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Aging and disease    2020, Vol. 11 Issue (3) : 477-479     DOI: 10.14336/AD.2020.0403
Commentary |
Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?
Öztürk Selçuk, Elçin Ayşe Eser, Elçin Yaşar Murat*
Tissue Engineering, Biomaterials and Nanobiotechnology Laboratory, Faculty of Science, Ankara University, Ankara, Turkey
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Mesenchymal stem cells (MSCs) bear a promising potential for regenerative medicine therapies and they repair damaged tissue through secretion of immune modulatory and anti-inflammatory molecules acting in a paracrine fashion. Coronavirus disease 2019 (COVID-19) has spread all over the world with high morbidity and mortality rates and there is no specific treatment for this infection. A recent study published in the journal reports that MSC infusion is safe and effective in patients suffering from COVID-19 induced pneumonia. In the light of this study and previous reports, we make additional comments about possible therapeutic effects of MSCs in COVID-19 infection.

Keywords COVID-19      mesenchymal stem cells      cell transplantation      pneumonia      immunomodulation     
Corresponding Authors: Elçin Yaşar Murat   
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These authors shared first-authorship.

Just Accepted Date: 03 April 2020   Issue Date: 13 May 2020
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Öztürk Selçuk
Elçin Ayşe Eser
Elçin Yaşar Murat
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Öztürk Selçuk,Elçin Ayşe Eser,Elçin Yaşar Murat. Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?[J]. Aging and disease, 2020, 11(3): 477-479.
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IdentifierPhaseStatusLocationCell typeEstimated enrollmentPrimary outcome measure
NCT042521181RecruitingChinaMSC20- Size of lesion area by chest radiograph or CT
- Side effects in MSC treatment group
NCT042769871Not yet recruitingChinaMSC-derived exosomes30- Adverse and severe adverse reaction
- Time to clinical improvement
NCT042991522Not yet recruitingN/ASCE-treated MNC20- Number of patients unable to complete SCE therapy
NCT04273646N/ANot yet recruitingChinaUC-MSC48- Pneumonia severity index
- Oxygenation index
NCT042881021-2RecruitingChinaMSC90- Size of lesion area and severity of pulmonary fibrosis by CT
NCT043025191Not yet recruitingN/ADental pulp MSC24- Disappear time of ground-glass shadow in the lungs
NCT043133221RecruitingJordanWJ-MSC5- Clinical outcome
- CT scan - RT-PCR results
NCT04293692N/AWithdrawnChinaUC-MSCN/A- Size of lesion area by chest imaging
- Blood oxygen saturation
NCT042695252RecruitingChinaUC-MSC10- Oxygenation index
Table 1  Clinical trials recorded in database about stem cells and COVID-19 infection by 27th of March 2020.
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