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Aging and disease    2020, Vol. 11 Issue (4) : 737-741     DOI: 10.14336/AD.2020.0518
Commentary |
COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?
Hipkiss Alan R*
Aston Research Centre for Healthy Ageing (ARCHA), Aston University, Birmingham, B4 7ET, UK
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Abstract  

It is suggested that the non-toxic dipeptide carnosine (beta-alanyl-L-histidine) should be examined as a potential protective agent against COVID-19 infection and inflammatory consequences especially in the elderly. Carnosine is an effective anti-inflammatory agent which can also inhibit CD26 and ACE2 activity. It is also suggested that nasal administration would direct the peptide directly to the lungs and escape the attention of serum carnosinase.

Keywords carnosine      acetyl-carnosine      inflammation      virus      olfaction      lungs      aging     
Corresponding Authors: Hipkiss Alan R   
About author:

These authors contributed equally to this work.

Just Accepted Date: 20 May 2020   Issue Date: 30 July 2020
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Hipkiss Alan R. COVID-19 and Senotherapeutics: Any Role for the Naturally-occurring Dipeptide Carnosine?[J]. Aging and disease, 2020, 11(4): 737-741.
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