF, Cadore EL, Alberton CL, Pinto RS, et al. (2016). Effects of Different Concurrent Resistance and Aerobic Training Frequencies on Muscle Power and Muscle Quality in Trained Elderly Men: A Randomized Clinical Trial. Aging Dis, 7:697-704.
[47] Sbardelotto ML, Pedroso GS, Pereira FT, Soratto HR, Brescianini SM, Effting PS, et al. (2017). The Effects of Physical Training are Varied and Occur in an Exercise Type-Dependent Manner in Elderly Men. Aging Dis, 8:887-898.
[48] Hita-Contreras F, Bueno-Notivol J, Martinez-Amat A, Cruz-Diaz D, Hernandez AV, Perez-Lopez FR (2018). Effect of exercise alone or combined with dietary supplements on anthropometric and physical performance measures in community-dwelling elderly people with sarcopenic obesity: A meta-analysis of randomized controlled trials. Maturitas, 116:24-35.
[1] Supplementary data Download
[1] Artur Anisiewicz, Beata Filip-Psurska, Agata Pawlik, Anna Nasulewicz-Goldeman, Tomasz Piasecki, Konrad Kowalski, Magdalena Maciejewska, Joanna Jarosz, Joanna Banach, Diana Papiernik, Andrzej Mazur, Andrzej Kutner, Jeanette A Maier, Joanna Wietrzyk. Calcitriol Analogues Decrease Lung Metastasis but Impair Bone Metabolism in Aged Ovariectomized Mice Bearing 4T1 Mammary Gland Tumours[J]. Aging and disease, 2019, 10(5): 977-991.
[2] Tatiana Rafaela Lemos Lima, Vívian Pinto Almeida, Arthur Sá Ferreira, Fernando Silva Guimarães, Agnaldo José Lopes. Handgrip Strength and Pulmonary Disease in the Elderly: What is the Link?[J]. Aging and disease, 2019, 10(5): 1109-1129.
[3] Raquel Maeso-Díaz, Martí Ortega-Ribera, Erica Lafoz, Juan José Lozano, Anna Baiges, Rubén Francés, Agustín Albillos, Carmen Peralta, Juan Carlos García-Pagán, Jaime Bosch, Victoria C Cogger, Jordi Gracia-Sancho. Aging Influences Hepatic Microvascular Biology and Liver Fibrosis in Advanced Chronic Liver Disease[J]. Aging and disease, 2019, 10(4): 684-698.
[4] Marcela Z. Campanini, Arthur E. Mesas, Jose Antonio Carnicero-Carreño, Fernando Rodríguez-Artalejo, Esther Lopez-Garcia. Duration and Quality of Sleep and Risk of Physical Function Impairment and Disability in Older Adults: Results from the ENRICA and ELSA Cohorts[J]. Aging and disease, 2019, 10(3): 557-569.
[5] Yaiza Potes, Zulema Pérez-Martinez, Juan C. Bermejo-Millo, Adrian Rubio-Gonzalez, María Fernandez-Fernández, Manuel Bermudez, Jose M. Arche, Juan J. Solano, Jose A. Boga, Mamen Oliván, Beatriz Caballero, Ignacio Vega-Naredo, Ana Coto-Montes. Overweight in the Elderly Induces a Switch in Energy Metabolism that Undermines Muscle Integrity[J]. Aging and disease, 2019, 10(2): 217-230.
[6] Yuxiao Liao,Zhao Peng,Liangkai Chen,Yan Zhang,Qian Cheng,Andreas K. Nüssler,Wei Bao,Liegang Liu,Wei Yang. Prospective Views for Whey Protein and/or Resistance Training Against Age-related Sarcopenia[J]. Aging and disease, 2019, 10(1): 157-173.
[7] Michael G. Flynn,Melissa M. Markofski,Andres E. Carrillo. Elevated Inflammatory Status and Increased Risk of Chronic Disease in Chronological Aging: Inflamm-aging or Inflamm-inactivity?[J]. Aging and disease, 2019, 10(1): 147-156.
[8] Manuel Scimeca, Federica Centofanti, Monica Celi, Elena Gasbarra, Giuseppe Novelli, Annalisa Botta, Umberto Tarantino. Vitamin D Receptor in Muscle Atrophy of Elderly Patients: A Key Element of Osteoporosis-Sarcopenia Connection[J]. Aging and disease, 2018, 9(6): 952-964.
[9] Vinicius Alota Ignacio Pereira, Fabio Augusto Barbieri, Alessandro Moura Zagatto, Paulo Cezar Rocha dos Santos, Lucas Simieli, Ricardo Augusto Barbieri, Felipe Pivetta Carpes, Lilian Teresa Bucken Gobbi. Muscle Fatigue Does Not Change the Effects on Lower Limbs Strength Caused by Aging and Parkinson’s Disease[J]. Aging and disease, 2018, 9(6): 988-998.
[10] Ashok K. Shetty, Maheedhar Kodali, Raghavendra Upadhya, Leelavathi N. Madhu. Emerging Anti-Aging Strategies - Scientific Basis and Efficacy[J]. Aging and disease, 2018, 9(6): 1165-1184.
[11] Patricia Sosa, Elena Alcalde-Estevez, Patricia Plaza, Nuria Troyano, Cristina Alonso, Laura Martinez-Arias, Andresa Evelem de Melo Aroeira, Diego Rodriguez-Puyol, Gemma Olmos, Susana Lopez-Ongil, Maria P. Ruiz-Torres. Hyperphosphatemia Promotes Senescence of Myoblasts by Impairing Autophagy Through Ilk Overexpression, A Possible Mechanism Involved in Sarcopenia[J]. Aging and disease, 2018, 9(5): 769-784.
[12] Binquan You, Bingbing Zhu, Xi Su, Feng Liu, Bingyin Wang. Gender Differences among Elderly Patients with Primary Percutaneous Coronary Intervention[J]. Aging and disease, 2018, 9(5): 852-860.
[13] da Rocha Erica Pires, Yokota Lais Gabriela, Sampaio Beatriz Motta, Cardoso Eid Karina Zanchetta, Dias Dayana Bitencourt, de Freitas Fernanda Moreira, Balbi Andre Luis, Ponce Daniela. Urinary Neutrophil Gelatinase-Associated Lipocalin Is Excellent Predictor of Acute Kidney Injury in Septic Elderly Patients[J]. Aging and disease, 2018, 9(2): 182-191.
[14] Li Xin, Zhou Xuan, Liu Howe, Chen Nan, Liang Juping, Yang Xiaoyan, Zhao Guoyun, Song Yanping, Du Qing. Effects of Elastic Therapeutic Taping on Knee Osteoarthritis: A Systematic Review and Meta-analysis[J]. Aging and disease, 2018, 9(2): 296-308.
[15] Welch Carly, K. Hassan-Smith Zaki, A. Greig Carolyn, M. Lord Janet, A. Jackson Thomas. Acute Sarcopenia Secondary to Hospitalisation - An Emerging Condition Affecting Older Adults[J]. Aging and disease, 2018, 9(1): 151-164.
Full text



Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail:
Powered by Beijing Magtech Co. Ltd