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Aging and disease    2021, Vol. 12 Issue (5) : 1323-1336     DOI: 10.14336/AD.2020.1229
Review Article |
The Role of SGLT2 Inhibitors in Vascular Aging
Le Liu1,2, Yu-Qing Ni1,2, Jun-Kun Zhan1,2,*, You-Shuo Liu1,2,*
1Department of Geriatrics, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China.
2Institute of Aging and Age-related Disease Research, Central South University, Changsha, Hunan 410011, China.
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Abstract  

Vascular aging is defined as organic and functional changes in blood vessels, in which decline in autophagy levels, DNA damage, MicroRNA (miRNA), oxidative stress, sirtuin, and apoptosis signal-regulated kinase 1 (ASK1) are integral thereto. With regard to vascular morphology, the increase in arterial stiffness, atherosclerosis, vascular calcification and high amyloid beta levels are closely related to vascular aging. Further closely related thereto, at the cellular level, is the aging of vascular endothelial cells (ECs) and vascular smooth muscle cells (VSMCs). Vascular aging seriously affects the health, economy and life of patients, but can be delayed by SGLT2 inhibitors through the improvement of vascular function. In the present article, a review is conducted of recent domestic and international progress in research on SGLT2 inhibitors,vascular aging and diseases related thereto, thereby providing theoretical support and guidance for further revealing the relationship between SGLT2 inhibitors and diseases related to vascular aging.

Keywords vascular aging      sodium-dependent glucose transporters 2 inhibitor      arterial stiffness      endothelial cells      vascular smooth muscle cells     
Corresponding Authors: Zhan Jun-Kun,Liu You-Shuo   
About author:

These authors equally contributed this work.

Just Accepted Date: 05 January 2021   Issue Date: 01 August 2021
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Liu Le
Ni Yu-Qing
Zhan Jun-Kun
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Cite this article:   
Liu Le,Ni Yu-Qing,Zhan Jun-Kun, et al. The Role of SGLT2 Inhibitors in Vascular Aging[J]. Aging and disease, 2021, 12(5): 1323-1336.
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http://www.aginganddisease.org/EN/10.14336/AD.2020.1229     OR
CanagliflozinDapagliflozinEmpagliflozin
Specification100mg;300mg5mg;10mg10mg;25mg
Dosage100mg daily, 300mg max5mg daily, 10mg max10mg daily, 25mg max
Half-life100mg: 10.6 h, 300mg: 13.1 h12.9h12.4h
Time to reach peak plasma concentration1h-2h2h1.5h
Oral bioavailability65%78%70-90%
Protein binding99%91%86.2%
MetabolismUGT1A9, UGT2B4, CYP3A4UGT1A9,
CYP
UGT2B7, UGT1A3, UGT1A8, UGT1A9
Excretion51.7% feces, 33% urine75% urine, 21% feces54.4% urine, 41.2% feces
Molecular formulaC24H25FO5S1/2H2OC21H25CIO6·C3H8O2·H2OC23H27ClO7
Volume of distribution83.5L118L73.8L
Table 1  Three common SGLT2 inhibitors
Figure 1.  The mechanism of vascular aging.
Figure 2.  The effect of SGLT2 inhibitor on vascular aging.
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