Please wait a minute...
 Home  About the Journal Editorial Board Aims & Scope Peer Review Policy Subscription Contact us
 
Early Edition  //  Current Issue  //  Open Special Issues  //  Archives  //  Most Read  //  Most Downloaded  //  Most Cited
Aging and disease    2020, Vol. 11 Issue (4) : 742-745     DOI: 10.14336/AD.2020.0619
Commentary |
Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities
Schwartz Michael D1,*, Emerson Stephen G2, Punt Jennifer3, Goff Willow D4
1Morsani College of Medicine, University of South Florida, Tampa, Florida, USA
2Immunology and Medicine, Columbia University, New York, NY 10027, USA
3Immunology, Pathobiology, University of Pennsylvania School of Veterinary Medicine, PA 19104, USA
4Colgate University, Hamilton, NY 13346, USA
Download: PDF(247 KB)   HTML
Export: BibTeX | EndNote | Reference Manager | ProCite | RefWorks    
Abstract  

Aging, type 2 diabetes, and male gender are major risk factors leading to increased COVID-19 morbidity and mortality. Thymic production and the export of naïve T cells decrease with aging through the effects of androgens in males and in type 2 diabetes. Furthermore, with aging, recovery of naïve T-cell populations after bone marrow transplantation is delayed and associated with an increased risk of chronic graft vs. host disease. Severe COVID-19 and SARS infections are notable for severe T-cell depletion. In COVID-19, there is unique suppression of interferon signaling by infected respiratory tract cells with intact cytokine signaling. A decreased naïve T-cell response likely contributes to an excessive inflammatory response and increases the odds of a cytokine storm. Treatments that improve naïve T-cell production may prove to be vital COVID-19 therapies, especially for these high-risk groups.

Keywords COVID-19      SARS-CoV-2      naïve T cells      type 2 diabetes      cytokine storm     
Corresponding Authors: Schwartz Michael D   
About author:

These authors contributed equally to this work.

Just Accepted Date: 23 June 2020   Issue Date: 30 July 2020
Service
E-mail this article
E-mail Alert
RSS
Articles by authors
Schwartz Michael D
Emerson Stephen G
Punt Jennifer
Goff Willow D
Cite this article:   
Schwartz Michael D,Emerson Stephen G,Punt Jennifer, et al. Decreased Naïve T-cell Production Leading to Cytokine Storm as Cause of Increased COVID-19 Severity with Comorbidities[J]. Aging and disease, 2020, 11(4): 742-745.
URL:  
http://www.aginganddisease.org/EN/10.14336/AD.2020.0619     OR
[1] Fulzele S, Sahay B, Yusufu I, Lee T, Sharma A, Kolhe R, et al. (2020). COVID-19 virulence in aged patients might be impacted by the host cellular microRNAs abundance/profile. Aging dis, 11;509-522.
[2] Diao B, Wang C, Tan Y, Chen X, Liu Y, Ning L, et al. (2020). Reduction and functional exhaustion of T cells in patients with coronavirus disease 2019 (COVID-19). Front Immunol, 11:827.
[3] Montecino-Rodriguez E, Berent-Maoz B, Dorshkind K (2013). Causes, consequences, and reversal of immune system aging. J Clin Invest, 123:958-65.
[4] Palmer DB (2013). The effect of age on thymic function. Front Immunol, 4:316.
[5] Ringhoffer S, Rojewski M, Döhner H, Bunjes D, Ringhoffer M (2013). T-cell reconstitution after allogeneic stem cell transplantation: assessment by measurement of the sjTREC/βTREC ratio and thymic naive T cells. Haematol Hematol J, 98:1600-8.
[6] Roux E, Dumont-Girard F, Starobinski M, Siegrist CA, Helg C, Chapuis B, et al. (2000) Recovery of immune reactivity after T-cell-depleted bone marrow transplantation depends on thymic activity. Blood, 96:2299-303.
[7] Soares MV, Azevedo RI, Ferreira IA, Bucar S, Ribeiro AC, Vieira A, et al. (2019). Naive and stem cell memory T cell subset recovery reveals opposing reconstitution patterns in CD4 and CD8 T cells in chronic graft vs. host disease. Front Immunol, 10:334.
[8] Pido-Lopez J, Imami N, Aspinall R (2001). Both age and gender affect thymic output: more recent thymic migrants in females than males as they age. Clin Exp Immunol, 125:409-13.
[9] Dworacki G, Urazayev O, Bekmukhambetov Y, Iskakova S, Frycz BA, Jagodziński PP, et al. (2015). Thymic emigration patterns in patients with type 2 diabetes treated with metformin. Immunology, 146:456-69.
[10] Zhu L, She ZG, Cheng X, Qin JJ, Zhang XJ, Cai J, et al. (2020). Association of blood glucose control and outcomes in patients with COVID-19 and pre-existing type 2 diabetes. Cell Metab, In press.
[11] Blanco-Melo D, Nilsson-Payant BE, Liu WC, Uhl S, Hoagland D, Møller R, et al. (2020). Imbalanced host response to SARS-CoV-2 drives development of COVID-19. Cell, In press.
[12] Zhou Q, Chen V, Shannon CP, Wei X, Xiang X, Wang X, et al. (2020). Interferon-α2b Treatment for COVID-19. Front Immunol, 11:1061.
[13] Hung IF, Lung KC, Tso EY, Liu R, Chung TW, Chu MY, et al. (2020). Triple combination of interferon beta-1b, lopinavir-ritonavir, and ribavirin in the treatment of patients admitted to hospital with COVID-19: an open-label, randomised, phase 2 trial. Lancet, In press.
[14] Montopoli M, Zumerle S, Vettor R, Rugge M, Zorzi M, Catapano CV, et al. (2020). Androgen-deprivation therapies for prostate cancer and risk of infection by SARS-CoV-2: a population-based study (n=4532). Ann Oncol, In press.
[15] Miguel-Angel P, Jenna DG, Jianda Y, Guenther K, Lauren L (2012). Recombinant human interleukin-7 (CYT107) promotes T-cell recovery after allogeneic stem cell transplantation. (2012). Blood, 120:4882-4891.
[16] Heng TS, Goldberg GL, Gray DH, Sutherland JS, Chidgey AP, Boyd RL (2005). Effects of castration on thymocyte development in two different models of thymic involution. J Immunol, 175:2982-93.
[17] Goldberg GL, King CG, Nejat RA, Suh DY, Smith OM, Bretz JC, et al. (2009). Luteinizing hormone-releasing hormone enhances T cell recovery following allogeneic bone marrow transplantation. J Immunol, 182:5846-54.
[1] Barzilai Nir,Appleby James C,Austad Steven N,Cuervo Ana Maria,Kaeberlein Matt,Gonzalez-Billault Christian,Lederman Stephanie,Stambler Ilia,Sierra Felipe. Geroscience in the Age of COVID-19[J]. Aging and disease, 2020, 11(4): 725-729.
[2] Pietro Gentile, Aris Sterodimas. Adipose Stem Cells (ASCs) and Stromal Vascular Fraction (SVF) as a Potential Therapy in Combating (COVID-19)-Disease[J]. Aging and disease, 2020, 11(3): 465-469.
[3] Hong Liu, Shiyan Chen, Min Liu, Hao Nie, Hongyun Lu. Comorbid Chronic Diseases are Strongly Correlated with Disease Severity among COVID-19 Patients: A Systematic Review and Meta-Analysis[J]. Aging and disease, 2020, 11(3): 668-678.
[4] Selçuk Öztürk, Ayşe Eser Elçin, Yaşar Murat Elçin. Mesenchymal Stem Cells for Coronavirus (COVID-19)-Induced Pneumonia: Revisiting the Paracrine Hypothesis with New Hopes?[J]. Aging and disease, 2020, 11(3): 477-479.
[5] Sankha Shubhra Chakrabarti, Upinder Kaur, Anindita Banerjee, Upasana Ganguly, Tuhina Banerjee, Sarama Saha, Gaurav Parashar, Suvarna Prasad, Suddhachitta Chakrabarti, Amit Mittal, Bimal Kumar Agrawal, Ravindra Kumar Rawal, Robert Chunhua Zhao, Indrajeet Singh Gambhir, Rahul Khanna, Ashok K Shetty, Kunlin Jin, Sasanka Chakrabarti. COVID-19 in India: Are Biological and Environmental Factors Helping to Stem the Incidence and Severity?[J]. Aging and disease, 2020, 11(3): 480-488.
[6] Xiaotian Dong, Mengyan Wang, Shuangchun Liu, Jiaqi Zhu, Yanping Xu, Hongcui Cao, Lanjuan Li. Immune Characteristics of Patients with Coronavirus Disease 2019 (COVID-19)[J]. Aging and disease, 2020, 11(3): 642-648.
[7] Zikuan Leng, Rongjia Zhu, Wei Hou, Yingmei Feng, Yanlei Yang, Qin Han, Guangliang Shan, Fanyan Meng, Dongshu Du, Shihua Wang, Junfen Fan, Wenjing Wang, Luchan Deng, Hongbo Shi, Hongjun Li, Zhongjie Hu, Fengchun Zhang, Jinming Gao, Hongjian Liu, Xiaoxia Li, Yangyang Zhao, Kan Yin, Xijing He, Zhengchao Gao, Yibin Wang, Bo Yang, Ronghua Jin, Ilia Stambler, Lee Wei Lim, Huanxing Su, Alexey Moskalev, Antonio Cano, Sasanka Chakrabarti, Kyung-Jin Min, Georgina Ellison-Hughes, Calogero Caruso, Kunlin Jin, Robert Chunhua Zhao. Transplantation of ACE2- Mesenchymal Stem Cells Improves the Outcome of Patients with COVID-19 Pneumonia[J]. Aging and disease, 2020, 11(2): 216-228.
[8] Le Gao, Shuqing Yu, Andrea Cipriani, Shanshan Wu, Yi Huang, Zilu Zhang, Jun Yang, Yixin Sun, Zhirong Yang, Sanbao Chai, Yuan Zhang, Linong Ji, Siyan Zhan, Feng Sun. Neurological Manifestation of Incretin-Based Therapies in Patients with Type 2 Diabetes: A Systematic Review and Network Meta-Analysis[J]. Aging and disease, 2019, 10(6): 1311-1319.
[9] Fei Han, Xiaochen Li, Juhong Yang, Haiyi Liu, Yi Zhang, Xiaoyun Yang, Shaohua Yang, Bai Chang, Liming Chen, Baocheng Chang. Salsalate Prevents β-Cell Dedifferentiation in OLETF Rats with Type 2 Diabetes through Notch1 Pathway[J]. Aging and disease, 2019, 10(4): 719-730.
[10] Zhen Jie, Lin Tong, Huang Xiaochen, Zhang Huiqiang, Dong Shengqi, Wu Yifan, Song Linlin, Xiao Rong, Yuan Linhong. Association of ApoE Genetic Polymorphism and Type 2 Diabetes with Cognition in Non-Demented Aging Chinese Adults: A Community Based Cross-Sectional Study[J]. Aging and disease, 2018, 9(3): 346-357.
Viewed
Full text


Abstract

Cited

  Shared   
Copyright © 2014 Aging and Disease, All Rights Reserved.
Address: Aging and Disease Editorial Office 3400 Camp Bowie Boulevard Fort Worth, TX76106 USA
Fax: (817) 735-0408 E-mail: editorial@aginganddisease.org
Powered by Beijing Magtech Co. Ltd